curriculum vitae

名前　　　山崎光章（やまざきみつあき）

生年月日　1957年2月17日生まれ

職歴

　
• 1982年 5月　　　　富山医科薬科大学附属病院医員（研修医）
　
• 1982年 7月　　　　富山医科薬科大学附属病院助手


• 1985年 11月　　　富山市民病院麻酔科医員
　 　
• 1987年 4月　　　　富山医科薬科大学医学部助手
　
• 1988年 6月　　　　富山医科薬科大学附属病院助手
　
• 1988年 10月　　　富山医科薬科大学附属病院講師
　
• 1993年 4月　　　　新潟労災病院麻酔科医長
　
• 1994年 4月　　　　富山医科薬科大学附属病院講師
　
• 1994年 10月　　　富山医科薬科大学附属病院集中治療部講師
　
• 1995年 3月　　　　Medical College of Wisconsin, Department of Anesthesiology
  〜1996年 3月　　　 (アメリカ合衆国）へpostdoctoral fellowとして留学


• 2000年 8月　　　　富山医科薬科大学医学部教授
　
• 2005年 10月～　 富山大学大学院医学薬学研究部教授


• 2011年 4月～2013年 3月　　　　富山大学附属病院副病院長兼任


• 2016年 4月～　　 富山大学附属病院副病院長(医療安全担当)兼任
　
• 現在、痛みセンター長を兼任

資格

　
• 医師国家試験合格（1982年）
　
• 麻酔科指導医
　
• 麻酔科標榜医
　
• 日本医師会認定産業医
　
• 日本ペインクリニック学会専門医
　
• 心臓血管麻酔専門医（暫定）
　
• 医学博士

学会活動

主な所属学会

日本麻酔学会、日本臨床麻酔学会、日本ペインクリニック学会、日本集中治療学会、 日本蘇生学会、日本救急医学会、日本臨床救急医学会、 米国麻酔学会、International Anesthesia Research Society

主な役員

日本麻酔科学会代議員
日本麻酔科学会理事（2015年5月～） 日本臨床麻酔学会評議員
日本心臓血管麻酔学会理事
日本循環制御医学会理事
日本集中治療学会東海・北陸地方会評議員
日本救急医学会北陸地方会評議員
東海・北陸ペインクリニック学会北陸地方会評議員
日本ペインクリニック学会理事（2011年4月～2015年7月）

賞罰

　
• 1994年 4月　日本麻酔学会山村記念賞

研究テーマ

　
• 麻酔薬の中枢神経作用に関する電気生理学的研究
　
• 鎮痛薬の鎮痛作用機序および副作用に関する研究
• 慢性痛と睡眠障害に関する研究
　
• 手術侵襲と炎症に関する研究

主な研究業績

1. Yamazaki M, Masuda T, Ito Y, Kuze S, and Momose Y. Changes in rat striatum catecholamine during hypoxia with reference to protective effects of flunarizine Pharmacol Toxicol, 70: 294-298,1992


2. Yamazaki M, Ito Y, Kuze S, Shibuya N, and Momose Y. Effects of ketamine on voltage-dependent Ca2+ currents in single smooth muscle cells from rabbit portal vein. Pharmacol, 45: 162-169,1992


3. Kuze S, Naruse T, Yamazaki M, Hirota K, Ito Y, and Miyahara T. Effects of sodium l-lactate and sodium racemic lactate on　intraoperative acid-base status. Anesth Analg, 75: 702-707,1992


4. Yamazaki M, Kamitani K, Ito Y, and Momose Y. Effects of halothane and diltiazem on L-type calcium currents in single smooth muscle cells from rabbit portal veins. Br J Anaesth, 73: 209-213,1994


5. Yamazaki M, Momose Y, Shakunaga K, Kamitani K, and Ito Y. The vasodilatory effects of ketamine on isolated rabbit portal veins. Pharmacol Toxicol, 76: 3-8,1995


6. Kamitani K, Yamazaki M, Yukitaka M, Ito Y, and Momose Y. Effects of propofol on isolated rabbit mesenteric arteries and veins. Br J Anaesth, 75: 457-461,1995


7. Yamazaki M, Stekiel TA, Bosnjak ZJ, Kampine JP, and Stekiel WJ. Effects of volatile anesthetic agents on in situ vascular smooth muscle transmembrane potential in resistance- and capacitance-regulating blood vessels. Anesthesiology, 88:1085-1095, 1998.


8. Kokita N, Stekiel TA, Yamazaki M, Bosnjak ZJ, Kampine JP, and Stekiel WJ. Potassium channel-mediated hyperpolarization of mesenteric vascular smooth muscle by isoflurane. Anesthesiology, 90: 779-788, 1999


9. Stekiel TA, Kokita N, Yamazaki M, Bosnjak ZJ, Kampine JP, and Stekiel WJ. Effect of isoflurane on in situ vascular smooth muscle transmembrane potential in spontaneous hypertension. Anesthesiology, 91: 207-214, 1999


10. Shigemura T, Hatakeyama N, Shibuya N, Yamazaki M, Masuda A, Chen FS, Momose Y, and Ito Y. Effects of propofol on contractile response and electrophysiological properties in single guinea-pig vetricular myocyte. Pharmacol Toxicol, 85: 111-114, 1999


11. Chen FS, Momose Y, Yamamura S, Okabe F, Hatakeyama N, Yamazaki M, Masuda A, and Ito Y. Effects of acetaldehyde on membrane potentials and ionic currents in single cardiac myocytes. Pharm Pharmacol Commun, 5: 565-570, 1999


12. Suzuki T, Aoki T, Kato H, Yamazaki M, and Misawa M. Effects of the 5-HT3 receptor antagonist ondansetron on the ketamine- and dizocilpine-induced place preferences in mice. European Journal of Pharmacology, 385: 99-102, 1999


13. Tsuji M, Takeda H, Matsumiya T, Nagase H, Yamazaki M, Narita M, Suzuki T.: A novel κopioid receptor agonist, trk-820, blocks the development of physical dependence on morphine in mice. Pharmacology Letter, 66: PL353-358, 2000.


14. Tsuji M, Yamazaki M, Takeda H, Matsumiya T, Nagase H, Tseng Leon F., Narita M, Suzuki T.: The novel kopioid receptor agonist trk-820 has no affect on the development of antinocieptive tolerance to morphine in mice. European Journal of Pharmacology, 394: 91-95, 2000.


15. Yamazaki M,Mizoguchi H, Ohsawa M, Tseng L F, Suzuki T, Narita M.: Implications of Ca2+ -activated Cl- channels in the δ-opioid receptor-mediated antinociception in the mouse spinal cord. Neuroscience Letters, 295: 113-115, 2000.


16. Yamazaki M, Suzuki T, Narita M,Andrzej W. L.： Theopioid peptide analogue biphalin induces less physical dependence than morphine. Life Scineces, 69:1023-1028,2001.


17. Yamazaki M., Nagakawa T., Hatakeyama N., Shibuya N., and Stekiel T A.：The effects of propofol on neural and endothelial control of in situ rat mesenteric vascular smooth muscle transmembrane potentials.Anesth Analg, 94：892-897,2002.


18. Sasaki R., Hirota K., Roth S. H., and Yamazaki M.：Extracellular Magnesium ion modifies the actions of volatile anesthetics in area CA1 of rat hippocampus in vitro. Anesthesiology. 96: 681-687, 2002.


19. Sasaki R, Hirota K, Yamazaki M.：Ionised magnesium concentrations in non-neurosurgical patients undergoing spinal anaesthesia. Anaesthesia，58：1246，2003．


20. Nagakawa T, Yamazaki M, Hatakeyama N, Stekiel TA.：The Mechanisms of propofol-mediated hyperpolarization of in situ rat mesenteric vascular smooth muscle. Anesth Analg，97：1639-1645，2003．


21. Masuda T, Ogawa H, Matsushima T, Kawamata S, Sasahara M, Kuroda K, Suzuki Y, Takata Y, Yamazaki M, Takusagawa F, Pitot H C.：Localization and hormonal control of serine dehydratase during metabolic acidosis differ markedly from those of phosphoenolpyruvate carboxykinase in rat kidney. The International Journal of Biochemistry & Cell Biology，35：1234-1247，2003．


22. Oe K, Narita M, Imai S, Shibasaki M, Kubota C, Kasukawa A, Hamaguchi M, Yajima Y, Yamazaki M, Suzuki T.：Inhibition of the morphine-induced rewarding effect by direct activation of spinal protein kinase C in mine. Psychopharmacology，177：55-60，2004.


23. Narita M, Kuzumaki N, Suzuki M, Narita M, Oe K, Yamazaki M, Yajima Y, Suzuki T.：Increased phosphorylated-μ-opioid receptor immunoreactivity in the mouse spinal cord following sciatic nerve ligation. Neuroscience Letters,354：148-152，2004．


24. Narita M, Oe K, Kato H, Shibasaki M, Narita M, Yajima Y, Yamazaki M, Suzuki T.：Implication of spinal protein kinase C in the suppression of morphine-induced rewarding effect under A neuropathic pain-like state in mice. Neuroscience，125：545-551，2004．


25. Narita M, Suzuki M, Imai S, Narita M, Ozaki S, Kishimoto Y, Oe K, Yajima Y, Ysmazaki M, Suzuki T.：Molecular mechanism of changes in the morphine-induced pharmacological actions under chronic pain-like state: Suppression of dopaminergic transmission in the brain. Life Sciences, 74：2655-2673，2004．


26. Narita M, Imai S, Oe K, Narita M, Kubota C, Yajima Y, Yamazaki M, Suzuki T.：Induction of c-fos expression in the mouse brain associated with hyperalgesia induced by intrathecal injection of protein kinase C activator. Brain Research, 1015：189-193，2004．


27. Kashii T, Gomi T, Oya T, Ishii Y, Oda H, Maruyama M, Kobayashi M, Masuda T, Yamazaki M, Nagata T, Tsukada K, Nakajima A, Tatsu K, Mori H, Takusagawa F, Ogawa H, Pitot HC.: Some biochemical and histochemical properties of human liver serine dehydratase. The International Journal of Biochemistry & Cell Biology, 37: 574-589, 2005.


28. Sasaki R, Hirota K, Roth. S. H., Yamazaki M.: Anoxic depolarization of rat hippocampal slices is prevented by thiopental but not by propofol or isoflurane. Br J Anaesth, 94: 486-491, 2005.


29. Asahi T, Hirota K, Sasaki R, Yamazaki M, Roth SH.:Intravenous anesthetics are more effective than volatile anesthetics on inhibitory pathways in rat hippocampal CA1. Anesth Analg 102: 772-778, 2006.


30. Yamada M, Hatakeyama N, Malykhina AP, Yamazaki M, Momose Y, Akbarali HI.:The effects of sevoflurane and propofol on QT interval and heterologously expressed human Ether-A-Go-Go related gene currents in xenopus oocytes. Anesth Analg,102:98-103,2006.


31. Narita M, Kaneko C, Miyoshi K, Nagumo Y, Kuzumaki N, Nakajima M, Nanjo K, Matsuzawa K, Yamazaki M, Suzuki T. Chronic pain induces anxiety with concomitant changes in opioidergic function in the amygdala. Neuropsychopharmacology 2006; 31, 739-750.


32. Kimura M, Shibukawa Y, Momose Y, Sugaya M, Yamamura S, Suzuki T, Hatakeyama N, Yamazaki M. Effects of thiopental on Ca2+ currents and intracellular Ca2+ transient in single atrial cells from guinea pig. Pharmacology 2007; 80. 33-39


33. Matsuda N, Takano Y, Kageyama SI, Hatakeyama N, Shakunaga K, Kitajima I, Yamazaki M, Hattori Y. Silencing of caspase-8 and caspase-3 by RNA interference prevents vascular endothelial cell injury in mice with endotoxic shock. Cardiovasc Res. 76, 132-140, 2007


34. Narita M, Nakajima M, Miyoshi K, Narita M, Nagumo Y, Miyatake M, Yajima y, Yanagida K, Yamazaki M, Suzuki T. Role of spinal voltage-dependent calcium channel alpha 2 delta-1 subunit in the expression of a neuropathic pain-like state in mice. Life Sciences; 80 2015-2045, 2007.


35. Matsuzawa-Yanagida K, Narita M, Nakajima M, Kuzumaki N, Niikura K, Nozaki H, Takagi T, Tamai E, Hareyama N, Terada M, Yamazaki M, Suzuki T. Usefulness of antidepressaants for improving he neuropathic pain-like state and pain-induced anxiety through actions at different brain sites. Neuropsychopharmacology, 33. 1952-65, 2008.


36. Terada M, Kuzumaki N, Hareyama N, Imai S, Niikura K, Narita M, Yamazaki M, Suzuki M, Narita M. Suppression of enriched environment-induced neurogenesis in a rodent model of neuropathic pain. Neuroscience Letter. 440. 314-8, 2008.


37. Hatakeyama N, Sakuraya F, Matsuda N, Kimura J, Kinoshita H, Kemmotsu O, Yamazaki M, Hattori Y. Pharmacological significance of the blocking action of the intravenous general anesthetic propofol of the slow component of the cardiac delayed rectifier K+ current. J Pharmacol Sci 110: 334-343, 2009


38. Haba M, Kinoshita H, Matsuda N, Azma T, Hama-Tomioka K, Hatakeyama N, Yamazaki M, Hatano Y. Beneficial effect of propofol on arterial adenosine triphosphate-sensitive K+ channel function impaired by thromboxane.. Anesthesiology 111: 279-86, 2009


39. Taketa Y, Niikura K, Kobayashi Y, Furuya M, Shimizu T, Narita M, Imai S, Kuzumaki N, Maitani Y, Yamazaki M, Inada E, Iseki M, Suzuki T, Narita M. Anesthesiology. 112: 418-431, 2010


40. Hirota K, Sasaki R, Sheldon HR, Yamazaki M. Presynaptic actions of general anesthetics are responsible for frequency-dependent modification of synaptic transmission in the rat hippocampal CA1. Anesth Analg, 110: 1607-1613,2010


41. Tange K, Kinoshita H, Minonishi t, Hatakeyama N, Matsuda N, Yamazaki M, Hatano Y. Cerebral oxygenation in the beach chair position before and during general anesthesia. Minerva Anesthesiologica, 70. 485-490, 2010


42. Niikura K, Furuya M, Narita M, Torigoe K, Kobayashi Y, Takemura Y, Yamazaki M, Horiuchi H, Enomoto T, Iseki M, Kinoshita H, Tomiyasu S, Imai S, Kuzumaki N, Suzuki T, Narita M. Enhancement of glutamatergic transmission in the cingulated cortex in response to mild noxious stimuli under a neuropathic pain-like state. Synapse, 65. 424-32, 2011


43. Takemura Y, Furuta S, Hirayama S, Miyasita K, Imai S,Narita M, Kuzumaki N, Tsukiyama Y, Yamazaki M, Suzuki T, Naita M. Upregulation of bradykinin receptors is implicated in the pain associated with caerulein-induced acute pancreatitis. Synapse. 65, 608-16, 2011


44. Takemura Y, Yamashita A, Horiuchi H, Furuya M, Yanase M, Niikura K, Imai S, Hatakeyama N, Kinoshita H, Tsukiyama Y, Senba E, Matoba M, Kuzumaki N, Yamazaki M, Suzuki T, Narita M. Effects of gabapentin on brain hyperactivity related to pain and sleep disturbance under a neuropathic pain-like state using fMRI and brain wave analysis. Synapse, 65, 668-76, 2011


45. Torigoe K, Nakahara K, Rahmadi M, Yoshizawa K, Horiuchi H, Hirayama S, Ima S, Kuzumaki N, Itoh T, Yamashita A, Shakunaga K, Yamazaki M, Nagase H, Matoba M, Suzuki T, Narita M. Usefulness of olanzapine as asn adjunct to oioid treatment and for the treatment of neuropathic pain. Anesthesiology. 116, 159-69, 2012


46. Aoki Y, Hatakeyama N, Yamamoto S, Kinishita H, Matsuda N, Hattori Y, Yamazaki M,. Role of ion channels in sepsis-induced atrial tachyarrhythmias in guinea pigs. Br J Pharmacol. 166, 390-400, 2012


47. Kinoshita H, Matsuda N, Iranami H, Ogawa K, Hatakeyama N, Azuma T, Kawahito S, Yamazaki M. Isoflurane pretreatment preserves adenosine triphosphate-sensitive K+ channel function in the human artery exposed to oxidative stress caused by high glucose levels. Anesth Analg, 115: 54-61, 2012.


48. Oishi H, Takano K, Tomita K, Takebe M, Yokoo H, Yamazaki M, Hattori Y. Olprinone and colforsin daropate alleviate septic lung inflammation and apotosis through CREB-independent activation of the Akt pathway. Am J Physiol Lung Cell Mol Physiol 303: L130-40, 2012
49. Ito H*, Yanase M, Yamashita A, Kitabatake C, Hamada A, Suhara Y, Narita M, Ikegami D, Sakai H, Yamazaki M, Narita M. Analysis of sleep disorders under pain using an optogenetic tool: possible involvement of the activation of dorsal raphe nucleus-serotonergic neurons. Molecular Brain. 2013 Dec 26; doi:10.1186/1756-6606-6-59.


50. Takebe M, Oishi H, Taguchi K, Aoki Y, Takashina M, Tomita K, Yokoo H, Takano Y, Yamazaki M, Hattori Y. Inhibition of histone deacetylases protects septic mice from lung and splenic apotosis. J Surg Res. 187, 559-570, 2014


51. Sakai H, Sagara A, Arakawa K, Sugiyama R, Hirosaki A, Takase K, Sato AJK, Chiba Y, Yamazaki M, Matoba M, Narita M. Mechanisms of cisplatin-induced muscle atrophy. Toxicology and Applied Pharmacology 278:190-199, 2014.


52. Masuda T, Yamazaki M, Fukuda M. Involvement of amygdala in learning and memory impairment due to permanebt bilateral carotid artery occlusion in rats. 富山大学医学会誌 24:6-10, 2013.


53. Mori Y, Yamada M, Akahori T, Hatakeyama N, Yamazaki M, Fujiwara Y, Kinishita H. Cerebral oxygenation in the beatch chair position before and during general anesthesia in patients with and without cardiovascular risk factors. Iournal of Clinical Anesthesia 27: 457-462, 2015.


54. Hori N, Yamazaki M, Narita M, et al（17人中11番目） Changes in the expression of IL-6-mediated microRNAs in the dorsal root ganglion under neuropathic pain in mice. Synapse 70(8): 317-24, 2016.

獲得研究費

• 1986　　　　科学研究費　一般研究Ｃ　　３年間　　　分担（代表：伊藤祐輔）
• 1990　　　　科学研究費　奨励研究Ａ　　　　　　　 　代表
• 1990　　　　科学研究費　一般研究Ｂ　　　　　　　 　分担（代表：伊藤祐輔）
• 1991　　　　科学研究費　奨励研究Ａ　　　　　　　 　代表
• 1992　　　　科学研究費　奨励研究Ａ　　　　　　　 　代表
• 1993　　　　科学研究費　奨励研究Ａ　　　　　　　 　代表
• 1993　　　　科学研究費　一般研究Ｂ　　２年間　　　分担（代表：伊藤祐輔）
• 1996　　　　科学研究費　一般研究Ｃ　　　　　　　 　分担（代表：渋谷伸子）
• 1996　　　　科学研究費　一般研究Ｃ　　１年間　　　代表
• 1997　　　　科学研究費　基盤研究Ｃ　　２年間　　　代表
• 1999　　　　科学研究費　基盤研究Ｂ　　４年間　　　代表
• 2004　　　　科学研究費　基盤研究Ｃ　　３年間　　　代表
• 2007　　　　科学研究費　基盤研究Ｃ　　２年間　　　代表
• 2009　　　　科学研究費　基盤研究Ｂ　　４年間　　　代表
• 2014　　　　科学研究費　基盤研究Ｃ　　３年間　　　代表

博士指導（主論文）

課程博士

佐々木利佳 Anesthesiology. 96: 681-687, 2002.　
大江公晴 Psychopharmacology，177：55-60，2004
松澤（柳田）聖実 Neuropsychopharmacology, 33. 1952-65, 2008
大石（寺田）美緒子 Neuroscience Letter. 440. 314-8, 2008
青木優太　 Br J Pharmacol. 166, 390-400, 2012
竹村佳記　 Synapse. 65, 608-16, 2011
大石博史　 Am J Physiol Lung Cell Mol Physiol 303: L130-40, 2012
武部真理子　 J Surg Research　187, 559-570, 2014
伊東久勝　　Molecular Brain. 2013 Dec 26; doi:10.1186/1756-6606-6-59.
服部瑞樹

論文博士

神谷和男 Br J Anaesth, 75: 457-461,1995
永川　保 Anesth Analg 97：1639-1645，2003
朝日丈尚 Anesth Analg 102: 772-778, 2006
山田正名 Anesth Analg,102:98-103, 2006