アトピー性皮膚炎患者の血清中や病変部においてMIF は強く発現し、その発現レベルは皮膚症状の改善に伴い低下する。また、MIFは病変部局所にとどまらず、全身のサイトカインネットワークの中でアトピー性皮膚炎の病態に関与している。
これまでに我々が同定したfused-S100蛋白質のひとつであるHornerinを中心に、未だ十分に機能が解明されていないTCHHL1やFLG2などの角化における役割や皮膚疾患との関連について研究を行っている。
本学の特徴の一つである漢方治療のエビデンスを確立するため、漢方に関する臨床および基礎研究を行っている。これまでに、アトピー性皮膚炎に対する漢方薬の効果をSCORADや血清TARC値など他覚的指標により評価し、苔癬化病変が主体の患者に桂枝茯苓丸が有効であることを明らかにした。また、桂枝茯苓丸に含まれるペオニフロリンが血管内皮細胞から産生される炎症性サイトカインを抑制することや、紫雲膏に含まれるアルカニンが熱ショック蛋白質を介して細胞保護機能関連遺伝子の発現を誘導し、表皮角化細胞における紫外線誘発アポトーシスを抑制することなども解明した。
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2022年
Mizawa M, Makino T, Oshima M, Hayashi M, Shimizu T.: Two cases of generalized granuloma annulare successfully treated with an excimer laser.
J Dermatol. (in press).
Kitayama S, Makino T, Hayashi M, Furukawa F, Torai R, Mizawa M, Ishii N, Hashimoto T, Shimizu T.: A case of linear IgA disease with IgA antibodies to type VII collagen demonstrated by immunofluorescence overlay antigen mapping.
Eur J Dermatol. 1;32(4):553-554, 2022.
Mori S, Makino T, Shimizu T.: Localized cutaneous nodular amyloidosis associated with Sjogren's syndrome and thymom.
Eur J Dermatol. 1;32(3):408-410, 2022.
Makino T, Terada Y, Mizawa M, Hirono K, Adachi Y, Aoki S, Kubo A, Shimizu T.: Identification of a de novo mutation of the elastin gene by targeted exome sequencing in autosomal dominant cutis laxa.
Clin Exp Dermatol. 47(10):1895-1897, 2022.
Yamagishi N, Takahashi JI, Zhou Y, Yokoyama S, Makino T, Shimizu T, Sakurai H.: Non-canonical Regulation of EGFR by the Air Pollutant 9,10-henanthrenequinone.
Biol Pharm Bull. 45(10):1553-1558, 2022.
Kitayama S, Makino T, Torai R, Mizawa M, Shimizu T.: Dermoscopic and histological findings in Cronkhite-Canada syndrome: a report of two cases.
Int J Dermatol. (in press).
Kitayama S, Makino T, Kataoka K, Mori S, Furukawa F, Torai R, Mizawa M, Shimizu T.: Valacyclovir-induced drug reaction with eosinophilia and systemic symptoms.
Eur J Dermatol. 1;32(4):538-539, 2022.
Kataoka K, Makino T, Mori S, Furukawa F, Torai R, Anzawa K, Takeda K, Shimizu A, Shimizu T.: Multiple subcutaneous candida abscesses on the lower leg in an immunocompromised patient.
Eur J Dermatol. 1;32(4):540-542, 2022.
Makino T, Sugiyama H, Oshima M, Mizawa M, Shimizu T.: Cutaneous gnathostomiasis caused by Gnathostoma spinigerum.
Br J Dermatol. 186(5):e198-e199, 2022.
Mizawa M, Makino T, Furukawa F, Torai R, Shimizu T.: Efficacy of Q-switched ruby laser treatment for pigmented fungiform papillae of the tongue.
J Dermatol. 49(4):e133-e134, 2022.
Makino T, Kataoka K, Kitayama S, Mizawa M, Shimizu T.: Successful treatment with excimer laser for cutaneous lesion of sarcoidosis.
J Dermatol. 49(7):e236-e237. 2022.
Kitayama S, Makino T, Mizawa M, Shimizu T.: Newborn twins with neonatal pemphigoid gestationis.
J Dermatol. ;49(5):e157-e158, 2022.
Matsui Y, Sasaki J, Takatsuka S, Takenouchi T. : Natural course of pediatric longitudinal melanonychia: a retrospective cohort study in Japan.
J Am Acad Dermatol. 86(4):946-948, 2022.
Torai R, Makino T, Matsui Y, Shimizu T.: Adult T-cell leukemia/lymphoma showing parakeratosis variegate.
Int J Dermatol. 61(2):e59-e61, 2022.
2021年
MatsuiY, Makino T, Asano R, Hounoki H, Shimizu T.: Immunohistochemical Examination of Cutaneous Vasculitis in a Case of Cogan's Syndrome.
Indian J Dermatol. 66:(6)706, 2021.
Sasaki J, Matsui Y, Takatsuka S, Takenouchi T.: Less extensive reconstructive surgery for full-thickness lower eyelid defect.
JAAD Case Rep. 5;13:8-10, 2021.
Furukawa F, Makino T, Torai R, Mori S, Terada Y, Seki T, Shimizu T.: Effectiveness of combined bexarotene and excimer laser treatment for folliculotropic mycosis fungoides.
Eur J Dermatol . 17;31(4):567-568, 2021.
Yoto A, Makino T, Mizawa M, Matsui Y, Takemoto K, Furukawa F, Kataoka K, Nakano H, Sawamura D, Shimizu T.: Two cases of Hailey-Hailey disease effectively treated with apremilast and a review of reported cases.
J Dermatol. 48(12):1945-1948, 2021.
Sasaki J, Matsui Y, Takatsuka S, Takenouchi T.: Dermatologist's role in a cancer hospital: An overview of in-hospital consultations.
J Dermatol. 48(7):1098-1100, 2 021.
Hounoki H, Shinoda K, Matui A, Okumura M, Yamaguchi S, Kakeshita K, Yamazaki H, Koike T, Makino T, Tobe K.:A Case of Systemic Lupus Erythematosus and Antineutrophil Cytoplasmic Antibodies-Associated Vasculitis Overlap Syndrome.
Case Rep Rheumatol. 7;2021:6690658, 2021.
Takahashi N, Tajiri K, Kagoyama K, Tanaka S, Yasuda.:CD8 Positive T Lymphocyte Infiltration of Liver Metastases of Uveal Melanoma: A Case Report.
Front Oncol. 2;11:672660, 2021.
Yoshida N, Yamamoto S, Hamashima T, Okuno N, Okita N, Horikawa S, Hayashi M, Dang TC, Nguyen QL, Nishiyama K, Makino T, Ishii Y, Tomihara K, Shimizu T, Shibuya M, Noguchi M, Sasahara M.: Dysregulation of Amphiregulin stimulates the pathogenesis of cystic lymphangioma.
Proc Natl Acad Sci USA . 11;118(19):e2019580118, 2021.
Mizawa M, Matsumura K, Hamazaki K, Furukawa F, Makino T, Shimizu T, Inadera H, Japan Environment and Children’s Study Group.: Infantile hemangioma and the risk factors in a Japanese population: A nationwide longitudinal study - The Japan Environment and Children's Study (JECS).
J Invest Dermatol. 141(11):2745-2748.e2, 2021.
Mizawa M, Makino T, Furukawa F, Shimizu T.: Japanese case of classic plaque-like actinic lichen planus.
J Dermatol. 48(9):e466-e467, 2021.
Yoshihisa Y, Rehman MU, Andoh T, Tabuchi Y, Makino T, Shimizu T.: Overexpression of D-dopachrome tautomerase increases UVB-induced skin tumourigenesis in mice.
FASEB J. 35:e21671, 2021.
Matsui Y, Sasaki J, Takatsuka S, Takenouchi T: Observation policy for sentinel node metastasis of melanoma: comparative study with completion lymph node dissection in Japanese patients.
J Dermatol. 48(8):1221-1228, 2021.
Andoh T, Yoshihisa Y, Rehman MU, Tabuchi Y, Shimizu T.: Berberine induces anti-atopic dermatitis effects through the downregulation of cutaneous EIF3F and MALT1 in NC/Nga mice with atopy-like dermatitis.
Biochem Pharmacol. 185:114439, 2021.
Asano R, Shinoda K, Tsuda R, Hounoki H, Kawataka M, Makino T, Imura J, Hamaguchi Y, Tobe K.: Anti-TIF1γ antibody-positive dermatomyositis in a 15-year-old boy with Epstein-Barr virus-related nasopharyngeal cancer receiving nivolumab. Rheumatology (Oxford). 18,60(6):e197-e199, 2021.
Furukawa F, Makino T, Mori S, Shimizu T.: Successful treatment of acne fulminans with the combination of prednisolone and diaminodiphenylsulfone.
J Dermatol. 48(2):e120-e121. 2021.
Shimizu K, Makino T, Shimizu T.: Re-pigmentation within hypopigmented lesions of pigmentary mosaicism.
Clin Exp Dermatol. 46(3):565-567, 2021.
Makino T, Kagoyama K, Murabe C, Nakamura T, Shimizu T.: Association of Development of Solar Elastosis with Increased Expression of Fibrillin-1, LTBP-2 and Fibulin-4 in Combination with Decreased Expression of LTBP-4.
Acta Derm Venereol. 13;101(1), 2021.
Tohmatsu Y, Imura J, Sakai T, Takagi K, Minamisaka T, Tanaka S, Noguchi A, Nakajima T, Nagata T, Makino T, Shimizu T, Fujii T.: Expression of laminin-5 gamma 2 chain predicts invasion of extramammary Paget's disease cell.
APMIS. 29:3-8, 2021.
2020年
Kagoyama K, Makino T, Minamisaka T, Shimizu T.: Intravascular myopericytoma on the right dorsal foot.
Eur J Dermatol. 1;30(6):736-737, 2020.
Makino T, Mizawa M, Yoshihisa Y, Yamamoto S, Tabuchi Y, Masashi Miyai M, Hibino T, Shimizu T.: Trichohyalin-like 1 protein plays a crucial role in proliferation and anti-apoptosis of normal human keratinocytes and squamous cell carcinoma cells.
Cell Death Discov. 27;6:109, 2020.
Matsui Y, Makino T, Torai R, Shimizu T.:Neutrophilic myositis developing in a case of systemic lupus erythematosus.
Eur J Dermatol. 1;30(4):432-433. 2020.
Jawaid P, Rehman MU, Zhao QL, Misawa M, Ishikawa K, Hori M, Shimizu T, Saitoh J, Noguchi K, Kondo T.: Small size gold nanoparticles enhance apoptosis-induced by cold atmospheric plasma via depletion of intracellular GSH and modification of oxidative stress.
Cell Death Discov. 10;6:83. 2020.
Matsuda T , Kambe N , Ueki Y, Kanazawa N, Izawa K , Honda Y, Kawakami A, Takei S, Tonomura K, Inoue M, Kobayashi H, Okafuji I, Sakurai Y, Kato N, Maruyama Y, Inoue Y, Otsubo Y, Makino T, Okada S, Kobayashi I, Yashiro M, Ito S, Fujii H, Kondo Y, Okamoto N, Ito S, Iwata N, Kaneko U, Doi M, Hosokawa J, Ohara O, Saito MK, Nishikomori R, PIDJ members in the JSIAD; PIDJ (Primary Immunodeficiency and Autoinflammatory Diseases Database Project) members in the JSIAD (Japanese Society for Immunodeficiency and Autoinflammatory Diseases) .: Clinical characteristics and treatment of 50 cases of Blau syndrome in Japan confirmed by genetic analysis of the NOD2 mutation.
Ann Rheum Dis. 79(11):1492-1499. 2020.
Makino T, Matsui Y, Torai R, Mizawa M, Shimizu T.: Agminated flexural melanocytic nevus associatedcolchicine with Langerhans cell histiocytosis.
J Dermatol. 47(7):e275-e276. 2020.
Matsui Y, Makino T, Kagoyama K, Takemoto K, Shimizu T.: Co-existence of basal cell carcinoma and squamous cell carcinoma in a single burn scar region.
Burns Open. 4:64-66, 2020.
Hayashi M, Makino T, Mori N, Mizawa M, Shimizu T.: Effectiveness of pazopanib for local and lung metastases in Stewart-Treves syndrome.
Eur J Dermatol. 30:68-69, 2020.
Furukawa F, Makino T, Takemoto K, Mizawa M, Arita K, Hamashima T, Shimizu T.: Sarcoid reactions in the skin caused by mantle cell lymphoma.
Eur J Dermatol. 30(1):57-58, 2020.
Mizawa M, Andoh T, Shimizu T.: Gardenia Fruit-Related Blue-Gray Skin Pigmentation.
JAMA Dermatol. 156(3):351-353.2020.
Furukawa F, Mizawa M, Shimizu T.: Treatment of dermatosis papulosa nigra using a carbon dioxide laser.
J Cosmet Dermatol. 19:2572-2575, 2020.
Yoshihisa Y, Andoh T, Rehman MU, Shimizu T.: The regulation of protein kinase CK2 by apigenin is involved in the inhibition of UVB-induced macrophage migration inhibitory factor-mediated hyperpigmentation.
Phytother Res. 34(6):1320-1328.2020.
Kagoyama K, Makino T, Shimizu T.: Successful treatment of recalcitrant planter warts by carbon dioxide laser with a computerized scanner.
Br J Dermatol. 182(3):809-811. 2020.
2019年
Sugita Y, Makino T, Matsui K, Shimizu T.: Reactive eccrine syringofibroadenoma on the heel, clinically mimicking squamous cell carcinoma.
Case Rep Dermatol Med. 2019:4735739, 2019.
Matsui Y, Makino T, Ishii N, Hashimoto T, Shimizu T.: Detection of IgG antibodies to BP180 NC16a and C-terminal domains and LAD-1 in nivolumab-associated bullous pemphigoid.
Eur J Dermatol. 29(5):554-555, 2019.
Arase N, Tanemura A, Jin H, Nishioka M, Aoyama Y, Oiso N, Matsunaga K, Suzuki T, Nishigori C, Kawamura T, Shimizu T, Ito A, Fukai K, Abe Y, Yang L, Tsuruta D, Takeoka K, Iwatani Y, Hidaka Y, Nishida M, Yamauchi-Takihara K, Arase H, Fujimoto M, Katayama I.: Autoantibodies detected in patients with vitiligo vulgaris but not in those with rhododendrol-induced leukoderma.
J Dermatol Sci. 95(2):80-83, 2019.
Andoh T, Akasaka C, Shimizu K, Lee JB, Yoshihisa Y, Shimizu T.: Involvement of α-Melanocyte-Stimulating Hormone-Thromboxane A2 System on Itching in Atopic Dermatitis.
Am J Pathol. 189(9):1775-1785, 2019.
Mizawa M, Makino T, Nakano H, Sawamura D, Shimizu T.: Erythropoietic protoporphyria in a Japanese population.
Acta Derm Venereol. 99(7):634-639, 2019.
Takemoto K, Makino T, Mizawa M, Kubo Y, Shimizu T.: Detection of a missense mutation Y449H of the K10 gene in a patient with a severe phenotype of epidermolytic ichthyosis.
Eur J Dermatol. 29：227-228, 2019.
Shimizu K, Andoh T, Makino T,Yoshihisa Y, Mizawa M, Shimizu T.: Mechanisms of itching in mycosis fungoides: grade of itching correlates with eosinophil infiltration and kallikrein 5 expression.
Eur J Dermatol. 29:268-273, 2019.
Makino T, Mizawa M, Yoshihisa Y, Shimizu T.: Ultraviolet B irradiation increases the expression of trichohyalin-like 1 protein in human skin xenotransplants.
Clin Exp Dermatol. 44(7):773-776, 2019.
Makino T & Shimizu T.: Review article: Fibrillar-type dermatitis herpetiformis.
Eur J Dermatol. 29:115-20,2019.
2018年
Kagoyama K, Andoh T, Shimizu T.: Enlarging the irradiation spot to include the edge of hyperkeratotic papules using a CO2 surgical laser dramatically and effectively treats lichen amyloidosis.
Eur J Dermatol. 28:837-839,2018.
Yoshihisa Y, Rehman MU, Nakagawa M, Matsukuma S, Makino T, Mori H, Shimizu T.:Inflammatory cytokine-mediated induction of serine racemase in atopic dermatitis.
J Cell Mol Med. 22: 3133-3138, 2018.
Torai R, Makino T, Mizawa M, Shimomura Y, Shimizu T.:A novel missense mutation in exon 3 of the TRPS1 gene in a patient with a mild phenotype of tricho-rhino-phalangeal syndrome type 1.
Eur J Dermatol. 1;28(2):271-272, 2018.
Yanagihara M, Makino T, Shimizu T, Mochizuki T.: Nerve alterations showing autophagy in two patients with lichen aureus.
J Cutan Pathol. 45(6):423-427, 2018.
Kurosaki Y, Suga Y, Negi O, Takamori K, Ishii N, Makino T, Shimizu T, Hashimoto T.: Monitoring of IgA antibodies to epidermal and tissue transglutaminases over an 18-month period in a Japanese patient with dermatitis herpetiformis.
J Dermatol. 45:e211-212,2018.
Mizawa M, Makino T, Hayashi M, Furukawa F, Shimizu T.:Lichen planus pemphigoides with palmoplantar hyperkeratosis.
Eur J Dermatol. 28(1)：100-101,2018.
Torai R, Makino T, Mizawa M, Hayashi M, Furukawa F, Niimi H, Shimizu T.:Recurrent deep vein thrombosis with a protein S Tokushima mutation.
Br J Dermatol. 178 :e7-e8,2018.
2017年
Furukawa F, Mizawa M, Makino T, Torai R, Shimizu T.:Efficacy of new low-dose oral anticoagulants in recalcitrant livedoid vasculopathy.
BMJ Case Rep. Jul 24;2017.
Watanabe S, Ohnishi T, Yuasa A, Kiyota H, Iwata S, Kaku M, Watanabe A, Sato J, Hanaki H, Manabe M, Suzuki T, Otsuka F, Aihara M, Iozumi K, Tamaki T, Funada Y, Shinozaki M, Kobayashi M, Okuda M, Kikyo G, Kikuchi K, Okada Y, Takeshima M, Kaneko O, Ogawa N, Ito R, Okuyama R, Shimada S, Shimizu T, Hatta N, Manabu M, Tsutsui K, Tanaka T, Miyachi Y, Asada H, Furukawa F, Kurokawa I, Iwatsuki K, Hide M, Muto M, Yamamoto O, Niihara H, Takagaki K, Kubota Y, Sayama K, Sano S, Furue M, Kanekura T.: The first nationwide surveillance of antibacterial susceptibility patterns of pathogens isolated from skin and soft-tissue infections in dermatology departments in Japan.
J Infect Chemother. 23:503-511.2017.
Makino T, Yoshihisa Y, Mizawa M, Tsutsui K, Nishijima C, Inaoki M, Shimizu T.: Increased serum levels of Th2-type cytokines and eotaxin in fibrillar-type dermatitis herpetiformis.
Acta Derm Venereol. 97(5):642-643, 2017.
Andoh T, Shimizu T.: Increase in sensory sensitivity around, but not in the central part of, the hyperkeratotic papule in lichen amyloidosis.
Br J Dermatol. 177:e143-4,2017.
Makino T, Hara H, Mizawa M, Shimizu A, Kaira K, Shimizu T.: Detection of human papillomavirus type 35 in recurrent Bowen's disease lesions of the fingers.
Eur J Dermatol. 27:198-200, 2017.
Makino T, Ishida W, Hamashima T, Mizawa M, Sasahara M, Shimizu T.: An intermediate vascular tumour between kaposiform hemangioendothelioma and tufted angioma with regression of the skin lesion.
Eur J Dermatol. Apr 1;27(2):175-176, 2017.
Mizawa M, Makino T, Furukawa F, Torai R, Nakano H, Sawamura D, Shimizu T.: The 6-year follow-up of a Japanese patient with silent erythropoietic protoporphyria.
JAAD Case Rep. 3:169-171, 2017.
2016年
Yoshihisa Y, Rehman MU, Kondo T, Shimizu T.: Role of macrophage migration inhibitory factor in heat-induced apoptosis in keratinocytes.
FASEB J. 30:3870-3877, 2016.
Sugita Y, Makino T, Mizawa M, Shimizu T.: Mugwort-mustard allergy syndrome due to broccoli consumption.
Case Rep Dermatol Med. 2016:8413767, 2016.
Rehman MU, Jawaid P, Zhao QL, Li P, Narita K, Katoh T, Shimizu T, Kondo T.:Low-dose spiruchostatin-B, a potent histone deacetylase inhibitor enhances radiation-induced apoptosis in human lymphoma U937 cells via modulation of redox signaling.
Free Radic Res. 50:596-610, 2016.
Jawaid P, Rehman MU, Zhao QL, Takeda K, Ishikawa K, Hori M, Shimizu T, Kondo T.: Helium-based cold atmospheric plasma-induced reactive oxygen species-mediated apoptotic pathway attenuated by platinum nanoparticles.
J Cell Mol Med. 20(9):1737-48, 2016.
Winge MC, Ohyama B, Dey CN, Boxer LM, Li W, Ehsani-Chimeh N, Truong AK, Wu D, Armstrong AW, Makino T, Davidson M, Starcevic D, Kislat A, Nguyen NT, Hashimoto T, Homey B, Khavari PA, Bradley M, Waterman EA, Marinkovich MP.: RAC1 activation drives pathologic interactions between the epidermis and immune cells.
J Clin Invest. 2016 Jul 1;126(7):2661-77.
Mizawa M, Makino T, Inami C, Shimizu T.: Jumi-haidoku-to (Shi-Wei-Ba-Du-Tang), a Kampo Formula, ecreases the disease activity of palmoplantar pustulosis.
Dermatol Res Pract. 2016: 4060673,2016.
Makino T, Mizawa M, Seki Y, Hayashi M, Shimizu T.: Decreased filaggrin-2 expression in the epidermis in a case of pityriasis rotunda.
Clin Exp Dermatol, 41：215-217,2016.
Mizawa M, Makino T, Nakano H, Sawamura D, Shimizu T.: Incomplete erythropoietic protoporphyria caused by a splice site modulator homozygous IVS3-48C polymorphism in the ferrochelatase gene.
Br J Dermatol. 174:172-175, 2016.
Jawaid P, Rehman MU, Hassan MH, Zhao QL, Li P, Miyamoto Y, Misawa M, Ogawa R, Shimizu T, Kondo T.: Effect of Platinum Nanoparticles on Cell Death Induced. Ultrasound in Human Lymphoma U937 Cells.
Ultrason Sonochem. 31,206-215, 2016.
Arch Dermatol Res. 308(3):213-7, 2016.
Makino T, Hara H, Hamashima T, Mizawa M, Seki Y, Hayashi H, Shimizu T.; Hodgkin lymphoma presenting as subcutaneous masses in the left upper arm.
J Dermatol. 43:1244-1246, 2016.
Yoshihisa Y, Andoh T, Matsunaga K, Shimizu T.; Efficacy of the astaxanthin for the treatment in a murine model of atopic dermatitis.
PLoS One. 29;11(3):e0152288, 2016.
Hara H, Makino T, Shimizu T.: Annular pustular psoriasis associated with colon cancer.
Eur J Dermatol. 1;26(1):104-5, 2016.
Makino T, Shimizu K, Mizawa M, Nakano H, Sawamura D, Shimizu T.: A novel deletion mutation of the ATP2C1 gene in a family with Hailey-Hailey disease.
Eur J Dermatol. 26:414-416,2016.
2015年
Mizawa M, Makino T, Nakamura T, Yamaguchi S, Taki H, Shimizu T.: Exacerbation of symptoms in Blau syndrome/early-onset sarcoidosis following delivery.
Eur J Dermatol. 25:620-622,2015.
Kagoyama K, Makino T, Ueda C, Takegami Y, Shimizu T.: Detection of cytomegalovirus in the gastric ulcer of a patient with drug-induced hypersensitivity syndrome.
JAAD Case Rep. 215-218, 2015.
Yoshihisa Y, Rehman MU, Yamakoshi-Shibutani T, Shimizu T.: In vitro effects of zinc on the cytokine production from peripheral blood mononuclear cells in patients with zinc allergy.
Springerplus. 4:404,2015.
Shimizu K, Andoh T, Yoshihisa Y, Shimizu T.: Histamine released from epidermal keratinocytes plays a role in α-melanocyte-stimulating hormone-induced itching in mice.
Am J Pathol. 185:3003-3010,2015.
Makino T, Mizawa M, Seki Y, Hayashi M, Shimizu T.: Decreased filaggrin-2 expression in the epidermis in a case of pityriasis rotunda.
Clin Exp Dermatol. 25:619-620,2015.
Mori N, Makino T, Mizawa M, Kagoyama K, Kanegane H, Sakaguchi H, Miyazono T, Shimizu T.: Late presentation of X-linked dyskeratosis congenita with a missense mutation in codon 350 of the dyskerin protein.
Eur J Dermatol. 25:75-76, 2015.
Matsui K, Makino T, Mizawa M,Hamashima T, Hanakawa H, Hatta N, Sasahara M, Shimizu T.: Extramammary Paget’s disease arising from Cowden syndrome.
Eur J Dermatol. 25:89-91, 2015.
Nagata Y, Yoshihisa Y, Rehman MU, Matsunaga K, Kitaichi N, Shimizu T.: Role of macrophage migration inhibitory factor (MIF) in pollen-induced allergic conjunctivitis and pollen dermatitis in mice.
PLoS One. 10:e0115593, 2015.
