Takamura, Y., Tamura, R., Zhou, T.L., Kobayashi, T., Tran, A.H., Eifuku, S., Ono, T. Spatial firing properties of lateral septal neurons. Hippocampus
16: 635-644 2006. [査読有]
The
present study describes the spatial firing properties of neurons in the lateral
septum (LS). LS neuronal activity was recorded in rats as they performed a
spatial navigation task in an open field. In this task, the rat acquired an
intracranial self-stimulation (ICSS) reward when it entered a certain place,
the location that varied randomly from trial to trial. Of 193 neurons recorded
in the LS, 81 showed place-related activity. The majority of the tested neurons
changed place-related activity when spatial relations between environmental
cues were altered by rotating intra-field (proximal) cues. The comparison of
place activities between LS place-related neurons recorded in the present study
and hippocampal place cells recorded in our previous study, using identical
behavioral and recording procedures, revealed that spatial parameters (spatial
information content, coherence, and cluster size) were smaller in the LS than
in the hippocampus. Of 193 LS neurons, 86 were influenced by ICSS rewards; 31
of these 86 were also place-related. These results, together with previous
anatomical and behavioral observations, suggested that the spatial information
sent from the hippocampus to the LS is modulated and interacted with signals
related to reward in the LS.
Key words:
spatial information; intracranial self-stimulation; lateral septal
nuclei; hippocampus; place cells.