研究業績

2017年

21. Yamamoto M, Inohara H, Nakagawa T*. Targeting Metabolic Pathways for Head and Neck Cancers Therapeutics. Cancer Metastasis Rev. 36(3): 503-514. (2017) (*Corresponding author)

20. Nawaz A, Aminuddin A, Kado T, Takikawa A, Yamamoto S, Tsuneyama K, Igarashi Y, Ikutani M, Nishida Y, Nagai Y, Takatsu K, Imura J, Sasahara M, Okazaki Y, Ueki K, Okamura T, Tokuyama K, Ando A, Matsumoto M, Mori H, Nakagawa T, Kobayashi N, Saeki K, Usui I, Fujisaka S, Tobe T. CD206+ M2-like macrophages regulate systemic glucose metabolism by inhibiting proliferation of adipocyte progenitors. Nat Commun. 8(1): 286. (2017)

19. Talukdar G, Inoue R, Yoshida T, Ishimoto T, Yaku K, Nakagawa T, Mori H. Novel role of serine racemase in anti-apoptosis and metabolism. Biochim Biophys Acta. 1861(1): 3378–3387. (2017)

2016年

18. Takikawa A, Mahmood A, Nawaz A, Kado T, Okabe K, Yamamoto S, Arif A, Senda S, Tsuneyama K, Igarashi Y, Ikutani M, Nagai Y, Takatsu K, Fukuhara A, Koizumi K, Imura J, Goda N, Sasahara S, Shimomura I, Matsumoto M, Saeki K, Nakagawa T, Fujisaka S, Usui I, Tobe T. HIF-1α in myeloid cells promotes adipose tissue remodeling toward insulin resistance. Diabetes. 65(12): 3649-3659. (2016)

17. Sasaki Y, Nakagawa T, Mao X, DiAntonio A, Milbrandt J. NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion. eLife. 5:e19749 (2016)

16. Takikawa A, Usui I, Fujisaka S, Ikutani M, Senda S, Hattori S, Tsuneyama K, Koshimizu Y, Inoue R, Tanaka-Hayashi A, Nakagawa T, Nagai Y, Takatsu K, Sasaoka T, Mori H, Tobe K. Deletion of SIRT1 in myeloid cells impairs glucose metabolism with enhancing inflammatory response to adipose tissue hypoxia. Diabetology Int. 7(1): 59-68. (2016)

15. Yamamoto M, Hikosaka K, Mahmood A, Tobe K, Shojaku H, Nakagawa T*. Nmnat3 is dispensable in mitochondrial NAD level maintenance in vivo. PLOS ONE 11(1): e0147037. (2016) (*Corresponding author)

2015年

14. Yoon MJ, Yoshida M, Johnson S, Takikawa A, Usui I, Tobe K, Nakagawa T, Yoshino J, Imai SI. SIRT1-Mediated eNAMPT Secretion
from Adipose Tissue Regulates Hypothalamic NAD+ and Function in Mice. Cell Metab. 21(1): 1-12. (2015)

2014年

13. Hikosaka K, Ikutani M, Shito M, Kazuma K, Gulshan M, Nagai Y, Takatsu K, Konno H, Tobe K, Kanno H, Nakagawa T*. Deficiency of Nicotinamide Mononucleotide Adenylyltransferase 3 (Nmnat3) Causes Hemolytic Anemia by Altering the Glycolytic Flow in Mature Erythrocytes. J Biol Chem. 289(21): 14796-14811. (2014) (*Corresponding author)

12. Nakagawa T*, Guarente L, SnapShot: Sirtuins, NAD and Aging. Cell Metab. 20(1): 192. (2014) (*Co-Corresponding author)

11. Sasaki T, Kikuchi O, Shimpuku M, Susanti VY, Yokota-Hashimoto H, Taguchi R, Shibusawa N, Sato T, Tang L, Amano K, Kitazumi T, Kuroko M, Fujita Y, Maruyama J, Lee YS, Kobayashi M, Nakagawa T, Minokoshi Y, Harada A, Yamada M, Kitamura T. Hypothalamic SIRT1 prevents age-associated weight gain by improving leptin sensitivity in mice. Diabetologia. 57(4): 819-831. (2014)



2013年以前

10. Nakagawa T, Guarente L, Sirtuins at a glance. J Cell Sci. 124(6): 833-838. (2011)

9. Nakagawa T, Guarente L. Urea Cycle Regulation by Mitochondrial Sirtuin, SIRT5. Aging. 1(6): 578-581. (2009)

8. Nakagawa T, Lomb D, Haigis MC, Guarente L. SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle. Cell. 137(3): 560–570. (2009)

7. Mizuta T, Shimizu S, Matsuoka Y, Nakagawa T, Tsujimoto Y. A BAX/BAK- independent mechanism of cytochrome c release. J Biol Chem. 282(22): 16623-16630. (2007)

6. Tsujimoto Y, Nakagawa T, Shimizu S. Mitochondrial membrane permeability transition and cell death. Biochim Biophys Acta. 1757(9-10): 1297-1300. (2006)

5. Nakagawa T, Shimizu S, Watanabe T, Yamaguchi O, Otsu K, Hirotaka Y, Inohara H, Kubo T, Tsujimoto Y. Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic, but not apoptotic cell death. Nature. 434(7033): 652-658. (2005)

4. Inohara H, Inoue T, Akahani S, Yamamoto Y, Takenaka Y, Nakagawa T, Isohashi F, Kubo T. Concurrent Chemoradiotherapy with Cisplatin and Docetaxel for Advanced Head and Neck Cancer. A Phase I Study. Anticancer Research. 24(6): 4135-4140. (2004)

3. Nakagawa T, Hattori K, Iwata N, Tsujimura T. Papillary cystadenocarcinoma arising from minor salivary glands in the anterior portion of the tongue. Auris Nasus Larynx. 29(1): 87-90. (2002)

2. Iwata N, Hattori K, Nakagawa T, Tsujimura T. Hemangioma of the nasal cavity: a clinicopathologic study. Auris Nasus Larynx. 29(4): 335-339. (2002)

1. Kawai Y, Morimoto S, Sakaguchi K, Yoshino H, Yotsui T, Hirota S, Inohara H, Nakagawa T, Hattori K, Kubo T, Yang J, Fujiwara N, Ogihara T. Oncogenic osteomalacia secondary to nasal tumor with decreased urinary excretion of cAMP. J Bone Miner Metab. 19(1): 61-64. (2001)