研究業績
当講座では、国内外の学術誌や学会で多数の研究成果を発表しています。
教育・研究の実績をご紹介します。
最新の研究論文
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病態・病理学講座の発表論文一覧です。
最新の研究成果については、お問い合わせください。
2025
学会報告
Yamamoto S.
Advanced in Tumor Pathobiology Research: From Basic Research to Clinical Applications.
International Scientific Conference on Pathology; 2025 Apr 24; Ha Noi, Viet Nam.
髙田尚良
リンパ腫診断考ーその理想像を追求して「統合診断の意義」.
第114回日本病理学会総会; 2025 Apr 17-19; 仙台.(シンポジウム)
奥野のり子, 山本誠士, 藤川美和, 国沢智巳, 笹原正清, 髙田尚良.
マウス脳髄鞘低形成巣における線維芽細胞の活性化機序.
第114回日本病理学会総会; 2025 Apr 17-19; 仙台.
山本誠士.
オミクス解析によるデータ駆動型の病態解明研究.
日本血管生物医学会特別集会; 2025 Feb 22-23; 東京
Okuno N, Yamamoto S, Fujikawa M, Sasahara M, Takata K.
The mechanism of perivascular fibroblast activation in demyelinating lesions of the mouse brain.
日本血管生物医学会特別集会; 2025 Feb 22-23; 東京.
井波綾香, 奥野のり子, 笹原正清, 髙田尚良, 山本誠士.
リンパ管内皮細胞におけるGeneXの機能解析.
日本血管生物医学会特別集会; 2025 Feb 22-23; 東京
髙田尚良
CD30陽性リンパ腫(HL, ALCL)の標的治療開発.
第7回リンパ腫分子病態研究会; 2025 Jan 18-19; 埼玉.
2024
著 書
髙田尚良.
WHO分類第5版による白血病・リンパ系腫瘍の病態学; 原発性体腔液リンパ腫, 末梢性T細胞リンパ腫非特定型.
中外医学社; p.427-429, 618-621, 東京, 2024.
山本誠士.
医学のあゆみ;【血管・リンパ管研究の最前線と治療への展開】リンパ管の形成と関連する病態リンパ管腫の増悪メカニズムに対する考察と展望.
東京医学社; 289(13), p.1056-1060, 東京, 2024.
原 著
Aoki T, Jiang A, Xu A, Yin Y, Gamboa A, Milne K, Takata K, Miyata-Takata T, Chung S, Rai S, Wu S, Warren M, Strong C, Goodyear T, Morris K, Chong LC, Hav M, Colombo AR, Telenius A, Boyle M, Ben-Neriah S, Power M, Gerrie AS, Weng AP, Karsan A, Roth A, Farinha P, Scott DW, Savage KJ, Nelson BH, Merchant A, Steidl C.
Spatially resolved tumor microenvironment predicts treatment outcomes in relapsed/refractory Hodgkin lymphoma.
J Clin Oncol. 2024, 42(9):1077-1087.doi: 10.1200/JCO.23.01115.
Kato S, Hamada M, Okamoto A, Yamashita D, Miyoshi H, Arai H, Satou A, Gion Y, Sato Y, Tsuyuki Y, Miyata-Takata T, Takata K, Asano N, Takahashi E, Ohshima K, Tomita A, Hosoda W, Nakamura S, Okuno Y.
EBV+ nodal T/NK-cell lymphoma associated with clonal hematopoiesis and structural variations of the viral genome.
Blood Adv. May 14;8(9):2138-2147. doi: 10.1182/bloodadvances.2023012019.
Li J, Chin CR, Ying HY, Meydan C, Teater MR, Xia M, Farinha P, Takata K, Chu CS, Jiang Y, Eagles J, Passerini V, Tang Z, Rivas MA, Weigert O, Pugh TJ, Chadburn A, Steidl C, Scott DW, Roeder RG, Mason CE, Zappasodi R, Béguelin W, Melnick AM.
Loss of CREBBP and KMT2D cooperate to accelerate lymphomagenesis and shape the lymphoma immune microenvironment.
Nat Commun. 2024 Apr 3;15(1):2879. doi: 10.1038/s41467-024-47012-1.
Takata K, Miyata-Takata T, Sato Y.
Frequent CDKN2B/P15 and DAPK1 methylation in duodenal follicular lymphoma is related to duodenal reactive lymphoid hyperplasia.
J Clin Exp Hematop. 2024;64(2):129-137. doi: 10.3960/jslrt.24020.
Takata K, Miyata-Takata T, Nishikori A, Haratake T, Sato Y.
T-cell receptor gamma gene rearrangement analysis on classic Hodgkin lymphoma using BIOMED-2 assay: a paraffin-embedded tissue analysis of one hundred cases.
J Clin Exp Hematop. 2024;64(2):138-143. doi: 10.3960/jslrt.24027.
Makino T, Mizawa M, Takemoto K, Yamamoto S, Shimizu T.
Effect of tumour necrotic factor- α , interleukin-17 andinterleukin-22 on the expression of filaggerin-2 and hornerin: Analysis of a three-dimensional psoriatic skin model.
SkinHealth Dis. 2024 Sep 5; 4(6): e440. doi: 10.1002/ski2.440.
Sarkozy C, Wu S, Takata K, Aoki T, Neriah SB, Milne K, Goodyear T, Strong C, Rastogi T, Hilton LK, Lai D, Sehn LH,Farinha P, Nelson BH, Weng A, Marra M, Scott DW, Craig JW, Steidl C, Roth A. Integrated single cell analysis reveals coevolutionof malignant B cells and tumor micro-environment in transformed follicular lymphoma.
Cancer Cell. 2024 Sep 9;42(9): 1003-1017. doi: 10.1016/j.ccell.2024.07.012.
症例報告
Okuno N, Takagi K, Nakajima T, Fujinami H, Hirabayashi K, Sasahara M.
Primary Gastric Alveolar Rhabdomyosarcoma: A Potent Mimicker of Neuroendocrine Carcinoma.
Cureus. 2024 Sep 22; 16(9): e69907. doi: 10.7759/cureus.69907.
Fusegawa T, Tomita T, Okuno N, Akai T, Kuroda S.
Hemorrhage from metastatic brain epithelioid hemangioendothelioma: A case report.
Neuropathology. 2024 Oct; 44(5): 343. doi: 10.1111/neup.12969.
総 説
髙田尚良.
WHO/ICC分類における低悪性度B細胞リンパ腫.
血液内科. 2024 Dec 28; 89(6): 599-604.
学会報告
Takata K, Iioka H, Tomida S, Liu Y, Okuda S, Usuda H, Kawasaki T, Kitadate A, Takahashi N, Duns G, Sato Y, Steidl C, Ennishi D.
Identification of a Novel Function of B2M Involving T-Cell Exhaustion Via P-Selectin Ligand Upregulation in Diffuse Large B-Cell Lymphoma.
The 66th ASH Annual Meeting and Exposition; 2024 Dec 7-10; San Diego, USA
Rai S, Aoki T, Duns G, Jiang A, Lytle A, Yin Y, Kishida M, Li MY, Smorra D, Lee C, Milne K, Telenius A, O`Brien L, Takata K, Miyata-Takata T, Boyle M, Ben-Neriah S, Weng AP, Roth A, Nelson BH, Hilton LK, Farinha P, Savage KJ, Scott DW, Steidl C.
CSF2RB Mutations Result in Cytokine-Dependent Gain-of-Function Phenotypes in Classic Hodgkin Lymphoma.
The 66th ASH Annual Meeting and Exposition; 2024 Dec 7-10; San Diego, USA
山本誠士.
Suppression of angiogenesis is observed in the wound healing area of macrophage-deficient mice.
IVBM2024(International Vascular Biology Meeting); 2024 Jul 2-5; Amsterdam.
山本誠士.
ヒト嚢胞性リンパ管腫増悪分子メカニズムの解析.
第48回日本リンパ学会総会; 2024 Jun 6-8; 仙台.(招待講演)
髙田尚良.
治療選択肢から考える低悪性度B細胞リンパ腫の鑑別診断.
第113回日本病理学会総会; 2024 Mar 28-30; 名古屋.(招待講演)
高田尚良.
低悪性度B細胞リンパ腫(LGBCL)の病理診断ポイント.
第113回日本病理学会総会ランチョンセミナー;2024 Mar 28-30;名古屋.(シンポジウム)
藤井みのり, 奥野のり子.
アミロイドーシスを伴う急性無石性胆嚢炎の一切除例.
第13回日本臨床外科学会富山県支部例会; 2024 Dec 14; 富山.
山本誠士.
中枢神経系のペリサイトに関するこれまでの発見と展望.
第47回日本分子生物学会年会; 2024 Nov 26-29; 福岡.(招待講演)
丸山邦隆, 富田隆浩, 奥野のり子, 赤井卓也, 浜田さおり, 黒田敏.
トルコ鞍部germinomaの一例.
第14回剣ニューロオンコロジーセミナー; 2024 Nov 9; 富山.
釣浩之, 奥野のり子, 今井千速.
骨肉腫の1例.
第60回北陸小児癌症例検討会; 2024 Sep 28; 金沢.
奥野のり子, 野口映, 市原有美, 高木康司, 南坂尚, 平林健一, 笹原正清.
骨化性筋炎の1例.
第92回日本病理学会中部支部交見会; 2024 Jul 20; 富山.
直井友亮, 千々松良太, 浦田知宏, 角南一貴, 今井利, 名和由一郎, 平松靖史, 山本和彦, 藤井総一郎, 吉田功, 矢野朋文, 高田尚良, 佐藤康晴, 前田嘉信, 遠西大輔.
ABC-DLBCLにおけるCD79B発現低下の臨床的・生物学的意義の解明と検証.
第64回日本リンパ網内系学会学術集会・総会第27回日本血液病理研究会; 2024 Jun 27-29; 東京.
仙田幸音, 岡澤成祐, 松代祐來, 田邊祐貴,野原裕史, 古川大祐, 橋爪萌, 林加奈, 村山望, 高田巨樹, 勢藤善大, 徳井宏太郎, 今西信悟, 三輪敏郎, 猪又峰彦, 林龍二, 松井祥子, 奥野のり子.
好中球優位の胸水を呈したG-CSF産生腫瘍が疑われた悪性胸膜中皮腫の1剖検例.
第93回呼吸器合同北陸地方会; 2024 Jun 26-27; 福井.
山本誠士, 林政雄, 奥野のり子, 濱島丈, 伊東史子, 笹原正清.
マウスLLC皮下移植モデルにおけるPDGFRαの機能解析(Functional analysis of PDGFRalpha in the mouse model of LLC subcutaneous implantation).
第113回日本病理学会総会; 2024 Mar 28-30; 名古屋.
奥野のり子, 山本誠士, 濱島丈, Dang Son Tung, 藤川美和, 国沢智巳, 笹原正清.
進行型多発性硬化症の炎症巣におけるPDGFの役割(The role of PDGFR signal in the inflammation of progressive multiple sclerosis).
第113回日本病理学会総会; 2024 Mar 28-30; 名古屋.
ダン・ツンソン, 山本誠士, 奥野のり子, 濱島丈, 藤川美和, 国沢智巳, 林政雄, レ・ティトゥチャン , 江尻暁里, 笹原正清.
神経幹細胞における血小板由来成長因子受容体α遺伝子の抗老化作用(The anti-senescence effects of platelet derived growth factor alpha gene in neural stem cell).
第113回日本病理学会総会; 2024 Mar 28-30; 名古屋.
2023
著 書
高田尚良
非腫瘍性疾患病理アトラス; リンパ組織.
文光堂, p252-254, 東京, 2023.
原 著
Shah SB, Carlson CR, Lai K, Zhong Z, Marsico G, Lee KM, Félix Vélez NE, Abeles EB, Allam M, Hu T, Walter LD, Martin KE, Gandhi K, Butler SD, Puri R, McCleary-Wheeler AL, Tam W, Elemento O, Takata K, Steidl C, Scott DW, Fontan L, Ueno H, Cosgrove BD, Inghirami G, García AJ, Coskun AF, Koff JL, Melnick A, Singh A.
Combinatorial treatment rescues tumour-microenvironment-mediated attenuation of MALT1 inhibitors in B-cell lymphomas.
Nat Mater. 2023 Apr;22(4):511-523. doi: 10.1038/s41563-023-01495-3.
Takashima Y, Yamamoto S, Okuno N, Hamashima T, Son Tung Dang, Ngoc Dung Tran, Okita N, Fujikawa M, Thanh Chung Dang, Matsuo M, Takao K, Fujimori T, Mori H, Tobe K, Noguchi M, Sasahara M.
PDGF receptor signal mediates the contribution of Nestin-positive cell lineage to subcutaneous fat development.
BiochemBiophys Res Commun. 2023 May 28:658:27-35. doi: 10.1016/j.bbrc.2023.03.052.
症例報告
Yamada R, Miyata-TakataT, TanakaR, Komohara Y, Takata K.
Myeloid sarcoma incidentally found in lymph nodes dissected for advanced gastric cancer.
J Clin Exp Hematop. 2023;63(2):139-142. doi: 10.3960/jslrt.23013.
総説
Takata K.
Highlights: Follicular lymphoma
J Clin Exp Hematop. 2023;63(4):212-213. doi: 10.3960/jslrt.23051.
学会報告
Aoki T, Duns G, Rai S, Lytle A, Yin Y, Sarkozy C, Hung S, Milne K, Telenius A, O`Brien L, Strong C, Goodyear T, Wu S, Takata K, Miyata-Takata T, Boyle M, Ben-Neriah S, Weng AP, Roth A, Prica A, Kridel R, Nelson BH, Farinha P, Savage KJ, Scott DW, Steidl C.
Multi-Dimensional Molecular and Tumor-Microenvironment Analysis of Classic Hodgkin Lymphoma.
65th ASH annual meeting and exposition, 2023 Dec 9-12; San Diego, USA. (oral presentation)
Li J, Chin C, Ying HY, Meydan M, Teater M, Xia M, Farinha P, Takata K, Chu C, Rivas MA, Chadburn A, Steidl C, Scott DW, Roeder RG, Mason C, Beguelin W, Melnick AM.
Cooperative Super-Enhancer Inactivation through Loss of Crebbp and KMT2D Skews B Cell Fate Decisions and Yields T Cell-Depleted Lymphomas.
65th ASH annual meeting and exposition, 2023 Dec 9-12; San Diego, USA. (poster presentation)
Naoi Y, Chijimatsu R, Urata T, Sunami K, Imai T, Nawa Y, Hiramatsu Y, Yamamoto K, Fujii S, Yoshida I, Yano T, Ikeuchi K, Kobayashi K, Tani K, Murakami H, Ujiie H, Sato S, Takata K, Boyle M, Jiang A, Maeda Y, Scott DW, EnnishiD.
CD79 Expression Is Associated with Cell-of-Origin and Outcome in Diffuse Large B-Cell Lymphoma.
65th ASH annual meeting and exposition, 2023 Dec 9-12; San Diego, USA. (poster presentation)
奥野のり子.
髄鞘低形成マウス脳病変における血管周囲性線維芽細胞の解析.
第31回日本血管生物医学会学術集会 (心血管代謝週間CVMW2023); 2023 Dec 9-10; 神戸.
奥野のり子.
血管周囲細胞の推測航法的視点による存在意義の理解.
第46回日本分子生物学会年会; 2023 Dec 6-8; 神戸.(招待講演)
山本祥子, 松井恒志, 深川志保, 荒木美聡, 金谷瑛美, 関根慎一, 藤井努, 奥野のり子, 濱島丈.
乳腺原発腺様嚢胞癌の1例.
第31回日本乳癌学会学術総会; 2023 Jun 29-Jul 1; 横浜.
小梶恵利, 説田愛弓, 橋本亜紀子, 木屋千恵子, 奥野のり子, 濱島丈.
子宮内膜細胞診に腫瘍細胞が出現した子宮体部原発PEComaの1例.
第64回日本臨床細胞学会総会春期大会; 2023 Jun 9-11; 名古屋.
牧野輝彦, 竹本景太, 三澤恵, 山本誠士, 清水忠道.
アトピー性皮膚炎におけるfused S100蛋白質の発現はIL-4/13刺激に依存する 3D皮膚モデル解析.
第122回日本皮膚科学会総会; 2023 Jun 1-4; 横浜.
ダン・ツンソン, 奥野のり子, 濱島丈, 山本誠士, 藤川美和, 松島貴子, グエン・リンクアン, 林政雄, 国沢智巳, 笹原正清.
PDGFRα受容体は神経幹細胞ニッチのNAD+代謝と老化に関与する.(Involvement of PDGFR&alpha in the NAD+ metabolism and the senescence of neural stem cell niche).
第112回日本病理学会総会; 2023 Apr 13-15; 下関.
奥野のり子, 山本誠士, 濱島丈, ダン・ツンソン, 藤川美和, 国沢智巳, 笹原正清.
髄鞘低形成脳病変における線維芽細胞のシングルセル解析.
第112回日本病理学会総会; 2023 Apr 13-15; 下関.
濱島丈, 山本誠士, 奥野のり子, ダン・ソンツン, 笹原正清.
脳腫瘍に対する病理研究者としての克服戦略 血小板由来増殖因子受容体(PDGFR)は膠芽腫の治療標的となりうるか.
第112回日本病理学会総会; 2023 Apr 13-15; 下関.
2022
原 著
Kwon D, Takata K, Zhang Z, Chong L, Fraser B, Zeisler J, Miyata-Takata T, Merkens H, Rousseau J, Aoki T, Kuo HT, Tan R, Zhang C, Lau J, Villa D, Uribe CF, Lin KS, Steidl C, Benard F.
Targeting refractory mantle cell lymphoma for imaging and therapy using C-X-C chemokine receptor type 4 radioligands.
Clin Cancer Res. 2022 Apr 14;28(8):1628-1639. doi: 10.1158/1078-0432.CCR-21-3284.
Takata K, Chong LC, Ennishi D, Aoki T, Li MY, Thakur A, Healy S, Viganò E, Dao T, Kwon D, Duns G, Nielsen JS, Ben-Neriah S, Tse E, Hung SS, Boyle M, Mun SS, Bourne CM, Woolcock B, Telenius A, Kishida M, Rai S, Zhang AW, Bashashati A, Saberi S, D'Antonio G, Nelson BH, Shah SP, Hoodless PA, Melnick AM, Gascoyne RD, Connors JM, Scheinberg DA, Béguelin W, Scott DW, Steidl C.
Tumor-associated antigen PRAME exhibits dualistic functions that are targetable in diffuse large B cell lymphoma.
J Clin Invest. 2022 May 16;132(10):e145343. doi: 10.1172/JCI145343.
Bourne CM, Mun SS, Dao T, Aretz ZEH, Molvi Z, Gejman RS, Daman A, Takata K, Steidl C, Klatt MG, Scheinberg DA.
Unmasking the suppressed immunopeptidome of EZH2 mutated diffuse large B-cell lymphomas with combination drug treatment.
Blood Adv. 2022 Jul 26;6(14):4107-4121. doi: 10.1182/bloodadvances.2021006069.
Colombo AR, Hav M, Singh M, Xu A, Gamboa A, Lemos T, Gerdtsson E, Chen D, Houldsworth J, Shaknovich R, Aoki T, Chong L, Takata K, Chavez EA, Steidl C, Hicks J, Kuhn P, Siddiqi I, Merchant A.
Single-cell spatial analysis of tumor immune architecture in diffuse large B-cell lymphoma.
Blood Adv. 2022 Aug 23;6(16):4675-4690. doi: 10.1182/bloodadvances.2022007493.
Nawaz A, Bilal M, Fujisaka S, Kado T, Aslam MR, Ahmed S, Okabe K, Igarashi Y, Watanabe Y, Kuwano T, Tsuneyama K, Nishimura A, Nishida Y, Yamamoto S, Sasahara M, Imura J, Mori H, Matzuk MM, Kudo F, Manabe I, Uezumi A, Nakagawa T, Oishi Y, Tobe K.
Depletion of CD206+ M2-like macrophages induces fibro-adipogenic progenitors activation and muscle regeneration.
Nat Commun. 2022 Nov 21;13(1):7058. doi: 10.1038/s41467-022-34191-y.
Yamamoto S, Yamamoto S, Akai T, Sasahara M, Kuroda S.
Differentiation of Fibroblasts Into Myofibroblasts in the Arachnoid Membrane of Moyamoya Disease.
Stroke. 2022 Nov;53(11):3465-3473. doi: 10.1161/STROKEAHA.122.039961.
症例報告
Sakai A, Igarashi T, Yoshioka I, Shibuya K, Kimura N, Tohmatsu Y, Watanabe T, Hirano K, Tanaka H, Onoda S, Okuno N, Hamashima T, Imura J, Satake T, Fujii T.
A 47-Year-Old Man with Advanced Distal Pancreatic Carcinoma and an Initial Partial Response to Chemotherapy Requiring Celiac Axis Reconstruction of the Common Hepatic Artery and Left Gastric Artery.
Am J Case Rep. 2022 Sep 10:23:e936840. doi: 10.12659/AJCR.936840.
学会報告
Sarkozy C, Wu S, Takata K, Aoki T, Ben-Neria S, Milne K, Nelson BH, Weng AP, Scott DW, Craig JW, Steidl C, Roth A.
Integrated Single Cell Analysis Reveals Co-Evolution of Malignant B Cells and the Tumor Microenvironment in Transformed Follicular Lymphoma.
64th ASH annual meeting and exposition. 2022 Dec 10-13; New Orleans USA. (oral presentation)
Yamamoto S, Azuma E, Okuno N, Hamashima T, Sasahara M.
The role of macrophages in the perivascular space.
IVBM2022; 2022 Oct 13-17; San Francisco Bay Area (Oakland), CA, USA.
山本誠士.
血管周囲細胞に対する再考察.
第45回日本分子生物学会年会; 2022 Nov 30-Dec 2; 幕張.(招待講演)
高田尚良.
WHO分類におけるDLBCLと類縁疾患の病理診断.
第61回日本臨床細胞学会秋季大会; 2022 Nov 5-6; 仙台.(シンポジウム)
高田尚良, 野口晋佐.
日本血液病理研究会ケースカンファレンス.
第62回日本リンパ網内系学会総会; 2022 Jun.23-25; 埼玉.(シンポジウム)
高田尚良.
リンパ腫におけるゲノム解析の病理学的診断・研究への応用.
第111回日本病理学会総会; 2022 Apr 14-16; 神戸.(シンポジウム)
奥野のり子, 濱島丈, 笹原正清.
高分化型乳頭状中皮腫の一例.
第33回北陸病理集談会; 2022 Oct 22; 石川県七尾市和倉温泉.
松田未央, 山本誠士, 奥野のり子, 濱島丈, 山内直岳, 笹原正清.
PDGFRシグナルは血管正常化をベースとするglioma治療の有力なターゲットである.
第111回日本病理学会総会; 2022 Apr 14-16; 神戸.
林政雄, 山本誠士, 吉田尚史, 高島侑美, Dang Tung Son, 奥野のり子, 濱島丈, 伊東史子, 笹原正清.
PDGFRαノックアウトマウスを用いたLLC皮下移植モデルにおける腫瘍発育動態の解析.
第111回日本病理学会総会; 2022 Apr 14-16; 神戸.
奥野のり子, 山本誠士, 濱島丈, 藤川美和, 松島貴子, 山内直岳, 笹原正清.
髄膜固有線維芽細胞は, 髄鞘低形成脳の炎症性組織改変を誘導する.
第111回日本病理学会総会; 2022 Apr 14-16; 神戸.
ダン・ツンソン, 奥野のり子, 濱島丈, 山本誠士, 山内直岳, 藤川美和, 松島貴子, グエン・リンクアン, 林政雄, 笹原正清.
PDGFRαは神経幹細胞の老化に関与する(An involvement of PDGFR α in the senescence of neural stem/progenitor cells).
第111回日本病理学会総会; 2022 Apr 14-16; 神戸.
山本誠士, 奥野のり子, 濱島丈, 林政雄, 吉田尚史, 堀川慎二郎, 山内直岳, 笹原正清.
マウス皮下血管新生モデルを用いたPDGFRβの血管新生における役割の検討.
第111回日本病理学会総会; 2022 Apr 14-16; 神戸.
山本誠士.
組織修復におけるマクロファージの役割.
第2回血管研究会; 2022 Feb 22-23; オンライン.(招待講演)
2021
原 著
Sarkozy C, Hung SS, Chavez EA, Duns G, Takata K, Chong LC, Aoki T, Jiang A, Miyata-Takata T, Telenius A, Slack GW, Molina TJ, Ben-Neriah S, Farinha P, Dartigues P, Damotte D, Mottok A, Salles GA, Casasnovas RO, Savage KJ, Laurent C, Scott DW, Traverse-Glehen A, Steidl C.
Mutational landscape of gray zone lymphoma.
Blood. 2021 Apr 1;137(13):1765-1776. doi: 10.1182/blood.2020007507.
Razzaghi R, Agarwal S, Kotlov N, Plotnikova O, Nomie K, Huang DW, Wright GW, Smith GA, Li M, Takata K, Yamadi M, Yao C, O'Shea JJ, Phelan JD, Pittaluga S, Scott DW, Muppidi JR.
Compromised counterselection by FAS creates an aggressive subtype of germinal center lymphoma.
J Exp Med. 2021 Mar 1;218(3):e20201173. doi: 10.1084/jem.20201173.
Tomita S, Kikuti YY, Carreras J, Sakai R, Takata K, Yoshino T, Bea S, Campo E, Missiaglia E, Bouilly J, Letourneau A, de Leval L, Nakamura N.
Monomorphic epitheliotropic intestinal T-ell lymphoma in Asia frequently shows SETD2 alterations.
Cancers (Basel). 2020 Nov 27;12(12):3539. doi: 10.3390/cancers12123539.
Duns G, Viganò E, Ennishi D, Sarkozy C, Hung SS, Chavez E, Takata K, Rushton C, Jiang A, Ben-Neriah S, Woolcock BW, Slack GW, Hsi ED, Craig JW, Hilton LK, Shah SP, Farinha P, Mottok A, Gascoyne RD, Morin RD, Savage KJ, Scott DW, Steidl C.
Characterization of DLBCL with a PMBL gene expression signature.
Blood. 2021 Jul 15;138(2):136-148. doi: 10.1182/blood.2020007683.
Aoki T, Chong LC, Takata K, Milne K, Marshall A, Chavez EA, Miyata-Takata T, Ben-Neriah S, Unrau D, Telenius A, Boyle M, Weng AP, Savage KJ, Scott DW, Farinha P, Shah SP, Nelson BH, Steidl C.
Single-cell profiling reveals the importance of CXCL13/CXCR5 axis biology in lymphocyte-rich classic Hodgkin lymphoma.
Proc Natl Acad Sci U S A. 2021 Oct 12;118(41):e2105822118. doi: 10.1073/pnas.2105822118.
Akai T, Hatta T, Sakata-Haga H, Yamamoto S, Otani H, Yamamoto S, Kuroda S.
Cerebrospinal fluid may flow out from the brain through the frontal skull base and choroid plexus: a gold colloid and cadaverine injection study in mouse fetus.
Childs Nerv Syst. 2021 Oct;37(10):3013-3020. doi: 10.1007/s00381-021-05253-1.
Kuwano T, Izumi H, Aslam MR, Igarashi Y, Bilal M, Nishimura A, Watanabe Y, Nawaz A, Kado T, Ikuta K, Yamamoto S, Sasahara M, Fujisaka S, Yagi K, Mori H, Tobe K.
Generation and characterization of a Meflin-CreERT2 transgenic line for lineage tracing in white adipose tissue.
PLoS One. 2021 Mar 24;16(3):e0248267. doi: 10.1371/journal.pone.0248267.
Yoshida N, Yamamoto S, Hamashima T, Okuno N, Okita N, Horikawa S, Hayashi M, Dang TC, Nguyen QL, Nishiyama K, Makino T, Ishii Y, Tomihara K, Shimizu T, Shibuya M, Noguchi M, Sasahara M.
Dysregulation of Amphiregulin stimulates the pathogenesis of cystic lymphangioma.
Proc Natl Acad Sci U S A. 2021 May 11;118(19):e2019580118. doi: 10.1073/pnas.2019580118.
Nguyen QL, Okuno N, Hamashima T, Dang ST, Fujikawa M, Ishii Y, Enomoto A, Maki T, Nguyen HN, Nguyen VT, Fujimori T, Mori H, Andrae J, Betsholtz C, Takao K, Yamamoto S, Sasahara M.
Vascular PDGFR-alpha protects against BBB dysfunction after stroke in mice.
Angiogenesis. 2021 Feb;24(1):35-46. doi: 10.1007/s10456-020-09742-w.
Morita M, Kaizawa T, Yoda T, Oyama T, Asakura R, Matsumoto S, Nagai Y, Watanabe Y, Watanabe S, Kobayashi H, Kawaguchi K, Yamamoto S, Shimozawa N, So T, Imanaka T.
Bone marrow transplantation into Abcd1-deficient mice: distribution of donor derived-cells and biological characterization of the brain of the recipient mice.
J Inherit Metab Dis. 2021 May;44(3):718-727. doi: 10.1002/jimd.12346.
症例報告
山内直岳, 濱島丈, 奥野のり子, 田中真一, 野口映, 鈴木賀代, 安田剛敏, 井村穣二, 長谷川匡, 笹原正清.
30年の経過を経て高異型度の領域が出現した末梢神経鞘腫瘍の1例.
診断病理. 38(3): 285-94. 2021.
学会報告
山本誠士, 吉田尚史, 奥野のり子, 濱島丈, 笹原正清.
ヒト嚢胞性リンパ管腫増悪分子メカニズムの解析.
第110回日本病理学会総会; 2021 Apr 22-24; 東京都新宿区.
高島侑美, 山本誠士, 濱島丈, 奥野のり子, 榎本篤, 冨原圭, 野口誠, 笹原正清.
マウス膵管癌細胞と腫瘍関連線維芽細胞の機能的関連(Functional correlation between mouse pancreatic duct carcinoma cell and cancer associated fibroblast).
第110回日本病理学会総会; 2021 Apr 22-24; 東京都新宿区.
奥野のり子, 濱島丈, Nguyen Quang Linh, Dang Son Tung, 藤川美和, 松島貴子, 山本誠士, 笹原正清.
髄膜から動員される血管周囲性の線維芽細胞の役割(Functional significance of the perivascular fibroblasts recruited from meninges).
110回日本病理学会総会; 2021 Apr 22-24; 東京都新宿区.
Nguyen Quang Linh, 奥野のり子, 冨原圭, 濱島丈, Dang Son Tung, 藤川美和, 松島貴子, 山本誠士, 笹原正清.
オリゴデンドロサイト前駆細胞は脳卒中関連の炎症反応の引き金になります(Oligodendrocyte Progenitor cells trigger stroke-related inflammatory responses).
第110回日本病理学会総会; 2021 Apr 22-24; 東京都新宿区.
濱島丈, 山内直岳, 奥野のり子, 山本誠士, 笹原正清.
特異な悪性度の進展経過をしめした悪性末梢神経鞘腫瘍の一例(A case of malignant peripheral neves sheath tumor with aberrant exacerbation of malignancy).
第110回日本病理学会総会; 2021 Apr 22-24; 東京都新宿区.
林政雄, 山本誠士, 吉田尚史, 高島侑美, Sang Yang, Nguyen Quang Linh, Dang Son Tung, 奥野のり子, 濱島丈, 伊東史子, 笹原正清.
LLC皮下移植モデルにおけるPDGFRαノックアウトマウスの腫瘍発育動態の解析.
第110回日本病理学会総会; 2021 Apr 22-24; 東京都新宿区.
川口アエ, 山本誠士, 奥野のり子, 濱島丈, 山内直岳, 笹原正清.
創傷治癒部位におけるCD206陽性マクロファージ由来血管新生因子の解析(Analysis of the CD206-positive macrophage-derived angiogenic factor at woundheling area) .
第110回日本病理学会総会; 2021 Apr 22-24; 東京都新宿区.
Nguyen Quang Linh, 奥野のり子, 冨原圭, 濱島丈, Dang Son Tung, 藤川美和, 松島貴子, 山本誠士, 笹原正清.
虚血後乏突起膠前駆細胞により活性化するミクログリア/マクロファージ(Oligodendroglia progenitor cells activated microglial cells/macrophages after ischemia).
第110回日本病理学会総会; 2021 Apr 22-24; 東京都新宿区.
2020
原 著
Ennishi D, Healy S, Bashashati A, Saberi S, Hother C, Mottok A, Chan FC, Chong L, Abraham L, Kridel R, Boyle M, Meissner B, Aoki T, Takata K, Woolcock BW, Viganò E, Gold M, Molday LL, Molday RS, Telenius A, Li MY, Wretham N, Dos Santos N, Wong M, Viller NN, Uger RA, Duns G, Baticados A, Madero A, Bristow BN, Farinha P, Slack GW, Ben-Neriah S, Lai D, Zhang AW, Salehi S, Shulha HP, Chiu DS, Mostafavi S, Gerrie AS, Huang DW, Rushton C, Villa D, Sehn LH, Savage KJ, Mungall AJ, Weng AP, Bally MB, Morin RD, Cohen Freue GV, Staudt LM, Connors JM, Marra MA, Shah SP, Gascoyne RD, Scott DW, Steidl C.
TMEM30A loss-of-function mutations drive lymphomagenesis and confer therapeutically exploitable vulnerability in B-cell lymphoma.
Nat Med. 2020 Apr;26(4):577-588. doi: 10.1038/s41591-020-0757-z.
Aoki T, Chong LC, Takata K, Milne K, Hav M, Colombo A, Chavez EA, Nissen M, Wang X, Miyata-Takata T, Lam V, Vigano E, Woolcock BW, Telenius A, Li MY, Healy S, Ghesquiere C, Kos D, Goodyear T, Veldman J, Zhang AW, Kim J, Saberi S, Ding J, Farinha P, Weng AP, Savage KJ, Scott DW, Krystal G, Nelson BH, Mottok A, Merchant A, Shah SP, Steidl C.
Single cell transcriptome analysis reveals disease-defining T cell subsets in the tumor microenvironment of classic Hodgkin lymphoma.
Cancer Discov. 2020 Mar;10(3):406-421. doi: 10.1158/2159-8290.CD-19-0680.
Béguelin W, Teater M, Meydan C, Hoehn KB, Phillip JM, Soshnev AA, Venturutti L, Rivas MA, Calvo-Fernández MT, Gutierrez J, Camarillo JM, Takata K, Tarte K, Kelleher NL, Steidl C, Mason CE, Elemento O, Allis CD, Kleinstein SH, Melnick AM.
Mutant EZH2 Induces a Pre-malignant Lymphoma Niche by Reprogramming the Immune Response.
Cancer Cell. 2020 May 11;37(5):655-673.e11. doi: 10.1016/j.ccell.2020.04.004.
Sarkozy C, Chong L, Takata K, Chavez EA, Miyata-Takata T, Duns G, Telenius A, Boyle M, Slack GW, Laurent C, Farinha P, Molina TJ, Copie-Bergman C, Damotte D, Salles GA, Mottok A, Savage KJ, Scott DW, Traverse-Glehen A, Steidl C.
Gene expression profiling of gray zone lymphoma.
Blood Adv. 2020 Jun 9;4(11):2523-2535. doi: 10.1182/bloodadvances.2020001923.
Makino T, Mizawa M, Yoshihisa Y, Yamamoto S, Tabuchi Y, Miyai M, Hibino T, Sasahara M, Shimizu T.
Trichohyalin-like 1 protein plays a crucial role in proliferation and anti-apoptosis of normal human keratinocytes and squamous cell carcinoma cells.
ell Death Discov. 2020 Oct 27:6:109. doi: 10.1038/s41420-020-00344-5.
Nishida Y, Nawaz A, Kado T, Takikawa A, Igarashi Y, Onogi Y, Wada T, Sasaoka T, Yamamoto S, Sasahara M, Imura J, Tokuyama K, Usui I, Nakagawa T, Fujisaka S, Kunimasa Y, Tobe K.
Astaxanthin stimulates mitochondrial biogenesis in insulin resistant muscle via activation of AMPK pathway.
J Cachexia Sarcopenia Muscle. 2020 Feb;11(1):241-258. doi: 10.1002/jcsm.12530.
Fujisaka S, Usui I, Nawaz A, Igarashi Y, Okabe K, Furusawa Y, Watanabe S, Yamamoto S, Sasahara M, Watanabe Y, Nagai Y, Yagi K, Nakagawa T, Tobe K.
Bofutsushosan improves gut barrier function with a bloom of Akkermansiamuciniphila and improves glucose metabolism in mice with diet-induced obesity.
Sci Rep. 2020 Mar 26;10(1):5544. doi: 10.1038/s41598-020-62506-w.
Watanabe E, Wada T, Okekawa A, Kitamura F, Komatsu G, Onogi Y, Yamamoto S, Sasahara M, Kitada M, Koya D, Tsuneki H, Sasaoka T.
Stromal cell-derived factor 1 (SDF1) attenuates platelet-derived growth factor-B (PDGF-B)-induced vascular remodeling for adipose tissue expansion in obesity.
Angiogenesis. 2020 Nov;23(4):667-684. doi: 10.1007/s10456-020-09738-6.
Hayashi T, Yamamoto S, Hamashima T, Mori H, Sasahara M, Kuroda S.
Critical role of platelet-derived growth factor-α in angiogenesis after indirect bypass in a murine moyamoya disease model.
J Neurosurg. 2020 May 22;134(5):1535-1543. doi: 10.3171/2020.3.JNS193273.
Hamashima T, Ishii Y, Nguyen QL, Okuno N, Sang Y, Matsushima T, Kurashige Y, Takebayashi H, Mori H, Fujimori T, Yamamoto S, Sasahara M.
Oligodendrogenesis and Myelin Formation in the Forebrain Require Platelet-derived Growth Factor Receptor-alpha.
Neuroscience. 2020 Jun 1:436:11-26. doi: 10.1016/j.neuroscience.2020.04.001. Epub 2020 Apr 9.
症例報告
Nishiyama N, Ikehata Y, Okuno N, Sasahara M, Sakamaki I, Yamamoto Y, Kitamura H.
A rare case of synchronous bilateral epididymal and testicular metastases of urothelial carcinoma of the bladder after intravesical bacillus Calmette-Guerin.
Int Cancer Conf J. 2020 Sep 30;10(1):59-62. doi: 10.1007/s13691-020-00448-w.
学会報告
Aoki T, Chong LC, Takata K, Milne K, Chavez E, Miyata-Takata T, Ben-Neriah S, Unrau D, Telenius A, Boyle M, Farinha P, Weng AP, Savage KJ, Scott DW, Shah SP, Nelson BH, Steidl C.
Single Cell Profiling Reveals Unique CXCL13 Positive T Cell Subsets in the Tumor Microenvironment of Lymphocyte Rich Classic Hodgkin Lymphoma.
62nd ASH annual meeting and exposition; 2020 Dec 5-8; San Diego USA. (poster presentation)
Takata K, Aoki T, Chong LC, Milne K, Miyata-Takata T, Singh K, Goodyear T, Farinha P, Slack GW, Sehn LH, Savage KJ, Nelson BH, Scott DW, Steidl C.
Identification of LAG3+ T Cell Populations in the Tumor Microenvironment of Classical Hodgkin Lymphoma and B-Cell Non-Hodgkin Lymphoma.
62nd ASH annual meeting and exposition; 2020 Dec 5-8; San Diego USA. (poster presentation)
Takata K, Chong LC, Ennishi D, Thakur A, Healy S, Viganò E, Dao T, Nielsen JS, Ben-Neriah S, Aoki T, Tse E, Hung SS, Li MY, Boyle M, Mun SS, Bourne C, Woolcock B, Telenius A, Zhang A, Bashashati A, Saberi S, Antonio GD, Nelson BH, Shah SP, Hoodless PA, Melnick AM, Gascoyne RD, Connors JM, Scheinberg DA, Béguelin W, Scott DW, Steidl C.
The tumor associated antigen PRAME exhibits dualistic functions that are targetable in diffuse large B cell lymphoma.
62nd ASH annual meeting and exposition; 2020 Dec 5-8; San Diego USA. (oral presentation)
Makino T, Mizawa M, Yoshihisa Y, Yamamoto S, Tabuchi Y, Miyai M, Shimizu T.
Trichohyalin-like 1 protein plays a crucial role in the proliferation of normal human keratinocytes and squamous cell carcinoma.
日本研究皮膚科学会第45回年次学術大会・総会; 2020 Dec 21-23; 名古屋.
Yamamoto S, Yoshida N, Hamashima T, Okuno N, Horikawa S, Ishii Y, Sasahara M.
PDGFRβ knockout fibroblasts are involved in the formation of cyst-like lymphatic vessels.
第109回日本病理学会総会; 2020 Apr 16-18; 福岡.
Nguyen QL, Yamamoto S, Okuno N, Hamashima T, Sang Y, Hayashi M, Dang ST, Takashima Y, Sasahara M.
Distinctive role of PDGFRα-expressing two cell populations in ischemic stroke.
第109回日本病理学会総会; 2020 Apr 16-18; 福岡.
林政雄, 山本誠士, 吉田尚史, 高島侑美, Sang Y, Nguyen QL, Dang ST, 奥野のり子, 濱島丈, 笹原正清.
LLC皮下移植モデルにおけるPDGFRαノックアウトマウスの腫瘍発育動態の解析.
第109回日本病理学会総会; 2020 Apr 16-18; 福岡.
Patent
山本誠士, 笹原正清, 濱島丈, 奥野のり子.
inventors; 富山大学
assignee. 嚢胞性リンパ管腫治療薬.
特願2020-201580. 2020 Dec 4.
2019
原 著
Takata K, Saito K, Maruyama S, Miyata-Takata T, Iioka H, Okuda S, Ling Y, Karube K, Miki Y, Maeda Y, Yoshino T, Steidl C, Kondo E.
Identification of TRA-1-60-positive cells as a potent refractory population in follicular lymphomas.
Cancer Sci. 2019 Jan;110(1):443-457. doi: 10.1111/cas.13870.
Ennishi D, Jiang A, Boyle M, Collinge B, Grande BM, Ben-Neriah S, Rushton C, Tang J, Thomas N, Slack GW, Farinha P, Takata K, Miyata-Takata T, Craig J, Mottok A, Meissner B, Saberi S, Bashashati A, Villa D, Savage KJ, Sehn LH, Kridel R, Mungall AJ, Marra MA, Shah SP, Steidl C, Connors JM, Gascoyne RD, Morin RD, Scott DW.
Double-Hit Gene Expression Signature Defines a Distinct Subgroup of Germinal Center B-Cell-Like Diffuse Large B-Cell Lymphoma.
J Clin Oncol. 2019 Jan 20;37(3):190-201. doi: 10.1200/JCO.18.01583. Epub 2018 Dec 3.
Gion Y, Takeuchi M, Shibata R, Takata K, Miyata-Takata T, Orita Y, Tachibana T, Yoshino T, Sato Y.
Up-regulation of activation-induced cytidine deaminase and its strong expression in extra-germinal centres in IgG4-related disease.
Sci Rep. 2019 Jan 24;9(1):761. doi: 10.1038/s41598-018-37404-x.
Ennishi D, Takata K, Béguelin W, Duns G, Mottok A, Farinha P, Bashashati A, Saberi S, Boyle M, Meissner B, Ben-Neriah S, Woolcock BW, Telenius A, Lai D, Teater M, Kridel R, Savage KJ, Sehn LH, Morin RD, Marra MA, Shah SP, Connors JM, Gascoyne RD, Scott DW, Melnick AM, Steidl C.
Molecular and Genetic Characterization of MHC Deficiency Identifies EZH2 as Therapeutic Target for Enhancing Immune Recognition.
Cancer Discov. 2019 Apr;9(4):546-563. doi: 10.1158/2159-8290.CD-18-1090.
Watanabe Y, Nagai Y, Honda H, Okamoto N, Yanagibashi T, Ogasawara M, Yamamoto S, Imamura R, Takasaki I, Hara H, Sasahara M, Arita M, Hida S, Taniguchi S, Suda T, Takatsu K.
Bidirectional crosstalk between neutrophils and adipocytes promotes adipose tissue inflammation.
FASEB J. 2019 Nov;33(11):11821-11835. doi: 10.1096/fj.201900477RR. Epub 2019 Jul 29.
Dang TC, Ishii Y, Nguyen V, Yamamoto S, Hamashima T, Okuno N, Nguyen QL, Sang Y, Ohkawa N, Saitoh Y, Shehata M, Takakura N, Fujimori T, Inokuchi K, Mori H, Andrae J, Betsholtz C, Sasahara M.
Powerful Homeostatic Control of Oligodendroglial Lineage by PDGFRα in Adult Brain.
Cell Rep. 2019 Apr 23;27(4):1073-1089.e5. doi: 10.1016/j.celrep.2019.03.084.
Shen J, Xu G, Zhu R, Yuan J, Ishii Y, Hamashima T, Matsushima T, Yamamoto S, Takatsuru Y, Nabekura J, Sasahara M.
PDGFR-b restores blood-brain barrier functions in a mouse model of focal cerebral ischemia.
J Cereb Blood Flow Metab. 2019 Aug;39(8):1501-1515. doi: 10.1177/0271678X18769515.
症例報告
一松啓介, 上村吉穂, 江川雅之, 奥野のり子, 寺畑信太郎.
腎Tubulocystic carcinomaの1例.
泌尿器科紀要.65(4):139- 2019.
上村吉穂, 一松啓介, 江川雅之, 奥野のり子, 寺畑信太郎, 木村圭一.
腎静脈内腫瘍塞栓を伴った右腎盂癌の1例.
泌尿器科紀要. 65(4):145. 2019.
学会報告
Yamamoto S.
The roles of PDGFRβ in pathogenesis and regeneration.
New Advance in Medical Educaion,Research and Treatment; 2019 Feb 28- Mar 1; Ha Noi. (Invited lecture)
Sarkozy C, Hung S, Takata K, Chavez E, Aoki T, Duns G, Slack GW, Telenius A, Miyata-Takata T, Viganò E, Molina TJ, Damotte D, Ben-Neriah S, Copie-Bergman C, Laurent C, Mottok A, Salles G, Savage KJ, Scott DW, Traverse-Glehen A, Steidl C.
Mutational Landscape of Grey Zone Lymphoma.
61st ASH Annual meeting and exposition, 2019 Dec 7-10; Orland USA. (oral presentation)
Aoki T, Chong LC, Takata K, Milne K, Hav M, Colombo A, Chavez E, Miyata-Takata T, Lam V, Ghesquiere C, Kos D, Goodyear T, Zhang AW, Wang X, Saberi S, Ding JW, Farinha P, Weng AP, Savage KJ, Scott DW, Krystal G, Nelson BH, Mottok A, Merchant A, Shah SP, Steidl C.
Single Cell Transcriptome Analysis Reveals Disease-Defining T Cell Subsets in the Tumor Microenvironment of Classic Hodgkin Lymphoma.
61st ASH Annual meeting and exposition, 2019 Dec 7-10; Orland USA. (oral presentation)
Takata K, Chong LC, Thakur A, Aoki T, Mottok A, Chavez E, Farinha P, Slack GW, Hoodles P, Shah SP, Scott DW, Steidl C.
PRAME Expression Is Correlated with Treatment Outcome and Specific Features of the Tumor Microenvironment in Classical Hodgkin Lymphoma.
61st ASH Annual meeting and exposition, 2019 Dec 7-10; Orland USA. (poster presentation)
Nakaoka H, Hirono K, Yamamoto S, Takasaki I, Takahashi K, Okabe M, Miyao N, Ibuki K, Ozawa S, Ichida F.
MicroRNA-145-5p and MicroRNA-320a encapsulated in endothelial microparticles contribute to the progression of vasculitis in acute Kawasaki disease.
AHA Scientific Sessions 2019; 2019 Nov 16-18; Philadelphia.
Yamamoto S, Okuno N, Hamashima T, Sasahara M.
The roles of PDGFRβ in pathogenesis and regeneration of the CNS.
AAVBM2019; 2019 Sep 19-22; Sydney, Australia.
山本誠士.
ペリサイトのheterogeneityが関与する組織再生と破綻.
第42回日本分子生物学会年会; 2019 Dec 3-6; 福岡.(招待講演)
山本誠士.
Heterogeneousなペリサイトが神経組織の破綻と再生に深く関与する.
第61回日本平滑筋学会総会, シンポジウム; 2019 Aug 1-3; 名古屋.(招待講演)
山本誠士.
脳血管発生とペリサイト −その発生源に迫る−
第124回日本解剖学会総会, シンポジウム; 2019 Mar 27-29; 新潟.(招待講演)
山本誠士, 奥野のり子, 濱島丈, 笹原正清.
組織の恒常性と破綻に関与するheterogeneousなペリサイト.
CVMW2019; 2019 Dec 14-15; 神戸.
Hamashima T, Ishii Y, Yamamoto S, Ngyuen QL, Okuno N, Sang Y, Matsushima T, Kurashige Y, Sasahara M.
The role of PDGFR α in the oligodendrogenesis and myelin formation in forebrain.
BRAIN & BRAIN PET 2019 (The 29th International Symposium on Cerebral Blood Flow, Metabolism and Function); 2019 Jul 4-7; Yokohama.(ポスター)
Sang Y, Hamashima T, Yamamoto S, Okuno N, Ngyuen QL, Ishii Y, Sasahara M.
Diverse effects of PDGF signals in glioma growth.
BRAIN & BRAIN PET 2019 (The 29th International Symposium on Cerebral Blood Flow, Metabolism and Function); 2019 Jul 4-7; Yokohama.(ポスター)
Ngyuen QL, Dang TC, Hamashima T, Sang Y, Okuno N, Ishii Y, Sasahara M, Yamamoto S.
PDGFRα controls dynamicremodelling of oligodendrocyte progenitor cells in adult brain.
BRAIN & BRAIN PET 2019 (The 29th International Symposium on Cerebral Blood Flow, Metabolism and Function); 2019 Jul 4-7; Yokohama.(ポスター)
山本誠士, 濱島丈, 奥野のり子, 石井陽子, 笹原正清.
中枢神経系の微小血管を被覆するペリサイトのheterogeneity.
第108回日本病理学会総会; 2019 May 9-11; 東京.
桑洋, 山本誠士, 濱島丈, 奥野のり子, 倉茂洋一, 松島貴子, Nguyen Quang Linh, 石井陽子, 笹原正清.
神経膠腫におけるPDGF阻害後に誘導される血管表現型(Vascular phenotypes induced after PDGF inhibition in glioma).
第108回日本病理学会総会; 2019 May 9-11; 東京.(ポスター)
グエンクアン・リン, 山本誠士, 濱島丈, 奥野のり子, 桑洋, 笹原正清.
PDGFRαは成体脳のSVZに存在する神経幹細胞の増殖や分化に重要である(PDGFRa controls the stem cell activities in the subventricular zone stem cells in adult mouse brain).
第108回日本病理学会総会; 2019 May 9-11; 東京.(ポスター)
山田萌, 山本誠士, 山田浩太, 濱島丈, 奥野のり子, 石井陽子, 笹原正清.
線維芽細胞の遊走におけるPDGFR二量体シグナルの役割.
第108回日本病理学会総会; 2019 May 9-11; 東京.(ポスター)
垣内寿枝子, 寺畑信太郎, 奥野のり子, 又野禎也.
Triple lymphomaの1例.
第108回日本病理学会総会; 2019 May 9-11; 東京.(ポスター)
2018
著 書
能島舞, 田端哲也, 高田尚良, 吉野正.
リンパ腫アトラス(第5版).
文光堂, p120-122, p123-128, 東京, 2018.
原 著
Muhammad K, Rudolf R, Pham DAT, Klein-Hessling S, Takata K, Matsushita N, Ellenrieder V, Kondo E, Serfling E.
Induction of Short NFATc1/αA Isoform Interferes with Peripheral B Cell Differentiation.
Front Immunol. 2018 Jan 24:9:32. doi: 10.3389/fimmu.2018.00032.
Miyaoka M, Kikuti YY, Carreras J, Ikoma H, Hiraiwa S, Ichiki A, Kojima M, Ando K, Yokose T, Sakai R, Hoshikawa M, Tomita N, Miura I, Takata K, Yoshino T, Takizawa J, Bea S, Campo E, Nakamura N.
Clinicopathological and genomic analysis of double-hit follicular lymphoma: comparison with high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements.
Mod Pathol. 2018 Feb;31(2):313-326. doi: 10.1038/modpathol.2017.134.
Fujii M, Takata K, Chuang SS, Miyata-Takata T, Ando M, Sato Y, Yoshino T.
A20 (TNFAIP3) Alterations in Primary Intestinal Diffuse Large B-cell Lymphoma.
Acta Med Okayama. 2018 Feb;72(1):23-30. doi: 10.18926/AMO/55659.
Tabata T, Takata K, Miyata-Takata T, Sato Y, Ishizawa S, Kunitomo T, Nagakita K, Ohnishi N, Taniguchi K, Noujima-Harada M, Maeda Y, Tanimoto M, Yoshino T.
Characteristic Distribution Pattern of CD30-positive Cytotoxic T Cells Aids Diagnosis of Kikuchi-Fujimoto Disease.
Appl Immunohistochem Mol Morphol. 2018 Apr;26(4):274-282. doi: 10.1097/PAI.0000000000000411.
Viganò E, Gunawardana J, Mottok A, Van Tol T, Mak K, Chan FC, Chong L, Chavez E, Woolcock B, Takata K, Twa D, Shulha HP, Telenius A, Kutovaya O, Hung SS, Healy S, Ben-Neriah S, Leroy K, Gaulard P, Diepstra A, Kridel R, Savage KJ, Rimsza L, Gascoyne R, Steidl C.
Somatic IL4R mutations in primary mediastinal large B-cell lymphoma lead to constitutive JAK-STAT signaling activation.
Blood. 2018 May 3;131(18):2036-2046. doi: 10.1182/blood-2017-09-808907.
Tari A, Kitadai Y, Mouri R, Takigawa H, Asaoku H, Mihara K, Takata K, Fujihara M, Yoshino T, Koga T, Fujimori S, Tanaka S, Chayama K.
Watch-and-wait policy versus rituximab-combined chemotherapy in Japanese patients with intestinal follicular lymphoma.
J Gastroenterol Hepatol. 2018 Aug;33(8):1461-1468. doi: 10.1111/jgh.14100.
Yamashita D, Shimada K, Takata K, Miyata-Takata T, Kohno K, Satou A, Sakakibara A, Nakamura S, Asano N, Kato S.
Reappraisal of nodal Epstein-Barr Virus-negative cytotoxic T-cell lymphoma: Identification of indolent CD5+ diseases.
Cancer Sci. 2018 Aug;109(8):2599-2610. doi: 10.1111/cas.13652.
Omote S, Takata K, Tanaka T, Miyata-Takata T, Ayada Y, Noujima-Harada M, Omote R, Tabata T, Sato Y, Toyokawa T, Kato H, Yagi T, Okada H, Yoshino T.
Overexpression of folate receptor alpha is an independent prognostic factor for outcomes of pancreatic cancer patients.
Med Mol Morphol. 2018 Dec;51(4):237-243. doi: 10.1007/s00795-018-0197-8.
Miyata-Takata T, Chuang SS, Takata K, Toji T, Maeda Y, Sato Y, Yoshino T.
Expression of T-cell receptor signalling pathway components in extranodal NK/T-cell lymphoma.
Histopathology. 2018 Dec;73(6):1030-1038. doi: 10.1111/his.13728.
Yamada K, Hamashima T, Ishii Y, Yamamoto S, Okuno N, Yoshida N, Yamada M, Huang TT, Shioda N, Tomihara K, Fujimori T, Mori H, Fukunaga K, Noguchi M, Sasahara M.
Different PDGF Receptor Dimers Drive Distinct Migration Modes of the Mouse Skin Fibroblast.
Cell Physiol Biochem. 2018;51(3):1461-1479. doi: 10.1159/000495594.
Igarashi Y, Nawaz A, Kado T, Bilal M, Kuwano T, Yamamoto S, Sasahara M, Jiuxiang X, Inujima A, Koizumi K, Imura J, Shibahara N, Usui I, Fujisaka S, Tobe K.
Partial depletion of CD206-positive M2-like macrophages induces proliferation of beige progenitors and enhances browning after cold stimulation.
Sci Rep. 2018 Oct 1;8(1):14567. doi: 10.1038/s41598-018-32803-6.
Kitahara H, Kajikawa S, Ishii Y, Yamamoto S, Hamashima T, Azuma E, Sato H, Matsushima T, Shibuya M, Shimada Y, Sasahara M.
The Novel Pathogenesis of Retinopathy Mediated by Multiple RTK Signals is Uncovered in Newly Developed Mouse Model.
EBioMedicine. 2018 May:31:190-201. doi: 10.1016/j.ebiom.2018.04.021.
Ogura K, Sato-Matsushita M, Yamamoto S, Hori T, Sasahara M, Iwakura Y, Saiki I, Tahara H, Hayakawa Y.
NK Cells Control Tumor-Promoting Function of Neutrophils in Mice.
Cancer Immunol Res. 2018 Mar;6(3):348-357. doi: 10.1158/2326-6066.CIR-17-0204.
Nawaz A, Mehmood A, Kanatani Y, Kado T, Igarashi Y, Takikawa A, Yamamoto S, Okabe K, Nakagawa T, Yagi K, Fujisaka S, Tobe K.
Publisher Correction: Sirt1 activator induces proangiogenic genes in preadipocytes to rescue insulin resistance in diet-induced obese mice.
Sci Rep. 2018 Sep 26;8(1):14597. doi: 10.1038/s41598-018-32600-1.
Nakaoka H, Hirono K, Yamamoto S, Takasaki I, Takahashi K, Kinoshita K, Takasaki A, Nishida N, Okabe M, Ce W, Miyao N, Saito K, Ibuki K, Ozawa S, Adachi Y, Ichida F.
MicroRNA-145-5p and microRNA-320a encapsulated in endothelial microparticles contribute to the progression of vasculitis in acute Kawasaki Disease.
Sci Rep. 2018 Jan 17;8(1):1016. doi: 10.1038/s41598-018-19310-4.
総 説
Takata K, Miyata-Takata T, Sato Y, Iwamuro M, Okada H, Tari A, Yoshino T.
Gastrointestinal follicular lymphoma: Current knowledge and future challenges.
Pathol Int. 2018 Jan;68(1):1-6. doi: 10.1111/pin.12621.
Yoshino T, Takata K, Tanaka T, Sato Y, Tari A, Okada H.
Recent progress in follicular lymphoma in Japan and characteristics of the duodenal type.
Pathol Int. 2018 Dec;68(12):665-676. doi: 10.1111/pin.12733.
岩室雅也, 高田尚良, 近藤英生, 岡田裕之.
節外性リンパ腫診療の進歩】消化管濾胞性リンパ腫の診断と治療.
血液内科.2018; 76 (3):340-345.
岡田裕之, 田中健大, 岩室雅也, 神崎洋光, 川野誠司, 河原祥朗, 高田尚良, 吉野正
知っておきたい十二指腸病変】十二指腸非乳頭部隆起性病変十二指腸リンパ腫の診断
胃と腸. 2018; 53(12):1587-1594.
学会報告
Takata K, Ennishi D, Bashashati A, Saberi S, Chong LC, Healy S, Viganò E, Nielsen JS, Antonio GD, Nelson BH, Shah SP, Connors JM, Gascoyne RD, Scott DW, Steidl C.
PRAME deletions are associated with decreased immunogenicity, apoptosis resistance and poor outcomes in diffuse large B-cell lymphoma.
60th ASH Annual meeting and exposition; 2018 Dec 1-4; San Diego USA. (oral presentation)
Yamamoto S, Kitahara H, Kajikawa S, Azuma E, Hamashima T, Ishii Y, Sato H, Shibuya M, Sasahara M.
The hallmarks of human DR are efficiently reproduced in novel retinopathy mouse model.
International Vasucular Biology Meeting; 2018 Jun 3-7; HelsinkiFinland.
Miyata-Takata T, Chuang SS, Takata K, Sato Y, Yoshino T.
Expression of TCR signaling pathway components in extranodal NK/T-cell lymphoma.
107th USCAP Annual meeting; 2018Mar 17-23; VancouverCanada. (oral presentation)
山本誠士, 北原英幸, 梶川清芽, 東英梨月, 濱島丈, 澁谷正史, 笹原正清.
新規マウス網膜症モデルの開発と病態増悪分子メカニズムの検討.
第26回日本血管生物医学会学術集会(心血管代謝週間2018); 2018 Dec 7-8; 東京.
山本誠士.
血管内皮細胞が産生するE-EVの生物学. ワークショップネオ血管学が解き明かす, 多様性に満ちた脈管系新世界.
第41回日本分子生物学会年会; 2018 Nov 28-30; 横浜.(招待講演)
又野禎也, 辻紀章, 奥野のり子, 寺畑信太郎.
胃以外のMALTリンパ腫の検討. (Non-gastric extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue)
第80回日本血液学会学術集会; 2018 Oct 12-14; 大阪.
山本誠士.
ペリサイトの細胞系譜と疾患増悪への関与.
第10回 Stroke Science Academy; 2018 Oct 9; 福岡.
山本誠士, 北原英幸, 梶川清芽, 東英梨月, 濱島丈, 石井陽子, 佐藤光, 澁谷正史, 笹原正清.
新規マウス網膜症モデルの開発と病理学的検討. (Development of novel mouse model for human diabetic retinopathy).
第107回日本病理学会総会; 2018 Jun 21-23; 札幌.
濱島丈, 山本誠士, 松島貴子, 倉茂洋一, 石井陽子, 笹原正清.
PDGFR αは生後の髄鞘形成性細胞の生存に必須である.
第107回日本病理学会総会; 2018 Jun 21-23; 札幌.
グエンバンデ, 濱島丈, 石井陽子, 山本誠士, 桑洋, 倉茂洋一, 松島貴子, 笹原正清.
PDGF alpha受容体は脳室下帯の神経幹細胞活性を制御する. (PDGFR-alpha may control the stem cell activities in the adult subventricular zone)
第107回日本病理学会総会; 2018 Jun 21-23; 札幌.
桑洋, 山本誠士, 石井陽子, 濱島丈, グエンバンデ, 笹原正清.
PDGF-B induced inhibitory microenvironments for glioma growth.
第107回日本病理学会総会; 2018 Jun 21-23; 札幌.
垣内寿枝子, 奥野のり子, 寺畑信太郎.
慢性骨髄性白血病を背景として皮膚外Sweet病を合併した一例.
第107回日本病理学会総会; 2018 Jun 21-23; 札幌.
稲田貢三子, 寺畑信太郎, 新居絵里, 生水貫人, 奥野のり子, 石倉宗浩, 西田秀昭, 福田弘幸, 蟹谷智勝, 三井由紀子.
子宮体癌を契機にリンチ症候群の診断に至った1例.
第59回日本臨床細胞学会総会 (春期大会); 2018 Jun 1-3; 札幌.
林沙貴, 金木昌弘, 瀧鈴佳, 奥野のり子, 寺畑信太郎, 清原薫.
嚢胞内出血を契機に発見された巨大intraductal papillary carcinomaの1例.
第26回日本乳癌学会学術総会; 2018 May 16-18; 京都.
清原薫, 林沙貴, 金木昌弘, 瀧鈴佳, 寺畑信太郎, 奥野のり子, 稲坂淳.
治療方針の決定に難渋した原発不明癌の1例.
第26回日本乳癌学会学術総会; 2018 May 16-18; 京都.
稲邑克久, 岡村利之, 藤原秀, 高田佳子, 奥野のり子, 寺畑信太郎, 河合博志.
当院におけるHp陰性胃癌の実態調査.
第95回日本消化器内視鏡学会総会; 2018 May 10-12; 東京.
2017
原 著
Noujima-Harada M, Takata K, Miyata-Takata T, Sakurai H, Igarashi K, Ito E, Nagakita K, Taniguchi K, Ohnishi N, Omote S, Tabata T, Sato Y, Yoshino T.
Frequent downregulation of BTB and CNC homology 2 expression in Epstein-Barr virus-positive diffuse large B-cell lymphoma.
Cancer Sci. 2017 May;108(5):1071-1079. doi: 10.1111/cas.13213.
Hu LM, Takata K, Miyata-Takata T, Asano N, Takahashi E, Furukawa K, Miyoshi H, Satou A, Kohno K, Kosugi H, Kinoshita T, Hirooka Y, Goto H, Nakamura S, Kato S.
Clinicopathological analysis of 12 patients with Epstein-Barr virus-positive primary intestinal T/natural killer-cell lymphoma (EBV+ ITNKL).
Histopathology. 2017 Jun;70(7):1052-1063. doi: 10.1111/his.13172.
Gion Y, Iwaki N, Takata K, Takeuchi M, Nishida K, Orita Y, Tachibana T, Yoshino T, Sato Y.
Clinicopathological analysis of methotrexate-associated lymphoproliferative disorders: comparison of diffuse large B-cell lymphoma and classical Hodgkin lymphoma types.
Cancer Sci. 2017 Jun;108(6):1271-1280. doi: 10.1111/cas.13249.
Miyata-Takata T, Takata K, Kato S, Hu LM, Noujima-Harada M, Chuang SS, Sato Y, Maeda Y, Yoshino T.
Clinicopathological analysis of primary central nervous system NK/T cell lymphoma: rare and localized aggressive tumour among extranasal NK/T cell tumours.
Histopathology. 2017 Aug;71(2):287-295. doi: 10.1111/his.13223.
Lee YY, Takata K, Wang RC, Yang SF, Chuang SS.
Primary gastrointestinal anaplastic large cell lymphoma.
Pathology. 2017 Aug;49(5):479-485. doi: 10.1016/j.pathol.2017.05.007.
Wu CC, Takahashi E, Asano N, Miyata-Takata T, Takata K, Furukawa K, Elsayed AA, Hu LM, Satou A, Kohno K, Kosugi H, Ohashi K, Kinoshita T, Nakamura S, Kato S.
Primary cutaneous NK/T-cell lymphoma of nasal type: an age-related lymphoproliferative disease?
Hum Pathol. 2017 Oct:68:61-68. doi: 10.1016/j.humpath.2017.08.025.
Iwamuro M, Takata K, Hayashi E, Kawano S, Hiraoka S, Kawahara Y, Yoshino T, Okada H.
The Usefulness of Colonoscopy for the Detection of Ileal Involvement in Intestinal Follicular Lymphoma Patients.
Acta Med Okayama. 2017 Oct;71(5):391-398. doi: 10.18926/AMO/55436.
Washio K, Oka T, Abdalkader L, Muraoka M, Shimada A, Oda M, Sato H, Takata K, Kagami Y, Shimizu N, Kato S, Kimura H, Nishizaki K, Yoshino T, Tsukahara H.
Gene expression analysis of hypersensitivity to mosquito bite, chronic active EBV infection and NK/T-lymphoma/leukemia.
Leuk Lymphoma. 2017 Nov;58(11):2683-2694. doi: 10.1080/10428194.2017.1304762.
森田誠市, 尾矢剛志, 石井陽子, ヘムラグル・サビット, 徳永綾乃, 石澤伸, 山本誠士, 濱島丈, 倉茂洋一, 松島貴子, 塚田一博, 笹原正清.
マウス肝臓星細胞の活性化における血小板由来増殖因子ベータ受容体の役割. (THE ROLE OF PLATELET-DERIVED GROWTH FACTOR RECEPTOR β IN THE ACTIVATION OF MOUSE HEPATIC STELLATE CELLS)
Toyama Med J. 27(1): 14-22. 2017. https://doi.org/10.57561/tmjutmed.27.1_14.
Yamamoto S, Muramatsu M, Azuma E, Ikutani M, Nagai Y, Sagara H, Koo BN, Kita S, O'Donnell E, Osawa T, Takahashi H, Takano K, Dohmoto M, Sugimori M, Usui I, Watanabe Y, Hatakeyama N, Iwamoto T, Komuro I, Takatsu K, Tobe K, Niida S, Matsuda N, Shibuya M, Sasahara M.
A subset of cerebrovascular pericytes originates from mature macrophages in the very early phase of vascular development in CNS.
Sci Rep. 2017 Jun 20;7(1):3855. doi: 10.1038/s41598-017-03994-1.
Onogi Y, Wada T, Kamiya C, Inata K, Matsuzawa T, Inaba Y, Kimura K, Inoue H, Yamamoto S, Ishii Y, Koya D, Tsuneki H, Sasahara M, Sasaoka T.
PDGFRβ Regulates Adipose Tissue Expansion and Glucose Metabolism via Vascular Remodeling in Diet-Induced Obesity.
Diabetes. 2017 Apr;66(4):1008-1021. doi: 10.2337/db16-0881.
Yamazaki T, Nalbandian A, Uchida Y, Li W, Arnold TD, Kubota Y, Yamamoto S, Ema M, Mukouyama Y.
Tissue myeloid progenitors differentiate into pericytes through TGF-β signaling in developing skin vasculature.
Cell Rep. 2017 Mar 21;18(12):2991-3004. doi: 10.1016/j.celrep.2017.02.069.
Nawaz A, Aminuddin A, Kado T, Takikawa A, Yamamoto S, Tsuneyama K, Igarashi Y, Ikutani M, Nishida Y, Nagai Y, Takatsu K, Imura J, Sasahara M, Okazaki Y, Ueki K, Okamura T, Tokuyama K, Ando A, Matsumoto M, Mori H, Nakagawa T, Kobayashi N, Saeki K, Usui I, Fujisaka S, Tobe K.
CD206+ M2-like macrophages regulate systemic glucose metabolism by inhibiting proliferation of adipocyte progenitors.
Nat Commun. 2017 Aug 18;8(1):286. doi: 10.1038/s41467-017-00231-1.
総 説
Ishii Y, Hamashima T, Yamamoto S, Sasahara M.
Pathogenetic significance and possibility as a therapeutic target of platelet derived growth factor.
Pathol Int. 2017 May;67(5):235-246. doi: 10.1111/pin.12530.
高田尚良, 谷口恒平, 高田友子, 吉野正.
乳腺原発DLBCLの分子生物学的特徴.
血液内科; 2017 74(1):121-125.
学会報告
山本誠士, 濱島丈, 石井陽子, 藤森俊彦, 森寿, 笹原正清.
神経発生期におけるPDGFR α陽性細胞のfate mapping解析
CVMW2017 心血管代謝週間, 第25回日本血管生物医学会学術集会; 2017 Dec 8-10; 大阪.
山本誠士.
ワークショップ; 中枢神経系ペリサイトの heterogeneity.
第40回日本分子生物学会年会; 2017 Dec 6-9; 神戸.
小野木康弘, 和田努, 神谷知江, 稲田健人, 松澤崇俊, 稲葉有香, 木村久美, 井上啓, 山本誠士, 石井陽子, 恒枝宏史, 笹原正清, 笹岡利安.
脂肪血管ペリサイトの動的変化を起点とした脂肪組織肥大化機構の解明.
第60回日本糖尿病学会年次学術集会; 2017 May 18-20; 名古屋.
山本誠士, 北原英幸, 梶川清芽, 石井陽子, 濱島丈, 東英梨月, 松島貴子, 澁谷正史, 嶋田豊, 笹原正清.
網膜症の発症と進展にはPDGFRおよびVEGFRを介したシグナルが重要である. (PDGFR and VEGFR signalings play key roles in the onset and progression of retinopathy)
第106回日本病理学会総会; 2017 Apr 27-29; 東京.
Nguyen Van De, 石井陽子, 山本誠士, 濱島丈, 笹原正清.
PDGF-alpha受容体は成熟マウスの脳室下帯の神経幹細胞の活動に関与する.(Involvement of PDGFR-alpha in neural stem cell activities in subventricular zone of adult mouse)
第106回日本病理学会総会; 2017 Apr 27-29; 東京.
桑洋, 石井陽子, 山本誠士, 濱島丈, 笹原正清.
経膠腫由来PDGF-Bと宿主のPDGF受容体シグナリングは腫瘍間質を改変する. (Glioma-derived PDGF-B and host PDGF-receptor signaling remodel cancer stroma)
第106回日本病理学会総会; 2017 Apr 27-29; 東京.
吉田尚史, 山本誠士, 堀川慎二郎, 濱島丈, 石井陽子, 笹原正清.
結合組織リモデリングにおけるPDGFR βシグナルのリンパ管形成に対する関与.
第106回日本病理学会総会; 2017 Apr 27-29; 東京.
和田努, 小野木康弘, 松澤崇俊, 山本誠士, 石井陽子, 笹原正清, 恒枝宏史, 笹岡利安.
脂肪組織の肥大化における脂肪血管ペリサイトの局在変化の意義.
第90回日本内分泌学会学術総会; 2017 Apr 20-22; 京都.
守田雅志, 大山拓郎, 冨田勇, 螺澤太郎, 松本隼, 渡辺志朗, 渡邊康春, 長井良憲, 高津聖志, 山本誠士, 石井陽子, 笹原正清, 今中常雄.
骨髄移植による副腎白質ジストロフィー発症抑制機構移植マウス中枢神経系の生化学的解析.
日本薬学会第137年会; 2017 Mar 24-27; 仙台.
2016
原 著
Iwamuro M, Okada H, Takata K, Takenaka R, Inaba T, Mizuno M, Kobashi H, Tanaka S, Yoshioka M, Kondo E, Yoshino T, Yamamoto K.
Colorectal Manifestation of Follicular Lymphoma.
Intern Med. 2016;55(1):1-8. doi: 10.2169/internalmedicine.55.5393.
Win KT, Liau JY, Chen BJ, Takata K, Chen CY, Li CC, Hsiao CH, Chuang SS.
Primary Cutaneous Extranodal Natural Killer/T-Cell Lymphoma Misdiagnosed as Peripheral T-Cell Lymphoma:The Importance of Consultation/Referral and Inclusion of EBV In Situ Hybridization for Diagnosis.
Appl Immunohistochem Mol Morphol. 2016 Feb;24(2):105-11. doi: 10.1097/PAI.0000000000000162.
Iwamuro M, Hiraoka S, Okada H, Kawai Y, Miyabe Y, Takata K, Kawano S, Yamamoto K.
Lymphoid hyperplasia of the colon and its association with underlying allergic airway diseases.
Int J Colorectal Dis. 2016 Feb;31(2):313-7. doi: 10.1007/s00384-015-2392-6.
Tari A, Asaoku H, Takata K, Fujimori S, Tanaka S, Fujihara M, Koga T, Yoshino T.
The role of "watch and wait" in intestinal follicular lymphoma in rituximab era.
Scand J Gastroenterol. 2016 Mar;51(3):321-8. doi: 10.3109/00365521.2015.1087589.
Taniguchi K, Takata K, Chuang SS, Miyata-Takata T, Sato Y, Satou A, Hashimoto Y, Tamura M, Nagakita K, Ohnishi N, Noujima-Harada M, Tabata T, Kikuti YY, Maeda Y, Nakamura N, Tanimoto M, Yoshino T.
Frequent MYD88 L265P and CD79B Mutations in Primary Breast Diffuse Large B-Cell Lymphoma.
Am J Surg Pathol. 2016 Mar;40(3):324-34. doi: 10.1097/PAS.0000000000000592.
Izushi Y, Teshigawara K, Liu K, Wang D, Wake H, Takata K, Yoshino T, Takahashi HK, Mori S, Nishibori M.
Soluble form of the receptor for advanced glycation end-products attenuates inflammatory pathogenesis in a rat model of lipopolysaccharide-induced lung injury.
J Pharmacol Sci. 2016 Apr;130(4):226-34. doi: 10.1016/j.jphs.2016.02.005.
Hayashi K, Michiue H, Yamada H, Takata K, Nakayama H, Wei FY, Fujimura A, Tazawa H, Asai A, Ogo N, Miyachi H, Nishiki T, Tomizawa K, Takei K, Matsui H.
Fluvoxamine, an anti-depressant, inhibits human glioblastoma invasion by disrupting actin polymerization.
Sci Rep. 2016 Mar 18:6:23372. doi: 10.1038/srep23372.
Abdalkader L, Oka T, Takata K, Sato H, Murakami I, Otte AP, Yoshino T.
Aberrant differential expression of EZH1 and EZH2 in Polycomb repressive complex 2 among B- and T/NK-cell neoplasms.
Pathology. 2016 Aug;48(5):467-82. doi: 10.1016/j.pathol.2016.05.002.
Nagakita K, Takata K, Taniguchi K, Miyata-Takata T, Sato Y, Tari A, Ohnishi N, Noujima-Harada M, Omote S, Nakamura N, Iwamuro M, Maeda Y, Okada H, Tanimoto M, Yoshino T.
Clinicopathological features of 49 primary gastrointestinal diffuse large B-cell lymphoma cases; comparison with location, cell-of-origin, and frequency of MYD88 L265P.
Pathol Int. 2016 Aug;66(8):444-52. doi: 10.1111/pin.12439.
Iga N, Miyoshi K, Takata K, Hirano Y, Konishi Y, Otani S, Sugimoto S, Yamane M, Miyoshi S, Oto T.
Visualization of bronchial circulation at bronchial anastomotic site using bronchial fluorescein angiography technique.
Interact Cardiovasc Thorac Surg. 2016 Nov;23(5):716-721. doi: 10.1093/icvts/ivw210.
Ohnishi N, Takata K, Miyata-Takata T, Sato Y, Tari A, Gion Y, Noujima-Harada M, Taniguchi K, Tabata T, Nagakita K, Omote S, Takahata H, Iwamuro M, Okada H, Maeda Y, Yanai H, Yoshino T.
CD10 down expression in follicular lymphoma correlates with gastrointestinal lesion involving the stomach and large intestine.
Cancer Sci. 2016 Nov;107(11):1687-1695. doi: 10.1111/cas.13031.
Zhang X, Takata K, Cui W, Miyata-Takata T, Sato Y, Noujima-Harada M, Yoshino T.
Protocadherin γ A3 is expressed in follicular lymphoma irrespective of BCL2 status and is associated with tumor cell growth.
Mol Med Rep. 2016 Nov;14(5):4622-4628. doi: 10.3892/mmr.2016.5808.
Ohtsuka T, Sakaguchi M, Yamamoto H, Tomida S, Takata K, Shien K, Hashida S, Miyata-Takata T, Watanabe M, Suzawa K, Soh J, Youyi C, Sato H, Namba K, Torigoe H, Tsukuda K, Yoshino T, Miyoshi S, Toyooka S.
Interaction of cytokeratin 19 head domain and HER2 in the cytoplasm leads to activation of HER2-Erk pathway.
Sci Rep. 2016 Dec 23:6:39557. doi: 10.1038/srep39557.
Saito K, Nakaoka H, Takasaki I, Hirono K, Yamamoto S, Kinoshita K, Miyao N, Ibuki K, Ozawa S, Watanabe K, Bowles NE, Ichida F.
MicroRNA-93 may control vascular endothelial growth factor A in circulating peripheral blood mononuclear cells in acute Kawasaki disease.
Pediatr Res. 2016 Sep;80(3):425-32. doi: 10.1038/pr.2016.93.
Takikawa A, Mahmood A, Nawaz A, Kado T, Okabe K, Yamamoto S, Arif A, Senda S, Tsuneyama K, Ikutani M, Watanabe Y, Igarashi Y, Nagai Y, Takatsu K, Koizumi K, Imura J, Goda N, Sasahara M, Matsumoto M, Saeki K, Nakagawa T, Fujisaka S, Usui I, Tobe K.
HIF-1α in Myeloid Cells Promotes Adipose Tissue Remodeling Toward Insulin Resistance.
Diabetes. 2016 Dec;65(12):3649-3659. doi: 10.2337/db16-0012.
Yamamoto S, Azuma E, Muramatsu M, Hamashima T, Ishii Y, Sasahara M.
Significance of Extracellular Vesicles: Pathobiological Roles in Disease.
Cell Struct Funct. 2016 Nov 25;41(2):137-143. doi: 10.1247/csf.16014.
Watanabe Y, Nagai Y, Honda H, Okamoto N, Yamamoto S, Hamashima T, Ishii Y, Tanaka M, Suganami T, Sasahara M, Miyake, K, Takatsu K.
Isoliquiritigenin Attenuates Adipose Tissue Inflammation in vitro and Adipose Tissue Fibrosis through Inhibition of Innate Immune Responses in Mice.
Sci Rep. 2016 Mar 15:6:23097. doi: 10.1038/srep23097.
Zheng Y, Yamamoto S, Ishii Y, Sang Y, Hamashima T, Van De N, Nishizono H, Inoue R, Mori H, Sasahara M.
Glioma-Derived Platelet-Derived Growth Factor-BB Recruits Oligodendrocyte Progenitor Cells via Platelet-Derived Growth Factor Receptor-α and Remodels Cancer Stroma.
Am J Pathol. 2016 May;186(5):1081-91. doi: 10.1016/j.ajpath.2015.12.020.
Sato H, Ishii Y, Yamamoto S, Azuma E, Takahashi Y, Hamashima T, Umezawa A, Mori H, Kuroda S, Endo S, Sasahara M.
PDGFR-β Plays a Key Role in the Ectopic Migration of Neuroblasts in Cerebral Stroke.
Stem Cells. 2016 Mar;34(3):685-98. doi: 10.1002/stem.2212. Epub 2015 Oct 4.
症例報告
Iwamuro M, Kimura K, Kondo E, Nada T, Nakamura E, Takata K, Tanaka T, Otsuka F, Yoshino T, Okada H.
Endoscopic detection of the gastric lesions of peripheral T-cell lymphoma.
Ecancermedicalscience. 2016 Mar 3:10:625. doi: 10.3332/ecancer.2016.625.
Iwamuro M, Takata K, Kawano S, Fujii N, Kawahara Y, Yoshino T, Okada H.
Magnifying Endoscopic Features of Follicular Lymphoma Involving the Stomach: A Report of Two Cases.
Case Rep Gastrointest Med. 2016:2016:2082698. doi: 10.1155/2016/2082698.
Igawa T, Hayashi T, Ishiguro K, Maruyama Y, Takeuchi M, Takata K, Yoshino T, Sato Y.
IgG4-producing lymphoma arising in a patient with IgG4-related disease.
Med Mol Morphol. 2016 Dec;49(4):243-249. doi: 10.1007/s00795-016-0139-2.
総 説
Iwamuro M, Kondo E, Takata K, Yoshino T, Okada H.
Diagnosis of follicular lymphoma of the gastrointestinal tract: A better initial diagnostic workup.
World J Gastroenterol. 2016 Jan 28;22(4):1674-83. doi: 10.3748/wjg.v22.i4.1674.
Yamamoto S, Azuma E, Muramatsu M, Hamashima T, Ishii Y, Sasahara M.
Significance of extracellular vesicles: pathobiological roles in disease.
Cell Struct Funct. 2016 Nov 25;41(2):137-143. doi: 10.1247/csf.16014.
高田尚良, 吉野正.
消化管濾胞性リンパ腫の分子生物学的特徴と臨床病態.
血液内科. 2016;72:16-20.
学会報告
Yamamoto S, Azuma E, Ishii Y, Hamashima T, Sato H, Sasahara M.
PDGFRβ plays an important role in the ectopic migration of neuroblasts in association with blood vessels in cerebral stroke.
The 14th Korea-Japan Joint Symposium on Vascular Biology; 2016 Dec 8-10; Nagasaki.
Yamamoto S, Ishii Y, Hamashima T, Sato H, Azuma E, Sasahara M.
PDGFRβ plays a key role in the ectopic migration of neuroblasts along with blood vessels in cerebral stroke.
The 19th International Vascular Biology Meeting; 2016 Oct 30-Nov 3; Boston, USA.
Kitahara H, Yamamoto S, Kajikawa S, Azuma E, Hamashima T, Ishii Y, Sato H, Shimada Y, Sasahara M.
Developed novel rodent model of diabetic retinopathy after conditional Pdgfrb gene targeting.
The 19th International Vascular Biology Meeting; 2016 Oct 30-Nov 3; Boston, USA.
Satou H, Yamamoto S, Kuroda S, Sasahara M, Watanabe S, Watanabe K.
PDGFR-β plays a key role in the ectopic migration of neuroblasts in cerebral stroke.
5th Mt.BANDAI& Pan-Pacific Joint Neurosurgical Convention; 2016 Apr 7-10; Phnom Penh, Cambodia.
高田尚良
節外性リンパ腫の臨床病理学的分子生物学的研究.
第62回日本病理学会秋期特別総会(学術研究賞A演説); 2016 Nov 9-11; 金沢.(特別講演)
山本誠士.
中枢神経系ペリサイトの起源に迫る. ペリサイトを認識し研究することの重要性.
第39回日本分子生物学会年会; 2016 Nov 30-Dec 2; 横浜. (招待講演)
山本誠士.
Micro RNAによる細胞間互恵関係の構築様式.
第45回日本心脈管作動物質学会年会; 2016 Feb 5-6; 徳島. (招待講演)
東英梨月, 山本誠士, 村松昌, 濱島丈, 石井陽子, 藤原章雄, 竹屋元裕, 新飯田俊平, 笹原正清.
マウス創傷治癒モデルにおけるM2 macrophageの機能解析.
第39回日本分子生物学会年会; 2016 Nov 30-Dec 2; 横浜.
小野木康弘, 和田努, 神谷知江, 稲田健人, 稲葉有香, 木村久美, 井上啓, 山本誠士, 石井陽子, 恒枝宏史, 笹原正清, 笹岡利安.
PDGFRβは血管リモデリングを介して脂肪組織肥大化とインスリン抵抗性を助長する.
第59回日本糖尿病学会年次学術集会; 2016 May 19-21; 京都.
石井陽子, 山本誠士, 鄭陽, 桑洋, 濱島丈, 笹原正清.
Glioma由来PDGF-BBは, PDGFRαを介してオリゴデンドロサイト前駆細胞を動員し, 腫瘍間質を改変する. (Glioma-derived PDGF-BB recruits oligodendrocyte progenitor cells and remodels cancer stroma)
第105回日本病理学会総会; 2016 May 12-14; 仙台.
濱島丈, 石井陽子, 山本誠士, 布村晴香, Nguyen Van De, 松島貴子, 倉茂洋一, 笹原正清.
条件的PDGFR-αノックアウトマウスにおける稀突起膠細胞の発生.
第105回日本病理学会総会; 2016 May 12-14; 仙台.
山本誠士, 石井陽子, 濱島丈, 佐藤光, 東英梨月, 笹原正清.
神経前駆細胞の脳梗塞部位への遊走におけるPDGFRβシグナルの重要性. (PDGFRbeta plays a key role in the ectopic migration of neuroblasts in cerebral stroke)
第105回日本病理学会総会; 2016 May 12-14; 仙台.
北原英幸, 山本誠士, 梶川清芽, 濱島丈, 石井陽子, 笹原正清.
PDGF受容体β抑制マウスは生後早期から進行期ヒト糖尿病網膜症の病態を再現する.
第105回日本病理学会総会; 2016 May 12-14; 仙台.
Nguyen Van De, 石井陽子, 山本誠士, 濱島丈, Dang Thanh Chung, 倉茂洋一, 松島貴子, 笹原正清.
ネスチン陽性の未熟な細胞はオリゴデンドロサイト前駆細胞の再生に関与する.(Nestin+ immature cells are involved in the regeneration of oligodendrocyte progenitor cells)
第105回日本病理学会総会; 2016 May 12-14; 仙台.
吉田尚史, 山本誠士, 堀川慎二郎, 濱島丈, 石井陽子, 笹原正清.
結合組織リモデリングにおけるPDGFR betaシグナルの重要性.
第105回日本病理学会総会; 2016 May 12-14; 仙台.
小野木康弘, 和田努, 神谷知江, 稲田健人, 山本誠士, 石井陽子, 恒枝宏史, 笹原正清, 笹岡利安.
脂肪組織リモデリングを起点とした肥満病態形成機構の解明.
日本薬学会第136年会; 2016 Mar 26-29; 横浜.
2015
原 著
Takeuchi M, Ohno K, Takata K, Gion Y, Tachibana T, Orita Y, Yoshino T, Sato Y.
Interleukin 13-positive mast cells are increased in immunoglobulin G4-related sialadenitis.
Sci Rep. 2015 Jan 9:5:7696. doi: 10.1038/srep07696.
Takata K, Hong ME, Sitthinamsuwan P, Loong F, Tan SY, Liau JY, Hsieh PP, Ng SB, Yang SF, Pongpruttipan T, Sukpanichnant S, Kwong YL, Hyeh Ko Y, Cho YT, Chng WJ, Matsushita T, Yoshino T, Chuang SS.
Primary Cutaneous NK/T-cell Lymphoma, Nasal Type and CD56-positive Peripheral T-cell Lymphoma: A Cellular Lineage and Clinicopathologic Study of 60 Patients From Asia.
Am J Surg Pathol. 2015 Jan;39(1):1-12. doi: 10.1097/PAS.0000000000000312.
Iwamuro M, Okada H, Takata K, Kawai Y, Kawano S, Nasu J, Kawahara Y, Tanaka T, Yoshino T, Yamamoto K.
Magnified endoscopic features of duodenal follicular lymphoma and other whitish lesions.
Acta Med Okayama. 2015;69(1):37-44. doi: 10.18926/AMO/53120.
Murakami I, Matsushita M, Iwasaki T, Kuwamoto S, Kato M, Nagata K, Horie Y, Hayashi K, Imamura T, Morimoto A, Imashuku S, Gogusev J, Jaubert F, Takata K, Oka T, Yoshino T.
Interleukin-1 loop model for pathogenesis of Langerhans cell histiocytosis.
Cell Commun Signal. 2015 Feb 22:13:13. doi: 10.1186/s12964-015-0092-z.
Kato S, Asano N, Miyata-Takata T, Takata K, Elsayed AA, Satou A, Takahashi E, Kinoshita T, Nakamura S.
T-cell receptor (TCR) phenotype of nodal Epstein-Barr virus (EBV)-positive cytotoxic T-cell lymphoma (CTL): A clinicopathologic study of 39 cases.
Am J Surg Pathol. 2015 Apr;39(4):462-71.doi: 10.1097/PAS.0000000000000323.
Iwamuro M, Okada H, Kawano S, Shiode J, Takenaka R, Imagawa A, Inaba T, Suzuki S, Nishimura M, Mizuno M, Araki M, Mannami T, Ueki T, Kobashi H, Fukatsu H, Tanaka S, Omoto A, Kawai Y, Kitagawa T, Toyokawa T, Takata K, Yoshino T, Takaki A, Yamamoto K.
A multicenter survey of enteroscopy for the diagnosis of intestinal follicular lymphoma.
Oncol Lett. 2015 Jul;10(1):131-136. doi: 10.3892/ol.2015.3251.
Toji T, Takata K, Sato Y, Miyata-Takata T, Hayashi E, Habara T, Maeda Y, Tanimoto M, Yoshino T.
Serum level of soluble interleukin-2 receptor correlates with CD25 expression in patients with T lymphoblastic lymphoma.
J Clin Pathol. 2015 Aug;68(8):622-7. doi: 10.1136/jclinpath-2015-202934.
Ohno K, Sato Y, Ohshima K, Takata K, Miyata-Takata T, Takeuchi M, Gion Y, Tachibana T, Orita Y, Ito T, Swerdlow SH, Yoshino T.
A subset of ocular adnexal marginal zone lymphomas may arise in association with IgG4-related disease.
Sci Rep. 2015 Aug 27:5:13539. doi: 10.1038/srep13539.
Takata K, Noujima-Harada M, Miyata-Takata T, Ichimura K, Sato Y, Miyata T, Naruse K, Iwamoto T, Tari A, Masunari T, Sonobe H, Okada H, Iwamuro M, Mizobuchi K, Gion Y, Yoshino T.
Clinicopathologic analysis of 6 lymphomatoid gastropathy cases: expanding the disease spectrum to CD4-CD8+ cases.
Am J Surg Pathol. 2015 Sep;39(9):1259-66. doi: 10.1097/PAS.0000000000000443.
Tomita S, Kikuti YY, Carreras J, Kojima M, Ando K, Takasaki H, Sakai R, Takata K, Yoshino T, Bea S, Campo E, Nakamura N.
Genomic and immunohistochemical profiles of enteropathy-associated T-cell lymphoma in Japan.
Mod Pathol. 2015 Oct;28(10):1286-96. doi: 10.1038/modpathol.2015.85.
Miyata-Takata T, Takata K, Toji T, Goto N, Kasahara S, Takahashi T, Tari A, Noujima-Harada M, Miyata T, Sato Y, Yoshino T.
Elevation of serum interleukins 8, 4, and 1β levels in patients with gastrointestinal low-grade B-cell lymphoma.
Sci Rep. 2015 Dec 17:5:18434. doi: 10.1038/srep18434.
Horikawa S, Ishii Y, Hamashima T, Yamamoto S, Mori H, Fujimori T, Shen J, Inoue R, Nishizono H, Itoh H, Majima M, Abraham D, Miyawaki T, Sasahara M.
PDGFRα plays a crucial role in connective tissue remodeling.
Sci Rep. 2015 Dec 7:5:17948. doi: 10.1038/srep17948.
Yamamoto S, Niida S, Azuma E, Yanagibashi T, Muramatsu M, Huang TT, Sagara H, Higaki S, Ikutani M, Nagai Y, Takatsu K, Miyazaki K, Hamashima T, Mori H, Matsuda N, Ishii Y, Sasahara M.
Inflammation-induced endothelial cell-derived extracellular vesicles modulate the cellular status of pericytes.
Sci Rep. 2015 Feb 17:5:8505. doi: 10.1038/srep08505.
Sugimori M, Hayakawa Y, Boman BM, Fields JZ, Awaji M, Kozano H, Tamura R, Yamamoto S, Ogata T, Yamada M, Endo S, Kurimoto M, Kuroda S.
Discovery of Power-Law Growth in the Self-Renewal of Heterogeneous Glioma Stem Cell Populations.
PLoS One. 2015 Aug 18;10(8):e0135760. doi: 10.1371/journal.pone.0135760.
症例報告
Kitagawa J, Goto N, Shibata Y, Nakamura N, Nakamura H, Kanemura N, Hara T, Takata K, Sato Y, Yoshino T, Tsurumi H.
Peripheral T-Cell Lymphoma, Not Otherwise Specified and Concurrent Seminoma in Testis.
J Clin Exp Hematop. 2015;55(3):169-74. doi: 10.3960/jslrt.55.169.
Goto N, Tsurumi H, Takami T, Futamura M, Morimitsu K, Takata K, Sato Y, Yoshino T, Adachi S, Saito K, Yamakawa M.
Cytokeratin-positive fibroblastic reticular cell tumor with follicular dendritic cell features: a case report and review of the literature.
Am J Surg Pathol. 2015 Apr;39(4):573-80. doi: 10.1097/PAS.0000000000000362.
Seki A, Iwamuro M, Yoshioka M, Fujii N, Okada H, Nose S, Takata K, Yoshino T, Yamamoto K.
Primary Duodenal Follicular Lymphoma Treated With Rituximab Monotherapy and Followed-up for 15 Years.
Acta Med Okayama. 2015;69(5):301-6. doi: 10.18926/AMO/53676.
Iwamuro M, Okada H, Takata K, Fujii N, Kawano S, Kawahara Y, Yoshino T, Yamamoto K.
Magnifying Endoscopic Observation of Duodenal Involvement of Follicular Lymphoma before and after Chemotherapy.
Intern Med. 2015;54(14):1741-5. doi: 10.2169/internalmedicine.54.4390.
Igawa T, Sato Y, Kawai H, Kondo E, Takeuchi M, Miyata-Takata T, Takata K, Yoshino T.
Spontaneous regression of plasmablastic lymphoma in an elderly human immunodeficiency virus (HIV)-negative patient.
Diagn Pathol. 2015 Oct 6:10:183. doi: 10.1186/s13000-015-0421-y.
Iwamuro M, Kondo E, Otsuka F, Takata K, Yoshino T, Kawahara Y, Okada H.
Detection of Minute Duodenal Follicular Lymphoma Lesions Using Magnifying Endoscopy.
Acta Med Okayama. 2016;70(2):139-44. doi: 10.18926/AMO/54193.
濱島丈,石井陽子,山本誠士,名倉里織,深原一晃,芳村直樹,笹原正清.
梅毒性大動脈炎の1例.
診断病理. 2015 32(1): 46-9.
総 説
高田尚良, 吉野正.
濾胞性リンパ腫のhistologic gradingと特殊型、in situ病変認識の意義.
血液内科. 2015 70: 14-20.
高田尚良, 吉野正.
私のこの1枚 消化管濾胞性リンパ腫.
血液フロンティア. 2015 25: 297-300.
高田尚良, 吉野正.
リンパ腫における最近のトピックス 濾胞性リンパ腫.
病理と臨床. 2015 33: 468-475.
高田尚良, 吉野正.
皮膚原発NK/T細胞リンパ腫の臨床病理学的特徴.
血液内科. 2015 70: 516-520.
学会報告
Yamamoto S.
Analysis of the inflammation related miRNA encapsulated in the endothelial derived extracellular vesicles.
Asia-Australia Vascular Biology Meeting (AAVBM) and the 13th Japan-Korea Joint Symposium on Vascular Biology; 2015 Oct 15-17; Busan, Korea. (Invited lecture)
Onogi Y, Wada T, Kamiya C, Inata K, Yamamoto S, Ishii Y, Sasahara M, Inaba Y, Kimura K, Inoue H, Nishizono H, Tsuneki H, Sasaoka T.
Depletion of platelet-derived growth factor receptor β prevented adipose tissue expansion and insulin resistance in diet-induced obesity.
Keystone Symposia: Diabetes: New Insights into Molecular Mechanisms and Therapeutic Strategies; 2015 Oct 25-29; Kyoto.
高田尚良
Molecular and Clinicopathological analysis in extranodal lymphomas.
第104回日本病理学会総会; 2015 Apr 30-May 2; 名古屋.(特別講演)
山本誠士.
周皮細胞(ペリサイト)の病態生理学的重要性.
BMB2015(第38回日本分子生物学会年会, 第88回日本生化学会大会合同大会); 2015 Dec 1-4; 神戸.(招待講演)
山本誠士.
血管炎症モデルにおける血管内皮細胞とペリサイトのインタラクション.
CVMW2015 心血管代謝週間; 2015 Dec 10-12; 神戸.(招待講演)
高田尚良, 吉野正.
Primary cutaneous NK/T-cell lymphoma and indolent T-cell lymphoma: recent advances in rare subtypes.
第55回日本リンパ網内系学会学術総会; 2015 Jul 9-11; 岡山.(シンポジウム)
高田尚良, 吉野正.
Indolent T-cell lymphomaの臨床病理学的特徴.
第104回日本病理学会総会; 2015 Apr 30-May 2; 名古屋.(シンポジウム)
小野木康弘, 和田努, 神谷知江, 稲田健人, 稲葉有香, 木村久美, 井上啓, 山本誠士, 石井陽子, 笹原正清, 恒枝宏史, 笹岡利安.
脂肪組織肥大化におけるPDGF依存的血管新生の意義.
第27回分子糖尿病学シンポジウム; 2015 Dec 5; 東京.
原祥子, 山本誠士, 北原英幸, 濱島丈, 石井陽子, 藤森俊彦, 笹原正清.
PDGFRα陽性細胞のfate mapping解析.
BMB2015(第38回日本分子生物学会年会, 第88回日本生化学会大会合同大会); 2015 Dec 1-4; 神戸.
小野木康弘, 和田努, 神谷知江, 稲田健人, 山本誠士, 石井陽子, 笹原正清, 恒枝宏史, 笹岡利安.
脂肪組織肥大およびインスリン抵抗性進展におけるPDGFの関与.
第66回日本薬理学会北部会; 2015 Sep 18; 富山.
Ishii Y, Yamamoto S, Sato H, Hamashima T, Sasahara M.
PDGFR-β signaling is involved in CXCL12/SDF-1 mediated neuroblast migration in ischemic brain.
The 38th annual meeting of the Japan neuoscience society; 2015 July 28-31; Kobe.
瀧川章子, Mahmood Arshad, Nawaz Allah, 角朝信, 山本誠士, 常山幸一, 岡部圭介, 仙田聡子, 中川崇, 薄井勲, 合田亘人, 戸辺一之.
マクロファージ特異的HIF-1α欠損による食餌性肥満マウスの糖代謝・脂肪組織への影響.
第58回日本糖尿病学会年次学術集会; 2015 May 21-24; 下関.
小野木康弘, 和田努, 神谷知江, 稲田健人, 山本誠士, 石井陽子, 笹原正清, 恒枝宏史, 笹岡利安.
PDGFシグナル遮断がインスリン抵抗性に与える影響.
第58回日本糖尿病学会年次学術集会; 2015 May 21-24; 下関.
濱島丈, 石井陽子, 山本誠士, 副田翔, 米田哲, 齋藤滋, 笹原正清.
羊水過少が指摘された後に子宮内胎児死亡となったFetal thrombotic vasculopathyの一剖検例.
第104回日本病理学会総会; 2015 Apr 30-May 2; 名古屋.
山本誠士, 東英梨月, 村松昌, 濱島丈, 石井陽子, 新飯田俊平, 笹原正清.
マウス創傷治癒モデルにおける多機能型マクロファージの解析.
第104回日本病理学会総会; 2015 Apr 30-May 2; 名古屋.
北原英幸, 山本誠士, 梶川清芽, 濱島丈, 石井陽子, 笹原正清.
PDGF受容体-β抑制マウスによる進行期のヒト糖尿病網膜症モデルの確立.
第104回日本病理学会総会; 2015 Apr 30-May 2; 名古屋.
鄭陽, 桑洋, 石井陽子, 山本誠士, 濱島丈, 笹原正清.
PDGF受容体サブユニットは異なる様式でグリオーマ微小環境に関与する. (Distinctive involvement of PDGF receptor subunits in microenvironments of glioma)
第104回日本病理学会総会; 2015 Apr 30-May 2; 名古屋.
Huang Ting Ting, 石井陽子, 山田浩太, 山本誠士, 濱島丈, 笹原正清.
PDGF受容体の二量体は,それぞれ遊走線維芽細胞に異なった形態を誘導する. (PDGF-receptor dimers differentially regulate the cell shape of migrating fibroblast)
第104回日本病理学会総会; 2015 Apr 30-May 2; 名古屋.
松本隼, 守田雅志, 渡邉康春, 長井良憲, 小林博司, 山本誠士, 石井陽子, 笹原正清, 高津聖志, 今中常雄.
モデルマウスを用いた副腎白質ジストロフィーに対する骨髄移植効果の解析.
日本薬学会第135年会; 2015 Mar 25-28; 神戸.
2014
著 書
高田尚良, 吉野正.
リンパ腫・骨髄腫の最新療法
中山書店, p2-13, 東京, 2014
高田尚良, 吉野正.
リンパ腫アトラス(第4版)
文光堂, p100-105, p106-107, p186-189, p134-137, 東京, 2014
原 著
Murakami I, Matsushita M, Iwasaki T, Kuwamoto S, Kato M, Horie Y, Hayashi K, Imamura T, Morimoto A, Imashuku S, Gogusev J, Jaubert F, Takata K, Oka T, Yoshino T.
Merkel cell polyomavirus DNA sequences in peripheral blood and tissues from patients with Langerhans cell histiocytosis.
Hum Pathol. 2014 Jan;45(1):119-26. doi: 10.1016/j.humpath.2013.05.028.
Iwamuro M, Shinagawa K, Okada H, Takata K, Yoshino T, Yamamoto K.
Elevated soluble IL-2 receptor levels correlate with tumor bulk of follicular lymphomas with intestinal involvement.
Clin Biochem. 2014 Feb;47(3):191-5. doi: 10.1016/j.clinbiochem.2013.11.026.
Iwamuro M, Okada H, Takata K, Nose S, Miyatani K, Yoshino T, Yamamoto K.
Diagnostic accuracy of endoscopic biopsies for the diagnosis of gastrointestinal follicular lymphoma: a clinicopathologic study of 48 patients.
Ann Diagn Pathol. 2014 Apr;18(2):99-103. doi: 10.1016/j.anndiagpath.2013.12.006.
Murakami I, Matsushita M, Iwasaki T, Kuwamoto S, Kato M, Horie Y, Hayashi K, Gogusev J, Jaubert F, Nakamoto S, Yamakawa M, Nakamine H, Takata K, Oka T, Yoshino T.
High viral load of Merkel cell polyomavirus DNA sequences in Langerhans cell sarcoma tissues.
Infect Agent Cancer. 2014 May 6:9:15. doi: 10.1186/1750-9378-9-15.
Iwatani K, Takata K, Sato Y, Miyata-Takata T, Iwaki N, Sawada-Kitamura S, Sonobe H, Tamura M, Saito K, Miyatani K, Yamasaki R, Yamadori I, Fujii N, Terasaki Y, Tanimoto M, Nakamura N, Yoshino T.
Low-grade B-cell lymphoma presenting primarily in the bone marrow.
Hum Pathol. 2014 Jul;45(7):1379-87. doi: 10.1016/j.humpath.2014.02.010.
Takata K, Tanino M, Ennishi D, Tari A, Sato Y, Okada H, Maeda Y, Goto N, Araki H, Harada M, Ando M, Iwamuro M, Tanimoto M, Yamamoto K, Gascoyne RD, Yoshino T.
Duodenal follicular lymphoma: comprehensive gene expression analysis with insights into pathogenesis.
Cancer Sci. 2014 May;105(5):608-15. doi: 10.1111/cas.12392.
Takeuchi M, Sato Y, Yasui H, Ozawa H, Ohno K, Takata K, Gion Y, Orita Y, Tachibana T, Itoh T, Asano N, Nakamura S, Swerdlow SH, Yoshino T.
Epstein-Barr virus-infected cells in IgG4-related lymphadenopathy with comparison with extranodal IgG4-related disease.
Am J Surg Pathol. 2014 Jul;38(7):946-55. doi: 10.1097/PAS.0000000000000206.
Takahashi Y, Takata K, Kato S, Sato Y, Asano N, Ogino T, Hashimoto K, Tashiro Y, Takeuchi S, Masunari T, Hiramatsu Y, Maeda Y, Tanimoto M, Yoshino T.
Clinicopathological analysis of 17 primary cutaneous T-cell lymphoma of the γδ phenotype from Japan.
Cancer Sci. 2014 Jul;105(7):912-23. doi: 10.1111/cas.12439.
Takeuchi M, Sato Y, Ohno K, Tanaka S, Takata K, Gion Y, Orita Y, Ito T, Tachibana T, Yoshino T.
T helper 2 and regulatory T-cell cytokine production by mast cells: a key factor in the pathogenesis of IgG4-related disease.
Mod Pathol. 2014 Aug;27(8):1126-36. doi: 10.1038/modpathol.2013.236.
Miyata-Takata T, Takata K, Yamanouchi S, Sato Y, Harada M, Oka T, Tanaka T, Maeda Y, Tanimoto M, Yoshino T.
Detection of T-cell receptor gamma gene rearrangement in paraffin-embedded T or natural killer/T-cell lymphoma samples using the BIOMED-2 protocol.
Leuk Lymphoma. 2014 Sep;55(9):2161-4. doi: 10.3109/10428194.2013.871634.
Yamaguchi M, Takata K, Yoshino T, Ishizuka N, Oguchi M, Kobayashi Y, Isobe Y, Ishizawa K, Kubota N, Itoh K, Usui N, Miyazaki K, Wasada I, Nakamura S, MatsunoY, Oshimi K, Kinoshita T, Tsukasaki K, Tobinai K.
Prognostic biomarkers in patients with localized natural killer/T-cell lymphoma treated with concurrent chemoradiotherapy.
Cancer Sci. 2014 Nov;105(11):1435-41. doi: 10.1111/cas.12526.
Murakami I, Takata K, Matsushita M, Nonaka D, Iwasaki T, Kuwamoto S, Kato M, Mohri T, Nagata K, Kitamura Y, Yoshino T, Hayashi K.
Immunoglobulin expressions are only associated with MCPyV-positive merkel cell carcinomas but not with MCPyV-negative ones: comparison of prognosis.
Am J Surg Pathol. 2014 Dec;38(12):1627-35. doi: 10.1097/PAS.0000000000000279.
症例報告
Ohno K, Sato Y, Ohshima K, Takata K, Ando M, Abd Al-Kader L, Iwaki N, Takeuchi M, Orita Y, Yoshino T.
IgG4-related disease involving the sclera.
Mod Rheumatol. 2014 Jan;24(1):195-8. doi: 10.3109/14397595.2013.852842.
Iwamuro M, Miyabe Y, Hanae K, Yoshinari K, Takata K, Murakami T, Hirofumi M, Yamamoto K.
Regression of metastatic colon tumor from primary adenocarcinoma of the lung due to fistulisation to the bowel lumen.
Ecancermedicalscience. 2014 Mar 20:8:412. doi: 10.3332/ecancer.2014.412.
Iwamuro M, Takenaka R, Mori A, Fujiki S, Miyake T, Asakura S, Okada H, Takata K, Yoshino T, Yamamoto K.
Rapidly progressed primary intestinal follicular lymphoma with elevation of soluble interleukin-2 receptor levels.
Case Rep Oncol Med. 2014:2014:549248. doi: 10.1155/2014/549248.
Morichika D, Sato-Hisamoto A, Hotta K, Takata K, Iwaki N, Uchida K, Minami D, Kubo T, Tanimoto M, Kiura K.
Fatal Candida septic shock during systemic chemotherapy in lung cancer patient receiving corticosteroid replacement therapy for hypopituitarism: a case report.
Jpn J Clin Oncol. 2014 May;44(5):501-5. doi: 10.1093/jjco/hyu019.
Yamada T, Goto N, Tsurumi H, Takata K, Sato Y, Yoshino T, Moriwaki H, Kito Y, Takeuchi T, Iwata H.
Mantle cell lymphoma with a unique pattern of CD5 expression: a case report with review of the literatures.
Med Mol Morphol. 2014 Sep;47(3):169-75. doi: 10.1007/s00795-013-0060-x.
Iwamuro M, Kawai Y, Takata K, Miyabe Y, Okada H, Yamamoto K.
Reactive lymphoid hyperplasia with a lipomatous component associated with fecal compaction in an appendiceal orifice.
Intern Med. 2014;53(10):1049-53. doi: 10.2169/internalmedicine.53.1635.
Miyata-Takata T, Takata K, Sato Y, Taniguchi K, Takahashi Y, Ohara N, Yoshino T.
A case of diffuse large B-cell lymphoma transformed from primary duodenal follicular lymphoma.
Pathol Int. 2014 Oct;64(10):527-32. doi: 10.1111/pin.12197.
総 説
Takata K, Miyata-Takata T, Sato Y, Yoshino T.
Pathology of follicular lymphoma.
J Clin Exp Hematop. 2014;54(1):3-9. doi: 10.3960/jslrt.54.3.
高田尚良, 岡田裕之, 岩室雅也, 田利晶, 吉野正.
濾胞性リンパ腫とマントル細胞リンパ腫の病理.
胃と腸. 2014;49(5):649-655. Doi: https://doi.org/10.11477/mf.1403114146
学会報告
Takata K, Yoshino T.
Mantle cell lymphoma morphologically mimicking multicentric Castleman’s disease.
Congress of the international academy of pathology (IAP). 2014 Oct5-10; Thailand.(招聘講演)
Takata K, Yoshino T.
Intestinal follicular lymphoma.
12th Japanese-Korean lymphoma conference. 2014Jan 24-26; Nagoya.(シンポジウム)
Takata K, Hong ME, Sitthinasuwan P, Loong F, Tan SY, Liau JY, Hsieh PP, Ng SB, Yang F, Pongruttipan T, Sukpanichnant S, Kwong YL, Ko H, Cho YT, Yoshino T, Chuang SS.
Primary cutaneous natural killer/T-cell lymphoma, nasal type, and CD56-positive peripheral T-cell lymphoma: a retrospective study of 61 patients from Asia.
103rd USCAP Annual meeting.2014 Mar 1-7; San Diego, USA.(poster presentation)
高田尚良.
腸管悪性リンパ腫の特徴および病理診断.
第54回日本リンパ網内系学会学術総会. 2014 Jun 19-21; 山形.(シンポジウム)
Takata K, Yoshino T.
Intestinal follicular lymphoma.
第54回日本リンパ網内系学会学術総会. 2014 Jun 19-21; 山形.(シンポジウム)
山本誠士, 東英梨月, 濱島丈, 石井陽子, 笹原正清.
ニッチ形成因子としての血管内皮細胞由来因子の解析.
第37回日本分子生物学会年会. 2014 Nov 25-27; 横浜.
梶川清芽, 山本誠士, 北原英幸, 濱島丈, 石井陽子, 笹原正清.
ヒト糖尿病網膜症を再現するマウス網膜症モデルの解析.
第37回日本分子生物学会年会. 2014 Nov 25-27; 横浜.
東英梨月,山本誠士, 村松昌, 濱島丈, 石井陽子, 新飯田俊平, 笹原正清.
マウス創傷治癒モデルにおけるmacrophageの機能解析.
第37回日本分子生物学会年会.2014 Nov 25-27; 横浜.
小野木康弘, 和田努, 神谷知江, 稲田健人, 山本誠士, 石井陽子, 恒枝宏史, 笹原正清, 笹岡利安.
PDGFを介した脂肪組織肥大化およびインスリン抵抗性進展機構の解明.
日本薬学会北陸支部第126回例会. 2014 Nov 16; 金沢.
神谷知江, 和田努, 小野木康弘, 稲田健人, 山本誠士, 石井陽子, 笹原正清, 恒枝宏史, 笹岡利安.
肥満に伴う脂肪組織の慢性炎症と糖代謝に対するPDGFシグナルの関与の検討.
第14回日本内分泌学会北陸支部学術集会. 2014 Nov 9; 金沢.
Yamamoto S, Azuma E, Hamashima T, Ishii Y, Sasahara M.
Secreted miRNA plays an important role in the endothelial vascular niche.
The 18th International Vascular Biology Meeting. 2014 Apr 14-17; Kyoto.
Sasahara M, Chung Thanh Dang, Ishii Y, Hamashima T, Yamamoto S, Ohkawa N, Saitoh Y, Inokuchi K, Mori H.
PDGFR-α inactivation induces maturation of OPCs and recruitment and transdifferentiation of MSCs into OPCs.
The 37th annual meeting of the Japan neuroscience society. 2014 Sep 11-13; Yokohama.
山本誠士, 山田浩太, 石井陽子, 濱島丈, 笹原正清.
PDGFR二量体の皮膚線維芽細胞の遊走における役割の解明.
第103回日本病理学会総会. 2014 Apr 24-26; 広島.
Dang Thanh Chung, 石井陽子, 濱島丈, 山本誠士, 笹原正清.
PDGFR-α regulates the dynamism of oligodendrocytes in the adult mouse brain.
第103回日本病理学会総会. 2014 Apr 24-26; 広島.
Chung Thanh Dang, Ishii Y, Yamamoto S,Hamashima T, Ohkawa N, Saitoh Y, Inokuchi K, Mori H, Sasahara M.
PDGFR-α regulates the dynamism of oligodendrocytes through recruitment of perivascular mesenchymal stem cells in the adult mouse brain.
The 18th International Vascular Biology Meeting. 2014 Apr 14-17; Kyoto.
Yamada K, Yamamoto S, Hamashima T, Isii Y, Noguchi M, Sasahara M.
PDGF receptor dimers drive distinct migration of the mouse skin fi broblast.
The 18th International Vascular Biology Meeting. 2014 Apr 14-17; Kyoto.
Sato H, Yamamoto S, Sasahara M.
Redirected migration of the DCX + cells guided by blood vessels toward ischemic core.
The 18th International Vascular Biology Meeting. 2014 Apr 14-17; Kyoto.
Horikawa S, Yamamoto S, Hamashima T, Ishii Y, Sasahara M.
PDGFR-α is essential for the connective tissue remodeling.
The 18th International Vascular Biology Meeting. 2014 Apr 14-17; Kyoto.
Azuma E, Yamamoto S, Muramatsu M, Hamashima T, Ishii Y, Niida S, Sasahara M.
Multifunctional macrophages contribute to angiogenesis and vascular homeostasis in skin wound healing site.
The 18th International Vascular Biology Meeting. 2014 Apr 14-17; Kyoto.
Shen J, Ishii Y, OuYang X , Yuan J , Zhu R , Xu G, Thanh Chung Dang , Hamashima T, Matsushima T, Yamamoto S, Sasahara M.
Involvement of PDGFR-β in blood-brain barrier function after cerebral ischemia.
The 18th International Vascular Biology Meeting. 2014 Apr 14-17; Kyoto.
2013
原 著
Takata K, Sato Y, Nakamura N, Tokunaka M, Miki Y, Yukie Kikuti Y, Igarashi K, Ito E, Harigae H, Kato S, Hayashi E, Oka T, Hoshii Y, Tari A, Okada H, Al-Kader LA, Maeda Y, Tanimoto M, Kinoshita T, Yoshino T.
Duodenal follicular lymphoma lacks AID but expresses BACH2 and has memory B-cell characteristics.
Mod Pathol. 2013 Jan;26(1):22-31. doi: 10.1038/modpathol.2012.127.
Shimoura Y, Sato Y, Takata K, Orita Y, Nakamura S, Mano S, Yoshino T.
Usefulness of immunoglobulin light-chain restriction on immunocytochemical double staining for the cytological diagnosis of B cell non-Hodgkin's lymphoma.
Acta Cytol. 2013;57(1):84-90. doi: 10.1159/000342475.
Murakami I, Morimoto A, Oka T, Kuwamoto S, Kato M, Horie Y, Hayashi K, Gogusev J, Jaubert F, Imashuku S, Al-Kadar LA, Takata K, Yoshino T.
IL-17A receptor expression differs between subclasses of Langerhans cell histiocytosis, which might settle the IL-17A controversy.
Virchows Arch. 2013 Feb;462(2):219-28. doi: 10.1007/s00428-012-1360-6.
Ando M, Sato Y, Takata K, Nomoto J, Nakamura S, Ohshima K, Takeuchi T, Orita Y, Kobayashi Y, Yoshino T.
A20 (TNFAIP3) deletion in Epstein-Barr virus-associated lymphoproliferative disorders/lymphomas.
PLoS One. 2013;8(2):e56741. doi: 10.1371/journal.pone.0056741.
Toda H, Sato Y, Takata K, Orita Y, Asano N, Yoshino T.
Clinicopathologic analysis of localized nasal/paranasal diffuse large B-cell lymphoma.
PLoS One. 2013;8(2):e57677. doi: 10.1371/journal.pone.0057677.
Sato Y, Takeuchi M, Takata K, Ohno K, Iwaki N, Orita Y, Goto N, Hida AI, Iwamoto T, Asano N, Ito T, Hanakawa H, Yanai H, Yoshino T.
Clinicopathologic analysis of IgG4-related skin disease.
Mod Pathol. 2013 Apr;26(4):523-32. doi: 10.1038/modpathol.2012.196.
Igawa T, Sato Y, Takata K, Iwaki N, Tanaka T, Asano N, Maeda Y, Orita Y, Nakamura N, Nakamura S, Yoshino T.
De novo CD5-positive diffuse large B-cell lymphomas show high specificity for cyclin D2 expression.
DiagnPathol. 2013 May 15:8:81. doi: 10.1186/1746-1596-8-81.
Kikuchi T, Tokunaka M, Kikuti YY, Carreras J, Ogura G, Takekoshi S, Kojima M, Ando K, Hashimoto Y, Abe M, Takata K, Yoshino T, Muto A, Igarashi K, Nakamura N.
Over-expression of BACH2 is related to ongoing somatic hypermutation of the immunoglobulin heavy chain gene variable region of de novo diffuse large B-cell lymphoma.
Pathol Int. 2013 Jul;63(7):339-44. doi: 10.1111/pin.12076.
Hayashi E, Takata K, Sato Y, Tashiro Y, Tachiyama Y, Sawada-Kitamura S, Hiramatsu Y, Sugiguchi S, Nose S, Hirokawa M, Ando M, Abd Alkader L, Maeda Y, Tanimoto M, Yoshino T.
Distinct morphologic, phenotypic, and clinical-course characteristics of indolent peripheral T-cell lymphoma.
Hum Pathol. 2013 Sep;44(9):1927-36. doi: 10.1016/j.humpath.2013.03.002.
Abd Al Kader L, Oka T, Takata K, Sun X, Sato H, Murakami I, Toji T, Manabe A, Kimura H, Yoshino T.
In aggressive variants of non-Hodgkin lymphomas, Ezh2 is strongly expressed and polycomb repressive complex PRC1.4 dominates over PRC1.2.
Virchows Arch. 2013 Nov;463(5):697-711. doi: 10.1007/s00428-013-1428-y.
症例報告
Iwamuro M, Kawai Y, Takata K, Kawano S, Yoshino T, Okada H, Yamamoto K.
Primary intestinal follicular lymphoma: How to identify follicular lymphoma by routine endoscopy.
World J Gastrointest Endosc. 2013 Jan 16;5(1):34-8. doi: 10.4253/wjge.v5.i1.34.
Abd Al-Kader L, Sato Y, Takata K, Ohshima K, Sogabe Y, Fujii K, Iwaki N, Yoshino T.
A case of conjunctival follicular lymphoma mimicking mucosa-associated lymphoid tissue lymphoma.
J Clin Exp Hematop. 2013;53(1):49-52. doi: 10.3960/jslrt.53.49.
Iwaki N, Sato Y, Takata K, Kondo E, Ohno K, Takeuchi M, Orita Y, Nakao S, Yoshino T.
Atypical hyaline vascular-type castleman's disease with thrombocytopenia, anasarca, fever, and systemic lymphadenopathy.
J Clin Exp Hematop. 2013;53(1):87-93. doi: 10.3960/jslrt.53.87.
Iwamuro M, Okuda M, Yumoto E, Suzuki S, Shirakawa A, Takata K, Yoshino T, Okada H, Yamamoto K.
Magnifying endoscopy for intestinal follicular lymphoma is helpful for prompt diagnosis.
Gut Liver. 2013 Mar;7(2):258-61. doi: 10.5009/gnl.2013.7.2.258.
Imasawa T, Kitamura H, Nishimura M, Kawaguchi T, Takata K, Yoshino T, Sugisaki Y.
Lupus nephritis class I accompanied by tubulointerstitial nephritis with marked T-lymphocyte infiltration in an HTLV-1 positive patient.
CEN Case Rep. 2013 May;2(1):90-97. doi: 10.1007/s13730-012-0044-z.
Iwamuro M, Kawai Y, Takata K, Okada H, Yamamoto K.
Observation of lymphangioma of the duodenum by a magnifying endoscope with a narrow-band imaging system.
Case Rep Gastroenterol. 2013 May 24;7(2):229-33. doi: 10.1159/000351831.
Iwamuro M, Kawai Y, Yamawaki Y, Takata K, Yamamoto K.
Precursor B lymphoblastic lymphoma involving the stomach.
Case Rep Gastrointest Med. 2013:2013:930918. doi: 10.1155/2013/930918.
Iwamuro M, Imagawa A, Kobayashi N, Kubota Y, Miyatani K, Takata K, Okada H.
Synchronous adenocarcinoma and follicular lymphoma of the stomach.
Intern Med. 2013;52(8):907-12. doi: 10.2169/internalmedicine.52.7948.
Iwaki N, Sato Y, Kurokawa T, Maeda Y, Ohno K, Takeuchi M, Takata K, Orita Y, Nakao S, Yoshino T.
B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma without mediastinal disease: mimicking nodular sclerosis classical Hodgkin lymphoma.
Med Mol Morphol. 2013 Sep;46(3):172-6. doi: 10.1007/s00795-013-0038-8.
Kato S, Miyata T, Takata K, Shimada S, Ito Y, Tomita A, Elsayed AA, Takahashi E, Asano N, Kinoshita T, Kimura H, Nakamura S.
Epstein-Barr virus-positive cytotoxic T-cell lymphoma followed by chronic active Epstein-Barr virus infection-associated T/NK-cell lymphoproliferative disorder: a case report.
Hum Pathol. 2013 Dec;44(12):2849-52. doi: 10.1016/j.humpath.2013.05.025.
総 説
高田尚良, 佐藤康晴, 中村直哉, 徳中摩美, 三木由香里, 菊池イアーラ幸江, 五十嵐和彦, 伊藤悦郎, 張替秀雄, 加藤省一, 林詠子, 岡剛史, 星井嘉信, 田利晶, 岡田裕之, Mohamado ABD Alkader Lamia, 前田嘉信, 谷本光音, 木下朝博, 吉野正.
十二指腸濾胞性リンパ腫はAIDの発現を欠くがBACH2の発現を有しmemory B細胞としての性質を有する.
岡山医学会雑誌. 2013 125 (2):103-107. Doi: 10.4044/joma.125.103.
高田尚良, 吉野正.
消化管に発生する濾胞性リンパ腫の細胞起源.
血液内科. 2013;66 (4):508-513.
学会報告
Takata K, Tanino M, Ennishi D, Tari A, Sato Y, Okada H, Goto N, Maeda Y, Gascoyne RD, Yoshino T.
Duodenal follicular lymphoma shares characteristics of MALT lymphoma: Comprehensive gene expression analysis with insights into pathogenesis.
102nd USCAP Annual meeting; 2013 Mar 2-8; Baltimore USA. (poster presentation)
高田尚良, 吉野正.
消化管DLBCLの病理診断.
第53回日本リンパ網内系学会学術総会; 2013 May 16-18; 京都.(シンポジウム)
笹原正清, Jie Shen, 石井陽子, 山本誠士, 濱島丈, Chung T Dang, 松島貴子, 倉茂洋一.
血小板由来増殖因子β受容体は虚血脳における脳血液関門の機能に重要である. (PDGFR-β is involved in BBB function after cerebral ischemia)
Neuro2013; 2013 Jun 20-23; 京都.
高田尚良, 吉野正.
消化管濾胞性リンパ腫の最新知見.
第102回日本病理学会総会; 2013 Jun 6-8; 札幌.(シンポジウム)
笹原正清, Shen Jie, 石井陽子, 濱島丈, 山本誠士, 松島貴子, 倉茂洋一, Dang Thanh Chung.
PDGF受容体は脳血液関門のバリアー機能に重要である.
第102回日本病理学会総会; 2013 Jun 6-8; 札幌.
濱島丈, 石井陽子, Shen Jie, 山本誠士, 松島貴子, 倉茂洋一, 笹原正清.
神経特異的なPDGFR-αノックアウトマウスにおける髄鞘形成障害.
第102回日本病理学会総会; 2013 Jun 6-8; 札幌.
山本誠士, 東英梨月, 村松昌, 濱島丈, 石井陽子, 新飯田俊平, 笹原正清.
血管内皮細胞の炎症病態に関連するmiRNAの解析.
第102回日本病理学会総会; 2013 Jun 6-8; 札幌.
堀川慎二郎, 石井陽子, 山本誠士, 濱島丈, 笹原正清.
血小板由来増殖因子α受容体は線維芽細胞に発現し新生肉芽形成に関与する.
第102回日本病理学会総会; 2013 Jun 6-8; 札幌.
佐藤光, Jie Shen, 濱島丈, 石井陽子, 山本誠士, Dang Thanh Chung, 笹原正清.
脳虚血後のBBB機能におけるPDGFR-βの役割. (Roles of PDGFR-β in BBB functions after cerebral ischemia)
第102回日本病理学会総会; 2013 Jun 6-8; 札幌.
山田浩太, 笹原正清, 石井陽子, 濱島丈, 山本誠士.
マウス皮膚線維芽細胞の遊走におけるPDGF受容体の役割の解明.
第102回日本病理学会総会; 2013 Jun 6-8; 札幌.
2012
原 著
Habara T, Sato Y, Takata K, Iwaki N, Okumura H, Sonobe H, Tanaka T, Orita Y, Abd Al-Kader L, Asano N, Ennishi D, Yoshino T.
Germinal center B-cell-like versus non-germinal center B-cell-like as important prognostic factor for localized nodal DLBCL.
J Clin Exp Hematop. 2012;52(2):91-9. doi: 10.3960/jslrt.52.91.
Hagiwara M, Tomita A, Takata K, Shimoyama Y, Yoshino T, Tomita Y, Nakamura S.
Primary cutaneous CD30 positive T-cell lymphoproliferative disorders with aberrant expression of PAX5: report of three cases.
Pathol Int. 2012 Apr;62(4):264-70. doi: 10.1111/j.1440-1827.2011.02784.x.
Sato Y, Inoue D, Asano N, Takata K, Asaoku H, Maeda Y, Morito T, Okumura H, Ishizawa S, Matsui S, Miyazono T, Takeuchi T, Kuroda N, Orita Y, Takagawa K, Kojima M, Yoshino T.
Association between IgG4-related disease and progressively transformed germinal centers of lymph nodes
Mod Pathol. 2012 Jul;25(7):956-67. doi: 10.1038/modpathol.2012.54.
Iwamuro M, Okada H, Takata K, Shinagawa K, Fujiki S, Shiode J, Imagawa A, Araki M, Morito T, Nishimura M, Mizuno M, Inaba T, Suzuki S, Kawai Y, Yoshino T, Kawahara Y, Takaki A, Yamamoto K.
Diagnostic role of 18F-fluorodeoxyglucose positron emission tomography for follicular lymphoma with gastrointestinal involvement.
World J Gastroenterol. 2012 Nov 28;18(44):6427-36; discussion p.6434. doi: 10.3748/wjg.v18.i44.6427.
Shen J, Ishii Y, Xu G, Dang TC, Hamashima T, Matsushima T, Yamamoto S, Hattori Y, Takatsuru Y, Nabekura J, Sasahara M.
PDGFR-β as a positive regulator of tissue repair in a mouse model of focal cerebral ischemia.
J Cereb Blood Flow Metab. 2012 Feb;32(2):353-67. doi: 10.1038/jcbfm.2011.136.
症例報告
Sato Y, Ohshima K, Takata K, Huang X, Cui W, Ohno K, Yoshino T.
Ocular adnexal IgG4-producing mucosa-associated lymphoid tissue lymphoma mimicking IgG4-related disease.
J Clin Exp Hematop. 2012;52(1):51-5. doi: 10.3960/jslrt.52.51.
Takeuchi K, Iwamuro M, Imagawa A, Kubota Y, Miyatani K, Takata K, Okada H.
Primary follicular lymphoma of the duodenum with erosions as atypical macroscopic features.
Case Rep Med. 2012:2012:582607. doi: 10.1155/2012/582607.
Iwamuro M, Okada H, Takata K, Kawano S, Kawahara Y, Nasu J, Shinagawa K, Yoshino T, Yamamoto K.
Primary follicular lymphoma of the duodenum relapsing 11 years after resection.
Intern Med. 2012;51(9):1031-5. doi: 10.2169/internalmedicine.51.7060.
Takeuchi M, Sato Y, Takata K, Kobayashi K, Ohno K, Iwaki N, Orita Y, Yoshino T.
Cutaneous multicentric Castleman's disease mimicking IgG4-related disease.
Pathol Res Pract. 2012 Dec 15;208(12):746-9. doi: 10.1016/j.prp.2012.09.006.
総 説
吉野正, 高田尚良.
造血器腫瘍学-基礎と臨床の最新研究動向-造血器腫瘍の診断と治療;診断・検査法.
日本臨床. 2012;70(2):193-197.
高田尚良, 吉野正.
Laboratory Techniques(第4回)病理学からのアプローチ:リンパ節の扱い方とその実際.
Trends in hematological malignancies. 2012;4:160-164.
高田尚良, 吉野正.
消化管濾胞性リンパ腫研究と今後の展望.
血液内科. 2012;64(3):359-364.
岡田裕之, 高田尚良, 吉野正, 品川克至, 山本和秀.
消化管濾胞性リンパ腫治療の現況-多施設共同研究による臨床病理学的検索も含めて.
臨牀消化器内科. 2012;27(13):1717-1724.
学会報告
Takata K, Sato Y, Nakamura N, Kato S, Hayashi E, Yoshino T.
Gastrointestinal follicular lymphoma: distinction of duodenal follicular lymphoma.
11th Japanese-Korean lymphoma conference; 2012 Korea.(シンポジウム)
2011
原 著
Huang X, Takata K, Sato Y, Tanaka T, Ichimura K, Tamura M, Oka T, Yoshino T.
Downregulation of the B-cell receptor signaling component CD79b in plasma cell myeloma: a possible post transcriptional regulation.
Pathol Int. 2011 Mar;61(3):122-9. doi: 10.1111/j.1440-1827.2010.02634.x.
Takata K, Okada H, Ohmiya N, Nakamura S, Kitadai Y, Tari A, Akamatsu T, Kawai H, Tanaka S, Araki H, Yoshida T, Okumura H, Nishisaki H, Sagawa T, Watanabe N, Arima N, Takatsu N, Nakamura M, Yanai S, Kaya H, Morito T, Sato Y, Moriwaki H, Sakamoto C, Niwa Y, Goto H, Chiba T, Matsumoto T, Ennishi D, Kinoshita T, Yoshino T.
Primary gastrointestinal follicular lymphoma involving the duodenal second portion is a distinct entity: a multicenter, retrospective analysis in Japan.
Cancer Sci. 2011 Aug;102(8):1532-6. doi: 10.1111/j.1349-7006.2011.01980.x.
Igawa T, Sato Y, Takata K, Fushimi S, Tamura M, Nakamura N, Maeda Y, Orita Y, Tanimoto M, Yoshino T.
Cyclin D2 is overexpressed in proliferation centers of chronic lymphocytic leukemia/small lymphocytic lymphoma.
Cancer Sci. 2011 Nov;102(11):2103-7. doi: 10.1111/j.1349-7006.2011.02046.x.
Cui W, Che L, Sato Y, Huang X, Takata K, Orita Y, Goto N, Maeda Y, Tanimoto M, Yoshino T.
Nodal follicular lymphoma without complete follicular dendritic cell networks is related to localized clinical stage.
Pathol Int. 2011 Dec;61(12):737-41. doi: 10.1111/j.1440-1827.2011.02736.x.
Tamura M, Takata K, Sato Y, Nakamura N, Kikuti YY, Ichimura K, Tanaka T, Tari A, Maeda Y, Tanimoto M, Okada H, Yoshino T.
Germinal center B-cell-like diffuse large B-cell lymphoma of the duodenum is associated with t(14;18) translocation.
Pathol Int. 2011 Dec;61(12):742-8. doi: 10.1111/j.1440-1827.2011.02748.x.
症例報告
Sato Y, Kojima M, Takata K, Huang X, Hayashi E, Manabe A, Miki Y, Yoshino T.
Immunoglobulin G4-related lymphadenopathy with inflammatory pseudotumor-like features.
Med Mol Morphol. 2011 Sep;44(3):179-82. doi: 10.1007/s00795-010-0525-0.
Tanaka T, Megahed N, Takata K, Asano N, Niwa Y, Hirooka Y, Goto H.
A case of lymphomatoid gastropathy:An indolent CD56-positive atypical gastric lymphoid proliferation, mimicking aggressive NK/T cell lymphomas.
Pathol Res Pract. 2011 Dec 15;207(12):786-9. doi: 10.1016/j.prp.2011.09.012.
総 説
高田尚良、吉野正
濾胞性リンパ腫の診療・研究に組織学的gradingは必要か? (特集リンパ系腫瘍診療のresearch questions)
血液内科. 2011;63(1):1-7.
高田尚良、吉野正
上部消化管のリンパ増殖性疾患.
病理と臨床.2011;29(9):968-977.
学会報告
高田尚良, 吉野正.
消化管濾胞性リンパ腫研究と今後の展望.
第51回日本リンパ網内系学会学術総会; 2011 Jul 1-2; 福岡.(シンポジウム)
2010
著 書
高田尚良, 吉野正.
WHO血液腫瘍分類.
医薬ジャーナル社; p.353-357, 東京, 2010.
高田尚良, 吉野正.
病理と臨床 臨時増刊号 病理形態学キーワード.
文光堂; p318-319, 東京, 2010.
高田尚良, 吉野正.
悪性リンパ腫ハンドブック.
南光堂; p82-85, 東京, 2010.
高田尚良, 吉野正.
腫瘍病理鑑別診断アトラス 皮膚腫瘍II.
文光堂; p194-197, 東京, 2010.
原 著
Sato H, Oka T, Shinnou Y, Kondo T, Washio K, Takano M, Takata K, Morito T, Huang X, Tamura M, Kitamura Y, Ohara N, Ouchida M, Ohshima K, Shimizu K, Tanimoto M, Takahashi K, Matsuoka M, Utsunomiya A, Yoshino T.
Multi-step aberrant CpG island hyper-methylation is associated with the progression of adult T-cell leukemia/lymphoma.
Am J Pathol. 2010 Jan;176(1):402-15. doi: 10.2353/ajpath.2010.090236.
Takahata H, Ohara N, Ichimura K, Tanaka T, Sato Y, Morito T, Takata K, Kojima M, Kobata T, Yoshino T.
BAFF-R is expressed on B-cell lymphomas depending on their origin, and is related to proliferation index of nodal diffuse large B-cell lymphomas.
J Clin Exp Hematop. 2010;50(2):121-7. doi: 10.3960/jslrt.50.121.
Sato Y, Kojima M, Takata K, Morito T, Mizobuchi K, Tanaka T, Inoue D, Shiomi H, Iwao H, Yoshino T.
Multicentric Castleman's disease with abundant IgG4-positive cells: a clinical and pathological analysis of six cases.
J Clin Pathol. 2010 Dec;63(12):1084-9. doi: 10.1136/jcp.2010.082958.
症例報告
血液・腫瘍科.2009;58:612-617.
総 説
Sato Y, Notohara K, Kojima M, Takata K, Masaki Y, Yoshino T.
IgG4-related disease: historical overview and pathology of hematological disorders.
Pathol Int. 2010 Apr;60(4):247-58. doi: 10.1111/j.1440-1827.2010.02524.x.
高田尚良, 吉野正.
消化管濾胞性リンパ腫.
病理と臨床臨時増刊号.2010;28:318-319.
高田尚良, 吉野正.
低悪性度B細胞リンパ腫濾胞性リンパ腫.
病理と臨床.2010;28:720-726.
学会報告
Takata K.
Case presentation T-3.
3rd Japan-Taiwan slide case conference (slide discussant); 2010; Taiwan.(招聘講演)
高田尚良, 吉野正.
我が国における消化管濾胞性リンパ腫の臨床病理学的検討.
第16回日本ヘリコバクター学会; 2010 Jun 24-25; 京都.(特別講演)
高田尚良.
悪性リンパ腫の基礎と甲状腺リンパ腫.
第43回甲状腺外科学会サイロイドクラブコンパニオンミーティング; 2010 Oct 14-15; 岡山.(シンポジウム)
高田尚良, 佐藤康晴, 吉野正.
臓器特異的リンパ腫.(特に消化管について)
第50回日本リンパ網内系学会学術集会; 2010Jun17-19; 新潟.(シンポジウム)
2009
原 著
Sato Y, Onishi N, Morito T, Takata K, Mizobuchi K, Nagatsuka H, Ichimura K, Tanaka T, Tamura M, Yoshino T.
Patients with localized primary non-tonsillar oral diffuse large B-cell lymphoma exhibit favorable prognosis despite a non-germinal center B-cell-like phenotype.
Cancer Sci. 2009 Jan;100(1):42-6. doi: 10.1111/j.1349-7006.2008.00995.x.
Hagiwara M, Takata K, Shimoyama Y, Yamamoto K, Takahashi E, Asano N, Iwase Y, Okazaki Y, Tamada Y, Yoshino T, Tomita Y, Nakamura S.
Primary cutaneous T-cell lymphoma of unspecified type with cytotoxic phenotype: clinicopathological analysis of 27 patients.
Cancer Sci. 2009 Jan;100(1):33-41. doi: 10.1111/j.1349-7006.2008.01000.x.
Sato Y, Kojima M, Takata K, Morito T, Asaoku H, Takeuchi T, Mizobuchi K, Fujihara M, Kuraoka K, Nakai T, Ichimura K, Tanaka T, Tamura M, Nishikawa Y, Yoshino T.
Systemic IgG4-related lymphadenopathy: a clinical and pathologic comparison to multicentric Castleman's disease.
Mod Pathol. 2009 Apr;22(4):589-99. doi: 10.1038/modpathol.2009.17.
Takata K, Sato Y, Nakamura N, Kikuti YY, Ichimura K, Tanaka T, Morito T, Tamura M, Oka T, Kondo E, Okada H, Tari A, Yoshino T.
Duodenal and nodal follicular lymphomas are distinct: the former lacks activation-induced cytidine deaminase and follicular dendritic cells despite ongoing somatic hypermutations.
Mod Pathol. 2009 Jul;22(7):940-9. doi: 10.1038/modpathol.2009.51.
Morito T, Fujihara M, Asaoku H, Tari A, Sato Y, Ichimura K, Tanaka T,Takata K, Tamura M, Yoshino T.
Serum soluble interleukin-2 receptor level and immunophenotype are prognostic factors for patients with diffuse large B-cell lymphoma.
Cancer Sci. 2009 Jul;100(7):1255-60. doi: 10.1111/j.1349-7006.2009.01167.x.
Nakahara H, Misawa H, Hayashi T, Kondo E, Yuasa T, Kubota Y, Seita M, Kawamoto H, Hassan WA, Hassan RA, Javed SM, Tanaka M, Endo H, Noguchi H, Matsumoto S, Takata K, Tashiro Y, Nakaji S, Ozaki T, Kobayashi N.
Bone repair by transplantation of hTERT-immortalized human mesenchymal stem cells in mice.
Transplantation. 2009 Aug 15;88(3):346-53. doi: 10.1097/TP.0b013e3181ae5ba2.
Kondo T, Oka T, Sato H, Shinnou Y, Washio K, Takano M, Morito T, Takata K, Ohara N, Ouchida M, Shimizu K, Yoshino T.
Accumulation of aberrant CpG hypermethylation by Helicobacter pylori infection promotes development and progression of gastric MALT lymphoma.
Int J Oncol. 2009 Sep;35(3):547-57. doi: 10.3892/ijo_00000366.
Tanaka T, Ichimura K, Sato Y, Takata K, Morito T, Tamura M, Kondo E, Ohara N, Yanai H, Sakai M, Takahashi S, Yoshino T.
Frequent downregulation or loss of CD79a expression in plasma cell myelomas: potential clue for diagnosis.
Pathol Int. 2009 Nov;59(11):804-8. doi: 10.1111/j.1440-1827.2009.02448.x.
総 説
高田尚良, 吉野正.
消化管原発濾胞性リンパ腫とは.
血液・腫瘍科.2009;58:612-617.
学会報告
高田尚良, 佐藤康晴, 中村直哉, 菊池・イアーラ幸江, 市村浩一, 田中健大, 守都敏晃, 田村麻衣子, 岡剛史, 近藤英作, 岡田裕之, 田利晶, 吉野正.
十二指腸濾胞性リンパ腫の臨床病理および分子生物学的解析.
第49回日本リンパ網内系学会学術総会; 2009 Jul 9-11; 兵庫.(シンポジウム)
2008
原 著
Sato Y , Ichimura K, Tanaka T, Takata K, Morito T, Sato H, Kondo E, Yanai H, Ohara N, Oka T, Yoshino T.
Duodenal follicular lymphomas share common characteristics with mucosa-associated lymphoid tissue lymphomas.
J Clin Pathol. 2008 Mar;61(3):377-81. doi: 10.1136/jcp.2007.049825.
Sato Y, Ohshima K, Ichimura K, Sato M, Yamadori I, Tanaka T, Takata K, Morito T, Kondo E, Yoshino T.
Ocular adnexal IgG4-related disease has uniform clinicopathology.
Pathol Int. 2008 Aug;58(8):465-70. doi: 10.1111/j.1440-1827.2008.02257.x.
Ohashi K, Rai K, Fujiwara Y, Osawa M, Hirano S, Takata K, Kondo E, Yoshino T, Takata M, Tanimoto M, Kiura K.
Induction of lung adenocarcinoma in transgenic mice expressing activated EGFR driven by the SP-C promoter.
Cancer Sci. 2008 Sep;99(9):1747-53. doi: 10.1111/j.1349-7006.2008.00875.x.
症例報告
Kawahara K, Sasada S, Nagano T, Suzuki H, Kobayashi M, Matsui K, Takata K, Yoshino T, Michida T, Iwasaki T.
Pleural MALT lymphoma diagnosed on thoracoscopic resection under local anesthesia using an insulation-tipped diathermic knife.
Pathol Int. 2008 Apr;58(4):253-6. doi: 10.1111/j.1440-1827.2008.02220.x.
Sato Y, Takata K, Ichimura K, Tanaka T, Morito T, Tamura M, Yoshino T.
IgG4-producing marginal zone B-cell lymphoma.
Int J Hematol. 2008 Nov;88(4):428-433. doi: 10.1007/s12185-008-0170-8.
総 説
高田尚良, 吉野正.
Keyword エピジェネティクス.
岡山医学会雑誌.2008;119:323-325.
市村浩一, 佐藤康晴, 髙田尚良, 守都敏晃, 吉野正.
悪性リンパ腫における分子病理診断の役割.
病理と臨床.2008;26:690-700.
2007
症例報告
高田尚良, 能勢聡一郎, 浜家一雄, 市村浩一, 田中健大, 佐藤康晴, 守都敏晃, 吉野正.
初回時生検で確定診断に至ることが困難であったホジキンリンパ腫の1例.
診断病理. 2007;24:344-347.
総 説
高田尚良, 吉野正.
H.pylori感染による悪性リンパ腫発症機構. (特集リンパ系腫瘍の分子病態解明の進歩)
血液・腫瘍科.2007;54:424-429.
高田尚良, 吉野正.
悪性リンパ腫の病理--WHO分類. (特集知っておきたい頭頸部悪性リンパ腫の知識)
臨床放射線. 2007;52:1735-1742.
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