Yuichi Hattori, M.D., Ph.D.

hattori

Yuichi Hattori, M.D., Ph.D
University of Toyama
Born:Akita, Japan



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Professor


Research Manager and Organizer

Academic Background

Ph.D., Hokkaido University, 1982
M.D., Hokkaido University, 1978

Reserch Experience

Professor , University of Toyama, 2005 -
Associate Professor, Hokkaido University, 1992 - 2005
Postdoctoral Fellow, Cornell University Medical College, 1982 - 1984

Award

Yamashita Taro Kensho Ikueikai Prize for Science, 1993
Journal of Smooth Muscle Research Best Download Prize, 2009

Memberships

The Japanese Pharmacological Society
Japanese College of Angiology
Japanese Section of International Society for Heart Research
Japanese Society for Circulation Research
Japanese Association of Cardiovascular Pharmacology
Japan Histamine Research Society
The Japanese Society of Clinical Pharmacology and Therapeutics
The Japanese Circulation Society
Physiological Society of Japan
The Japan Neuroscience Society
The American Society for Pharmacology and Experimental Therapeutics

Editorships

Associate Editor, Journal of Pharmacology and Experimental Therapeutics

Editorial Board, European Journal of Pharmacology

Editorial Board, Circulation Research

Biography

  He was born in Akita, Japan, in 1953. He received his M.D. degree from Hokkaido University, where he received the Ph.D. degree in 1982. From 1982 to 1984, He was a Postdoctoral Fellow of Cornell University Medical College. After serving as an Associate Professor of Hokkaido University School of Medicine, He works presently as a Professor of Molecular and Medical Pharmacology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama. In 1993, He was awarded a Yamashita Taro Kensho Ikueikai Prize for Science. His expertise lies in cardiovascular pharmacology, inflammatory and immunopharmacology, and diabetology. He serves as an Associate Editor of the Journal of Pharmacology and Experimental Therapeutics. He serves also as an Editorial Board Member of the European Journal of Pharmacology and of ISRN Pharmacology.

Publications

Books

  1. Rifkind AB, Hattori Y, Levi R, Hughes MJ, Quilley C, Alonso DR: The chick embryo as a model for PCB and dioxin toxicity: Evidence of cardiotoxicity and increased prostaglandin synthesis. In: Banbury Report 18, Biological mechanisms of dioxin action. eds. by Poland A, Kimbrough RD. pp.255-266, Cold Spring Harbor Laboratory. 1984.
  2. Levi R, Hattori Y, Burke JA, Guo Z-G, Hachfeld del Balzo U, Scott WA, Rouzer CA: Leukotriene C4 is released from the anaphylactic heart: A case for its direct negative inotropic effect. In: Prostaglandins, leukotrienes, and lipoxins. ed. by Bailey JM. pp.275-288, Plenum Publishing Corporation. 1985.
  3. Fukao M, Hattori Y, Kanno M, Sakuma I, Kitabatake A: Endothelium-dependent hyperpolarizations in arteries from diabetic rats. In: Endothelium-derived hyperpolarizing factor. ed. by Vanhoutte PM. pp.263-270, Harwood Academic Publishers. 1996.
  4. Hattori Y: Cardiac α-adrenoceptor system in diabetes. In: Current aspects of cellular and subcellular mechanisms of drug actions. eds. by Kanno M, Hattori Y. pp.1-12, Hokkaido University Medical Library Series Vol. 40. 2000.
  5. Matsuda N, Hattori Y, Kemmotsu O, Gando S: Pathological significance of over-production of histamine and altered transcriptional regulation of H1- and H2-receptors during septic shock. In: Histamine Research in the New Millennium. eds. by Watanabe T, Timmerman H, Yanai K. pp.173-178, Elsevier. 2001.
  6. Matsuda N, Hattori Y, Gando S: Histamine and sepsis. In: Histamine: Biology and Medical Aspects. eds. by Falus A, Grosman N, Darvas Zs. pp.135-139, SpringMed. 2004.
  7. Hattori Y, Matsuda N: Protection from lethal cell death in cecal ligation and puncture-induced sepsis mouse model by in vivo delivery of FADD siRNA. In:Targets in Gene Therapy. ed. by Yongping You. pp.409-422, InTech-Open Access Publisher 2011.

Reviews

  1. Hattori Y, Kanno M: Pharmacology and therapeutic potential of lemildipine, a highly vasculoselective dihydropyridine derivative with slow onset and long duration of action. Cardiovasc. Drug Rev, 14(4) 317-333, 1996.
  2. Hattori Y, Kanno M: Role of α1-adrenoceptor subtypes in production of the positive inotropic effects in mammalian myocardium: Implication for the α1-adrenoceptor subtype distribution. Life Sci, 62(17/18) 1449-1453, 1998.
  3. Hattori Y: Cardiac histamine receptors: Their pharmacological consequences and signal transduction pathways. Methods Find, Exp, Clin, Pharmacol, 21(2) 123-131, 1999.
  4. Matsuda N, Hattori Y: Systemic inflammatory response syndrome (SIRS): Molecular pathophysiology and gene therapy. J Pharmacol Sci, 101(3), 189-198, 2006.
  5. Matsuda N, Hattori Y: Vascular biology in sepsis: pathophysiological and therapeutic significance of vascular dysfunction. J Smooth Muscle Res, 43 (4), 117-137, 2007.
  6. Hayashi T, Yano K, Matsui-Hirai H, Yokoo H, Hattori Y, Iguchi A: Nitric oxide and endothelial cellular senescence. Pharmacol Ther, 120(3) (333-339) 2008.
  7. Hattori Y, Takano KI, Teramae H, Yamamoto S, Yokoo H, Matsuda N: Insights into sepsis therapeutic design based on the apoptotic death pathway. J Pharmacol Sci, 114(4) 354-365 2010.

Editorials

  1. Hattori Y, Yamamoto S, and Matsuda N: Sympathetic control of VEGF angiogenic signaling. Dual regulations by α2-adrenoceptor activation? Circ Res, 101 (7), 642-644, 2007.
  2. Tomita K, Takano K, Yokoo H, Hattori Y: Novel insights into beneficial consequences of statins in sepsis: Anti-inflammatory and anti-apoptotic mechanisms. Mol Cell Pharmacol 3 (2), 67-74, 2011.
  3. Taguchi K, Hattori Y: Unlooked-for significance of cardiac versus vascular effects of endothelin-1 in the pathophysiology of pulmonary arterial hypertension. Circ Res 112 (2), 227-229, 2013.

Original Articles

  1. Nakaya H, Hattori Y, Kanno M: Effects of calcium antagonists and lidocaine on conduction delay induced by acute myocardial ischemia in dogs. Jpn. J. Pharmacol. 30(5) 587-597, 1980.
  2. Hattori Y, Kanno M: Triphasic time course of inotropic effect mediated by α-adrenoceptors in the left atria of guinea pigs. Jpn. J. Pharmacol. 31(4) 543-551, 1981.
  3. Nakaya H, Hattori Y, Sakuma I, Kanno M: Effects of calcium antagonists on coronary circulation and conduction delay induced by myocardial ischemia in dogs: A comparative study with other coronary vasodilators. Eur. J. Pharmacol. 73(4) 273-281, 1981.
  4. Hattori Y, Kanno M: Influence of stimulation interval on inotropism mediated by α-adrenoceptors in the left atria of rabbits. Arch. Int. Pharmacodyn. Ther. 254(1) 119-133, 1981.
  5. Hattori Y, Kanno M: Differential influences of several α-adrenoceptor antagonists on α-adrenoceptor-mediated inotropic responses in the left atria of guinea pigs. Jpn. J. Pharmacol. 32(2) 359-368, 1982.
  6. Hattori Y, Kanno M: Effect of E-643 on α-adrenoceptor-mediated inotropic response to phenylephrine in the left atria of guinea pigs. Jpn. J. Pharmacol. 32(5) 963-965, 1982.
  7. Hattori Y, Kimura S, Fujii S, Kanno M: Effects of histamine on mechanical performance and biochemical and electrical activity in the heart of monkeys (Macaca fuscata). Eur. J. Pharmacol. 91(1) 11-19, 1983.
  8. Levi R, Burke JA, Guo Z-G, Hattori Y, Hoppens CM, McManus LM, Hanahan DJ, Pinckard RN: Acetyl glyceryl ether phosphorylcholine (AGEPC). A putative mediator of cardiac anaphylaxis in the guinea pig. Circ. Res. 54(2) 117-124, 1984.
  9. Kimura S, Hattori Y, Kanno M: Slow responses mediated by α-adrenoceptors in the cardiac muscles of the monkey (Macaca Fuscata). Arch. Int. Pharmacodyn. Ther. 268(1) 46-58, 1984.
  10. Hattori Y, Kanno M: Influences of extracellular calcium ions, verapamil, and calcium antagonistic cations on the positive inotropic effects mediated by α- and β-adrenoceptors in the left atria of rats. Gen. Pharmacol. 15(2) 91-97, 1984.
  11. Hattori Y, Levi R: Negative inotropic effect of leukotrienes: Leukotriene C4 and D4 inhibit calcium-dependent contractile responses in potassium-depolarized guinea-pig myocardium. J. Pharmacol. Exp. Ther. 230(3) 636-651, 1984.
  12. Hattori Y, Levi R: Adenosine selectively attenuates H2- and beta-mediated cardiac responses to histamine and norepinephrine: An unmasking of H1- and alpha-mediated responses. J. Pharmacol. Exp. Ther. 231(2) 215-223, 1984.
  13. Hattori Y, Kanno M: Effect of Ni2+ on the multiphasic positive inotropic responses to histamine mediated by H1-receptors in left atria of guinea pigs. Naunyn-Schmiedeberg’s Arch. Pharmacol. 329(2) 188-194, 1985.
  14. Hattori Y, Hazama S, Kanno M, Nakao Y: Inotropic effects of Ca2+ channel agonist and antagonists in neuraminidase-treated left atria of rats. Br. J. Pharmacol. 87(2) 299-305, 1986.
  15. Hattori Y, Levi R: Effect of PGD2 on cardiac contractility: A negative inotropism secondary to coronary vasoconstriction conceals a primary positive inotropic action. J. Pharmacol. Exp. Ther. 237 (3) 719-724, 1986.
  16. Hattori Y, Nakaya H, Tohse N, Kanno M: Vascular and cardiac effects of a new dihydropyridine derivative, YC-170: A comparison with Bay K 8644. J. Pharmacol. Exp. Ther. 238(2) 670-678, 1986.
  17. Nakaya H, Hattori Y, Tohse N, Kanno M: Voltage-dependent effects of YC-170, a dihydropyridine calcium channel modulator, in cardiovascular tissues. Naunyn-Schmiedeberg’s Arch. Pharmacol. 333(4) 421-430, 1986.
  18. Oyama Y, Kawasaki H, Hattori Y, Kanno M: Attenuation of endothelium-dependent relaxation in aorta from diabetic rats. Eur. J. Pharmacol. 131 (1) 75-78, 1986.
  19. Hattori Y, Azuma M, Gotoh Y, Kanno M: Negative inotropic effects of halothane, enflurane and isoflurane in papillary muscles from diabetic rats. Anesth. Analg. 66(1) 23-28, 1987.
  20. Hazama S, Hattori Y, Kanno M: Influence of N-ethylmaleimide on Na+-Ca2+ exchange across cardiac sarcolemma. Asia Pacific J. Pharmacol. 2(1) 1-6, 1987.
  21. Hattori Y, Sakuma I, Nakao Y, Kanno M: Pharmacological analysis of the cardiac actions of xamoterol, a beta adrenoceptor antagonist with partial agonistic activity, in guinea pig hearts: Evidence for involvement of adenylate cyclase system in its cardiac stimulant actions. J. Pharmacol. Exp. Ther. 242(3) 1077-1085, 1987.
  22. Tohse N, Hattori Y, Nakaya H, Kanno M: Effects of α-adrenoceptor stimulation on electrophysiological properties and mechanics in rat papillary muscle. Gen. Pharmacol. 18(5) 539-546, 1987.
  23. Nakaya H, Hattori Y, Nakao Y, Kanno M: Cardiac versus vascular effects of a new dihydropyridine derivative, CV-4093. In vitro comparison with other calcium antagonists. Eur. J. Pharmacol. 146(1) 35-43, 1988.
  24. Hattori Y, Nakaya H, Endou M, Nakao Y, Kanno M: Pharmacological profile of vasodilating action of carvedilol in isolated canine coronary artery. Drugs 36(Suppl. 6) 62-63, 1988.
  25. Hattori Y, Nakaya H, Tohse N, Kanno M: Effects of Ca2+ channel antagonists and ryanodine on H1-receptor mediated electromechanical response to histamine in guinea-pig left atria. Naunyn-Schmiedeberg’s Arch. Pharmacol. 337(3) 323-330, 1988.
  26. Hattori Y, Sakuma I, Kanno M: Differential effects of histamine mediated by histamine H1- and H2-receptors on contractility, spontaneous rate and cyclic nucleotides in the rabbit heart. Eur. J. Pharmacol. 153(2/3) 221-230, 1988.
  27. Hattori Y, Nakaya H, Endou M, Nakao Y, Kanno M: Vascular effects of carvedilol, a new β-adrenoceptor antagonist with vasodilating properties, in isolated canine coronary artery. J. Cardiovasc. Pharmacol. 13(4) 572-579, 1989.
  28. Hattori Y, Endou M, Shirota M, Kanno M: Dissociation of phosphoinositide hydrolysis and positive inotropic effect of histamine mediated by H1-receptors in guinea-pig left atria. Naunyn-Schmiedeberg’s Arch. Pharmacol. 340(2) 196-203, 1989.
  29. Endou M, Hattori Y, Nakaya H, Kanno M: Differential effects of somatostatin on atrial and ventricular contractile responses in guinea pig heart: Influence of pretreatment with islet-activating protein. J. Pharmacol. Exp. Ther. 250(2) 726-733, 1989.
  30. Tohse N, Hattori Y, Nakaya H, Endou M, Kanno M: Inability of endothelin to increase Ca2+ current in guinea-pig heart cells. Br. J. Pharmacol. 99(3) 437-438, 1990.
  31. Tohse N, Nakaya H, Hattori Y, Endou M, Kanno M: Inhibitory effect mediated by α1-adrenoceptors on transient outward current in isolated rat ventricular cells. Pflugers Arch. 415(5) 575-581, 1990.
  32. Hattori Y, Nakaya H, Endou M, Kanno M: Inotropic, electrophysiological and biochemical responses to histamine in rabbit papillary muscles: Evidence for coexistence of H1- and H2-receptors. J. Pharmacol. Exp. Ther. 253(1) 250-256, 1990.
  33. Nakaya H, Hattori Y, Tohse N, Shida S, Kanno M: β-adrenoceptor-mediated depolarization of the resting membrane in guinea-pig papillary muscles: changes in intracellular Na+, K+ and Cl- activities. Pflugers Arch. 417(2) 185-193, 1990.
  34. Endou M, Hattori Y, Tohse N, Kanno M: Protein kinase C is not involved in α1-adrenoceptor-mediated positive inotropic effect. Am. J. Physiol. (Heart Circ. Physiol.) 260(1) H27-H36, 1991.
  35. Hattori Y, Gando S, Endou M, Kanno M: Characterization of histamine receptors modulating inotropic and biochemical activities in rabbit left atria. Eur. J. Pharmacol. 196(1) 29-36, 1991.
  36. Hattori Y, Endou M, Gando S, Kanno M: Identification and characterization of histamine H1- and H2-receptors in guinea-pig left atrial membranes by [3H]-mepyramine and [3H]-tiotidine binding. Br. J. Pharmacol. 103(2) 1573-1579, 1991.
  37. Endou M, Gando S, Hattori Y, Kanno M: Binding profiles of class I antiarrhythmic agents to cardiac muscarinic receptors: Competitive and allosteric interactions with the receptors and their pharmacological significance. J. Pharmacol. Exp. Ther. 258(3) 992-998, 1991.
  38. Hattori Y, Kawasaki H, Abe K, Kanno M: Superoxide dismutase recovers altered endothelium-dependent relaxation in diabetic rat aorta. Am. J. Physiol. (Heart Circ. Physiol.) 261(4) H1086-H1094, 1991.
  39. Hattori Y, Nakaya H, Endou M, Kanno M: Pharmacological analysis of the positive inotropic effect of endothelin-1 in guinea pig left atria. J. Cardiovasc. Pharmacol. 17(Suppl. 7) S194-S196, 1991.
  40. Hattori Y, Azuma M, Kemmotsu O, Kanno M: Differential sensitivity of diabetic rat papillary muscles to negative inotropic effects of oxybarbiturates versus thiobarbiturates. Anesth. Analg. 74(1) 97-104, 1992.
  41. Endou M, Hattori Y, Nakaya H, Gotoh Y, Kanno M: Electrophysiologic mechanisms responsible for inotropic response to ketamine in guinea pig and rat myocardium. Anesthesiology 76(3) 409-418, 1992.
  42. Hattori Y, Nagashima M, Endo Y, Kanno M: Glibenclamide does not block arterial relaxation caused by vasoactive intestinal polypeptide. Eur. J. Pharmacol. 213(1) 147-150, 1992.
  43. Endou M, Hattori Y, Gando S, Kanno M: Selectivity of class I antiarrhythmic agents, disopyramide, pirmenol and pentisomide for the peripheral muscarinic M2 and M3 receptors. J. Cardiovasc. Pharmacol. 19(5) 674-681, 1992.
  44. Hattori Y, Endou M, Kanno M: Inhibition by 5-hydroxytryptamine of the beta adrenoceptor-mediated positive inotropic responses to catecholamines in rabbit papillary muscles: Direct interaction with beta adrenoceptors. J. Pharmacol. Exp. Ther. 261(3) 1160-1166, 1992.
  45. Nakaya H, Hattori Y, Endou M, Gando S, Kanno M: Electrophysiologic and anticholinergic effects of pirmenol enantiomers in guinea-pig myocardium. Naunyn-Schmiedeberg’s Arch. Pharmacol. 346(5) 555-562, 1992.
  46. Hattori Y, Takeda Y, Nakaya H, Kanno M: Induction by endogenous noradrenaline of an α1-adrenoceptor-mediated positive inotropic effect in rabbit papillary muscles. Br. J. Pharmacol. 109(4) 1232-1238, 1993.
  47. Gando S, Hattori Y, Kanno M: Altered cardiac adrenergic neurotransmission in streptozotocin-induced diabetic rats. Br. J. Pharmacol. 109(4) 1276-1281, 1993.
  48. Hattori Y, Nakaya H, Nishihira J, Kanno M: A dual-component positive inotropic effect of endothelin-1 in guinea pig left atria: A role of protein kinase C. J. Pharmacol. Exp. Ther. 266(3) 1202-1212, 1993.
  49. Hattori Y, Kawasaki H, Kanno M, Gando S, Fukao M: Attenuated contractile response of diabetic rat aorta to caffeine but not to noradrenaline in Ca2+-free medium. Eur. J. Pharmacol. 256(2) 215-219, 1994.
  50. Takeda Y, Hattori Y, Nakaya H, Kanno M: Enhancement of the positive inotropic effect mediated by α1-adrenoceptors in pertussis toxin-treated rabbit papillary muscles. Gen. Pharmacol. 25(4) 773-779, 1994.
  51. Hattori Y, Gando S, Nagashima M, Kanno M: Histamine receptors mediating a positive inotropic effect in guinea pig and rabbit ventricular myocardium: Distribution of the receptors and their possible intracellular coupling process. Jpn. J. Pharmacol. 65(4) 327-336, 1994.
  52. Akaishi Y, Hattori Y, Kanno M, Sakuma I, Kitabatake A: Pertussis toxin pretreatment alters agonist binding to β-adrenoceptors in rabbit ventricular myocardium. Res. Commun. Mol. Path. Pharmacol. 85(2) 171-179, 1994.
  53. Hattori Y, Imamura M, Akaishi Y, Kanno M: Inotropic changes induced by fluoroaluminates in rabbit left atrial muscles: possible involvement of G proteins. Br. J. Pharmacol. 114(1) 224-230, 1995.
  54. Gando S, Nishihira J, Hattori Y, Kanno M: Endothelin-1 does not phosphorylate phospholamban and troponin I in intact beating rat hearts. Eur. J. Pharmacol. (Mol. Pharmacol. Sect.) 289(2) 175-180, 1995.
  55. Hattori Y, Kawasaki H, Fukao M, Kanno M: Phorbol esters elicit Ca2+-dependent contractions in diabetic rat aorta. Eur. J. Pharmacol. 279(1) 51-58, 1995.
  56. Fukao M, Hattori Y, Kanno M, Sakuma I, Kitabatake A: Thapsigargin- and cyclopiazonic acid-induced endothelium-dependent hyperpolarization in rat mesenteric artery. Br. J. Pharmacol. 115(6) 987-992, 1995.
  57. Fukao M, Hattori Y, Kanno M, Sakuma I, Kitabatake A: Evidence for selective inhibition by lysophosphatidylcholine of acetylcholine-induced endothelium-dependent hyperpolarization and relaxation in rat mesenteric artery. Br. J. Pharmacol. 116(1) 1541-1544, 1995.
  58. Tohse N, Hattori Y, Ishigai Y, Kanno M: Electrophysiological effects of histamine H1-receptor stimulation on guinea-pig atrial cells. Heart Vessels (Suppl. 9) 71-73, 1995.
  59. Hattori M, Kawasaki H, Kanno M, Fukao M: Enhanced 5-HT2 receptor mediated contractions in diabetic rat aorta: Participation of Ca2+ channels associated with protein kinase C activity. J. Vasc. Res. 32(4) 220-229, 1995.
  60. Hattori Y, Fukao M, Houzen H, Qi F, Yamada Y, Kanno M: In vitro assessment of vascular selectivity of a new dihydropyridine derivative, NB-818. Eur. J. Pharmacol. 301(1-3) 99-106, 1996.
  61. Hattori Y, Nagashima M, Akaishi Y, Kanno M: α1-adrenoceptor subtype distribution and the coupling to phosphoinositide hydrolysis in rat and rabbit ventricular myocardium. Res. Commun. Mol. Path. Pharmacol. 93(3) 319-328, 1996.
  62. Fukao M, Hattori Y, Kanno M, Sakuma I, Kitabatake A: Structural diffeences in the ability of phospholipids to inhibit endothelium-dependent hyperpolarization by acetylcholine in rat mesenteric artery. Biochem. Biophys. Res. Commun. 227(2) 479-483, 1996.
  63. Nagashima M, Hattori Y, Akaishi Y, Tohse N, Sakuma I, Kitabatake A, Kanno M: α1-adrenoceptor subtypes mediating inotropic and electrophysiological effects in mammalian myocardium. Am. J. Physiol. (Heart Circ. Physiol.) 271(4) H1423-H1432, 1996.
  64. Hattori Y, Kawasaki H, Fukao M, Gando S, Akaishi Y, Kanno M: Diminishment of contractions associated with depolarization-evoked activation of Ca2+ channels in diabetic rat aorta. J. Vasc. Res. 33(6) 454-462, 1996.
  65. Fukao M, Hattori Y, Kanno M, Sakuma I, Kitabatake A: Evidence against a role of cytochrome P450-derived arachidonic acid metabolites in endothelium-dependent hyperpolarization by acetylcholine in rat isolated mesenteric artery. Br. J. Pharmacol. 120(3) 439-446, 1997.
  66. Akaishi Y, Hattori Y, Kanno M, Sakuma I, Kitabatake A: Agonist-independent tonic inhibitory influence of Gi on adenylate cyclase activity in rabbit ventricular myocardium and its removal by pertussis toxin: a role of empty receptor-mediated Gi activation. J. Mol. Cell. Cardiol. 29(2) 765-775, 1997.
  67. Fukao M, Hattori Y, Kanno M, Sakuma I, Kitabatake A: Sources of Ca2+ in relation to generation of acetylcholine-induced hyperpolarization in rat mesenteric artery. Br. J. Pharmacol. 120(7) 1328-1334, 1997.
  68. Nagashima M, Hattori Y, Tohse N, Kanno M: α1-Adrenoceptor subtype involved in the positive and negative inotropic responses to phenylephrine in rat papillary muscle. Gen. Pharmacol. 28(5) 721-725, 1997.
  69. Tomita F, Hattori Y, Kanno M, Kohya T, Sasaki M, Kitabatake A: Different regulation of myofilament Ca2+ sensitivity in β-escin-skinned cardiac and vascular smooth muscle. Eur. J. Pharmacol. 326(2/3) 157-162, 1997.
  70. Hattori Y, Kanno M: Involvement of α1B-adrenoceptors in the positive inotropic effect of endogenous noradrenaline in rabbit myocardium. Eur. J. Pharmacol. 329(2/3) 165-168, 1997.
  71. Fukao M, Hattori Y, Kanno M, Sakuma I, Kitabatake A: Alterations in endothelium-dependent hyperpolarization and relaxation in mesenteric arteries from streptozotocin-induced diabetic rats. Br. J. Pharmacol. 121(7) 1383-1391, 1997.
  72. Gando S, Hattori Y, Akaishi Y, Nishihira J, Kanno M: Impaired contractile response to beta adrenoceptor stimulation in diabetic rat hearts: Alterations in beta adrenoceptors-G protein-adenylate cyclase system and phospholamban phosphorylation. J. Pharmacol. Exp. Ther. 282(1) 475-484, 1997.
  73. Qi F, Sugihara T, Hattori Y, Yamamoto Y, Kanno M, Abe K: Functional and morphological damage of endothelium in rabbit ear artery following irradiation with cobalt60. Br. J. Pharmacol. 123(4) 653-660, 1998.
  74. Houzen H, Hattori Y, Kanno M, Kikuchi S, Tashiro K, Motomura M, Nakao Y, Nakamura T: Functional evaluation of inhibition of autonomic transmitter release by autoantibody from Lambert-Eaton myasthenic syndrome. Ann. Neurol. 43(5) 677-680, 1998.
  75. Tamada A, Hattori Y, Houzen H, Yamada Y, Sakuma I, Kitabatake A, Kanno M: Effects of β-adrenoceptor stimulation on contractility, [Ca2+]i, and Ca2+ current in diabetic rat cardiomyocytes. Am. J. Physiol. (Heart Circ. Physiol.) 274(6) H1849-H1857, 1998.
  76. Sato A, Hattori Y, Fukao M, Kanno M, Sakuma I, Kitabatake A: A role of myofilament Ca2+ sensitivity in enhanced vascular reactivity in cardiomyopathic hamsters. Eur. J. Pharmacol. 353(2/3) 247-256, 1998.
  77. Yoshimoto K, Hattori Y, Houzen H, Kanno M, Yasuda K: Histamine H1-receptor-mediated increase in the Ca2+ transient without a change in the Ca2+ current in electrically stimulated guinea-pig atrial myocytes. Br. J. Pharmacol. 124(8) 1744-1750, 1998.
  78. Sasaki M, Hattori Y, Tomita F, Moriishi K, Kanno M, Kohya T, Oguma K, Kitabatake A: Tyrosine phosphorylation as a convergent pathway of heterotrimeric G protein- and rho protein-mediated Ca2+ sensitivity of smooth muscle of rabbit mesenteric artery. Br. J. Pharmacol. 125(8) 1651-1660, 1998.
  79. Okada H, Fujii S, Sobel BE, Gao M, Koyama T, Hattori Y, Zaman AT, Sakuma I, Kitabatake A: Insulin and proinsulin regulate type-1 plasminogen activator inhibitor and type-1 collagen expression in rat cardiac microvascular endothelial cells: Potential role in development of coronary microvasculopathy. Pathogenesis 1(3) 179-188, 1999.
  80. Fukao M, Hattori Y, Sato A, Liu M-Y, Watanabe H, Kim TQ, Kanno M: Relationship between NaF- and thapsigargin-induced endothelium-dependent hyperpolarization in rat mesenteric artery. Br. J. Pharmacol. 126(7) 1567-1574, 1999.
  81. Sato A, Hattori Y, Watanabe M, Okamoto H, Tomioka H, Fukao M, Sakuma I, Kitabatake A, Kanno M: Effect of prolonged treatment with amlodipine on enhanced vascular contractility in cardiomyopathic hamsters. J. Cardiovasc. Pharmacol. 34(1) 124-131, 1999.
  82. Sugihara T, Hattori Y, Yamamoto Y, Qi F, Ichikawa R, Sato A, Liu M-Y, Abe K, Kanno M: Preferential impairment of nitric oxide-mediated endothelium-dependent relaxation in human cervical arteries after irradiation. Circulation 100(6) 635-641, 1999.
  83. Matsuda N, Hattori Y, Gando S, Akaishi Y, Kemmotsu O, Kanno M: Diabetes-induced down-regulation of β1-adrenoceptor mRNA expression in rat heart. Biochem. Pharmacol. 58(5) 881-885, 1999.
  84. Tomioka H, Hattori Y, Fukao M, Sato A, Liu M-Y, Sakuma I, Kitabatake A, Kanno M: Relaxation in different-sized rat blood vessels mediated by endothelium-derived hyperpolarizing factor: Importance of processes mediating precontractions. J. Vasc. Res. 36(4) 311-320, 1999.
  85. Hattori Y, Ishitani T, Tomita F, Gando S, Yokoshiki H, Azuma M, Kemmotsu O, Kanno M: Cardiac profile of EGIS-9377, a novel cardiotonic agent as a Ca2+ sensitizer with bradycardiac activity. Naunyn-Schmiedeberg’s Arch. Pharmacol. 360(5) 585-590, 1999.
  86. Hattori Y, Kawasaki H, Kanno M: Increased contractile responses to endothelin-1 and U46619 via a protein kinase C-mediated nifedipine-sensitive pathway in diabetic rat aorta. Res. Commun. Mol. Path. Pharmacol. 104(1) 73-80, 1999.
  87. Matsuda N, Hattori Y, Gando S, Watanuki S, Kemmotsu O, Kanno M: Differential gene transcriptional regulation of Gi isoforms and Gs protein expression in diabetic rat hearts. Naunyn-Schmiedeberg’s Arch. Pharmacol. 361(1) 53-60, 2000.
  88. Hattori Y, Matsuda N, Sato A, Watanuki S, Tomioka H, Kawasaki H, Kanno M: Predominant contribution of the G protein-mediated mechanism to NaF-induced vascular contractions in diabetic rats: Association with an increased level of Gqα expression. J. Pharmacol. Exp. Ther. 292(2) 761-768, 2000.
  89. Sato A, Hattori Y, Kanno M: Effects of genistein and daidzein on enhanced vascular reactivity and Ca2+ sensitivity in cardiomyopathic hamsters. Methods Find. Exp. Clin. Pharmacol. 22(1) 25-30, 2000.
  90. Sato A, Hattori Y, Sasaki M, Tomita F, Kohya T, Kitabatake A, Kanno M: Agonist-dependent difference in the mechanisms involved in Ca2+ sensitization of smooth muscle of porcine coronary artery. J. Cardiovasc. Pharmacol. 35(5) 814-821, 2000.
  91. Akaishi Y, Hattori Y, Yoshimoto K, Kitabatake A, Yasuda K, Kanno M: Involvement of tyrosine phosphorylation in the positive inotropic effect produced by H1-receptors with histamine in guinea-pig left atrium. Br. J. Pharmacol. 130(4) 907-915, 2000.
  92. Hattori Y, Matsuda N, Kimura J, Ishitani T, Tamada A, Gando S, Kemmotsu O, Kanno M: Diminished function and expression of the cardiac Na+-Ca2+ exchanger in diabetic rats: implication in Ca2+ overload. J. Physiol. 527(1) 85-94, 2000.
  93. Matsuda N, Hattori Y, Akaishi Y, Suzuki Y, Kemmotsu O, Gando S: Impairment of cardiac β-adrenoceptor cellular signaling by decreased expression of Gsα in septic rabbits. Anesthesiology 93(6) 1465-1473, 2000.
  94. Tomioka H, Hattori Y, Fukao M, Watanabe H, Akaishi Y, Sato A, Kim TQ, Sakuma I, Kitabatake A, Kanno M: Role of endothelial Ni2+-sensitive Ca2+ entry pathway in regulation of EDHF in porcine coronary artery. Am. J. Physiol. (Heart Circ. Physiol.) 280(2) H730-H737, 2001.
  95. Liu M-Y, Hattori Y, Fukao M, Sato A, Sakuma I, Kanno M: Alterations in EDHF-mediated hyperpolarization and relaxation in mesenteric arteries of female rats in long-term deficiency of oestrogen and during oestrus cycle. Br. J. Pharmacol. 132(5) 1035-1046, 2001.
  96. Fukao M, Watanabe H, Takeuchi K, Tomioka H, Hattori Y: Effects of SK&F 96365 and mefenamic acid on Ca2+ influx in stimulated endothelial cells and on endothelium-derived hyperpolarizing factor-mediated arterial hyperpolarization and relaxation. J. Cardiovasc. Pharmacol. 38(1) 130-140, 2001.
  97. Ishitani T, Hattori Y, Sakuraya F, Onozuka H, Makino T, Matsuda N, Gando S, Kemmotsu O: Effects of Ca2+ sensitizers on contraction, [Ca2+]i transient and myofilament Ca2+ sensitivity in diabetic rat myocardium: Potential usefullness as inotropic agents. J. Pharmacol. Exp. Ther. 298(2) 613-622, 2001.
  98. Tran Q-K, Watanabe H, Le H-Y, Takeuchi K, Hattori Y, Tomioka H, Ohashi K, Hayashi H: Insulin inhibits coronary endothelial calcium entry and coronary relaxation. J. Cardiovasc. Pharmacol. 38(6) 885-892, 2001.
  99. Sakuma I, Liu M-Y, Sato A, Hayashi T, Iguchi A, Kitabatake A, Hattori Y: Endothelium-dependent hyperpolarization and relaxation in mesenteric arteries of middle-aged rats: influence of oestrogen. Br. J. Pharmacol. 135(1) 48-54, 2002.
  100. Sakuma I, Akaishi Y, Tomioka H, Sato A, Kitabatake A, Hattori Y: Interactions of sildenafil with various vasodilators in isolated porcine coronary artery. Eur. J. Pharmacol. 437(3) 155-163, 2002.
  101. Jesmin S, Sakuma I, Hattori Y, Fujii S, Kitabatake A: Long-acting calcium channel blocker benidipine suppresses expression of angiogenic growth factors and prevents cardiac remodeling in a Type II diabetic rat model. Diabetologia 45(3) 402-415, 2002.
  102. Liu M-Y, Fukao M, Hattori Y: Effects of different tetra-n-alkylammonium ions on acetylcholine-induced endothelium-dependent hyperpolarization in rat mesenteric artery. J. Cardiovasc. Pharmacol. 39(5) 660-667, 2002.
  103. Jesmin S, Hattori Y, Sakuma I, Mowa CN, Kitabatake A: Role of ANG II in coronary capillary angiogenesis at the insulin-resistant stage of a NIDDM rat model. Am. J. Physiol. (Heart Circ. Physiol.) 283(4) H1387-H1397, 2002.
  104. Jesmin S, Sakuma I, Hattori Y, Kitabatake A: In vivo estrogen manipulations on coronary capillary network and angiogenic molecule expression in middle-aged female rats. Arterioscler. Thromb. Vasc. Biol. 22(11) 1591-1597, 2002.
  105. Jesmin S, Mowa CN, Matsuda N, Salah-eldin A, Togashi H, Sakuma I, Hattori Y, Kitabatake A: Evidence for a potential role of estrogen in the penis: Detection of estrogen receptor-α and -β messenger ribonucleic acid and protein. Endocrinology 143(12) 4764-4774, 2002.
  106. Liu M-Y, Hattori Y, Sato A, Ichikawa R, Zhang X-H, Sakuma I: Ovariectomy attenuates hyperpolarization and relaxation mediated by endothelium-derived hyperpolarizing factor in female rat mesenteric artery: a concomitant decrease in connexin-43 expression. J. Cardiovasc. Pharmacol. 40(6) 938-948, 2002.
  107. Matsuda N, Hattori Y, Sakuraya F, Kobayashi M, Zhang X-H, Kemmotsu O, Gando S: Hemodynamic significance of histamine synthesis and histamine H1- and H2-receptor gene expression during endotoxemia. Naunyn-Schmiedeberg’s Arch. Pharmacol. 366(6) 513-521, 2002.
  108. Makino T, Hattori Y, Matsuda N, Onozuka H, Sakuma I, Kitabatake A: Effects of angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade on beta-adrenoceptor signaling in heart failure produced by myocardial infarction in rabbits: Reversal of altered expression of beta-adrenoceptor kinase and Gialpha. J. Pharmacol. Exp. Ther. 304(1) 370-379, 2003.
  109. Jesmin S, Hattori Y, Sakuma I, Liu M-Y, Mowa CN, Kitabatake A: Estrogen deprivation and replacement modulate cerebral capillary density with vascular expression of angiogenic molecules in middle-aged female rats. J. Cereb. Blood Flow Metab. 23(2) 181-189, 2003.
  110. Zhang X-H, Matsuda N, Jesmin S, Sakuraya F, Gando S, Kemmotsu O, Hattori Y: Normalization by edaravone, a free radical scavenger, of irradiation-reduced endothelial nitric oxide synthase expression. Eur. J. Pharmacol. 476(1/2) 131-137 2003.
  111. Matsuda N, Hattori Y, Zhang X-H, Fukui H, Kemmotsu O, Gando S: Contractions to histamine in pulmonary and mesenteric arteries from endotoxemic rabbits: Modulation by vascular expression of inducible nitric-oxide synthase and histamine H1-receptors. J. Pharmacol. Exp. Ther. 307(1) 175-181, 2003.
  112. Kobayashi S, Endou M, Sakuraya F, Matsuda N, Zhang X-H, Azuma M, Echigo N, Kemmotsu O, Hattori Y, Gando S: The Sympathomimetic actions of l-ephedrine and d-pseudoephedrine: Direct receptor activation or norepinephrine release? Anesth. Analg. 97(5) 1239-1245, 2003.
  113. Jesmin S, Sakuma I, Hattori Y, Kitabatake A: Role of angiotensin II in altered expression of molecules responsible for coronary matrix remodeling in insulin-resistant diabetic rats. Arterioscler. Thromb. Vasc. Biol. 23(11) 2021-2026, 2003.
  114. Jesmin S, Sakuma I, Salah-eldin A, Nonomura K, Hattori Y, Kitabatake A: Diminished penile expression of vascular endothelial growth factor and its receptors at the insulin-resistant stage of a Type II diabetic rat model: a possible cause for erectile dysfunction in diabetes. J. Mol. Endocrinol. 31(3) 401-418, 2003. 115.
  115. Watanuki S, Matsuda N, Sakuraya F, Jesmin S, Hattori Y: Protein kinase C modulation of sarcoplasmic reticular function by protein kinase A-mediated phospholamban phosphorylation in diabetic rats. Br. J. Pharmacol. 141(2) 347-359, 2004.
  116. Jesmin S, Sakuma I, Hattori Y, Kitabatake A: Regulatory molecules for coronary expressions of VEGF and its angiogenic receptor KDR in hypoestrogenic middle-aged female rats. Mol. Cell. Biochem. 259(1-2) 189-196, 2004.
  117. Matsuda N, Jesmin S, Takahashi Y, Hatta E, Kobayashi Y, Matsuyama K, Kawakami N, Sakuma I, Gando S, Fukui H, Hattori Y, Levi R: Histamine H1 and H2 receptor gene and protein levels are differentially expressed in the hearts of rodents and humans. J. Pharmacol. Exp. Ther. 309(2) 786-795, 2004.
  118. Jesmin S, Mowa CN, Sakuma I, Matsuda N, Togashi H, Yoshioka M, Hattori Y, Kitabatake A: Aromatase is abundantly expressed by neonatal rat penis but downregulated in adulthood. J. Mol. Endocrinol. 33(2) 343-359, 2004.
  119. Jesmin S, Gando S, Matsuda N, Sakuma I, Kobayashi S, Sakuraya F, Hattori Y: Temporal changes in pulmonary expression of key precoagulant molecules in rabbits with endotoxin-induced acute lung injury: elevated expression levels of protease-activated receptors. Thromb. Haemost. 92(5) 966-979, 2004.
  120. Matsuda N, Hattori Y, Takahashi Y, Nishihira J, Jesmin S, Kobayashi M, Gando S: Therapeutic effect of in vivo transfection of transcription decoy to NF-κB on septic lung in mice. Am. J. Physiol. Lung Cell. Mol. Physiol. 287(6) L1248-L1255, 2004.
  121. Jesmin S, Sakuma I, Togashi H, Yamaguchi T, Ueno K, Yoshioka M, Hattori Y, Kitabatake A, Miyauchi T: Altered expression of endothelin and its receptors in the brain of SHR-SP at malignant hypertensive stage. J. Cardiovasc. Pharmacol. 44(Suppl. 1) S11-S15, 2004.
  122. Jesmin S, Sakuma I, Hattori Y, Kitabatake A, Miyauchi T: The calcium channel antagonist benidipine reduces plasma and cardiac endothelin-1 levels in Type II diabetic rat model. J. Cardiovasc. Pharmacol. 44(Suppl. 1) S49-S53, 2004.
  123. Jesmin S, Sakuma I, Togashi H, Yoshioka M, Hattori Y, Kitabatake A, Miyauchi T: Effects of endothelin receptor antagonist on expression of AT1 and AT2 receptors in the heart of SHR-SP. J. Cardiovasc. Pharmacol. 44(Suppl. 1) S59-S63, 2004.
  124. Jesmin S, Sakuma I, Togashi H, Yoshioka M, Hattori Y, Kitabatake A, Miyauchi T: Expression of endothelin receptors in the brain of SHR-SP and effects of an endothelin blocker. J. Cardiovasc. Pharmacol. 44(Suppl 1) S156-S159, 2004.
  125. Jesmin S, Sakuma I, Togashi H, Yoshioka M, Hattori Y, Kitabatake A, Miyauchi T: Brain expression of VEGF and its receptors in SHR-SP and effects of an endothelin blocker. J. Cardiovasc. Pharmacol. 44(Suppl. 1) S160-S164, 2004.
  126. Mowa CN, Jesmin S, Sakuma I, Usip S, Togashi H, Yoshioka M, Hattori Y, Papka R: Characterization of vascular endothelial growth factor (VEGF) in the uterine cervix over pregnancy: effects of denervation and implications for cervical ripening. J Histochem. Cytochem. 52(12) 1665-1674, 2004.
  127. Jesmin S, Hattori Y, Togashi H, Ueno K, Yoshioka M, Sakuma I: Age-related changes in cardiac expression of VEGF and its angiogenic receptor KDR in stroke-prone spontaneously hypertensive rats. Mol. Cell. Biochem. 272(1-2) 63-73, 2005.
  128. Matsuda N, Hattori Y, Jesmin S, Gando S: Nuclear factor-κB decoy oligodeoxynucleotides prevent acute lung injury in mice with cecal ligation and puncture-induced sepsis. Mol. Pharmacol. 67(4) 1018-1025, 2005.
  129. Zhao W, Darmanin S, Fu Q, Chen J, Cui H, Wang J, Okada F, Hamada J, Hattori Y, Kondo T, Hamuro J, Asaka M, Kobayashi M: Hypoxia suppresses the production of matrix metalloproteinases and the migration of human monocyte-derived dendric cells. Eur. J. Immunol. 35(12) 3468-3477, 2005.
  130. Jesmin S, Hattori Y, Maeda S, Zaedi S, Sakuma I, Miyauchi T: Subdepressor dose of benidipine ameliorates diabetic cardiac remodeling accompanied by normalization of upregulated endothelin system in rats. Am. J. Physiol. Heart Circ. Physiol. 290(5) H2146-H2154, 2006.
  131. Matsuda N, Nishihira J, Takahashi Y, Kemmotsu O, Hattori Y: Role of macrophage migration inhibitory factor in acute lung injury in mice with acute pancreatitis complicated by endotoxemia. Am. J. Resp. Cell Mol. Biol. 35(2) 198-205, 2006.
  132. Matsuda N, Hayashi T, Takahashi Y, Hattori Y: Phosphorylation of endothelial nitric-oxide synthase is diminished in mesenteric arteries from septic rabbits depending on the altered phosphatidylinositol 3-kinase/Akt pathway: Reversal effect of fluvastatin therapy. J Pharmacol Exp Ther 319, 1348-1354, 2006.
  133. Hayashi T, Matsui-Hirai H, Miyazaki-Akita A, Fukatsu A, Funami J, Ding Q-F, Kamalanathan S, Hattori Y, Ignarro LJ, Iguchi A: Endothelial cellular senescence is inhibited by nitric oxide: Implications in atheroscleorosis associated with menopause and diabetes. Proc Natl Acad Soc USA 103, 17018-17023, 2006.
  134. Miyazaki-Akita A, Hayashi T, Ding QF, Shiraishi H, Nomura T, Hattori Y, Iguchi A: 17β-Estradiol antagonizes the down-regulation of endothelial nitric-oxide synthase and GTP cyclohydrolase I by high glucose: Relevance to postmenopausal diabetic cardiovascular disease. J Pharmacol Exp Ther, 320 (2), 591-598, 2007.
  135. Jesmin S, Zaedi S, Shimojo N, Iemitsu M, Masuzawa K, Yamaguchi N, Mowa CN, Hattori Y, Miyauchi T: Endothelin antagonism normalizes VEGF signaling and cardiac function in STZ-induced diabetic rat hearts. Am J Physiol Endocrinol Metab, 292 (4), 1030-1040, 2007.
  136. Shimojo N, Jesmin S, Zaedi S, Otsuki, T, Maeda S, Yamaguchi N, Aonuma K, Hattori Y, Miyauchi T: Contributory role of VEGF overexpression in endothelin-1-induced cardiomyocyte hypertrophy. Am J Physiol Heart Circ Physiol, 293 (1), H474-H481, 2007.
  137. Fukatsu A, Hayashi T, Miyazaki-Akita A, Matsui-Hirai H, Furutate Y, Ishitsuka A, Hattori Y, Iguchi A: Possible usefulness of apocynin, an NADPH oxidase inhibitor, for nitrate tolerance: prevention of NO donor-induced endothelial cell abnormalities. Am J Physiol Heart Circ Physiol, 293 (1), H790-H797, 2007.
  138. Ohi Y, Ishii Y, Haji A, Noguchi S, Sasaoka T, Fujimori T, Nabeshima T, Sasahara M, and Hattori Y: Platelet-derived growyh factor (PDGF)-BB inhibits AMPA receptor-mediated synaptic transmission via PDGF receptor-β in murine nucleus tractus solitarius. Brain Res, 1159, 77-85, 2007.
  139. Matsuda N, Takano Y, Kageyama S, Hatakeyama N, Shakunaga K, Kitajima I, Yamazaki M, and Hattori Y: Silencing of caspase-8 and caspase-3 by RNA interference prevents vascular endothelial cell injury in mice with endotoxic shock. Cardiovasc Res, 76 (1), 132-140, 2007.
  140. Matsuda N, Yamazaki H, Takano K, Matsui K, Takano Y, Kenmotsu O, Hattori Y: Priming by lipopolysaccharide exaggerates acute lung injury and mortality in responses to peptidoglycan through up-regulation of Toll-like receptor-2 expression in mice. Biochem Pharmacol, 75(5), 1065-1075, 2008.
  141. Kamiyama K, Matsuda N, Yamamoto S, Takano K, Takano Y, Yamazaki H, Kageyama S, Yokoo H, Nagata T, Hatakeyama N, Tsukada K, Hattori Y: Modulation of glucocorticoid receptor expression, inflammation, and cell apoptosis in septic guinea-pig lungs using methylprednisolone. Am J Physiol Lung Cell Mol Physiol 295: L998-L1006, 2008.
  142. Matsuda N, Yamamoto S, Takano KI, Kageyama SI, Kurobe Y, Yoshiwara Y, Takano Y, Hattori Y: Silencing of Fas-associated Death Domain Protects Mice from Septic Lung Inflammation and Apoptosis. Am J Respir Crit Care Med, 179: 806-815, 2009.
  143. Hatakeyama N, Sakuraya F, Matsuda N, Kimura J, Kinoshita H, Kemmotsu O, Yamazaki M, Hattori Y: Pharmacological Significance of the Blocking Action of the Intravenous General Anesthetic Propofol on the Slow Component of Cardiac Delayed Rectifier K+ Current. J Pharmacol Sci, Vol. 110 (3), 334-343, 2009.
  144. Matsuda N, Yamamoto S, Yokoo H, Tobe K, Hattori Y: Nuclear factor-kappaB decoy oligodeoxynucleotides ameliorate impaired glucose tolerance and insulin resistance in mice with cecal ligation and puncture-induced sepsis. Crit Care Med 37 (10), 2791-2799, 2009.
  145. Naoyuki Matsuda, Hiroki Teramae, Seiji Yamamoto, Ken-ichi Takano, Yasuo Takano, and Yuichi Hattori: Increased death receptor pathway of apoptotic signaling in septic mouse aorta: effect of systemic delivery of FADD siRNA. Am J Physiol Heart Circ Physiol, 298 (1): H92-H101, 2010.
  146. Xiao-Hong Zhang, Hiroki Yokoo, Hiroshi Nishioka, Hajime Fujii, Naoyuki Matsuda, Toshio Hayashi and Yuichi Hattori: Beneficial effect of the oligomerized polyphenol oligonol on high glucose-induced changes in eNOS phosphorylation and dephosphorylation in endothelial cells. Br J Pharmacol, 159: 928–938, 2010.
  147. Naoyuki Matsuda, Hiroki Teramae, Motonori Futatsugi, Ken-ichi Takano, Seiji Yamamoto, Kengo Tomita, Takao Suzuki, Hiroki Yokoo, Kaoru Koike, and Yuichi Hattori: Up-Regulation of Histamine H4 Receptors Contributes to Splenic Apoptosis in Septic Mice: Counteraction of the Antiapoptotic Action of Nuclear Factor-kappa B. J Pharmacol Exp Ther, 332:730–737, 2010.
  148. Jesmin S, Mowa CN, Sultana SN, Shimojo N, Togashi H, Iwashima Y, Kato N, Sato A, Sakuma I, Hiroe M, Hattori Y, Yamaguchi N, Kobayashi H: VEGF signaling is disrupted in the hearts of mice lacking estrogen receptor alpha. Eur J Pharmacol 641 (2-3), 168-178,2010.
  149. Takano KI, Yamamoto S, Tomita K, Takashina M, Yokoo H, Matsuda N, Takano Y, Hattori Y: Successful Treatment of Acute Lung Injury with Pitavastatin in Septic Mice: Potential Role of Glucocorticoid Receptor Expression in Alveolar Macrophages. J Pharmacol Exp Ther 336(2), 381-90, 2011.
  150. Matsui-Hirai H, Hayashi T, Yamamoto S, Ina K, Maeda M, Kotani H, Iguchi A, Ignarro LJ, Hattori Y: Dose-Dependent Modulatory Effects of Insulin on Glucose-Induced Endothelial Senescence In Vitro and In Vivo: A Relationship between Telomeres and Nitric Oxide. J Pharmacol Exp Ther 337(3), 591-9, 2011.
  151. Kageyama S, Yokoo H, Tomita K, Kageyama-Yahara N, Uchimido R, Matsuda N, Yamamoto S, Hattori Y: High glucose-induced apoptosis in human coronary artery endothelial cells involves up-regulation of death receptors. Cardiovasc Diabetol, 10, 73, 2011.
  152. Ikutani M, Yanagibashi T, Ogasawara M, Tsuneyama K, Yamamoto S, Hattori Y, Kouro T, Itakura A, Nagai Y, Takaki S, Takatsu K: Identification of innate IL-5-producing cells and their role in lung eosinophil regulation and antitumor immunity. J Immunol 188 (2), 703-713, 2012.
  153. Shen J, Ishii Y, Xu G, Dang TC, Hamashima T, Matsushima T, Yamamoto S, Hattori Y, Takatsuru Y, Nabekura J, Sasahara M: PDGF-β as a positive regulator of tissue repair in a mouse model of focal cerebral ischemia. J Cereb Blood Flow Metab 32 (2), 353-367, 2012.
  154. Aoki Y, Hatakeyama S, Yamamoto S, Kinoshita H, Matsuda N, Hattori Y, Yamazaki M: Role of ion channels in sepsis-induced atrial tachyarrhythmias in guinea pigs. Br J Pharmacol 166 (1), 390-400, 2012.
  155. Oishi H, Takano K, Tomita K, Takebe M, Yokoo H, Yamazaki M, Hattori Y: Olprinone and colforsin daropate alleviate septic lung inflammation and apoptosis through CREB-independent activation of the Akt pathway. Am J Physiol Lung Cell Mol Physiol 303 (2), L130-L140, 2012.
  156. Yokoo H, Chiba S, Tomita K, Takashina M, Sagara H, Yagishita S, Takano Y, Hattori Y: Neurodegenerative evidence in mice brains with cecal ligation and puncture-induced sepsis: Preventive effect of the free radical scavenger edaravone. PLoS One 7 (12), e51539, 2012.

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