服部裕一

hattori

服部 裕一
Yuichi Hattori, M.D., Ph.D
富山大学大学院医学薬学研究部
分子医科薬理学講座 教授
出身:秋田市生まれ



前に戻る

教授


研究総括・オーガナイザー

学歴および職歴

秋田市生まれ。
北海道大学医学部卒業。
北海道大学大学院医学研究科博士課程修了後, 北海道大学医学部薬理学第二講座(現大学院医学研究科細胞薬理学分野)助手, 講師, 助教授を経て, 平成17年7月より現職。

海外留学渡航歴

昭和57年6月 昭和59年6月 コーネル医科大学薬理学講座 (Roberto Levi教授)

平成3年9月 平成3年11月 コーネル医科大学薬理学講座 (文部省在外研究員として)

賞 & 所 属 学 会

平成5年5月 第4回山下太郎顕彰育英会学術奨励賞

平成21年7月 平成20年度日本平滑筋学会Best Download賞

所 属 学 会

日本薬理学会(評議員),日本脈管学会(評議員),国際心臓研究学会日本部会(評議員),日本心脈管作動物質学会(評議員),日本循環薬理学会(幹事),日本ヒスタミン学会(幹事), 日本臨床薬理学会,日本循環器学会,日本生理学会,日本神経科学会, 米国薬理学会(ASPET)

Editorships

Associate Editor, Journal of Pharmacology and Experimental Therapeutics

Editorial Board, European Journal of Pharmacology

Editorial Board, Circulation Research

業績

著書(英文)

  1. Rifkind AB, Hattori Y, Levi R, Hughes MJ, Quilley C, Alonso DR: The chick embryo as a model for PCB and dioxin toxicity: Evidence of cardiotoxicity and increased prostaglandin synthesis. In: Banbury Report 18, Biological mechanisms of dioxin action. eds. by Poland A, Kimbrough RD. pp.255-266, Cold Spring Harbor Laboratory. 1984.
  2. Levi R, Hattori Y, Burke JA, Guo Z-G, Hachfeld del Balzo U, Scott WA, Rouzer CA: Leukotriene C4 is released from the anaphylactic heart: A case for its direct negative inotropic effect. In: Prostaglandins, leukotrienes, and lipoxins. ed. by Bailey JM. pp.275-288, Plenum Publishing Corporation. 1985.
  3. Fukao M, Hattori Y, Kanno M, Sakuma I, Kitabatake A: Endothelium-dependent hyperpolarizations in arteries from diabetic rats. In: Endothelium-derived hyperpolarizing factor. ed. by Vanhoutte PM. pp.263-270, Harwood Academic Publishers. 1996.
  4. Hattori Y: Cardiac α-adrenoceptor system in diabetes. In: Current aspects of cellular and subcellular mechanisms of drug actions. eds. by Kanno M, Hattori Y. pp.1-12, Hokkaido University Medical Library Series Vol. 40. 2000.
  5. Matsuda N, Hattori Y, Kemmotsu O, Gando S: Pathological significance of over-production of histamine and altered transcriptional regulation of H1- and H2-receptors during septic shock. In: Histamine Research in the New Millennium. eds. by Watanabe T, Timmerman H, Yanai K. pp.173-178, Elsevier. 2001.
  6. Matsuda N, Hattori Y, Gando S: Histamine and sepsis. In: Histamine: Biology and Medical Aspects. eds. by Falus A, Grosman N, Darvas Zs. pp.135-139, SpringMed. 2004.
  7. Hattori Y, Matsuda N: Protection from lethal cell death in cecal ligation and puncture-induced sepsis mouse model by in vivo delivery of FADD siRNA. In:Targets in Gene Therapy. ed. by Yongping You. pp.409-422, InTech-Open Access Publisher 2011.

総説(英文)

  1. Hattori Y, Kanno M: Pharmacology and therapeutic potential of lemildipine, a highly vasculoselective dihydropyridine derivative with slow onset and long duration of action. Cardiovasc. Drug Rev, 14(4) 317-333, 1996.
  2. Hattori Y, Kanno M: Role of α1-adrenoceptor subtypes in production of the positive inotropic effects in mammalian myocardium: Implication for the α1-adrenoceptor subtype distribution. Life Sci, 62(17/18) 1449-1453, 1998.
  3. Hattori Y: Cardiac histamine receptors: Their pharmacological consequences and signal transduction pathways. Methods Find, Exp, Clin, Pharmacol, 21(2) 123-131, 1999.
  4. Matsuda N, Hattori Y: Systemic inflammatory response syndrome (SIRS): Molecular pathophysiology and gene therapy. J Pharmacol Sci, 101(3), 189-198, 2006.
  5. Matsuda N, Hattori Y: Vascular biology in sepsis: pathophysiological and therapeutic significance of vascular dysfunction. J Smooth Muscle Res, 43 (4), 117-137, 2007.
  6. Hayashi T, Yano K, Matsui-Hirai H, Yokoo H, Hattori Y, Iguchi A: Nitric oxide and endothelial cellular senescence. Pharmacol Ther, 120(3) (333-339) 2008.
  7. Hattori Y, Takano KI, Teramae H, Yamamoto S, Yokoo H, Matsuda N: Insights into sepsis therapeutic design based on the apoptotic death pathway. J Pharmacol Sci, 114(4) 354-365 2010.

評論(英文)

  1. Hattori Y, Yamamoto S, and Matsuda N: Sympathetic control of VEGF angiogenic signaling. Dual regulations by α2-adrenoceptor activation? Circ Res, 101 (7), 642-644, 2007.
  2. Tomita K, Takano K, Yokoo H, Hattori Y: Novel insights into beneficial consequences of statins in sepsis: Anti-inflammatory and anti-apoptotic mechanisms. Mol Cell Pharmacol 3 (2), 67-74, 2011.
  3. Taguchi K, Hattori Y: Unlooked-for significance of cardiac versus vascular effects of endothelin-1 in the pathophysiology of pulmonary arterial hypertension. Circ Res 112 (2), 227-229, 2013.

原著(英文)

  1. Nakaya H, Hattori Y, Kanno M: Effects of calcium antagonists and lidocaine on conduction delay induced by acute myocardial ischemia in dogs. Jpn. J. Pharmacol. 30(5) 587-597, 1980.
  2. Hattori Y, Kanno M: Triphasic time course of inotropic effect mediated by α-adrenoceptors in the left atria of guinea pigs. Jpn. J. Pharmacol. 31(4) 543-551, 1981.
  3. Nakaya H, Hattori Y, Sakuma I, Kanno M: Effects of calcium antagonists on coronary circulation and conduction delay induced by myocardial ischemia in dogs: A comparative study with other coronary vasodilators. Eur. J. Pharmacol. 73(4) 273-281, 1981.
  4. Hattori Y, Kanno M: Influence of stimulation interval on inotropism mediated by α-adrenoceptors in the left atria of rabbits. Arch. Int. Pharmacodyn. Ther. 254(1) 119-133, 1981.
  5. Hattori Y, Kanno M: Differential influences of several α-adrenoceptor antagonists on α-adrenoceptor-mediated inotropic responses in the left atria of guinea pigs. Jpn. J. Pharmacol. 32(2) 359-368, 1982.
  6. Hattori Y, Kanno M: Effect of E-643 on α-adrenoceptor-mediated inotropic response to phenylephrine in the left atria of guinea pigs. Jpn. J. Pharmacol. 32(5) 963-965, 1982.
  7. Hattori Y, Kimura S, Fujii S, Kanno M: Effects of histamine on mechanical performance and biochemical and electrical activity in the heart of monkeys (Macaca fuscata). Eur. J. Pharmacol. 91(1) 11-19, 1983.
  8. Levi R, Burke JA, Guo Z-G, Hattori Y, Hoppens CM, McManus LM, Hanahan DJ, Pinckard RN: Acetyl glyceryl ether phosphorylcholine (AGEPC). A putative mediator of cardiac anaphylaxis in the guinea pig. Circ. Res. 54(2) 117-124, 1984.
  9. Kimura S, Hattori Y, Kanno M: Slow responses mediated by α-adrenoceptors in the cardiac muscles of the monkey (Macaca Fuscata). Arch. Int. Pharmacodyn. Ther. 268(1) 46-58, 1984.
  10. Hattori Y, Kanno M: Influences of extracellular calcium ions, verapamil, and calcium antagonistic cations on the positive inotropic effects mediated by α- and β-adrenoceptors in the left atria of rats. Gen. Pharmacol. 15(2) 91-97, 1984.
  11. Hattori Y, Levi R: Negative inotropic effect of leukotrienes: Leukotriene C4 and D4 inhibit calcium-dependent contractile responses in potassium-depolarized guinea-pig myocardium. J. Pharmacol. Exp. Ther. 230(3) 636-651, 1984.
  12. Hattori Y, Levi R: Adenosine selectively attenuates H2- and beta-mediated cardiac responses to histamine and norepinephrine: An unmasking of H1- and alpha-mediated responses. J. Pharmacol. Exp. Ther. 231(2) 215-223, 1984.
  13. Hattori Y, Kanno M: Effect of Ni2+ on the multiphasic positive inotropic responses to histamine mediated by H1-receptors in left atria of guinea pigs. Naunyn-Schmiedeberg’s Arch. Pharmacol. 329(2) 188-194, 1985.
  14. Hattori Y, Hazama S, Kanno M, Nakao Y: Inotropic effects of Ca2+ channel agonist and antagonists in neuraminidase-treated left atria of rats. Br. J. Pharmacol. 87(2) 299-305, 1986.
  15. Hattori Y, Levi R: Effect of PGD2 on cardiac contractility: A negative inotropism secondary to coronary vasoconstriction conceals a primary positive inotropic action. J. Pharmacol. Exp. Ther. 237 (3) 719-724, 1986.
  16. Hattori Y, Nakaya H, Tohse N, Kanno M: Vascular and cardiac effects of a new dihydropyridine derivative, YC-170: A comparison with Bay K 8644. J. Pharmacol. Exp. Ther. 238(2) 670-678, 1986.
  17. Nakaya H, Hattori Y, Tohse N, Kanno M: Voltage-dependent effects of YC-170, a dihydropyridine calcium channel modulator, in cardiovascular tissues. Naunyn-Schmiedeberg’s Arch. Pharmacol. 333(4) 421-430, 1986.
  18. Oyama Y, Kawasaki H, Hattori Y, Kanno M: Attenuation of endothelium-dependent relaxation in aorta from diabetic rats. Eur. J. Pharmacol. 131 (1) 75-78, 1986.
  19. Hattori Y, Azuma M, Gotoh Y, Kanno M: Negative inotropic effects of halothane, enflurane and isoflurane in papillary muscles from diabetic rats. Anesth. Analg. 66(1) 23-28, 1987.
  20. Hazama S, Hattori Y, Kanno M: Influence of N-ethylmaleimide on Na+-Ca2+ exchange across cardiac sarcolemma. Asia Pacific J. Pharmacol. 2(1) 1-6, 1987.
  21. Hattori Y, Sakuma I, Nakao Y, Kanno M: Pharmacological analysis of the cardiac actions of xamoterol, a beta adrenoceptor antagonist with partial agonistic activity, in guinea pig hearts: Evidence for involvement of adenylate cyclase system in its cardiac stimulant actions. J. Pharmacol. Exp. Ther. 242(3) 1077-1085, 1987.
  22. Tohse N, Hattori Y, Nakaya H, Kanno M: Effects of α-adrenoceptor stimulation on electrophysiological properties and mechanics in rat papillary muscle. Gen. Pharmacol. 18(5) 539-546, 1987.
  23. Nakaya H, Hattori Y, Nakao Y, Kanno M: Cardiac versus vascular effects of a new dihydropyridine derivative, CV-4093. In vitro comparison with other calcium antagonists. Eur. J. Pharmacol. 146(1) 35-43, 1988.
  24. Hattori Y, Nakaya H, Endou M, Nakao Y, Kanno M: Pharmacological profile of vasodilating action of carvedilol in isolated canine coronary artery. Drugs 36(Suppl. 6) 62-63, 1988.
  25. Hattori Y, Nakaya H, Tohse N, Kanno M: Effects of Ca2+ channel antagonists and ryanodine on H1-receptor mediated electromechanical response to histamine in guinea-pig left atria. Naunyn-Schmiedeberg’s Arch. Pharmacol. 337(3) 323-330, 1988.
  26. Hattori Y, Sakuma I, Kanno M: Differential effects of histamine mediated by histamine H1- and H2-receptors on contractility, spontaneous rate and cyclic nucleotides in the rabbit heart. Eur. J. Pharmacol. 153(2/3) 221-230, 1988.
  27. Hattori Y, Nakaya H, Endou M, Nakao Y, Kanno M: Vascular effects of carvedilol, a new β-adrenoceptor antagonist with vasodilating properties, in isolated canine coronary artery. J. Cardiovasc. Pharmacol. 13(4) 572-579, 1989.
  28. Hattori Y, Endou M, Shirota M, Kanno M: Dissociation of phosphoinositide hydrolysis and positive inotropic effect of histamine mediated by H1-receptors in guinea-pig left atria. Naunyn-Schmiedeberg’s Arch. Pharmacol. 340(2) 196-203, 1989.
  29. Endou M, Hattori Y, Nakaya H, Kanno M: Differential effects of somatostatin on atrial and ventricular contractile responses in guinea pig heart: Influence of pretreatment with islet-activating protein. J. Pharmacol. Exp. Ther. 250(2) 726-733, 1989.
  30. Tohse N, Hattori Y, Nakaya H, Endou M, Kanno M: Inability of endothelin to increase Ca2+ current in guinea-pig heart cells. Br. J. Pharmacol. 99(3) 437-438, 1990.
  31. Tohse N, Nakaya H, Hattori Y, Endou M, Kanno M: Inhibitory effect mediated by α1-adrenoceptors on transient outward current in isolated rat ventricular cells. Pflugers Arch. 415(5) 575-581, 1990.
  32. Hattori Y, Nakaya H, Endou M, Kanno M: Inotropic, electrophysiological and biochemical responses to histamine in rabbit papillary muscles: Evidence for coexistence of H1- and H2-receptors. J. Pharmacol. Exp. Ther. 253(1) 250-256, 1990.
  33. Nakaya H, Hattori Y, Tohse N, Shida S, Kanno M: β-adrenoceptor-mediated depolarization of the resting membrane in guinea-pig papillary muscles: changes in intracellular Na+, K+ and Cl- activities. Pflugers Arch. 417(2) 185-193, 1990.
  34. Endou M, Hattori Y, Tohse N, Kanno M: Protein kinase C is not involved in α1-adrenoceptor-mediated positive inotropic effect. Am. J. Physiol. (Heart Circ. Physiol.) 260(1) H27-H36, 1991.
  35. Hattori Y, Gando S, Endou M, Kanno M: Characterization of histamine receptors modulating inotropic and biochemical activities in rabbit left atria. Eur. J. Pharmacol. 196(1) 29-36, 1991.
  36. Hattori Y, Endou M, Gando S, Kanno M: Identification and characterization of histamine H1- and H2-receptors in guinea-pig left atrial membranes by [3H]-mepyramine and [3H]-tiotidine binding. Br. J. Pharmacol. 103(2) 1573-1579, 1991.
  37. Endou M, Gando S, Hattori Y, Kanno M: Binding profiles of class I antiarrhythmic agents to cardiac muscarinic receptors: Competitive and allosteric interactions with the receptors and their pharmacological significance. J. Pharmacol. Exp. Ther. 258(3) 992-998, 1991.
  38. Hattori Y, Kawasaki H, Abe K, Kanno M: Superoxide dismutase recovers altered endothelium-dependent relaxation in diabetic rat aorta. Am. J. Physiol. (Heart Circ. Physiol.) 261(4) H1086-H1094, 1991.
  39. Hattori Y, Nakaya H, Endou M, Kanno M: Pharmacological analysis of the positive inotropic effect of endothelin-1 in guinea pig left atria. J. Cardiovasc. Pharmacol. 17(Suppl. 7) S194-S196, 1991.
  40. Hattori Y, Azuma M, Kemmotsu O, Kanno M: Differential sensitivity of diabetic rat papillary muscles to negative inotropic effects of oxybarbiturates versus thiobarbiturates. Anesth. Analg. 74(1) 97-104, 1992.
  41. Endou M, Hattori Y, Nakaya H, Gotoh Y, Kanno M: Electrophysiologic mechanisms responsible for inotropic response to ketamine in guinea pig and rat myocardium. Anesthesiology 76(3) 409-418, 1992.
  42. Hattori Y, Nagashima M, Endo Y, Kanno M: Glibenclamide does not block arterial relaxation caused by vasoactive intestinal polypeptide. Eur. J. Pharmacol. 213(1) 147-150, 1992.
  43. Endou M, Hattori Y, Gando S, Kanno M: Selectivity of class I antiarrhythmic agents, disopyramide, pirmenol and pentisomide for the peripheral muscarinic M2 and M3 receptors. J. Cardiovasc. Pharmacol. 19(5) 674-681, 1992.
  44. Hattori Y, Endou M, Kanno M: Inhibition by 5-hydroxytryptamine of the beta adrenoceptor-mediated positive inotropic responses to catecholamines in rabbit papillary muscles: Direct interaction with beta adrenoceptors. J. Pharmacol. Exp. Ther. 261(3) 1160-1166, 1992.
  45. Nakaya H, Hattori Y, Endou M, Gando S, Kanno M: Electrophysiologic and anticholinergic effects of pirmenol enantiomers in guinea-pig myocardium. Naunyn-Schmiedeberg’s Arch. Pharmacol. 346(5) 555-562, 1992.
  46. Hattori Y, Takeda Y, Nakaya H, Kanno M: Induction by endogenous noradrenaline of an α1-adrenoceptor-mediated positive inotropic effect in rabbit papillary muscles. Br. J. Pharmacol. 109(4) 1232-1238, 1993.
  47. Gando S, Hattori Y, Kanno M: Altered cardiac adrenergic neurotransmission in streptozotocin-induced diabetic rats. Br. J. Pharmacol. 109(4) 1276-1281, 1993.
  48. Hattori Y, Nakaya H, Nishihira J, Kanno M: A dual-component positive inotropic effect of endothelin-1 in guinea pig left atria: A role of protein kinase C. J. Pharmacol. Exp. Ther. 266(3) 1202-1212, 1993.
  49. Hattori Y, Kawasaki H, Kanno M, Gando S, Fukao M: Attenuated contractile response of diabetic rat aorta to caffeine but not to noradrenaline in Ca2+-free medium. Eur. J. Pharmacol. 256(2) 215-219, 1994.
  50. Takeda Y, Hattori Y, Nakaya H, Kanno M: Enhancement of the positive inotropic effect mediated by α1-adrenoceptors in pertussis toxin-treated rabbit papillary muscles. Gen. Pharmacol. 25(4) 773-779, 1994.
  51. Hattori Y, Gando S, Nagashima M, Kanno M: Histamine receptors mediating a positive inotropic effect in guinea pig and rabbit ventricular myocardium: Distribution of the receptors and their possible intracellular coupling process. Jpn. J. Pharmacol. 65(4) 327-336, 1994.
  52. Akaishi Y, Hattori Y, Kanno M, Sakuma I, Kitabatake A: Pertussis toxin pretreatment alters agonist binding to β-adrenoceptors in rabbit ventricular myocardium. Res. Commun. Mol. Path. Pharmacol. 85(2) 171-179, 1994.
  53. Hattori Y, Imamura M, Akaishi Y, Kanno M: Inotropic changes induced by fluoroaluminates in rabbit left atrial muscles: possible involvement of G proteins. Br. J. Pharmacol. 114(1) 224-230, 1995.
  54. Gando S, Nishihira J, Hattori Y, Kanno M: Endothelin-1 does not phosphorylate phospholamban and troponin I in intact beating rat hearts. Eur. J. Pharmacol. (Mol. Pharmacol. Sect.) 289(2) 175-180, 1995.
  55. Hattori Y, Kawasaki H, Fukao M, Kanno M: Phorbol esters elicit Ca2+-dependent contractions in diabetic rat aorta. Eur. J. Pharmacol. 279(1) 51-58, 1995.
  56. Fukao M, Hattori Y, Kanno M, Sakuma I, Kitabatake A: Thapsigargin- and cyclopiazonic acid-induced endothelium-dependent hyperpolarization in rat mesenteric artery. Br. J. Pharmacol. 115(6) 987-992, 1995.
  57. Fukao M, Hattori Y, Kanno M, Sakuma I, Kitabatake A: Evidence for selective inhibition by lysophosphatidylcholine of acetylcholine-induced endothelium-dependent hyperpolarization and relaxation in rat mesenteric artery. Br. J. Pharmacol. 116(1) 1541-1544, 1995.
  58. Tohse N, Hattori Y, Ishigai Y, Kanno M: Electrophysiological effects of histamine H1-receptor stimulation on guinea-pig atrial cells. Heart Vessels (Suppl. 9) 71-73, 1995.
  59. Hattori M, Kawasaki H, Kanno M, Fukao M: Enhanced 5-HT2 receptor mediated contractions in diabetic rat aorta: Participation of Ca2+ channels associated with protein kinase C activity. J. Vasc. Res. 32(4) 220-229, 1995.
  60. Hattori Y, Fukao M, Houzen H, Qi F, Yamada Y, Kanno M: In vitro assessment of vascular selectivity of a new dihydropyridine derivative, NB-818. Eur. J. Pharmacol. 301(1-3) 99-106, 1996.
  61. Hattori Y, Nagashima M, Akaishi Y, Kanno M: α1-adrenoceptor subtype distribution and the coupling to phosphoinositide hydrolysis in rat and rabbit ventricular myocardium. Res. Commun. Mol. Path. Pharmacol. 93(3) 319-328, 1996.
  62. Fukao M, Hattori Y, Kanno M, Sakuma I, Kitabatake A: Structural diffeences in the ability of phospholipids to inhibit endothelium-dependent hyperpolarization by acetylcholine in rat mesenteric artery. Biochem. Biophys. Res. Commun. 227(2) 479-483, 1996.
  63. Nagashima M, Hattori Y, Akaishi Y, Tohse N, Sakuma I, Kitabatake A, Kanno M: α1-adrenoceptor subtypes mediating inotropic and electrophysiological effects in mammalian myocardium. Am. J. Physiol. (Heart Circ. Physiol.) 271(4) H1423-H1432, 1996.
  64. Hattori Y, Kawasaki H, Fukao M, Gando S, Akaishi Y, Kanno M: Diminishment of contractions associated with depolarization-evoked activation of Ca2+ channels in diabetic rat aorta. J. Vasc. Res. 33(6) 454-462, 1996.
  65. Fukao M, Hattori Y, Kanno M, Sakuma I, Kitabatake A: Evidence against a role of cytochrome P450-derived arachidonic acid metabolites in endothelium-dependent hyperpolarization by acetylcholine in rat isolated mesenteric artery. Br. J. Pharmacol. 120(3) 439-446, 1997.
  66. Akaishi Y, Hattori Y, Kanno M, Sakuma I, Kitabatake A: Agonist-independent tonic inhibitory influence of Gi on adenylate cyclase activity in rabbit ventricular myocardium and its removal by pertussis toxin: a role of empty receptor-mediated Gi activation. J. Mol. Cell. Cardiol. 29(2) 765-775, 1997.
  67. Fukao M, Hattori Y, Kanno M, Sakuma I, Kitabatake A: Sources of Ca2+ in relation to generation of acetylcholine-induced hyperpolarization in rat mesenteric artery. Br. J. Pharmacol. 120(7) 1328-1334, 1997.
  68. Nagashima M, Hattori Y, Tohse N, Kanno M: α1-Adrenoceptor subtype involved in the positive and negative inotropic responses to phenylephrine in rat papillary muscle. Gen. Pharmacol. 28(5) 721-725, 1997.
  69. Tomita F, Hattori Y, Kanno M, Kohya T, Sasaki M, Kitabatake A: Different regulation of myofilament Ca2+ sensitivity in β-escin-skinned cardiac and vascular smooth muscle. Eur. J. Pharmacol. 326(2/3) 157-162, 1997.
  70. Hattori Y, Kanno M: Involvement of α1B-adrenoceptors in the positive inotropic effect of endogenous noradrenaline in rabbit myocardium. Eur. J. Pharmacol. 329(2/3) 165-168, 1997.
  71. Fukao M, Hattori Y, Kanno M, Sakuma I, Kitabatake A: Alterations in endothelium-dependent hyperpolarization and relaxation in mesenteric arteries from streptozotocin-induced diabetic rats. Br. J. Pharmacol. 121(7) 1383-1391, 1997.
  72. Gando S, Hattori Y, Akaishi Y, Nishihira J, Kanno M: Impaired contractile response to beta adrenoceptor stimulation in diabetic rat hearts: Alterations in beta adrenoceptors-G protein-adenylate cyclase system and phospholamban phosphorylation. J. Pharmacol. Exp. Ther. 282(1) 475-484, 1997.
  73. Qi F, Sugihara T, Hattori Y, Yamamoto Y, Kanno M, Abe K: Functional and morphological damage of endothelium in rabbit ear artery following irradiation with cobalt60. Br. J. Pharmacol. 123(4) 653-660, 1998.
  74. Houzen H, Hattori Y, Kanno M, Kikuchi S, Tashiro K, Motomura M, Nakao Y, Nakamura T: Functional evaluation of inhibition of autonomic transmitter release by autoantibody from Lambert-Eaton myasthenic syndrome. Ann. Neurol. 43(5) 677-680, 1998.
  75. Tamada A, Hattori Y, Houzen H, Yamada Y, Sakuma I, Kitabatake A, Kanno M: Effects of β-adrenoceptor stimulation on contractility, [Ca2+]i, and Ca2+ current in diabetic rat cardiomyocytes. Am. J. Physiol. (Heart Circ. Physiol.) 274(6) H1849-H1857, 1998.
  76. Sato A, Hattori Y, Fukao M, Kanno M, Sakuma I, Kitabatake A: A role of myofilament Ca2+ sensitivity in enhanced vascular reactivity in cardiomyopathic hamsters. Eur. J. Pharmacol. 353(2/3) 247-256, 1998.
  77. Yoshimoto K, Hattori Y, Houzen H, Kanno M, Yasuda K: Histamine H1-receptor-mediated increase in the Ca2+ transient without a change in the Ca2+ current in electrically stimulated guinea-pig atrial myocytes. Br. J. Pharmacol. 124(8) 1744-1750, 1998.
  78. Sasaki M, Hattori Y, Tomita F, Moriishi K, Kanno M, Kohya T, Oguma K, Kitabatake A: Tyrosine phosphorylation as a convergent pathway of heterotrimeric G protein- and rho protein-mediated Ca2+ sensitivity of smooth muscle of rabbit mesenteric artery. Br. J. Pharmacol. 125(8) 1651-1660, 1998.
  79. Okada H, Fujii S, Sobel BE, Gao M, Koyama T, Hattori Y, Zaman AT, Sakuma I, Kitabatake A: Insulin and proinsulin regulate type-1 plasminogen activator inhibitor and type-1 collagen expression in rat cardiac microvascular endothelial cells: Potential role in development of coronary microvasculopathy. Pathogenesis 1(3) 179-188, 1999.
  80. Fukao M, Hattori Y, Sato A, Liu M-Y, Watanabe H, Kim TQ, Kanno M: Relationship between NaF- and thapsigargin-induced endothelium-dependent hyperpolarization in rat mesenteric artery. Br. J. Pharmacol. 126(7) 1567-1574, 1999.
  81. Sato A, Hattori Y, Watanabe M, Okamoto H, Tomioka H, Fukao M, Sakuma I, Kitabatake A, Kanno M: Effect of prolonged treatment with amlodipine on enhanced vascular contractility in cardiomyopathic hamsters. J. Cardiovasc. Pharmacol. 34(1) 124-131, 1999.
  82. Sugihara T, Hattori Y, Yamamoto Y, Qi F, Ichikawa R, Sato A, Liu M-Y, Abe K, Kanno M: Preferential impairment of nitric oxide-mediated endothelium-dependent relaxation in human cervical arteries after irradiation. Circulation 100(6) 635-641, 1999.
  83. Matsuda N, Hattori Y, Gando S, Akaishi Y, Kemmotsu O, Kanno M: Diabetes-induced down-regulation of β1-adrenoceptor mRNA expression in rat heart. Biochem. Pharmacol. 58(5) 881-885, 1999.
  84. Tomioka H, Hattori Y, Fukao M, Sato A, Liu M-Y, Sakuma I, Kitabatake A, Kanno M: Relaxation in different-sized rat blood vessels mediated by endothelium-derived hyperpolarizing factor: Importance of processes mediating precontractions. J. Vasc. Res. 36(4) 311-320, 1999.
  85. Hattori Y, Ishitani T, Tomita F, Gando S, Yokoshiki H, Azuma M, Kemmotsu O, Kanno M: Cardiac profile of EGIS-9377, a novel cardiotonic agent as a Ca2+ sensitizer with bradycardiac activity. Naunyn-Schmiedeberg’s Arch. Pharmacol. 360(5) 585-590, 1999.
  86. Hattori Y, Kawasaki H, Kanno M: Increased contractile responses to endothelin-1 and U46619 via a protein kinase C-mediated nifedipine-sensitive pathway in diabetic rat aorta. Res. Commun. Mol. Path. Pharmacol. 104(1) 73-80, 1999.
  87. Matsuda N, Hattori Y, Gando S, Watanuki S, Kemmotsu O, Kanno M: Differential gene transcriptional regulation of Gi isoforms and Gs protein expression in diabetic rat hearts. Naunyn-Schmiedeberg’s Arch. Pharmacol. 361(1) 53-60, 2000.
  88. Hattori Y, Matsuda N, Sato A, Watanuki S, Tomioka H, Kawasaki H, Kanno M: Predominant contribution of the G protein-mediated mechanism to NaF-induced vascular contractions in diabetic rats: Association with an increased level of Gqα expression. J. Pharmacol. Exp. Ther. 292(2) 761-768, 2000.
  89. Sato A, Hattori Y, Kanno M: Effects of genistein and daidzein on enhanced vascular reactivity and Ca2+ sensitivity in cardiomyopathic hamsters. Methods Find. Exp. Clin. Pharmacol. 22(1) 25-30, 2000.
  90. Sato A, Hattori Y, Sasaki M, Tomita F, Kohya T, Kitabatake A, Kanno M: Agonist-dependent difference in the mechanisms involved in Ca2+ sensitization of smooth muscle of porcine coronary artery. J. Cardiovasc. Pharmacol. 35(5) 814-821, 2000.
  91. Akaishi Y, Hattori Y, Yoshimoto K, Kitabatake A, Yasuda K, Kanno M: Involvement of tyrosine phosphorylation in the positive inotropic effect produced by H1-receptors with histamine in guinea-pig left atrium. Br. J. Pharmacol. 130(4) 907-915, 2000.
  92. Hattori Y, Matsuda N, Kimura J, Ishitani T, Tamada A, Gando S, Kemmotsu O, Kanno M: Diminished function and expression of the cardiac Na+-Ca2+ exchanger in diabetic rats: implication in Ca2+ overload. J. Physiol. 527(1) 85-94, 2000.
  93. Matsuda N, Hattori Y, Akaishi Y, Suzuki Y, Kemmotsu O, Gando S: Impairment of cardiac β-adrenoceptor cellular signaling by decreased expression of Gsα in septic rabbits. Anesthesiology 93(6) 1465-1473, 2000.
  94. Tomioka H, Hattori Y, Fukao M, Watanabe H, Akaishi Y, Sato A, Kim TQ, Sakuma I, Kitabatake A, Kanno M: Role of endothelial Ni2+-sensitive Ca2+ entry pathway in regulation of EDHF in porcine coronary artery. Am. J. Physiol. (Heart Circ. Physiol.) 280(2) H730-H737, 2001.
  95. Liu M-Y, Hattori Y, Fukao M, Sato A, Sakuma I, Kanno M: Alterations in EDHF-mediated hyperpolarization and relaxation in mesenteric arteries of female rats in long-term deficiency of oestrogen and during oestrus cycle. Br. J. Pharmacol. 132(5) 1035-1046, 2001.
  96. Fukao M, Watanabe H, Takeuchi K, Tomioka H, Hattori Y: Effects of SK&F 96365 and mefenamic acid on Ca2+ influx in stimulated endothelial cells and on endothelium-derived hyperpolarizing factor-mediated arterial hyperpolarization and relaxation. J. Cardiovasc. Pharmacol. 38(1) 130-140, 2001.
  97. Ishitani T, Hattori Y, Sakuraya F, Onozuka H, Makino T, Matsuda N, Gando S, Kemmotsu O: Effects of Ca2+ sensitizers on contraction, [Ca2+]i transient and myofilament Ca2+ sensitivity in diabetic rat myocardium: Potential usefullness as inotropic agents. J. Pharmacol. Exp. Ther. 298(2) 613-622, 2001.
  98. Tran Q-K, Watanabe H, Le H-Y, Takeuchi K, Hattori Y, Tomioka H, Ohashi K, Hayashi H: Insulin inhibits coronary endothelial calcium entry and coronary relaxation. J. Cardiovasc. Pharmacol. 38(6) 885-892, 2001.
  99. Sakuma I, Liu M-Y, Sato A, Hayashi T, Iguchi A, Kitabatake A, Hattori Y: Endothelium-dependent hyperpolarization and relaxation in mesenteric arteries of middle-aged rats: influence of oestrogen. Br. J. Pharmacol. 135(1) 48-54, 2002.
  100. Sakuma I, Akaishi Y, Tomioka H, Sato A, Kitabatake A, Hattori Y: Interactions of sildenafil with various vasodilators in isolated porcine coronary artery. Eur. J. Pharmacol. 437(3) 155-163, 2002.
  101. Jesmin S, Sakuma I, Hattori Y, Fujii S, Kitabatake A: Long-acting calcium channel blocker benidipine suppresses expression of angiogenic growth factors and prevents cardiac remodeling in a Type II diabetic rat model. Diabetologia 45(3) 402-415, 2002.
  102. Liu M-Y, Fukao M, Hattori Y: Effects of different tetra-n-alkylammonium ions on acetylcholine-induced endothelium-dependent hyperpolarization in rat mesenteric artery. J. Cardiovasc. Pharmacol. 39(5) 660-667, 2002.
  103. Jesmin S, Hattori Y, Sakuma I, Mowa CN, Kitabatake A: Role of ANG II in coronary capillary angiogenesis at the insulin-resistant stage of a NIDDM rat model. Am. J. Physiol. (Heart Circ. Physiol.) 283(4) H1387-H1397, 2002.
  104. Jesmin S, Sakuma I, Hattori Y, Kitabatake A: In vivo estrogen manipulations on coronary capillary network and angiogenic molecule expression in middle-aged female rats. Arterioscler. Thromb. Vasc. Biol. 22(11) 1591-1597, 2002.
  105. Jesmin S, Mowa CN, Matsuda N, Salah-eldin A, Togashi H, Sakuma I, Hattori Y, Kitabatake A: Evidence for a potential role of estrogen in the penis: Detection of estrogen receptor-α and -β messenger ribonucleic acid and protein. Endocrinology 143(12) 4764-4774, 2002.
  106. Liu M-Y, Hattori Y, Sato A, Ichikawa R, Zhang X-H, Sakuma I: Ovariectomy attenuates hyperpolarization and relaxation mediated by endothelium-derived hyperpolarizing factor in female rat mesenteric artery: a concomitant decrease in connexin-43 expression. J. Cardiovasc. Pharmacol. 40(6) 938-948, 2002.
  107. Matsuda N, Hattori Y, Sakuraya F, Kobayashi M, Zhang X-H, Kemmotsu O, Gando S: Hemodynamic significance of histamine synthesis and histamine H1- and H2-receptor gene expression during endotoxemia. Naunyn-Schmiedeberg’s Arch. Pharmacol. 366(6) 513-521, 2002.
  108. Makino T, Hattori Y, Matsuda N, Onozuka H, Sakuma I, Kitabatake A: Effects of angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade on beta-adrenoceptor signaling in heart failure produced by myocardial infarction in rabbits: Reversal of altered expression of beta-adrenoceptor kinase and Gialpha. J. Pharmacol. Exp. Ther. 304(1) 370-379, 2003.
  109. Jesmin S, Hattori Y, Sakuma I, Liu M-Y, Mowa CN, Kitabatake A: Estrogen deprivation and replacement modulate cerebral capillary density with vascular expression of angiogenic molecules in middle-aged female rats. J. Cereb. Blood Flow Metab. 23(2) 181-189, 2003.
  110. Zhang X-H, Matsuda N, Jesmin S, Sakuraya F, Gando S, Kemmotsu O, Hattori Y: Normalization by edaravone, a free radical scavenger, of irradiation-reduced endothelial nitric oxide synthase expression. Eur. J. Pharmacol. 476(1/2) 131-137 2003.
  111. Matsuda N, Hattori Y, Zhang X-H, Fukui H, Kemmotsu O, Gando S: Contractions to histamine in pulmonary and mesenteric arteries from endotoxemic rabbits: Modulation by vascular expression of inducible nitric-oxide synthase and histamine H1-receptors. J. Pharmacol. Exp. Ther. 307(1) 175-181, 2003.
  112. Kobayashi S, Endou M, Sakuraya F, Matsuda N, Zhang X-H, Azuma M, Echigo N, Kemmotsu O, Hattori Y, Gando S: The Sympathomimetic actions of l-ephedrine and d-pseudoephedrine: Direct receptor activation or norepinephrine release? Anesth. Analg. 97(5) 1239-1245, 2003.
  113. Jesmin S, Sakuma I, Hattori Y, Kitabatake A: Role of angiotensin II in altered expression of molecules responsible for coronary matrix remodeling in insulin-resistant diabetic rats. Arterioscler. Thromb. Vasc. Biol. 23(11) 2021-2026, 2003.
  114. Jesmin S, Sakuma I, Salah-eldin A, Nonomura K, Hattori Y, Kitabatake A: Diminished penile expression of vascular endothelial growth factor and its receptors at the insulin-resistant stage of a Type II diabetic rat model: a possible cause for erectile dysfunction in diabetes. J. Mol. Endocrinol. 31(3) 401-418, 2003. 115.
  115. Watanuki S, Matsuda N, Sakuraya F, Jesmin S, Hattori Y: Protein kinase C modulation of sarcoplasmic reticular function by protein kinase A-mediated phospholamban phosphorylation in diabetic rats. Br. J. Pharmacol. 141(2) 347-359, 2004.
  116. Jesmin S, Sakuma I, Hattori Y, Kitabatake A: Regulatory molecules for coronary expressions of VEGF and its angiogenic receptor KDR in hypoestrogenic middle-aged female rats. Mol. Cell. Biochem. 259(1-2) 189-196, 2004.
  117. Matsuda N, Jesmin S, Takahashi Y, Hatta E, Kobayashi Y, Matsuyama K, Kawakami N, Sakuma I, Gando S, Fukui H, Hattori Y, Levi R: Histamine H1 and H2 receptor gene and protein levels are differentially expressed in the hearts of rodents and humans. J. Pharmacol. Exp. Ther. 309(2) 786-795, 2004.
  118. Jesmin S, Mowa CN, Sakuma I, Matsuda N, Togashi H, Yoshioka M, Hattori Y, Kitabatake A: Aromatase is abundantly expressed by neonatal rat penis but downregulated in adulthood. J. Mol. Endocrinol. 33(2) 343-359, 2004.
  119. Jesmin S, Gando S, Matsuda N, Sakuma I, Kobayashi S, Sakuraya F, Hattori Y: Temporal changes in pulmonary expression of key precoagulant molecules in rabbits with endotoxin-induced acute lung injury: elevated expression levels of protease-activated receptors. Thromb. Haemost. 92(5) 966-979, 2004.
  120. Matsuda N, Hattori Y, Takahashi Y, Nishihira J, Jesmin S, Kobayashi M, Gando S: Therapeutic effect of in vivo transfection of transcription decoy to NF-κB on septic lung in mice. Am. J. Physiol. Lung Cell. Mol. Physiol. 287(6) L1248-L1255, 2004.
  121. Jesmin S, Sakuma I, Togashi H, Yamaguchi T, Ueno K, Yoshioka M, Hattori Y, Kitabatake A, Miyauchi T: Altered expression of endothelin and its receptors in the brain of SHR-SP at malignant hypertensive stage. J. Cardiovasc. Pharmacol. 44(Suppl. 1) S11-S15, 2004.
  122. Jesmin S, Sakuma I, Hattori Y, Kitabatake A, Miyauchi T: The calcium channel antagonist benidipine reduces plasma and cardiac endothelin-1 levels in Type II diabetic rat model. J. Cardiovasc. Pharmacol. 44(Suppl. 1) S49-S53, 2004.
  123. Jesmin S, Sakuma I, Togashi H, Yoshioka M, Hattori Y, Kitabatake A, Miyauchi T: Effects of endothelin receptor antagonist on expression of AT1 and AT2 receptors in the heart of SHR-SP. J. Cardiovasc. Pharmacol. 44(Suppl. 1) S59-S63, 2004.
  124. Jesmin S, Sakuma I, Togashi H, Yoshioka M, Hattori Y, Kitabatake A, Miyauchi T: Expression of endothelin receptors in the brain of SHR-SP and effects of an endothelin blocker. J. Cardiovasc. Pharmacol. 44(Suppl 1) S156-S159, 2004.
  125. Jesmin S, Sakuma I, Togashi H, Yoshioka M, Hattori Y, Kitabatake A, Miyauchi T: Brain expression of VEGF and its receptors in SHR-SP and effects of an endothelin blocker. J. Cardiovasc. Pharmacol. 44(Suppl. 1) S160-S164, 2004.
  126. Mowa CN, Jesmin S, Sakuma I, Usip S, Togashi H, Yoshioka M, Hattori Y, Papka R: Characterization of vascular endothelial growth factor (VEGF) in the uterine cervix over pregnancy: effects of denervation and implications for cervical ripening. J Histochem. Cytochem. 52(12) 1665-1674, 2004.
  127. Jesmin S, Hattori Y, Togashi H, Ueno K, Yoshioka M, Sakuma I: Age-related changes in cardiac expression of VEGF and its angiogenic receptor KDR in stroke-prone spontaneously hypertensive rats. Mol. Cell. Biochem. 272(1-2) 63-73, 2005.
  128. Matsuda N, Hattori Y, Jesmin S, Gando S: Nuclear factor-κB decoy oligodeoxynucleotides prevent acute lung injury in mice with cecal ligation and puncture-induced sepsis. Mol. Pharmacol. 67(4) 1018-1025, 2005.
  129. Zhao W, Darmanin S, Fu Q, Chen J, Cui H, Wang J, Okada F, Hamada J, Hattori Y, Kondo T, Hamuro J, Asaka M, Kobayashi M: Hypoxia suppresses the production of matrix metalloproteinases and the migration of human monocyte-derived dendric cells. Eur. J. Immunol. 35(12) 3468-3477, 2005.
  130. Jesmin S, Hattori Y, Maeda S, Zaedi S, Sakuma I, Miyauchi T: Subdepressor dose of benidipine ameliorates diabetic cardiac remodeling accompanied by normalization of upregulated endothelin system in rats. Am. J. Physiol. Heart Circ. Physiol. 290(5) H2146-H2154, 2006.
  131. Matsuda N, Nishihira J, Takahashi Y, Kemmotsu O, Hattori Y: Role of macrophage migration inhibitory factor in acute lung injury in mice with acute pancreatitis complicated by endotoxemia. Am. J. Resp. Cell Mol. Biol. 35(2) 198-205, 2006.
  132. Matsuda N, Hayashi T, Takahashi Y, Hattori Y: Phosphorylation of endothelial nitric-oxide synthase is diminished in mesenteric arteries from septic rabbits depending on the altered phosphatidylinositol 3-kinase/Akt pathway: Reversal effect of fluvastatin therapy. J Pharmacol Exp Ther 319, 1348-1354, 2006.
  133. Hayashi T, Matsui-Hirai H, Miyazaki-Akita A, Fukatsu A, Funami J, Ding Q-F, Kamalanathan S, Hattori Y, Ignarro LJ, Iguchi A: Endothelial cellular senescence is inhibited by nitric oxide: Implications in atheroscleorosis associated with menopause and diabetes. Proc Natl Acad Soc USA 103, 17018-17023, 2006.
  134. Miyazaki-Akita A, Hayashi T, Ding QF, Shiraishi H, Nomura T, Hattori Y, Iguchi A: 17β-Estradiol antagonizes the down-regulation of endothelial nitric-oxide synthase and GTP cyclohydrolase I by high glucose: Relevance to postmenopausal diabetic cardiovascular disease. J Pharmacol Exp Ther, 320 (2), 591-598, 2007.
  135. Jesmin S, Zaedi S, Shimojo N, Iemitsu M, Masuzawa K, Yamaguchi N, Mowa CN, Hattori Y, Miyauchi T: Endothelin antagonism normalizes VEGF signaling and cardiac function in STZ-induced diabetic rat hearts. Am J Physiol Endocrinol Metab, 292 (4), 1030-1040, 2007.
  136. Shimojo N, Jesmin S, Zaedi S, Otsuki, T, Maeda S, Yamaguchi N, Aonuma K, Hattori Y, Miyauchi T: Contributory role of VEGF overexpression in endothelin-1-induced cardiomyocyte hypertrophy. Am J Physiol Heart Circ Physiol, 293 (1), H474-H481, 2007.
  137. Fukatsu A, Hayashi T, Miyazaki-Akita A, Matsui-Hirai H, Furutate Y, Ishitsuka A, Hattori Y, Iguchi A: Possible usefulness of apocynin, an NADPH oxidase inhibitor, for nitrate tolerance: prevention of NO donor-induced endothelial cell abnormalities. Am J Physiol Heart Circ Physiol, 293 (1), H790-H797, 2007.
  138. Ohi Y, Ishii Y, Haji A, Noguchi S, Sasaoka T, Fujimori T, Nabeshima T, Sasahara M, and Hattori Y: Platelet-derived growyh factor (PDGF)-BB inhibits AMPA receptor-mediated synaptic transmission via PDGF receptor-β in murine nucleus tractus solitarius. Brain Res, 1159, 77-85, 2007.
  139. Matsuda N, Takano Y, Kageyama S, Hatakeyama N, Shakunaga K, Kitajima I, Yamazaki M, and Hattori Y: Silencing of caspase-8 and caspase-3 by RNA interference prevents vascular endothelial cell injury in mice with endotoxic shock. Cardiovasc Res, 76 (1), 132-140, 2007.
  140. Matsuda N, Yamazaki H, Takano K, Matsui K, Takano Y, Kenmotsu O, Hattori Y: Priming by lipopolysaccharide exaggerates acute lung injury and mortality in responses to peptidoglycan through up-regulation of Toll-like receptor-2 expression in mice. Biochem Pharmacol, 75(5), 1065-1075, 2008.
  141. Kamiyama K, Matsuda N, Yamamoto S, Takano K, Takano Y, Yamazaki H, Kageyama S, Yokoo H, Nagata T, Hatakeyama N, Tsukada K, Hattori Y: Modulation of glucocorticoid receptor expression, inflammation, and cell apoptosis in septic guinea-pig lungs using methylprednisolone. Am J Physiol Lung Cell Mol Physiol 295: L998-L1006, 2008.
  142. Matsuda N, Yamamoto S, Takano KI, Kageyama SI, Kurobe Y, Yoshiwara Y, Takano Y, Hattori Y: Silencing of Fas-associated Death Domain Protects Mice from Septic Lung Inflammation and Apoptosis. Am J Respir Crit Care Med, 179: 806-815, 2009.
  143. Hatakeyama N, Sakuraya F, Matsuda N, Kimura J, Kinoshita H, Kemmotsu O, Yamazaki M, Hattori Y: Pharmacological Significance of the Blocking Action of the Intravenous General Anesthetic Propofol on the Slow Component of Cardiac Delayed Rectifier K+ Current. J Pharmacol Sci, Vol. 110 (3), 334-343, 2009.
  144. Matsuda N, Yamamoto S, Yokoo H, Tobe K, Hattori Y: Nuclear factor-kappaB decoy oligodeoxynucleotides ameliorate impaired glucose tolerance and insulin resistance in mice with cecal ligation and puncture-induced sepsis. Crit Care Med 37 (10), 2791-2799, 2009.
  145. Naoyuki Matsuda, Hiroki Teramae, Seiji Yamamoto, Ken-ichi Takano, Yasuo Takano, and Yuichi Hattori: Increased death receptor pathway of apoptotic signaling in septic mouse aorta: effect of systemic delivery of FADD siRNA. Am J Physiol Heart Circ Physiol, 298 (1): H92-H101, 2010.
  146. Xiao-Hong Zhang, Hiroki Yokoo, Hiroshi Nishioka, Hajime Fujii, Naoyuki Matsuda, Toshio Hayashi and Yuichi Hattori: Beneficial effect of the oligomerized polyphenol oligonol on high glucose-induced changes in eNOS phosphorylation and dephosphorylation in endothelial cells. Br J Pharmacol, 159: 928–938, 2010.
  147. Naoyuki Matsuda, Hiroki Teramae, Motonori Futatsugi, Ken-ichi Takano, Seiji Yamamoto, Kengo Tomita, Takao Suzuki, Hiroki Yokoo, Kaoru Koike, and Yuichi Hattori: Up-Regulation of Histamine H4 Receptors Contributes to Splenic Apoptosis in Septic Mice: Counteraction of the Antiapoptotic Action of Nuclear Factor-kappa B. J Pharmacol Exp Ther, 332:730–737, 2010.
  148. Jesmin S, Mowa CN, Sultana SN, Shimojo N, Togashi H, Iwashima Y, Kato N, Sato A, Sakuma I, Hiroe M, Hattori Y, Yamaguchi N, Kobayashi H: VEGF signaling is disrupted in the hearts of mice lacking estrogen receptor alpha. Eur J Pharmacol 641 (2-3), 168-178,2010.
  149. Takano KI, Yamamoto S, Tomita K, Takashina M, Yokoo H, Matsuda N, Takano Y, Hattori Y: Successful Treatment of Acute Lung Injury with Pitavastatin in Septic Mice: Potential Role of Glucocorticoid Receptor Expression in Alveolar Macrophages. J Pharmacol Exp Ther 336(2), 381-90, 2011.
  150. Matsui-Hirai H, Hayashi T, Yamamoto S, Ina K, Maeda M, Kotani H, Iguchi A, Ignarro LJ, Hattori Y: Dose-Dependent Modulatory Effects of Insulin on Glucose-Induced Endothelial Senescence In Vitro and In Vivo: A Relationship between Telomeres and Nitric Oxide. J Pharmacol Exp Ther 337(3), 591-9, 2011.
  151. Kageyama S, Yokoo H, Tomita K, Kageyama-Yahara N, Uchimido R, Matsuda N, Yamamoto S, Hattori Y: High glucose-induced apoptosis in human coronary artery endothelial cells involves up-regulation of death receptors. Cardiovasc Diabetol, 10, 73, 2011.
  152. Ikutani M, Yanagibashi T, Ogasawara M, Tsuneyama K, Yamamoto S, Hattori Y, Kouro T, Itakura A, Nagai Y, Takaki S, Takatsu K: Identification of innate IL-5-producing cells and their role in lung eosinophil regulation and antitumor immunity. J Immunol 188 (2), 703-713, 2012.
  153. Shen J, Ishii Y, Xu G, Dang TC, Hamashima T, Matsushima T, Yamamoto S, Hattori Y, Takatsuru Y, Nabekura J, Sasahara M: PDGF-β as a positive regulator of tissue repair in a mouse model of focal cerebral ischemia. J Cereb Blood Flow Metab 32 (2), 353-367, 2012.
  154. Aoki Y, Hatakeyama S, Yamamoto S, Kinoshita H, Matsuda N, Hattori Y, Yamazaki M: Role of ion channels in sepsis-induced atrial tachyarrhythmias in guinea pigs. Br J Pharmacol 166 (1), 390-400, 2012.
  155. Oishi H, Takano K, Tomita K, Takebe M, Yokoo H, Yamazaki M, Hattori Y: Olprinone and colforsin daropate alleviate septic lung inflammation and apoptosis through CREB-independent activation of the Akt pathway. Am J Physiol Lung Cell Mol Physiol 303 (2), L130-L140, 2012.
  156. Yokoo H, Chiba S, Tomita K, Takashina M, Sagara H, Yagishita S, Takano Y, Hattori Y: Neurodegenerative evidence in mice brains with cecal ligation and puncture-induced sepsis: Preventive effect of the free radical scavenger edaravone. PLoS One 7 (12), e51539, 2012.

著書(和文)

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  3. 服部裕一,松田直之:V. エンドセリン 薬理作用と生理作用 線維芽細胞増殖作用. 臨床分子内分泌学(1) ―心血管内分泌代謝系(上)― 編集:松尾壽之 pp.612-616, 日本臨床社 2004.
  4. 服部裕一:合成ステロイドと非ステロイド性抗炎症薬. 生体侵襲と臓器管理.ー急性期病態の理解とその対応ー 編集:松田直之. 救急・集中治療 第20巻第9・10号 pp.1385-1393, 総合医学社 2008.
  5. 服部裕一:育毛剤. 安全性薬理試験マニュアル. 編集:安東賢太郎, 橋本敬太郎, 藤森観之助. pp.276-282, エル・アイ・シー 2009.
  6. 服部裕一:末梢神経薬理. 実践臨床薬理学. 編集:中谷晴昭, 大橋京一, 越前宏俊. pp.52-101, 朝倉書店 2010.
  7. 服部裕一:14章 抗炎症薬および免疫抑制薬, 20章 動脈硬化とリポ蛋白質代謝. ラング・デール薬理学. 監訳:樋口宗史, 前山一隆. pp.220-240, pp.313-322, 西村書店 2011.

総説(和文)

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  3. 菅野盛夫,服部裕一,深尾充宏:内皮由来過分極因子. 血管と内皮 9巻特別増刊号 pp.42-49, 1999.
  4. 佐久間一郎,深尾充宏,服部裕一,北畠顕:血管をめぐる課題:内皮由来過分極因子(EDHF)の心・循環系における役割. 血管と内皮 10巻特別増刊号 pp.19-29, 2000.
  5. 服部裕一,松田直之,丸藤哲:細胞内Ca2+調節機構および情報伝達系からみた糖尿病心の異常. Therapeutic Research 21巻3号 pp.559-562, 2000.
  6. 服部裕一:血流調整因子としてのEDHFとその病態生理学的意義. 循環制御 22巻3号 pp.186-193, 2001.
  7. 服部裕一,松田直之,牧野隆雄:心筋β-受容体シグナルトランスダクションの病態時における変化. Cardiovascular Anesthesia 6巻1号 pp.55-61, 2002.
  8. 松田直之,服部裕一:心筋細胞におけるGTP結合蛋白質の循環制御機構 ―循環器病態における最近の知見―. 循環制御 23巻2号 pp.171-179, 2002.
  9. 松田直之,服部裕一:敗血症性ショックにおけるヒスタミンシグナルの役割.循環制御 24巻2号 pp.118-123, 2003.
  10. 服部裕一:心臓ヒスタミンシグナル研究の新展開:分子薬理から実験治療学まで. 富山医科薬科大学医学会誌 16巻1号 pp.20-24, 2005.
  11. 服部裕一,松田直之: 敗血症におけるヒスタミン生成と受容体発現にかかわる転写調節機構. アレルギー科 21(5): 433-437, 2006.
  12. 松田直之,山本誠士,神山公希,畠山 登,渋谷伸子,服部裕一,山崎光章: Surviving Sepsis Campaign guidlines における relative adrenal insufficiency の対策. 救急医学,31(10):1362-1370, 2007.
  13. 松田直之, 山本誠士, 畠山登, 服部裕一: 敗血症性ショックにおける血管内皮細胞の機能異常. 日本薬理学会雑誌 131(2), 96-100, 2008.
  14. 山崎夕, 薄井勲, 横尾宏毅, 服部裕一, 戸邊一之: 臓器における糖代謝とその調節. 中枢神経. 日本臨床 66(Suppl 3), 300-303, 2008.
  15. 松田直之, 山本誠士, 寺前洋生, 高野健一, 別府賢, 山崎弘美, 横尾宏毅, 畠山登, 小池薫, 服部裕一:敗血症ショックにおけるアポトーシスの治療. 日本薬理学雑誌 134 (4), 198-201, 2009.
  16. 服部裕一:血管内皮細胞機能に及ぼす放射線照射の影響とその臨床的意義. 放射線生物研究 45 (1), 12-22, 2010.
  17. 服部裕一:糖質コルチコイドの作用と機序. ICUとCCU (集中治療医学) 35 (8), 597-603, 2011.
  18. 高野健一,大石博史,服部裕一:アポトーシス関連分子を標的とした敗血症性急性肺傷害の治療.日本薬理学雑誌 138 (4), 146-150, 2011.

原著(和文)

  1. 泉尭,西村泰一,酒井兼司,安孫子保,服部裕一,中谷晴昭,菅野盛夫:Atenololの心臓・血管におよぼす作用. 日薬理誌 76巻6号 505-513, 1980.
  2. 菅野盛夫,中谷晴昭,服部裕一,泉尭,西村泰一,酒井兼司,安孫子保:Atenololの心臓におよぼす作用およびβ-受容体遮断作用の心臓選択性. 日薬理誌 76巻7号 621-632, 1980.
  3. 服部裕一:諸種心房筋におけるα-受容器を介する変力作用の機序に関する研究. ―刺激頻度依存現象およびCa2+拮抗性物質の影響からみた解析― 北海道医学雑誌 57巻4号 437-455, 1982.
  4. 深尾充宏,服部裕一,川崎久郎,町田正晴,菅野盛夫:ウサギ大動脈におけるプロスタグランジンF2αとノルエピネフリンによる収縮反応機構の違いについて. ホスホリパーゼCおよびプロテインキナーゼC阻害薬による検討 血管 17巻3号 187-193, 1994.
  5. 元発芝,山本有平,杉原平樹,皆川英彦,服部裕一:放射線照射による血管内皮細胞の変化に関する基礎的研究. ―第1報:血管収縮弛緩反応の変化― 日本形成外科学会会誌 17巻1号 28-36, 1997.
  6. 玉田淳,服部裕一,山田陽一,丸藤哲,佐久間一郎,北畠顕,菅野盛夫:糖尿病病態心におけるβアドレナリン作動性受容体を介する陽性変力作用減弱の機序. 心電図 17巻4号 335-341, 1997.
  7. 元発芝,杉原平樹,山本有平,服部裕一:放射線照射による血管内皮細胞の変化に関する基礎的研究. ―第2報:血管内皮依存性弛緩反応のメカニズム― 日本形成外科学会会誌 17巻5号 286-291, 1997.
  8. 元発芝,杉原平樹,山本有平,皆川英彦,服部裕一:放射線照射による血管内皮細胞の変化に関する基礎的研究. ―第3報:形態学的変化― 日本形成外科学会会誌 17巻8号 483-490, 1997.
  9. 松田直之,丸藤哲,服部裕一,菅野盛夫,劔物修:敗血症性ショック初期動物モデルにおける心筋βアドレナリン受容体を介した陽性変力作用減弱に関する検討. 循環制御 20巻1号 18-25, 1999.
  10. 服部裕一,赤石康弘,尾谷透:シロスタゾールが著効した血管障害が疑われた糖尿病性有痛性神経障害の1症例. 新薬と臨床 48巻10号 1310-1313, 1999.
  11. 松田直之, 寺前洋生, 大田好紀, 角朝信, 内御堂亮, 小林亮介, 畠山登, 山崎光章, 服部裕一:敗血症性ショック動物モデルにおける初期輸液療法による炎症改善効果―NF-κB活性は輸液療法で抑制される―. 日本外科感染症学会雑誌 5(4), 313-322, 2008.
  12. 山本誠士, 村松昌, 東英梨月, 堂本光子, 大澤毅, 高橋宏行, 高野健一, 浦壁聡美, 新飯田俊平, 澁谷正史, 松田直之, 服部裕一: 神経発生期の血管発生に関与するペリサイトのリクルートメント. 脈管学 50(2), 197-201, 2010.

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