Kengo Tomita, Ph.D.


Wakana Ohashi, Ph.D.
University of Toyama

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Assistant Professor

Academic Background

Ph.D., University of Toyama, 2014
M.S., University of Toyama, 2010
B.S., Hoshi University, 2008

Research Experience

Assistant Professor, University of Toyama, 2015 -
Visiting Graduate Assistant, Weill Cornell Medical College, 2013 - 2015


The Japanese Pharmacological Society
Japanese Association of Cardiovascular Pharmacology


Original Articles

  1. Matsuda N, Teramae H, Futatsugi M, Takano K, Yamamoto S, Tomita K, Suzuki T, Yokoo H, Koike K, Hattori Y: Up-Regulation of Histamine H4 Receptors Contributes to Splenic Apoptosis in Septic Mice: Counteraction of the Antiapoptotic Action of Nuclear Factor-κB.
    J Pharmacol Exp Ther, 332:730–737, 2010.
  2. Takano KI, Yamamoto S, Tomita K, Takashina M, Yokoo H, Matsuda N, Takano Y, Hattori Y: Successful Treatment of Acute Lung Injury with Pitavastatin in Septic Mice: Potential Role of Glucocorticoid Receptor Expression in Alveolar Macrophages.
    J Pharmacol Exp Ther, 336:381-90, 2011.
  3. Kageyama S, Yokoo H, Tomita K, Kageyama-Yahara N, Uchimido R, Matsuda N, Yamamoto S, Hattori Y: High glucose-induced apoptosis in human coronary artery endothelial cells involves up-regulation of death receptors.
    Cardiovasc Diabetol, 10:73, 2011.
  4. Tomita K, Takano K, Yokoo H, Hattori Y: Novel Insights into Beneficial Consequences of Statins in Sepsis: Anti-inflammatory and Anti-apoptotic Mechanisms.
    Mol Cell Pharmacol, 3:67-74, 2011.
  5. Oishi H, Takano KI, Tomita K, Takebe M, Yokoo H, Yamazaki M, Hattori Y: Olprinone and colforsin daropate alleviate septic lung inflammation and apoptosis through CREB-independent activation of the Akt pathway.
    Am J Physiol Lung Cell Mol Physiol, 303:L130-40, 2012.
  6. Yokoo H, Chiba S, Tomita K, Takashina M, Sagara H, Yagisita S, Takano Y, Hattori Y: Neurodegenerative evidence in mice brains with cecal ligation and puncture-induced sepsis: preventive effect of the free radical scavenger edaravone.
    PLoS One,7:e51539, 2012.
  7. Aldi S, Robador PA, Tomita K, Di Lorenzo A, Levi R: IgE receptor-mediated mast-cell renin release.
    Am J Pathol. 184 (2), 376-81, 2014.
  8. Takebe M, Oishi H, Taguchi K, Aoki Y, Takashina M, Tomita K, Yokoo H, Takano Y, Yamazaki M, Hattori Y: Inhibition of histone deacetylases protects septic mice from lung and splenic apoptosis.
    J Surg Res. 187 (2), 559-570, 2014.
  9. Aldi S, Takano K, Tomita K, Koda K, Chan NY, Marino A, Salazar-Rodriguez M, Thurmond RL, Levi R: Histamine H4-receptors inhibit mast cell renin release in ischemia/reperfusion via protein kinase C ε-dependent aldehyde dehydrogenase type-2 activation.
    J Pharmacol Exp Ther. 349 (3), 508-17, 2014.
  10. Tomita K, Takashina M, Mizuno N, Sakata K, Hattori K, Imura J, Ohashi W, Hattori Y: Cardiac fibroblasts: contributory role in septic cardiac dysfunction.
    J Surg Res. 193(2):874-887, 2015.
  11. Aldi S, Marino A, Tomita K, Corti F, Anand R, Olson KE, Marcus AJ, Levi R: E-NTPDase1/CD39 modulates renin release from heart mast cells during ischemia/reperfusion: a novel cardioprotective role.
    FASEB J. 29, 61-69, 2015.
  12. Kambara K, Ohashi W, Tomita K, Takashina M, Fujisaka S, Hayashi R, Mori H, Tobe K, Hattori Y: In vivo depletion of CD206(+) M2 macrophages exaggerates lung injury in endotoxemic mice.
    Am J Pathol. 185(1):162-171, 2015.
  13. Abdelzaher LA, Imaizumi T, Suzuki T, Tomita K, Takashina M, Hattori Y.: Astaxanthin alleviates oxidative stress insults-related derangements in human vascular endothelial cells exposed to glucose fluctuations. Life Sci. 150 (1), 24–31, 2016.
  14. Testai L, Marino A, Piano I, Brancaleone V, Tomita K, Di Cesare Mannelli L, Martelli A, Citi V, Breschi MC, Levi R, Gargini C, Bucci M, Cirino G, Ghelardini C, Calderone V.: The novel H2S-donor 4-carboxyphenyl isothiocyanate promotes cardioprotective effects against ischemia/reperfusion injury through activation of mitoKATP channels and reduction of oxidative stress. Pharmacol Res. 113 (Pt A), 290–9, 2016.
  15. Takashina M, Inoue S, Tomihara K, Tomita K, Hattori K, Zhao QL, Suzuki T, Noguchi M, Ohashi W, Hattori Y.: Different effect of resveratrol to induction of apoptosis depending on the type of human cancer cells. Int J Oncol. 50 (3), 787–797, 2017.
  16. Sakai M, Suzuki T, Tomita K, Yamashita S, Palikhe S, Hattori K, Yoshimura N, Matsuda N, Hattori Y.:Diminished Responsiveness to Dobutamine as an Inotrope in Mice with Cecal Ligation and Puncture-Induced Sepsis: Attribution to Phosphodiesterase 4 Upregulation. Am J Physiol Heart Circ Physiol. 312 (6), H1224-H1237, 2017.
  17. Marino A, Sakamoto T, Robador PA, Tomita K, Levi R.:S1P1-mediated anti-RAS cardioprotection: pivotal role of mast cell ALDH2. J Pharmacol Exp Ther., 362(2):230–42, 2017.
  18. Misawa H, Ohashi W, Tomita K, Hattori K, Shimada Y, Hattori Y.:Prostacyclin mimetics afford protection against lipopolysaccharide/d-galactosamine-induced acute liver injury in mice. Toxicol Appl Pharmacol., 334 (2):55–65, 2017.
  19. Imaizumi T, Matsuda N, Tomita K, Palikhe S, Ohashi W, Hattori K, Hattori Y.: Activator Protein-1 Decoy Oligodeoxynucleotide Transfection Is Beneficial in Reducing Organ Injury and Mortality in Septic Mice. Crit Care Med., 46 (5), e435–e442, 2018.
  20. Kawakami M, Hattori M, Ohashi W, Fujimori T, Hattori K, Takebe M, Tomita K, Yokoo H, Matsuda N, Yamazaki M, Hattori Y.: Role of G protein-coupled receptor kinase 2 in oxidative and nitrosative stress-related neurohistopathological changes in a mouse model of sepsis-associated encephalopathy. J Neurochem., 145 (6):474–488, 2018.
  21. Yamashita S, Suzuki T, Iguchi K, Sakamoto T, Tomita K, Yokoo H, Sakai M, Misawa H, Hattori K, Nagata T, Watanabe Y, Matsuda N, Yoshimura N, Hattori Y.:Cardioprotective and functional effects of levosimendan and milrinone in mice with cecal ligation and puncture-induced sepsis. Naunyn Schmiedebergs Arch Pharmacol., 2018.
  22. Sakamoto T, Ohashi W, Tomita K, Hattori K, Matsuda N, Hattori Y.: Anti-inflammatory properties of cilostazol: Its interruption of DNA binding activity of NF-κB from the Toll-like receptor signaling pathways. Int Immunopharmacol., 62:120–131, 2018.

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