冨田賢吾

tomita

冨田 賢吾
Kengo Tomita, Ph.D.

現  職
富山大学大学院医学薬学研究部 
分子医科薬理学講座 助教

現在の主な研究テーマ 
敗血症性多臓器不全の分子病態機構の解明とその治療法の探索



前に戻る

助教


略  歴

2002年3月 千葉県立薬園台高等学校 卒業
2008年3月 星薬科大学 薬学部 卒業
2010年3月 富山大学大学院 医科学専攻 (麻酔科学講座) 修士課程修了
2013年2月 Weill Cornell Medical College (New York, NY, USA),
     Dept. Pharmacology (Dr. Levi lab), Visiting Graduate Assistant
2014年3月 富山大学大学院 東西統合医学専攻 (分子医科薬理学講座) 博士課程修了
2015年4月 - 現在 富山大学大学院 医学薬学研究部(医学)  助教
2015年4月 - 現在 沢田記念高岡整志会病院  非常勤薬剤師
2017年4月 - 現在 富山医療福祉専門学校 非常勤講師
現在に至る

賞、資 格 & 所 属 学 会

賞、資格

2008年4月 厚生労働省 薬剤師免許 (第417694号)
2010年3月 富山大学 学長賞
2010年3月 富山大学 修士(医科学)(富医薬修第160号)
2014年3月 富山大学 博士(医学) (富医薬博甲第136号)

所 属 学 会

日本薬理学会 (学術評議員)
日本循環薬理学会

業績

英文論文

  1. Matsuda N, Teramae H, Futatsugi M, Takano K, Yamamoto S, Tomita K, Suzuki T, Yokoo H, Koike K, Hattori Y: Up-Regulation of Histamine H4 Receptors Contributes to Splenic Apoptosis in Septic Mice: Counteraction of the Antiapoptotic Action of Nuclear Factor-κB.
    J Pharmacol Exp Ther, 332:730–737, 2010.
  2. Takano KI, Yamamoto S, Tomita K, Takashina M, Yokoo H, Matsuda N, Takano Y, Hattori Y: Successful Treatment of Acute Lung Injury with Pitavastatin in Septic Mice: Potential Role of Glucocorticoid Receptor Expression in Alveolar Macrophages.
    J Pharmacol Exp Ther, 336:381-90, 2011.
  3. Kageyama S, Yokoo H, Tomita K, Kageyama-Yahara N, Uchimido R, Matsuda N, Yamamoto S, Hattori Y: High glucose-induced apoptosis in human coronary artery endothelial cells involves up-regulation of death receptors.
    Cardiovasc Diabetol, 10:73, 2011.
  4. Tomita K, Takano K, Yokoo H, Hattori Y: Novel Insights into Beneficial Consequences of Statins in Sepsis: Anti-inflammatory and Anti-apoptotic Mechanisms.
    Mol Cell Pharmacol, 3:67-74, 2011.
  5. Oishi H, Takano KI, Tomita K, Takebe M, Yokoo H, Yamazaki M, Hattori Y: Olprinone and colforsin daropate alleviate septic lung inflammation and apoptosis through CREB-independent activation of the Akt pathway.
    Am J Physiol Lung Cell Mol Physiol, 303:L130-40, 2012.
  6. Yokoo H, Chiba S, Tomita K, Takashina M, Sagara H, Yagisita S, Takano Y, Hattori Y: Neurodegenerative evidence in mice brains with cecal ligation and puncture-induced sepsis: preventive effect of the free radical scavenger edaravone.
    PLoS One,7:e51539, 2012.
  7. Aldi S, Robador PA, Tomita K, Di Lorenzo A, Levi R: IgE receptor-mediated mast-cell renin release.
    Am J Pathol. 184 (2), 376-81, 2014.
  8. Takebe M, Oishi H, Taguchi K, Aoki Y, Takashina M, Tomita K, Yokoo H, Takano Y, Yamazaki M, Hattori Y: Inhibition of histone deacetylases protects septic mice from lung and splenic apoptosis.
    J Surg Res. 187 (2), 559-570, 2014.
  9. Aldi S, Takano K, Tomita K, Koda K, Chan NY, Marino A, Salazar-Rodriguez M, Thurmond RL, Levi R: Histamine H4-receptors inhibit mast cell renin release in ischemia/reperfusion via protein kinase C ε-dependent aldehyde dehydrogenase type-2 activation.
    J Pharmacol Exp Ther. 349 (3), 508-17, 2014.
  10. Tomita K, Takashina M, Mizuno N, Sakata K, Hattori K, Imura J, Ohashi W, Hattori Y: Cardiac fibroblasts: contributory role in septic cardiac dysfunction.
    J Surg Res. 193(2):874-887, 2015.
  11. Aldi S, Marino A, Tomita K, Corti F, Anand R, Olson KE, Marcus AJ, Levi R: E-NTPDase1/CD39 modulates renin release from heart mast cells during ischemia/reperfusion: a novel cardioprotective role.
    FASEB J. 29, 61-69, 2015.
  12. Kambara K, Ohashi W, Tomita K, Takashina M, Fujisaka S, Hayashi R, Mori H, Tobe K, Hattori Y: In vivo depletion of CD206(+) M2 macrophages exaggerates lung injury in endotoxemic mice.
    Am J Pathol. 185(1):162-171, 2015.
  13. Abdelzaher LA, Imaizumi T, Suzuki T, Tomita K, Takashina M, Hattori Y.: Astaxanthin alleviates oxidative stress insults-related derangements in human vascular endothelial cells exposed to glucose fluctuations. Life Sci. 150 (1), 24–31, 2016.
  14. Testai L, Marino A, Piano I, Brancaleone V, Tomita K, Di Cesare Mannelli L, Martelli A, Citi V, Breschi MC, Levi R, Gargini C, Bucci M, Cirino G, Ghelardini C, Calderone V.: The novel H2S-donor 4-carboxyphenyl isothiocyanate promotes cardioprotective effects against ischemia/reperfusion injury through activation of mitoKATP channels and reduction of oxidative stress. Pharmacol Res. 113 (Pt A), 290–9, 2016.
  15. Takashina M, Inoue S, Tomihara K, Tomita K, Hattori K, Zhao QL, Suzuki T, Noguchi M, Ohashi W, Hattori Y.: Different effect of resveratrol to induction of apoptosis depending on the type of human cancer cells. Int J Oncol. 50 (3), 787–797, 2017.
  16. Sakai M, Suzuki T, Tomita K, Yamashita S, Palikhe S, Hattori K, Yoshimura N, Matsuda N, Hattori Y.:Diminished Responsiveness to Dobutamine as an Inotrope in Mice with Cecal Ligation and Puncture-Induced Sepsis: Attribution to Phosphodiesterase 4 Upregulation. Am J Physiol Heart Circ Physiol. 312 (6), H1224-H1237, 2017.
  17. Marino A, Sakamoto T, Robador PA, Tomita K, Levi R.:S1P1-mediated anti-RAS cardioprotection: pivotal role of mast cell ALDH2. J Pharmacol Exp Ther., 362(2):230–42, 2017.
  18. Misawa H, Ohashi W, Tomita K, Hattori K, Shimada Y, Hattori Y.:Prostacyclin mimetics afford protection against lipopolysaccharide/d-galactosamine-induced acute liver injury in mice. Toxicol Appl Pharmacol., 334 (2):55–65, 2017.

このページの先頭へ