index-image

2017

【Ⅰ】Publications


  1. Ohashi W, Yamamine N, Imura J, Hattori Y.: SKL2001 suppresses colon cancer spheroid growth through regulation of the E-cadherin/β-Catenin complex. Biochem Biophys Res Commun., 493 (3):1342–8, 2017.
  2. Misawa H, Ohashi W, Tomita K, Hattori K, Shimada Y, Hattori Y.: Prostacyclin mimetics afford protection against lipopolysaccharide/d-galactosamine-induced acute liver injury in mice. Toxicol Appl Pharmacol., 334 (2):55–65, 2017.
  3. Marino A, Sakamoto T, Robador PA, Tomita K, Levi R.: S1P1-mediated anti-RAS cardioprotection: pivotal role of mast cell ALDH2. J Pharmacol Exp Ther., 362 (2):230–42, 2017.
  4. Sakai M, Suzuki T, Tomita K, Yamashita S, Palikhe S, Hattori K, Yoshimura N, Matsuda N, Hattori Y.: Diminished Responsiveness to Dobutamine as an Inotrope in Mice with Cecal Ligation and Puncture-Induced Sepsis: Attribution to Phosphodiesterase 4 Upregulation. Am J Physiol Heart Circ Physiol. 312 (6), H1224-H1237, 2017.
  5. Takashina M, Inoue S, Tomihara K, Tomita K, Hattori K, Zhao QL, Suzuki T, Noguchi M, Ohashi W, Hattori Y.: Different effect of resveratrol to induction of apoptosis depending on the type of human cancer cells. Int J Oncol. 50 (3), 787–797, 2017.
Review
  1. Hattori Y, Hattori K, Suzuki T, Matsuda N.: Recent advances in the pathophysiology and molecular basis of sepsis-associated organ dysfunction: Novel therapeutic implications and challenges. Pharmacol Ther. 177, 56-66, 2017
Commentaries
  1. Ohashi W, Hase K, Fukada T.:Emerging role of zinc homeostasis by zinc transporter ZIP7 in intestinal homeostatic self-renewal. Inflammation & Cell Signaling. 4, e1509, 2017.

【Ⅱ】International Conferences


  1. Wakana Ohashi, Koji Hase, Toshiyuki Fukada: Role of the zinc transporter SLC39A7/ZIP7 in intestinal homeostatic self-renewal. International Society for the ISZB meeting 2017, Symposium 3 Zinc transporters and signaling in physiology and disease; New Winds from East and West, Cyprus June 2017.
  2. Hiroki Misawa, Wakana Ohashi, Kengo Tomita, Yutaka Shimada, Yuichi Hattori: The Hepatoprotective Effects of Prostacyclin Mimetics Are Associated with Their Anti-Oxidative Actions. Experimental Biology 2017. Chicago, April 2017.

2016

【Ⅰ】Publications


  1. Hattori M, Yamazaki M, Ohashi W, Tanaka S, Hattori K, Todoroki K, Fujimori T, Ohtsu H, Matsuda N, Hattori Y.: Critical role of endogenous histamine in promoting end-organ tissue injury in sepsis. Intensive Care Med Exp. 4 (1), 36, 2016.
  2. Ohashi W, Kimura S, Iwanaga T, Furusawa Y, Irié T, Izumi H, Watanabe T, Hijikata A, Hara T, Ohara O, Koseki H, Sato T, Robine S, Mori H, Hattori Y, Watarai H, Mishima K, Ohno H, Hase K, Fukada T.: Zinc Transporter SLC39A7/ZIP7 Promotes Intestinal Epithelial Self-Renewal by Resolving ER Stress. PLoS Genet. 12 (10), e1006349, 2016.
  3. Testai L, Marino A, Piano I, Brancaleone V, Tomita K, Di Cesare Mannelli L, Martelli A, Citi V, Breschi MC, Levi R, Gargini C, Bucci M, Cirino G, Ghelardini C, Calderone V.: The novel H2S-donor 4-carboxyphenyl isothiocyanate promotes cardioprotective effects against ischemia/reperfusion injury through activation of mitoKATP channels and reduction of oxidative stress. Pharmacol Res. 113 (Pt A), 290–9, 2016.
  4. Abdelzaher LA, Imaizumi T, Suzuki T, Tomita K, Takashina M, Hattori Y.: Astaxanthin alleviates oxidative stress insults-related derangements in human vascular endothelial cells exposed to glucose fluctuations. Life Sci. 150 (1), 24–31, 2016.
  5. Kuwasako K, Sekiguchi T, Nagata S, Jiang D, Hayashi H, Murakami M, Hattori Y, Kitamura K, Kato J.: Inhibitory effects of two G protein-coupled receptor kinases on the cell surface expression and signaling of the human adrenomedullin receptor. Biochem Biophys Res Commun. 470 (4), 894–9, 2016.

【Ⅱ】International Conferences


  1. Mizuki Hattori, Wakana Ohashi, Mitsuaki Yamazaki, Yuichi Hattori: Histamine serves as an aggravating factor in major end-organ injury associated with sepsis. Experimental Biology 2016. San Diego, April 2016.
  2. Hiroki Misawa, Wakana Ohashi, Yutaka Shimada, Yuichi Hattori: Protective effect of ONO-1301, a long- acting prostacyclin agonist, on lipopolysaccharide/D-galactosamine-induced liver injury. Experimental Biology 2016. San Diego, April 2016.

2015

【Ⅰ】Publications


  1. Wang Q, Yokoo H, Takashina M, Sakata K, Ohashi W, Abedelzaher LA, Imaizumi T, Sakamoto T, Hattori K, Matsuda N, Hattori Y: Anti-Inflammatory Profile of Levosimendan in Cecal Ligation-Induced Septic Mice and in Lipopolysaccharide-Stimulated Macrophages. Crit Care Med. 43 (11), e508–20, 2015.
  2. Inoue S, Arai N, Tomihara K, Takashina M, Hattori Y, Noguchi M. Extracellular Ca(2+)-dependent enhancement of cytocidal potency of zoledronic acid in human oral cancer cells. Eur J Pharmacol. 2015 Aug 15;761:44–54.
  3. Nishida S, Tsuchida K, Satoh H: Comparative Study of Vasodilatation Induced by Rokumigan, Hachimijiogan, and Goshajinkigan in the Rat Aorta.J Integrative Med Ther. 2(1): 6, 2015.
  4. Maeda M, Hayashi T, Mizuno N, Hattori Y, Kuzuya M: Intermittent high glucose implements stress-induced senescence in human vascular endothelial cells: Role of superoxide production by NADPH oxidase. PLoS One 10 (4), e0123169, 2015.
  5. Sakata K, Kondo T, Mizuno N, Shoji M, Yasui H, Yamamori T, Inanami O, Yokoo H, Yoshimura N, Hattori Y: Roles of ROS and PKC-βII in ionizing radiation-induced eNOS activation in human vascular endothelial cells. Vascul Pharmacol. 70, 55–65, 2015.
  6. Kambara K, Ohashi W, Tomita K, Takashina M, Fujisaka S, Hayashi R, Mori H, Tobe K, Hattori Y: In vivo depletion of CD206(+) M2 macrophages exaggerates lung injury in endotoxemic mice. Am J Pathol. 185(1):162–171, 2015.
  7. Nagane M, Yasui H, Sakai Y, Yamamori T, Niwa K, Hattori Y, Kondo T, Inanami O: Activation of eNOS in endothelial cells exposed to ionizing radiation involves components of the DNA damage response pathway. Biochem Biophys Res Commun. 456(1):541–6, 2015.
  8. Aldi S, Marino A, Tomita K, Corti F, Anand R, Olson KE, Marcus AJ, Levi R: E-NTPDase1/CD39 modulates renin release from heart mast cells during ischemia/reperfusion: a novel cardioprotective role. FASEB J. 29, 61–9, 2015.
  9. Tomita K, Takashina M, Mizuno N, Sakata K, Hattori K, Imura J, Ohashi W, Hattori Y: Cardiac fibroblasts: contributory role in septic cardiac dysfunction. J Surg Res. 193(2):874–87, 2015.
Review
  1. Ohashi W, Hattori K, Hattori Y: Control of Macrophage Dynamics as a Potential Therapeutic Approach for Clinical Disorders Involving Chronic Inflammation. J Pharmacol Exp Ther., 354(3):240–50, 2015.
Commentaries
  1. Hattori Y, Hattori K, Hayashi T. Pleiotropic benefits of metformin: macrophage targeting its anti-inflammatory mechanisms. Diabetes. 2015 Jun;64(6):1907–9.
  2. Hattori Y, Hattori K, Suzuki T. Differential Modulation of Cardiac Sympathetic Neural Control and β-Adrenoceptor-G Protein Signaling Cascade in Rats With Type 1 and Type 2 Diabetes. Diabetes. 2015 Aug;64(8):2708-10.
  3. 【Ⅱ】International Conferences


    1. Kimimasa Sakata, Natsumi Mizuno, Takashi Kondo, Naoki Yoshimura, Yuichi Hattori. The mechanisms underlying irradiation-induced eNOS activation in human vascular endothelial cells. 15th International Congress of Radiation Research; 2015 May 25–29; Kyoto.

2014

【Ⅰ】Publications


  1. Aldi S, Takano K, Tomita K, Koda K, Chan NY, Marino A, Salazar-Rodriguez M, Thurmond RL, Levi R: Histamine H4-receptors inhibit mast cell renin release in ischemia/reperfusion via protein kinase C ε-dependent aldehyde dehydrogenase type-2 activation. J Pharmacol Exp Ther 349 (3), 508-17, 2014.
  2. Taguchi K, Sakata K, Ohashi W, Imaizumi T, Imura J, Hattori Y: Tonic inhibition by G protein-coupled receptor kinase 2 of Akt/endothelial nitric oxide synthase signaling in human vascular endothelial cells under conditions of hyperglycemia with high insulin levels. J Pharmacol Exp Ther 349 (2), 199-208, 2014.
  3. Takebe M, Oishi H, Taguchi K, Aoki Y, Takashina M, Tomita K, Yokoo H, Takano Y, Yamazaki M, Hattori Y: Inhibition of histone deacetylases protects septic mice from lung and splenic apoptosis. J Surg Res 187 (2), 559-570, 2014.
  4. Aldi S, Robador PA, Tomita K, Di Lorenzo A, Levi R: IgE receptor-mediated mast-cell renin release. Am J Pathol 184 (2), 376-81, 2014.
  5. Hayashi T, Yamaguchi T, Sakakibara Y, Taguchi K, Maeda M, Kuzuya M, Hattori Y: eNOS-dependent antisenscence effect of a calcium channel blocker in human endothelial cells. PLoS One 9 (2), e88391, 2014.
  6. Hayashi T, Kotani H, Yamaguchi T, Taguchi K, Iida M, Ina K, Maeda M, Kuzuya M, Hattori Y, Ignarro LJ: Endothelial cellular senescence is inhibited by liver X receptor activation with an additional mechanism for its atheroprotection in diabetes. Proc Natl Acad Sci USA 111 (3), 1168-1173, 2014.
Book
  1. Ohashi W, Hattori Y: Drugs that affect lipid metabolism. In: Side Effects of Drugs Annual, Vol 35. ed. by J.K. Aronson. pp.807-819, Elsevier Academic Press 2014.
  2. Ohashi W, Hattori Y: Drugs that affect lipid metabolism. In: Side Effects of Drugs Annual, Vol 36. ed. by S.D.Ray. pp.675-682, Elsevier Academic Press 2014.

【Ⅱ】International Conferences


  1. Kimimasa Sakata, Kumiko Taguchi, Wakana Ohashi, Joji Imura, Naoki Yoshimura, Yuichi Hattori: GRK2 is a tonic inhibitor of Akt/eNOS signaling in human vascular endothelial cells under conditions of hyperglycemia with high insulin levels. Experimental Biology 2011. San Diego, April 2014.

2013

【Ⅰ】Publications


Review
  1. Taguchi K, Hattori Y: Unlooked-for significance of cardiac versus vascular effects of endothelin-1 in the pathophysiology of pulmonary arterial hypertension. Circ Res, 112(2):227-9, 2013.

【Ⅱ】International Conferences


  1. Mariko Takebe, Hirofumi Oishi, Yuta Aoki, Yuichi Hattori, Mitsuaki Yamazaki: Possible role of epigenetic modifications in the pathology of sepsis. Euroanaesthesia 2013. Barcelona, June 2013.
  2. Hiroki Yokoo, Kumiko Taguchi, Yuichi Hattori: The oligomerized polyphenol oligonol ameliorates high glucose- and TNF-alpha-induced NADPH oxidase activation and insulin signaling downregulation in vascular endothelial cells. Experimental Biology 2013. Boston, April 2013.
  3. Hattori Y: Invited Lecture Protection from both inflammation and apoptosis as a novel therapeutic strategy for severe sepsis. The 4th Critical Care Conference in Thailand. Pattaya, June 27-29, 2013.

2012

【Ⅰ】Publications


Original Papers
  1. Yokoo H, Chiba S, Tomita K, Takashina M, Sagara H, Yagisita S, Takano Y, Hattori Y: Neurodegenerative evidence in mice brains with cecal ligation and puncture-induced sepsis: preventive effect of the free radical scavenger edaravone.PLoS One.,7:e51539, 2012.
  2. Nemoto S, Taguchi K, Matsumoto T, Kamata K, Kobayashi T: Pravastatin normalizes ET-1-induced contraction in the aorta of type 2 diabetic OLETF rats by suppressing the KSR1/ERK complex.Am J Physiol Heart Circ Physiol., 303:H893-902, 2012.
  3. Kobayashi T, Nemoto S, Ishida K, Taguchi K, Matsumoto T, Kamata K: Involvement of CaM kinase II in the impairment of endothelial function and eNOS activity in aortas of Type 2 diabetic rats.Clin Sci (Lond)., 123:375-86, 2012.
  4. Taguchi K, Morishige A, Matsumoto T, Kamata K, Kobayashi T: Enhanced estradiol-induced vasorelaxation in aortas from type 2 diabetic mice may reflect a compensatory role of p38 MAPK-mediated eNOS activation.Pflugers Arch., 464:205-15, 2012.
  5. Taguchi K, Matsumoto T, Kamata K, Kobayashi T: G protein-coupled receptor kinase 2, with β-arrestin 2, impairs insulin-induced Akt/endothelial nitric oxide synthase signaling in ob/ob mouse aorta.Diabetes., 61:1978-85, 2012.
  6. Taguchi K, Matsumoto T, Kamata K, Kobayashi T: Inhibitor of G protein-coupled receptor kinase 2 normalizes vascular endothelial function in type 2 diabetic mice by improving β-arrestin 2 translocation and ameliorating Akt/eNOS signal dysfunction.Endocrinology., 153:2985-96, 2012.
  7. Taguchi K, Matsumoto T, Kamata K, Kobayashi T: Angiotensin II type 2 receptor-dependent increase in nitric oxide synthase activity in the endothelium of db/db mice is mediated via a MEK pathway.Pharmacol Res., 66:41-50, 2012.
  8. Oishi H, Takano KI, Tomita K, Takebe M, Yokoo H, Yamazaki M, Hattori Y: Olprinone and colforsin daropate alleviate septic lung inflammation and apoptosis through CREB-independent activation of the Akt pathway. Am J Physiol Lung Cell Mol Physiol., 303:L130-40, 2012.
  9. Ishida K, Matsumoto T, Taguchi K, Kamata K, Kobayashi T: Pravastatin normalizes endothelium-derived contracting factor-mediated response via suppression of Rho-kinase signalling in mesenteric artery from aged type 2 diabetic rat.Acta Physiol (Oxf)., 205:255-65, 2012.
  10. Aoki Y, Hatakeyama N, Yamamoto S, Kinoshita H, Matsuda N, Hattori Y, Yamazaki M: Role of ion channels in sepsis-induced atrial tachyarrhythmias in guinea pigs. Br J Pharmacol., 166:390-400, 2012.
  11. Ishida K, Matsumoto T, Taguchi K, Kamata K, Kobayashi T: Protein kinase C delta contributes to increase in EP3 agonist-induced contraction in mesenteric arteries from type 2 diabetic Goto-Kakizaki rats.Pflugers Arch., 463:593-602, 2012.
  12. Shen J, Ishii Y, Xu G, Dang TC, Hamashima T, Matsushima T, Yamamoto S, Hattori Y, Takatsuru Y, Nabekura J, Sasahara M: PDGFR-β as a positive regulator of tissue repair in a mouse model of focal cerebral ischemia.J Cereb Blood Flow Metab., 32:353-67, 2012.
  13. Ikutani M, Yanagibashi T, Ogasawara M, Tsuneyama K, Yamamoto S, Hattori Y, Kouro T, Itakura A, Nagai Y, Takaki S, Takatsu K: Identification of innate IL-5-producing cells and their role in lung eosinophil regulation and antitumor immunity.J Immunol., 188:703-13, 2012.
  14. Nemoto S, Taguchi K, Matsumoto T, Kamata K, Kobayashi T: Aminoguanidine normalizes ET-1-induced aortic contraction in type 2 diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats by suppressing Jab1-mediated increase in ET(A)-receptor expression.Peptides., 33:109-19, 2012.
  15. Taguchi K, Matsumoto T, Kamata K, Kobayashi T: Akt/eNOS pathway activation in endothelium-dependent relaxation is preserved in aortas from female, but not from male, type 2 diabetic mice.Pharmacol Res., 65:56-65, 2012.

【Ⅱ】International Conferences


  1. Yokoo H, Lobna AA, Taguchi K, Hattori Y: Inhibition of hyperglycemia/cytokine-induced NADPH oxidase activation and preservation of insulin signaling by treatment with Oligonol: analysis in cultured porcine aortic endothelial cells. 20th International Congress on Nutrition and Integrative Medicine, July 21-22, 2012, Sapporo, Japan.
  2. Matsumoto T, Nemoto S, Taguchi K, Kamata K, Kobayashi T: Involvement of CaM kinase II in impairments of endothelial function and eNOS activity in aortas of type2 diabetic Goto-Kakizaki rats. Experimental Biology 2012, April 21-25, 2012, San Diego, CA.
  3. Matsumoto T, Taguchi K, Kamata K, Kobayashi T: Insulin-mediated Akt/eNOS signaling is defective in ob/ob mouse aorta due to negative regulation by translocated GRK2. Experimental Biology 2012, April 21-25, 2012, San Diego, CA.
  4. Yokoo H, Yamamoto S, Hattori Y: Expression of TNF-R1 and Fas in coronary arterioles of type2 diabetic mice. Experimental Biology 2012, April 21-25, 2012, San Diego, CA.

2011

【Ⅰ】Publications


Original Papers
  1. Tomita K, Takano K, Yokoo H, Hattori Y: Novel Insights into Beneficial Consequences of Statins in Sepsis: Anti-inflammatory and Anti-apoptotic Mechanisms Mol. Cell. Pharmacol., 3:67-74, 2011.
  2. Kageyama S, Yokoo H, Tomita K, Kageyama-Yahara N, Uchimido R, Matsuda N, Yamamoto S, Hattori Y: High glucose-induced apoptosis in human coronary artery endothelial cells involves up-regulation of death receptors. Cardiovasc Diabetol, 10:73, 2011. [IF 2.720]
  3. Matsui-Hirai H, Hayashi T, Yamamoto S, Ina K, Maeda M, Kotani H, Iguchi A, Ignarro LJ, Hattori Y: Dose-Dependent Modulatory Effects of Insulin on Glucose-Induced Endothelial Senescence In Vitro and In Vivo: A Relationship between Telomeres and Nitric Oxide. J Pharmacol Exp Ther, 337:591-9, 2011. [IF 4.017]
  4. Takano KI, Yamamoto S, Tomita K, Takashina M, Yokoo H, Matsuda N, Takano Y, Hattori Y: Successful Treatment of Acute Lung Injury with Pitavastatin in Septic Mice: Potential Role of Glucocorticoid Receptor Expression in Alveolar Macrophages. J Pharmacol Exp Ther, 336:381-90, 2011. [IF 4.017]
Book
  1. Hattori Y, Matsuda N: Protection from lethal cell death in cecal ligation and puncture-induced sepsis mouse model by in vivo delivery of FADD siRNA. In:Targets in Gene Therapy. ed. by Yongping You. pp.409-422, InTech-Open Access Publisher 2011.

【Ⅱ】International Conferences


  1. Yamamoto S, Azuma E, Yanagibashi T, Ikutani M, Nagai Y, Takatsu K, Miyazaki K, Dohmoto M, Muramatsu M, Niida S, Hattori Y: Endthelial microparticles behave as a bioactive carrier in the cellular interaction. The 19th Annual Meeting of the Japanese Vasclar Biology and Medicine Organization/ The 1st Asia-pacific Vascular Biology Meeting, December 8-9, 2011, Tokyo, Japan.
  2. Yamamoto S, Azuma E, Muramatsu M, Yanagibashi T, Ikutani M, Nagai Y, Takatsu K, Miyazaki K, Dohmoto M, Matsuda N, Niida S, Hattori Y: EMPs behave as the bioactive carrier in inflammatory condition. The Second Pacific Symposium on Vascular Biology, October 30-November 2, 2011, Jeju, Korea: 33.
  3. Hiroki Yokoo, Yuichi Hattori: Histopathological changes in septic mouse brain: effect of the free-radical scavenger edaravone. Experimental Biology 2011, April, 2010, Washington, DC.

2010

【Ⅰ】Publications


Original Papers
  1. Jesmin S, Mowa CN, Sultana SN, Mia S, Islam R, Zaedi S, Sakuma I, Hattori Y, Hiroe M, Yamaguchi N.: Estrogen receptor alpha and beta are both involved in the cerebral VEGF/Akt/NO pathway and cerebral angiogenesis in female mice. Biomed Res, 31:337-346, 2010 [IF 1.146]
  2. Muramatsu M, Yamamoto S, Osawa T, Shibuya M: Vascular endothelial growth factor receptor-1 signaling promotes mobilization of macrophage lineage cells from bone marrow and stimulates solid tumor growth. Cancer Research, 70(20):8211-21, 2010. [IF 7.543]
  3. Jesmin S, Mowa CN, Sultana SN, Shimojo N, Togashi H, Iwashima Y, Kato N, Sato A, Sakuma I, Hiroe M, Hattori Y, Yamaguchi N, Kobayashi H: VEGF signaling is disrupted in the hearts of mice lacking estrogen receptor alpha. Eur J Pharmacol 641 (2-3), 168-178,2010. [IF 2.585]
  4. Miyamoto S, Cooper L, Watanabe K, Yamamoto S, Inoue H, Mishima K, Saito I: Role of retinoic acid-related orphan receptor-α in differentiation of human mesenchymal stem cells along with osteoblastic lineage. Pathobiology, 77, 28-37, 2010. [IF 2.410]
  5. Zhang XH, Yokoo H, Nishioka H, Fujii H, Matsuda N, Hayashi T, Hattori Y: Beneficial effect of the oligomerized polyphenol oligonol on high glucose-induced changes in eNOS phosphorylation and dephosphorylation in endothelial cells. Br J Pharmacol, 159: 928–938, 2010. [IF 5.204]
  6. Matsuda N, Teramae H, Futatsugi M, Takano K, Yamamoto S, Tomita K, Suzuki T, Yokoo H, Koike K, Hattori Y: Up-Regulation of Histamine H4 Receptors Contributes to Splenic Apoptosis in Septic Mice: Counteraction of the Antiapoptotic Action of Nuclear Factor-κB. J Pharmacol Exp Ther, 332:730–737, 2010. [IF 4.093]
  7. Matsuda N, Teramae H, Yamamoto S, Takano K, Takano Y, Hattori Y: Increased death receptor pathway of apoptotic signaling in septic mouse aorta: effect of systemic delivery of FADD siRNA. Am J Physiol Heart Circ Physiol, 298: H92-H101, 2010. [IF 3.712]
Review
  1. Hattori Y, Takano KI, Teramae H, Yamamoto S, Yokoo H, Matsuda N: Insights into sepsis therapeutic design based on the apoptotic death pathway. J Pharmacol Sci, 114(4):354-65, 2010. [IF 2.345]

【Ⅱ】International Conferences


  1. Ken-ichi Takano, (Japan), S Yamamoto, K Tomita, H Yamazaki, H Yokoo, Y Takano, Y Hattori: Pitavastatin improves lung inflammation and survival in septic mice: prevention of reduced lung glucocorticoid receptors. WorldPharma2010 16th World Congress on Basic and Clinical Pharmacology, FC09.1.6, 17-23 July, 2010, Copenhagen, Denmark.
  2. Seiji Yamamoto, (Japan), M Muramatsu, E Azuma, M Dohmoto, S Kita, T Iwamoto, I Komuro, K Takano, S Niida, M Shibuya, N Matsuda, Y Hattori: CNS pericytes originate from the circulating hematopoietic progenitors. WorldPharma2010 16th World Congress on Basic and Clinical Pharmacology, Thu 286, 17-23 July, 2010, Copenhagen, Denmark.
  3. 3) Muramatsu M., Yamamoto S., Osawa T., and Shibuya M.: Involvement of Flt-1 signal in solid tumor growth and tumor angiogenesis via recruitment of macrophage-lineage cells. American Association for Cancer Research 101st Annual Meeting, 2010, 4, 17-21, Washington D.C.
  4. Yamamoto S, Muramatsu M, Azuma E, Dohmoto M, Koo BN, Mukouyama Y, Osawa T, Takahashi H, Takano KI, Watanabe Y, Ikutani M, Nagai Y, Takatsu K, Usui I, Tobe K, Niida S, Shibuya M, Matsuda N, Hattori Y: NG2 positive cerebral microvascular pericytes are potentially derived from circulating myeloid progenitors. The 16th International Vascular Biology Meeting, June 20-24, 2010, UCLA, Los Angeles, California: #838 (W99).
  5. Yamamoto S, Muramatsu M, Azuma E, Dohmoto M, Osawa T, Takahashi H, Takano KI, Ikutani M, Nagai Y, Takatsu K, Usui I, Tobe K, Niida S, Shibuya M, Matsuda N, Hattori Y: Cerebrovascular pericytes are potentially derived from the circulating myeloid progenitors. Keystone Symposia, Angiogenesis in Health and Disease, Feb 28-Mar 5, 2010, Keystone, Colorado: 321.
  6. Matsuda N, Hattori Y, Yamamoto S, Teramae H, Koike K: Inhaled TAK1 siRNA improves lung inflammation and apoptosis by reducing transcriptional activity of NF-κB and AP-1 in septic mice. Society of Critical Care Medicine 39th Critical Care Congress, Jan 9-13, 2010,Miami.

2009

【Ⅰ】Publications


Original Papers
  1. Yamazaki H, Ohi Y, Haji A: Mu-opioid and N-methyl-D-aspartate receptors are localized at laryngeal motoneurons of guinea pigs. Biol Pharm Bull. 32(2):293-296, 2009. [IF 1.765]
  2. Matsuda N, Yamamoto S, Yokoo H, Tobe K, Hattori Y: Nuclear factor-kappaB decoy oligodeoxynucleotides ameliorate impaired glucose tolerance and insulin resistance in mice with cecal ligation and puncture-induced sepsis. Crit Care Med 37 (10), 2791-2799, 2009. [IF 6.594]
  3. Hatakeyama N, Sakuraya F, Matsuda N, Kimura J, Kinoshita H, Kemmotsu O, Yamazaki M, Hattori Y: Pharmacological Significance of the Blocking Action of the Intravenous General Anesthetic Propofol on the Slow Component of Cardiac Delayed Rectifier K+ Current. J Pharmacol Sci, Vol. 110 (3), 334-343, 2009. [IF 2.599]
  4. Matsuda N, Yamamoto S, Takano KI, Kageyama SI, Kurobe Y, Yoshiwara Y, Takano Y, Hattori Y: Silencing of Fas-associated Death Domain Protects Mice from Septic Lung Inflammation and Apoptosis. Am J Respir Crit Care Med, 179: 806-815, 2009. [IF 9.792]

【Ⅱ】International Conferences


  1. Matsuda N, Hattori Y, Yamamoto S, Yamazaki H, Koike K: Impact of transcription factor decoy to AP-1 on the Lung apoptosis of septic mice. Society of critical Care Medicine 38th Critical Care Congress, 2009, 1, 31- 2, 4, Nashville.
  2. Matsuda N, Hattori Y, Hatakeyama N, Koike K: Acute lung inflammation induced by blood stream infection of candida glabrata in mice. Society of critical Care Medicine 38th Critical Care Congress, 2009, 1, 31- 2, 4, Nashville.
  3. Matsuda N, Hattori Y, Hatakeyama N, Koike K: Fluid resuscitation in rabbitas with endotozemic shock. Impact on regulation of NF-kappaB activation and production of inflammatory molecules. Society of critical Care Medicine 38th Critical Care Congress, 2009, 1, 31- 2, 4, Nashville.
  4. Hatakeyama N, Matsuda N, Yamamoto S, Aoki Y, Hattori Y, Yamazaki M: Involvement of Ca2+ and Na+ Channels in the mechanism of tachyarrhythmia in septic guinera pig atrium.Society of critical Care Medicine 38th Critical Care Congress, Jan 31-Feb 4, 2009, Nashville
  5. Yamamoto S: Vascular mural cells are potentially derived from the circulating myeloid progenitors. The 1st Toyama University-Chungnam National University Joint International Symposium, February 5-7, 2009, Chungnam National University, Daejeon, Korea.

2008

【Ⅰ】Publications


Original Papers
  1. Kamiyama K, Matsuda N, Yamamoto S, Takano Y, Yamazaki H, Takano K, Kageyama S, Yokoo H, Nagata T, Hatakeyama N, Tsukada K, Hattori Y: Modulation of glucocorticoid receptor expression, inflammation, and cell apoptosis in septic guinea-pig lungs using methylprednisolone. Am J Physiol Lung Cell Mol Physiol 295: L998-L1006, 2008. [IF 4.214]
  2. Matsuda N, Yamazaki H, Takano K, Matsui K, Takano Y, Kemmotsu O, Hattori Y: Priming by lipopolysaccharide exaggerates acute lung injury and mortality in responses to peptidoglycan through up-regulation of Toll-like receptor-2 expression in mice. Biochem Pharmacol 75: 1065-75, 2008. [IF 4.006]
Review
  1. Hayashi T, Yano K, Matsui-Hirai H, Yokoo H, Hattori Y, Iguchi A: Nitric oxide and endothelial cellular senescence. Pharmacol. Ther. 120: 333-339, 2008. [IF 7.968]

【Ⅱ】International Conferences


  1. Urakabe S, Yamamoto S, Takano K, Yokoo H, Ikutani M, Nagai Y, Takatsu K, Matsuda N, Hattori Y: Yolk sac derived progenitor cells form cell clusters and differentiate into endothelial cells and smooth muscle cells. The 6th Korea-Japan Joint Symposium on Vascular Biology And The 16th Annual Meeting of the Japan Vascular Biology and Medicine Organization JOINT MEETING, kanazawa, Japan, D-05, December 3-5, 2008.
  2. Yamamoto S, Muramatsu M, Koo B, Mukouyama Y, Osawa T, Sagara H, Takahashi H, Takano K, Urakabe S, Niida S, Shibuya M, Matsuda N, Hattori Y: Hematopoietic cells generate pericytes and contribute the CNS vasculature during development. The 6th Korea-Japan Joint Symposium on Vascular Biology And The 16th Annual Meeting of the Japan Vascular Biology and Medicine Organization JOINT MEETING, kanazawa, Japan, D-06, December 3-5, 2008.
  3. Kageyama S, Matsuda N, Kageyama N, Yamamoto S, Takano K, Fukuoka J, Yokoo H, Hattori Y: Up-regulation of death receptors contributes to high glucose-induced apoptosis in human coronary artery endothelial cells. The 6th Korea-Japan Joint Symposium on Vascular Biology And The 16th Annual Meeting of the Japan Vascular Biology and Medicine Organization JOINT MEETING, kanazawa, Japan, K-01, December 3-5, 2008.
  4. Muramatsu M, Yamamoto S, Shibuya M: Involvment of VEGFR-1 signal in solid tumor growth via promotion of macrophage-lineage cells function. The 6th Korea-Japan Joint Symposium on Vascular Biology And The 16th Annual Meeting of the Japan Vascular Biology and Medicine Organization JOINT MEETING, kanazawa, Japan, A-20, December 3-5, 2008.
  5. Yamamoto S, Muramatsu M, Osawa T, Sagara H, Murakami M, Takahashi H, Matsuda N, Hattori Y, Niida S, Shibuya M: Blood cell marker positive cells contribute to angiogenesis during the period of neurogenesis in the central nervous system. 15th International Vascular Biology Meeting, Sydney, Australia, P275, June 1-5, 2008.
  6. Matsuda N, Koike K, Kageyama SI, Yamamoto S, Hatakeyama N, Takano Y, Hattori Y: Gene silencing of FADD with small interfering RNA improves septic survival by prevention of apoptosis in main organs. Society of critical Care Medicine 37th Critical Care Congress, Honolulu, USA, Feb 2-6, 2008.
  7. Hatakeyama N, Aoki Y, Hattori Y, Yamazaki M, matsuda N: Mechanism of tachyarrhythmia in septic guinea pig atrial myocyte. Society of critical Care Medicine 37th Critical Care Congress, Honolulu, USA, Feb 2-6, 2008.
  8. Yamamoto S, Muramatsu M, Osawa T, Sagara H, Murakami M, Takahashi H, Matsuda N, Hattori Y, Niida S, Shibuya M: Pericyte recruitment during the neurogenesis period of the central nervous system. NAVBO, Developmental Vascular Biology Workshop III, Asilomar Conference Center, Pacific Grove, California, USA, 041, Jan 30-Feb 2, 2008.

2007

【Ⅰ】Publications


Original Papers
  1. Miyazaki-Akita A., Hayashi T., Ding QF., Shiraishi H., Nomura T., Hattori Y., and Iguchi A.: 17β-Estradiol antagonizes the down-regulation of endothelial nitric-oxide synthase and GTP cyclohydrolase I by high glucose: Relevance to postmenopausal diabetic cardiovascular disease. J Pharmacol Exp Ther, 320 (2): 591-598, 2007. [IF 3.956]
  2. Jesmin S., Zaedi S., Shimojo N., Iemitsu M., Masuzawa K., Yamaguchi N., Mowa CN., Hattori Y., and Miyauchi T.: Endothelin antagonism normalizes VEGF signaling and cardiac function in STZ-induced diabetic rat hearts. Am J Physiol Endocrinol Metab, 292 (4): 1030-1040, 2007. [IF 4.123]
  3. Shimojo N., Jesmin S., Zaedi S., Otsuki T., Maeda S., Yamaguchi N., Aonuma K., Hattori Y., and Miyauchi T.: Contributory role of VEGF overexpression in endothelin-1-induced cardiomyocyte hypertrophy. Am J Physiol Heart Circ Physiol, 293 (1): H474-H481, 2007. [IF 3.724]
  4. Fukatsu A., Hayashi T., Miyazaki-Akita A., Matsui-Hirai H., Furutate Y., Ishitsuka A., Hattori Y., and Iguchi A.: Possible usefulness of apocynin, an NADPH oxidase inhibitor, for nitrate tolerance: prevention of NO donor-induced endothelial cell abnormalities. Am J Physiol Heart Circ Physiol, 293 (1): H790-H797, 2007. [IF 3.724]
  5. Ohi Y., Ishii Y., Haji A., Noguchi S., Sasaoka T., Fujimori T., Nabeshima T., Sasahara M., and Hattori Y.: Platelet-derived growyh factor (PDGF)-BB inhibits AMPA receptor-mediated synaptic transmission via PDGF receptor-β in murine nucleus tractus solitarius. Brain Res, 1159: 77-85, 2007. [IF 2.341]
  6. Matsuda N., Takano Y., Kageyama S., Hatakeyama N., Shakunaga K., Kitajima I., Yamazaki M., and Hattori Y.: Silencing of caspase-8 and caspase-3 by RNA interference prevents vascular endothelial cell injury in mice with endotoxic shock. Cardiovasc Res, 76 (1): 132-140, 2007. [IF 5.826]
  7. Yokoo H., Nemoto T., Yanagita T., Satoh S., Yoshikawa N., Maruta T., and Wada A.: Glycogen synthase kinase-3β: homologous regulation of cell surface insulin receptor level via controlling insulin receptor mRNA stability in adrenal chromaffin cells. J Neurochem, 103(5): 1883-96, 2007. [IF 4.260]
Reviews
  1. Hattori Y, Yamamoto S, Matsuda N: Sympathetic control of VEGF angiogenic signaling. Dual regulations by alpha2-adrenoceptor activation? Circ Res, 101 (7): 642-644, 2007. [IF 9.854]
  2. Matsuda N., and Hattori Y.: Vascular biologyin sepsis: pathophysiological and therapeutic significance of vascular dysfunction. J Smooth Muscle Res, 43 (4): 117-137, 2007.

【Ⅱ】International Conferences


  1. Muramatsu M., Murakami M., Yamamoto S., Wang F., Yamauchi M., Shibuya M.: Suppression of Solid Tumor Growth in VEGF Receptor-1 Tyrosine Kinase-deficient mouse. The First Pacific Meeting for Angiogenesis and Lymphangiogenesis, 2007,11,12-14,Korea.

2006

【Ⅰ】Publications


Original Papers
  1. Haji A, Ohi Y: Ryanodine receptor/Ca2+ release mechanisms in rhythmically active respiratory neurons of cats in vivo. Neuroscience 140, 343-354, 2006. [IF 3.410]
  2. Matsuda N, Nishihira J, Takahashi Y, Kemmotsu O, Hattori Y: Role of macrophage migration inhibitory factor in acute lung injury in mice with acute pancreatitis complicated by endotoxemia. Am J Respir Cell Mol Biol 35, 198-205, 2006. [IF 3.988]
  3. Matsuda N, Hayashi T, Takahashi Y, Hattori Y: Phosphorylation of endothelial nitric-oxide synthase is diminished in mesenteric arteries from septic rabbits depending on the altered phosphatidylinositol 3-kinase/Akt pathway: Reversal effect of fluvastatin therapy. J Pharmacol Exp Ther 319, 1348-1354, 2006. [IF 4.098]
  4. Morimura K, Ohi Y, Yamamura H, Ohya S, Muraki K, Imaizumi Y: Two-step Ca2+ intracellular release underlies excitation-contraction coupling in mouse urinary bladder myocytes. Am J Physiol Cell Physiol 290, C388-C403, 2006. [IF 3.942]
  5. Minamizawa K, Goto H, Ohi Y, Shimada Y, Terasawa K, Haji A: Effect of d-pseudoephedrine on cough reflex and its mode of action in guinea pigs. J Pharmacol Sci 102, 136-142, 2006. [IF 1.792]
  6. Hayashi T, Matsui-Hirai H, Miyazaki-Akita A, Fukatsu A, Funami J, Ding Q-F, Kamalanathan S, Hattori Y, Ignarro LJ, Iguchi A: Endothelial cellular senescence is inhibited by nitric oxide: Implications in atheroscleorosis associated with menopause and diabetes. Proc Natl Acad Soc USA 103, 17018-17023, 2006. [IF 10.231]
  7. Jesmin S, Hattori Y, Maeda S, Zaedi S, Sakuma I, Miyauchi T: Subdepressor dose of benidipine ameliorates diabetic cardiac remodeling accompanied by normalization of upregulated endothelin system in rats. Am J Physiol Heart Circ Physiol 290, H2146-H2154, 2006. [IF 3.560]
Review
  1. Matsuda N, Hattori Y: Systemic inflammatory response syndrome (SIRS): Molecular pathophysiology and gene therapy. J Pharmacol Sci 101, 189-198, 2006. [IF 1.792]

【Ⅱ】International Conferences


  1. Matsuda N,Hattori Y, Takahashi Y,Gando S: Prevention of sepsis-induced acute lung injury by small interfering RNA for inhibition of tissue factor expression. Society of Critical Care Medicine 35th Critical Care Congress Jan 7-11 2006, San Francisco, CA.
  2. Matsuda N,Hattori Y,Takahashi Y,Gando S,Kemmotsu O: Sepsis-induced changes in the signaling mechanisms for glucose transport 4 translocation to the membrane. Society of Critical Care Medicine 35th Critical Care Congress Jan 7-11 2006, San Francisco, CA.
  3. Gando S,Matsuda N,Sawamura A,Hayakawa M: High macrophage migration inhibitory factor levels in disseminated intravascular coagulation patients with septic inflammatory response syndrome and sepsis. Society of Critical Care Medicine 35th Critical Care Congress Jan 7-11 2006, San Francisco, CA.
  4. Matsuda N: Altered signaling transduction of glucose transport 4 translocation to the membrane in sepsis-induced hyperglycemia. The 6th Joint Scientific Congress of Korean-Japanese Intensivist Symposium. March 2,2006, Osaka.
  5. Matsuda N,Hattori Y, Gando S: siRNA targeting caspase-3 and -8 prevents endothelial cell derangements in septic mice. Europian Society of Intensive Care Medicine 19th Annual Congress. Sep 24-27, 2006,Barcelona.
  6. Matsuda N,Yamazaki Y,Hattori Y: Reversal effects of fluvastatin on Akt activity in the mesenteric artery of septic rabbits. 2006 Annual Meeting of American Society of Anesthesiologysts, Oct 15, 2006, Chicago.
  7. Hama K,Kinoshita H,Matsuda N,Tohyama S,Hatano Y: Sevoflurane but not propofol inhibits activity of Rho kinase in the porcine coronary artery. 2006 Annual Meeting of American Society of Anesthesiologysts. Oct 15, 2006, Chicago.
  8. Matsuda N,Yamazaki Y,Hattori Y: Pro-apoptotic gene silencing in septic mouse aorta by small interfering RNA. 2006 Annual Meeting of American Society of Anesthesiologysts the Special ASCCA/Journal Session. Oct 16 2006, Chicago.
  9. Kamiyama K,Matsuda N,Nagata T,Tsukada K,Hattori Y: Cardiac expression of glucocorticoid receptor α in mice. International Society for Heart Resarch 23th Annual Meeting, Dec 1-2 2006, Chiba.

2005

【Ⅰ】Publications


Original Papers
  1. Ohi Y, Yamazaki H, Takeda R, Haji A: Functional and morphological organization of the nucleus tractus solitarious in the fictive cough reflex of guinea pigs. Neurosci Res 53: 201-209, 2005. [IF 2.155]
  2. Yamazaki H, Haji A, Ohi Y, Takeda R: Effects of progesterone on apneic events during behaviorally defined sleep in male rats. Life Sci 78: 383-388. [IF 2.158]
  3. Zhao W, Daemanin S, Fu Q, Chen J, Cui H, Wang J, Okada F, Hamada J, Hattori Y, Kondo T, Hamuro J, Asaka M, Kobayashi M: Hypoxia suppresses the production of matrix metalloproteinases and the migration of human monocyte-derived dendritic cells. Eur J Immunol 35: 3468-3477, 2005. [IF 5.005]
  4. Matsuda N, Hattori Y, Jesmin S, Gando S: Nuclear factor-κB decoy oligodeoxynucleotides prevent acute lung injury in mice with cecal ligation and puncture-induced sepsis. Mol Pharmacol 67: 1018-1025, 2005. [IF 5.080]
  5. Jesmin S, Hattori Y, Togashi H, Ueno K, Yoshioka M, Sakuma I: Age-related changes in cardiac expression of VEGF and its angiogenic receptor KDR in stroke-prone spontaneously hypertensive rats. Mol Cell Biochem 272: 63-73, 2005. [IF 1.714]

【Ⅱ】International Conferences


  1. Matsuda N, Hattori Y, Gando S, Kemmotsu O: AP-1 decoy oligonucleotides can improve acute lung injury by suppressing upregulation of inflammatory receptors and enzymes in septic mice. Society of Critical Care Medicine, 34th Critical Care Congress. January 2005, Phoenix.
  2. Matsuda N, Hattori Y, Gando S, Kemmotsu O: Olprinon normalizes eNOS phosphorylation via upregulation of VEGF and HGF in mesenteric arteries from endotoxemic rabbits. Society of Critical Care Medicine, 34th Critical Care Congress. January 2005, Phoenix.

page top