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Outline

Public health is the process of mobilizing and engaging local, state, national, and international resources to assure the conditions in which people can be healthy. The scope of our activity covers all the important fields of social medicine. If you have some interest in our department, please feel free to contact with us.
TEL +81-76-434-7275
FAX+81-76-434-5023
Please add "@med.u-toyama.ac.jp" to Email.

Research Interest

  1. Epidemiological Study on Children's Environmental Health
  2. Fundamental Study of Environmental Chemicals
  3. Prevention of Non-communicable Diseases
  4. Occupational Health

Members

  • Professor and Chairman:
    Hidekuni INADERA, MD and PhD. Email: inadera
  • Associate Professor:
    Kei HAMAZAKI, MD and PhD. Email: keihama
  • Assistant Professor:
    ZG CUI, MD and PhD. Email: sai
  • Assistant Professor:
    Akiko TSUCHIDA, MSc. Email: aktsuchi

Selected Publications

2018

◆ Original articles

  1. Mitsuda N, Eitoku M, Yamasaki K, Sakaguchi M, Yasumitsu-Lovell K, Maeda N, Fujieda M, Suganuma N; Japan Environment & Children’s Study (JECS) Group. Nausea and vomiting during pregnancy associated with lower incidence of preterm births: the Japan Environment and Children's Study (JECS). BMC Pregnancy Childbirth. 2018 Jun 27; 18(1): 268.
  2. Michikawa T, Nitta H, Nakayama SF, Yamazaki S, Isobe T, Tamura K, Suda E, Ono M, Yonemoto J, Iwai-Shimada M, Kobayashi Y, Suzuki G, Kawamoto T; Japan Environment and Children’s Study Group. Baseline profile of participants in the Japan Environment and Children’s Study (JECS). J Epidemiol. 2018 Feb 5; 28(2): 99-104.
  3. Cui ZG, Jin YJ, Sun L, Zakki SA, Li ML, Feng QW, Kondo T, Ogawa R, Inadera H. Potential hazards of fenvalerate in massive pollution influence the apoptosis sensitivity. J Appl Toxicol. 2018 Feb; 38(2): 240-7.
  4. Zakki SA, Cui ZG, Sun L, Feng QW, Li ML, Inadera H. Baicalin augments hyperthermia-induced apoptosis in U937 cells and modulates the MAPK pathway via ROS generation. Cell Physiol Biochem. 2018; 45(6): 2444-60.
  5. Hamazaki K, Takamori A, Tsuchida A, Kigawa M, Tanaka T, Ito M, Adachi Y, Saito S, Origasa H, Inadera H, and Japan Environment and Children’s Study (JECS) Group. Dietary intake of fish and n-3 polyunsaturareted fatty acids and risks of perinatal depression: The Japan Environment and Children’s Study (JECS). J Psychiatr Res. 2018 Mar; 98: 9-16.
  6. Sun L, Cui ZG, Zakki SA, Feng QW, Li ML, Inadera H. Mechanistic study of nonivamide enhancement of hyperthermia-induced apoptosis in U937 cells. Free Rad Biol Med. 2018 May 20; 120: 147-59.
  7. Tanaka R, Tsuji M, Senju A, Kusuhara K, Kawamoto T, Japan Environment and Children’s Study Group. Dietary differences in male workers among smaller occupational groups within large occupational categories: Findings from the JapanEnvironment and Children'sStudy (JECS). Int J Environ Res Public Health. 2018 May 11; 15(5). pii: E961.
  8. Hamazaki K, Iso H, Eshak E.S, Ikehara S, Ikeda A, Iwasaki M, Hamazaki T, Tsugane S, for the JPHC Study Group. Plasma Levels of n-3 Fatty Acids and Risk of Coronary Heart Disease Among Japanese: The Japan Public Health Center-based (JPHC) Study. Atherosclerosis. 2018 May; 272: 226-32.
  9. Watanabe N, Matsuoka Y, Kumachi M, Hamazaki K, Horikoshi M, Furukawa TA. Omega-3 fatty acids for a better mental state in working populations - Happy Nurse Project: A 52-week randomized controlled trial. J Psychiatr Res. 2018 Jul; 102: 72-80.
  10. Yamamoto-Hanada K, Ishitsuka K, Pak K, Saito M, Ayabe T, Mezawa H, Konishi M, Yang L, Matsumoto K, Saito H, Ohya Y; Japan Environment and Children's Study (JECS) Group. Allergy and mental health among pregnant women in the JapanEnvironment and Children'sStudy. J Allergy Clin Immunol Pract. 2018July-Aug; 6(4): 1421-4.e2.
  11. Ishikawa T, Obara T, Nishigori H, Nishigori T, Metoki H, Ishikuro M, Tatsuta N, Mizuno S, Sakurai K, Nishijima, Murai Y, Fujiwara I, Arima T, Nakai K, Yaegashi N, Kuriyama S, Mano N; JECS Group. Update on the prevalence and determinants of folic acid use in Japan evaluated with 91 538 pregnant women: the Japan Environment and Children'sStudy. J Matern Fetal Neonatal Med. 2018 Aug; 19: 1-10.
  12. Tanaka R, Tsuji M, Asakura K, Senju A, Shibata E, Kusuhara K, Morokuma S, Sanefuji M, Kawamoto T; Japan Environment and Children’s Study Group. Variation in men's dietary intake between occupations, based on data from the Japan Environment and Children's Study. Am J Mens Health. 2018 Sep; 12(5): 1621-34.
  13. Saito M, Yamamoto-Hanada K, Pak K, Ayabe T, Mezawa H, Ishitsuka K, Konishi M, Yang L, Matsumoto K, Saito H, Ohya Y; Japan Environment and Children's Study (JECS) Group. Having small-for-gestational-age infants was associated with maternal allergic features in the JECS birth cohort. Allergy. 2018 Sep; 73(9): 1908-11.
  14. Iwai-Shimada M, Nakayama SF, Isobe T, Michikawa T, Yamazaki S, Nitta H, Takeuchi A, Kobayashi Y, Tamura K, Suda E, Ono M, Yonemoto J, Kawamoto T; Japan Environment and Children’s Study Group. Questionnaire results on exposure characteristics of pregnant women participating in the Japan Environment and Children Study (JECS). Environ Health Prev Med. 2018 Sep 15; 23(1): 45.
  15. Piao JL, Jin YJ, Li ML, Zakki SA, Sun L, Feng QW, Zhou D, Kondo T, Cui ZG, Inadera H. Excessive oxidative stress in the synergistic effects of shikonin on the hyperthermia-indeced apoptosis. Curr Mol Med. 2018 Oct; 18(5): 322-34.
  16. Takami M, Tsuchida A, Takamori A, Aoki S, Ito M, Kigawa M, Kawakami C, Hirahara F, Hamazaki K, Inadera H, Ito S, and the Japan Environment & Children’s Study (JECS) Group. Effects of physical activity during pregnancy on preterm delivery and mode of delivery: The Japan Environment and Children's Study, birth cohort study. PLoS One. 2018 Oct 29;13(10): e0206160.
  17. Tsuji M, Shibata E, Morokuma S, Tanaka R, Senju A, Araki S, Sanefuji M, Koriyama C, Yamamoto M, Ishihara Y, Kusuhara K, Kawamoto T; Japan Environment & Children's Study Group. The association between whole blood concentrations of heavy metals in pregnant women and premature births: The Japan Environment and Children's Study (JECS). Environ Res. 2018 Oct; 166: 562-9.
  18. Oguri T, Ebara T, Nakayama SF, Sugiura-Ogasawara M, Kamijima M; Japan Environment and Children’s Study Group. Association between maternal blood cadmium and lead concentrations and gestational diabetes mellitus in the JapanEnvironment and Children'sStudy. Int Arch Occup Environ Health. 2018 Oct 30. doi: 10.1007/s00420-018-1367-7.
  19. Sugiura-Ogasawara M, Ebara T, Yamada Y, Shoji N, Matsuki T, Kano H, Kurihara T, Omori T, Tomizawa M, Miyata M, Kamijima M, Saitoh S; Japan Environment, Children’s Study (JECS) Group. Adverse pregnancy and perinatal outcome in patients with recurrent pregnancy loss: Multiple imputation analyses with propensity score adjustment applied to a large-scale birth cohort of the JapanEnvironment and Children'sStudy. Am J Reprod Immunol. 2018 Nov 14; e13072.
  20. Tsuchida A, Hamazaki K, Matsumura K, Miura K, Kasamatsu H, Inadera H, Japan Environment and Children's Study (JECS). Changes in the association between postpartum depression and mother-infant bonding by parity: Longitudinal results from the Japan Environment and Children's Study. J Psychiatric Res. 2018 Nov 28; 110: 110-16.
  21. Yoshida T, Matsumura K, Tsuchida A, Hamazaki K, Inadera H; Japan Environment and Children’s Study Group. Association between cesarean section and constipation in infants: The Japan Environment and Children’s Study (JECS). BMC Res Notes. 2018 Dec 12; 11(1): 882.
  22. Tanaka R, Tsuji M, Kusuhara K, Kawamoto T; Japan Environment and Children’s Study Group. Association between time-related work factors and dietary behaviors: results from the Japan Environment and Children's Study (JECS). Environ Health Prev Med. 2018 Dec 14; 23(1): 62.
  23. Morisaki N, Nagata C, Yasuo S, Morokuma S, Kato K, Sanefuji M, Shibata E, Tsuji M, Senju A, Kawamoto T, Ohga S, Kusuhara K; Japan Environment and Children’s Study Group. Optimal protein intake during pregnancy for reducing the risk of fetal growth restriction: the JapanEnvironment and Children'sStudy. Br J Nutr. 2018 Dec; 120(12): 1432-40.
  24. Okubo R, Noguchi H, Hamazaki K, Sekiguchi M, Kinoshita T, Katsumata N, Narisawa T, Uezono Y, Xiao J, Matsuoka YJ. Association between blood polyunsaturated fatty acid levels and depressive symptoms in breast cancer survivors. Prostaglandins Leukot Essent Fatty Acids. 2018 Dec; 139: 9-13.

◆ Review articles

  1. Okubo R, Chen C, Sekiguchi M, Hamazaki K, Matsuoka YJ. Mechanisms underlying the effects of n-3 polyunsaturated fatty acids on fear memory processing and their hypothetical effects on fear of cancer recurrence in cancer survivors. Prostaglandins Leukot Essent Fatty Acids. 2018 Apr; 131: 14-23.

2017

◆ Books

  1. Ogawa R, Kagiya G, Watanabe A, Morii A, Cui ZG, Kondo T. A Simple Method for Constructing Artificial Promoters Activated in Response to Ultrasound Stimulation. Methods Mol Biol 2017 .

◆ Original articles

  1. Hamazaki K, Maekawa M, Toyota T, Dean B, Hamazaki T, Yoshikawa T. Fatty acid composition of the postmortem corpus callosum of patients with schizophrenia, bipolar disorder, or major depressive disorder. Eur Psychiat 2017 Jan; 39:51-56
  2. Sakurai K, Nishigori H, Nishigori T, Mizuno S, Obara T, Iwama N, Watanabe Z, Ishikuro M, Tatsuta N, Nishijima I, Sugawara J, Fujiwara I, Arima T, Kuriyama S, Metoki H, Takahashi F, Nakai K, Yaegashi N; Japan Environment & Children’s Study Group. Incidence of domestic violence against pregnant females after the Great East Japan Earthquake in Miyagi prefecture: The JapanEnvironment and Children's Study. Disaster Med Public Health Prep. 2017 Apr;11(2):216-226.
  3. Nishigori H, Obara T, Nishigori T, Metoki H, Ishikuro M, Mizuno S, Sakurai K, Tatsuta N, Nishijima I, Fujiwara I, Arima T, Nakai K, Mano N, Kuriyama S, Yaegashi N; Japan Environment & Children's Study Group. Drug use before and during pregnancy in Japan: The JapanEnvironment and Children'sStudy. Pharmacy (Basel) 2017Apr 10; 5(2).
  4. Nishigori H, Obara T, Nishigori T, Mizuno S, Metoki H, Hoshiai T, Watanabe Z, Sakurai K, Ishikuro M, Tatsuta N, Nishijima I, Fujiwara I, Kuriyama S, Arima T, Nakai K, Yaegashi N; Japan Environment & Children's Study Group. Selective serotonin reuptake inhibitors and risk of major congenital anomalies for pregnancies in Japan:A nationwide birth cohort study of the Japan Environment and Children’s Study (JECS).Congenit Anom (Kyoto). 2017 May;57(3):72-78.
  5. Nishigori H, Nishigori T, Sakurai K, Mizuno S, Obara T, Metoki H, Watanabe Z, Iwama N, Ishikuro M, Tatsuta N, Nishijima I, Sugawara J, Kuriyama S, Fujiwara I, Arima T, Nakai K, Takahashi F, Yaegashi N; Japan Environment & Children’s Study Group. Pregnant women's awareness of social capital in the Great East Japan Earthquake-affected areas of Miyagi prefecture: The JapanEnvironment and Children's Study. Disaster Med Public Health Prep. 2017 Jun;11(3):355-364.  
  6. Muchanga SMJ, Yasumitsu-Lovell K, Eitoku M, Mbelambela EP, Ninomiya H, Komori K, Tozin R, Maeda N, Fujieda M, Suganuma N; Japan Environment and Children's Study Group. Precoception gynecological risk factors of postpartum depression among Japanese women: The Japan Environment and Children’s Study (JECS). J Affect Disord. 2017 Aug 1;217:34-41.
  7. Morokuma S, Shimokawa M, Kato K, Sanefuji M, Shibata E, Tsuji M, Senju A, Kawamoto T, Kusuhara K; Japan Environment & Children’s Study Group. Maternal sleeep and small for gestational age infants in the Japan Environment and Children’s Study;a cohort study BMC Res Notes. 2017 Aug 11;10(1):394.
  8. Yamamoto-Hanada K, Yang L, Ishitsuka K, Ayabe T, Mezawa H, Konishi M, Shoda T, Matsumoto K, Saito H, Ohya Y; Japan Environment and Children’s Study Group. Allergic profiles of mothers and fathers in the Japan Environment and Children’s Study (JECS): a nationwide birth cohort study. World Allergy Organ J. 2017 Aug 7;10(1):24.
  9. Yamashita A, Noguchi N, Hamazaki K, Sato Y, Narisawa T, Kawashima Y, Usuki M, Nishi D, Yoshimasu H, Horikawa N, Matsuoka YJ. Serum polyunsaturated fatty acids and risk of psychiatric disorder after acute coronary syndrome: a prospective cohort study. J Affect Disord. 2017 Aug; 15;218:306-312
  10. Matsuoka YJ, Sawada N, Mimura M, Shikimoto R, Nozaki S, Hamazaki K, Uchitomi Y, Tsugane S. Dietary fish, n-3 polyunsaturated fatty acid consumption, and depression risk in Japan: a population-based prospective cohort study. Transl Psychiatry 2017 Sep; 26:7(9):e1242
  11. Maekawa M, Watanabe A, Iwayama Y, Kimura T, Hamazaki K, Balan S, Ohba H, Hisano Y, Nozaki Y, Ohnishi T, Toyoshima M, Shimamoto C, Iwamoto K, Bundo M, Osumi N, Takahashi E, Takashima A, Yoshikawa T. Polyunsaturated fatty acid deficiency during neurodevelopment in mice models the prodromal state of schizophrenia through epigenetic changes in nuclear receptor genes. Transl Psychiatry 2017 Sep; 5;7(9):e1229
  12. Noguchi H, Nishi D, Matsumura K, Hamazaki K, Hamazaki T, Matsuoka YJ. Limited effect of omega-3 fatty acids on the quality of life in survivors of traumatic injury: A randomized, placebo-controlled trial Prostaglandins Leukot Essent Fatty Acids. 2017 Dec; 127:1-5

◆ Review articles

  1. Inadera H. Personal perspective on Environmental Health and Preventive Medicine. Environ Health Prev Med (2017) 22:16

2016

◆ Books

  1. Hamazaki T, Hamazaki K. Handbook of Lipids in Human Function: Fatty Acids. 米国: Elsevier; 2016. Chapter 17, What Are the Physiological Roles of Mead Acid (5,8,11-Eicosatrienoic Acid)? p. 483-497.
  2. Ogawa R, Morii A, Watanabe A, Cui ZG, Kondo T. (2016). Bioeffects of Ultrasound and Its Therapeutic Application. In:Muthupandian AshokkumarSpriger. Handbook of Ultrasonics and Sonochemistry, 1-26. Singapore: Springer.

◆ Original articles

  1. Watanabe Z, Iwama N, Nishigori H, Nishigori T, Mizuno S, Sakurai K, Ishikuro M, Obara T, Tatsuta N, Nishijima I, Fujiwara I, Nakai K, Arima T, Takeda T, Sugawara J, Kuriyama S, Metoki H, Yaegashi N; Japan Environment & Children's Study Group. Psychological distress during pregnancy in Miyagi after the Great East Japan Earthquake: The Japan Environment and Children's Study. J Affect Disord 2016 Jan 15; 190:341-348.
  2. Hamazaki K, Harauma A, Otaka Y, Moriguchi T, Inadera H. Serum n-3 polyunsaturated fatty acids and psychological distress in early pregnancy: Adjunct case-control study of the Japan Environment and Children's Study. Transl Psychiatry 2016 Feb 16;6:e737.
  3. Yoneda N, Yoneda S, Niimi H, Ueno T, Hayashi S, Ito M, Shiozaki A, Urushiyama D, Hata K, Suda W, Hattori M, Kigawa M, Kitajima I, Saito S. Polymicrobial Amniotic Fluid Infection with Mycoplasma/Ureaplasma and Other Bacteria Induces Severe Intra-Amniotic Inflammation Associated with Poor Perinatal Prognosis in Preterm Labor. Am J Reprod Immunol. 2016.Feb. 75(2): 112-125
  4. Yoneda S, Shiozaki A, Yoneda N, Ito M, Shima T, Fukuda K, Ueno T, Niimi H, Kitajima I, Kigawa M, Saito S. Antibiotic therapy increases the risk of preterm birth in preterm labor without intra-amniotic microbes, but may prolong the gestation period in preterm labor with microbes, evaluated by rapid and high sensitive PCR system. Am J Reprod Immunol. 2016 Apr 75(4): 440-450
  5. Kanatani KT, Hamazaki K, Inadera H, Sugimoto N, Shimizu A, Noma H, Onishi K, Takahashi Y, Itazawa T, Egawa M, Sato K, Go T, Ito I, Kurozawa Y, Konishi I, Adachi Y, Nakayama T; Japan Environment & Children's Study Group. Effect of desert dust exposure on allergic symptoms: A natural experiment in Japan.Ann Allergy Asthma Immunol. 2016 May; 116(5): 425-430.e7.
  6. Hamazaki K, Maekawa M, Toyota T, Iwayama Y, Dean B, Hamazaki T, Yoshikawa T. Fatty acid composition and fatty acid binding protein expression in the postmortem frontal cortex of patients with schizophrenia: A case-control study. Schizophr Res. 2016 Mar; 171(1-3):225-32.
  7. Hamazaki K, Suzuki N, Kitamura K, Hattori A, Nagasawa T, Itomura M, Hamazaki T. Is vaccenic acid (18:1t n-7) associated with an increased incidence of hip fracture? An explanation for the calcium paradox. Prostaglandins Leukot Essent Fatty Acids. 2016 Jun; 109:8-12.
  8. Kinoshita Y, Yoshizawa K, Hamazaki K, Emoto Y, Yuri T, Yuki M, Kawashima H, Shikata N, Tsubura A. Dietary effects of mead acid on N-methyl-N-nitrosourea-induced mammary cancers in female Sprague-Dawley rats. Biomed Rep. 2016 Jan; 4(1): 33-39.
  9. Nishi D, Su KP, Usuda K, Chiang YJ, Guu TW, Hamazaki K, Nakaya N, Sone T, Sano Y, Ito H, Isaka K, Hashimoto K, Hamazaki T, Matsuoka YJ. Omega-3 fatty acid supplementation for expectant mothers with depressive symptoms in Japan and Taiwan: an open-label trial. Psychiatry Clin Neurosci. 2016 Jun; 70(6):253-4.
  10. Sakurai K, Nishigori H, Nishigori T, Mizuno S, Obara T, Iwama N, Watanabe Z, Ishikuro M, Tatsuta N, Nishijima I, Sugawara J, Fujiwara I, Arima T, Kuriyama S, Metoki H, Takahashi F, Nakai K, Yaegashi N; Japan Environment & Children's Study Group. Incidence of domestic violence against pregnant females after the Great East Japan Earthquake in Miyagi Prefecture: The JapanEnvironment and Children's Study. Disaster Med Public Health Prep. 2016 Jul 27:1-11.
  11. Morokuma S, Shimokawa M, Kato K, Sanefuji M, Shibata E, Tsuji M, Senju A, Kawamoto T, Kusuhara K ; Japan Environment & Children's Study Group.Relationship between hyperemesis gravidarum and small-for-gestational-age in the Japanese population: the Japan Environment and Children's Study (JECS).BMC Pregnancy Childbirth 2016 Aug26; 16:247.
  12. Nishi D, Su KP, Usuda K, Chiang YJ, Guu TW, Hamazaki K, Nakaya N, Sone T, Sano Y, Tachibana Y, Ito H, Isaka K, Hashimoto K, Hamazaki T, Matsuoka YJ. The synchronized trial on expectant mothers with depressive symptoms by omega-3 PUFAs (SYNCHRO): Study protocol for a randomized controlled trial. BMC Psychiatry. 2016 Sep; 16(1):321.
  13. Mizuno S, Nishigori H, Sugiyama T, Takahashi F, Iwama N, Watanabe Z, Sakurai K, Ishikuro M, Obara T, Tatsuta N, Nishijima I, Fujiwara I, Arima T, Kuriyama S, Metoki H, Nakai K, Inadera H, Yaegashi N; Japan Environment & Children's Study Group. Association between social capital and the prevalence of gestational diabetes mellitus: An interim report of the Japan Environment and Children's Study. Diabetes Res Clin Pract. 2016 Oct; 120: 132-141.
  14. Hamazaki K, Harauma A, Tanabe S, Namai M, Moriguchi T, Inadera H. Association of serum n-3 polyunsaturated fatty acids with psychological distress in the second and third trimesters of pregnancy: Adjunct Study of Japan Environment and Children's Study. Prostaglandins Leukot Essent Fatty Acids 2016 Nov; 114:21-27.
  15. Harada T, Taniguchi F, Onishi K, Kurozawa Y, Hayashi K, Harada T; Japan Environment & Children's Study Group. Obstetrical complications in women with endometriosis: A cohort study in Japan. PloS One 2016 Dec 22: 11(12): e0168476.

  16. Suzuki K, Shinohara R, Sato M, Otawa S, Yamagata Z; Japan Environment & Children's Study Group. Association between maternal smoking during pregnancy and birth weight:an appropriately adjusted model from the Japan Environment and Children's Study. J Epidemiol 2016; 26(7): 371-377.
  17. Takahashi F, Nishigori H, Nishigori T, Mizuno S, Obara T, Metoki H, Sakurai K, Ishikuro M, Iwama N, Tatsuta N, Nishijima I, Fujiwara I, Arima T, Nakai K, Sugiyama T, Kuriyama S, Yaegashi N; Japan Environment & Children's Study Group. Fermented food consumption and psychological distress in pregnant women: a nationwide birth cohort study of the JapanEnvironment and Children's Study. Tohoku J Exp Med. 2016; 240(4): 309-321.

◆ Others

  1. Inadera H. Best reviewer award. Environ Health Prev Med 2016, 21(6):603.