1. Yokose J, Okubo-Suzuki R, Nomoto M, Ohkawa N, Nishizono H, Suzuki A, Matsuo M, Tsujimura S, Takahashi Y, Nagase M, Watabe AM, Sasahara M, Kato F, Inokuchi K. (2017)
    Overlapping memory trace indispensable for linking, but not recalling, individual memories.
    Science, 355: 398-403. doi:10.1126/science.aal2690
    論文要旨( Science へリンク)
    Topics へリンク( 論文内容、マスコミ報道 )

  1. 井ノ口馨:記憶をつくり変える. 日経サイエンス 11月号. 28-37, (2017)
  2. 横瀬 淳,井ノ口馨:個々の記憶どうしをつなぐ神経細胞集団のメカニズム. 実験医学 35, 1480-1483, (2017)

  1. 鈴木 章円,横瀬 淳,井ノ口 馨: 記憶想起,脳科学辞典(オンライン辞典), (2017)  記憶想起(脳科学辞典へリンク)
  2. 大川 宜昭,野本 真順,井ノ口 馨: 記憶固定化,脳科学辞典(オンライン辞典), (2017) doi:10.14931/bsd.7435  記憶固定化(脳科学辞典へリンク)


  1. Nomoto M., Ohkawa N., Nishizono H., Yokose J., Suzuki A., Matsuo M., Tsujimura S., Takahashi Y., Nagase M., Watabe A.M., Kato F., and Inokuchi K. (2016)
    ] Cellular tagging as a neural network mechanism for behavioral tagging.
    Nature Communications, 7: 12319. doi:10.1038/ncomms12319
    論文要旨( Nature Communications へリンク)
    Topics へリンク( 論文内容、マスコミ報道 )

  2. Okubo-Suzuki R., Saitoh Y., Shehata M., Zhao Q., Enomoto H., and Inokuchi K. (2016)
    Frequency-specific stimulations induce reconsolidation of long-term potentiation in freely moving rats.
    Molecular Brain, 9:36. doi:10.1186/s13041-016-0216-4
    論文要旨( Molecular Brain へリンク)
  1. 佐野良威,大川宜昭,鈴木章円,井ノ口 馨:記憶痕跡とメモリーアロケーション. 生体の科学・特集 記憶ふたたび, 67, 22-26, (2016)
  2. 井ノ口馨:虚記憶を創り出す:細胞集成体理論を基として. 神経心理学 32, 3-9, (2016)
  3. 鈴木章円,井ノ口馨:Q&A-神経科学の素朴な疑問 Q ど忘れはどうして起こるのですか?. 月刊 臨床神経科学 ブレインマシンインターフェース 34, 245, (2016)


  1. Omura Y., Carvalho M., Inokuchi K. and Fukai T. (2015) A lognormal recurrent network model for burst generation during hippocampal sharp waves. J. Neurosci., 35(43), 14585-14601. doi:10.1523/JNEUROSCI.4944-14.2015
    論文要旨(J. Neurosci. へリンク)

  2. Nihonmatsu I., Ohkawa N., Saitoh Y. and Inokuchi K. (2015) Targeting of ribosomal protein S6 to dendritic spines by in vivo high frequency stimulation to induce long-term potentiation in the dentate gyrus. Biology Open, 4, 1387-1394. doi: 10.1242/bio.013243
    論文要旨(Biology Open へリンク)

  3. Ohkawa N., Saitoh Y., Suzuki A., Tsujimura S., Murayama E., Kosugi S., Nishizono H., Matsuo M., Takahashi Y., Nagase M., Sugimura Y.K., Watabe A.M., Kato F., and Inokuchi K. (2015) Artificial Association of Pre-stored Information to Generate a Qualitatively New Memory. Cell Reports, Volume 11, Issue 2, p261-269, 14 April 2015. DOI: 10.1016/j.celrep.2015.03.017
    論文要旨(Cell Reports へリンク)

    【 論文内容の解説 】JST
    【 プレスリリース 】
     ◆ 日経新聞
     ◆ Nature
     ◆ EurekAlert
     ◆ SciGuru Science News
     ◆ 北日本新聞
     ◆ 4月3日のNHKニュースでも研究内容が紹介されました。

  4. Tsubota T., Okubo-Suzuki R., Ohashi Y., Tamura K., Ogata K., Yaguchi M., Matsuyama M., Inokuchi K., and Miyashita Y. (2015) Cofilin1 Controls Transcolumnar Plasticity in Dendritic Spines in Adult Barrel Cortex. PLoS. Biol., 13(2), e1002070. DOI: 10.1371/journal.pbio.1002070
    論文要旨(PLoS. Biol.へリンク)

  1. 大川宜昭,井ノ口馨:オプトジェネティクスによる記憶の操作. 実験医学 33, 3065-3069, (2015)

  1. 大川 宜昭, 浦川 将:記憶のダイナミクスとそのメカニズム,リハビリテーションのためのニューロサイエンス 脳科学からみる機能回復, メジカルビュー社,89-104 (2015)
  2. 井ノ口馨:記憶をあやつる,角川選書,角川書店,(2015)  著書紹介(角川書店へリンク)


  1. Sano Y., Shobe J.L., Zhou M., Huang S., Shuman T., Cai D.J., Golshani P., Kamata M. and Silva A.J. (2014) CREB Regulates Memory Allocation in the Insular Cortex. Curr. Biol., online 11/13. DOI: http://dx.doi.org/10.1016/j.cub.2014.10.018 論文要旨(Curr. Biol.へリンク)
  2. Lee Y.S., Ehninger D., Zhou M., Oh J.Y., Kang M., Kwak C., Ryu H.H., Butz D., Araki T., Cai Y., Balaji J., Sano Y., Nam C.I., Kim H.K., Kaang B.K., Burger C., Neel B.G. and Silva A.J. (2014) Mechanism and treatment for learning and memory deficits in mouse models of Noonan syndrome. Nat. Neurosci., online 11/10. doi:10.1038/nn.3863 論文要旨(Nat. Neurosci.へリンク)

  1. 佐野良威,井ノ口馨:メモリーアロケーションのメカニズム. 生体の科学 65, 482-483, (2014)
  2. Shehata M. and Inokuchi K. (2014) Does autophagy work in synaptic plasticity and memory? Reviews in the Neurosciences , 25, 543-557. doi:10.1016/j.celrep.2015.03.017 論文要旨(Reviews in the Neurosciencesへリンク)
  3. Kitamura T. and Inokuchi K. (2014) Role of the Adult Neurogenesis in Hippocampal-Cortical Memory Consolidation. Molecular Brain, 7, 13. doi:10.1186/1756-6606-7-13 論文要旨(Molecular Brainへリンク)

  1. Okada, D. and Inokuchi, K.: Activity-Dependent Protein Transport as a Synaptic Tag,in Synaptic Tagging and Capture (Sajikumar, S. ed.), Chapter 6, p79-98, Springer, New York (2015) doi:10.1007/978-1-4939-1761 -7   要旨(Springer, New Yorkへリンク)

  2. 辞典
    1. 鈴木 章円,大川 宜昭,野本 真順,井ノ口 馨: 記憶痕跡,脳科学辞典(オンライン辞典), (2014) doi:10.14931/bsd.3737  記憶痕跡(脳科学辞典へリンク)

    2. 翻訳
      1. 井ノ口 馨,野本真順: 第56章 経験とシナプス結合の精緻化,カンデル神経科学 第5版, メディカル・サイエンス・インターナショナル,1234-1257,(2014)   カンデル神経科学 第5版(メディカル・サイエンス・インターナショナルへリンク)
      2. 井ノ口 馨,横瀬 淳: 付録E ニューラルネットワーク,カンデル神経科学 第5版, メディカル・サイエンス・インターナショナル,1545-1566,(2014)   カンデル神経科学 第5版(メディカル・サイエンス・インターナショナルへリンク)


  1. 井ノ口馨:恐怖記憶研究鳥瞰-最近の知見と展望-. 不安障害研究 5, 13-21, (2013)

  1. 井ノ口馨:記憶をコントロールする-分子脳科学の挑戦-,岩波科学ライブラリー,岩波書店,(2013)  著書紹介(岩波書店へリンク)
  2. 井ノ口馨:スパインの動態と可塑性(真鍋俊也,森寿,渡辺雅彦,岡野栄之,宮川剛 編)  脳神経科学イラストレイテッド 改訂第3版,羊土社,52-57 (2013)


  1. Ohkawa N., Saitoh Y., Tokunaga E., Nihonmatsu I., Ozawa F., Murayama A., Shibata F., Kitamura T. and Inokuchi K. (2012) Spine formation pattern of adult-born neurons is differentially modulated by the induction timing and location of hippocampal plasticity. PLoS ONE, 7, e45270. doi:10.1371/journal.pone.0045270 論文(PLoS ONEへリンク)
  2. Shehata M., Matsumura H., Okubo-Suzuki R., Ohkawa N. and Inokuchi K. (2012) Neuronal-stimulation induces autophagy in hippocampal neurons that is involved in AMPA receptor degradation after chemical LTD. Journal of Neuroscience, 32, 10413-10422. doi:10.1523/JNEUROSCI.4533-11.2012 論文要旨(The Journal of Neuroscienceへリンク)
  3. Kitamura T., Okubo-Suzuki R., Takashima N., Murayama A., Hino T., Nishizono H., Kida S., and Inokuchi K. (2012) Hippocampal function is not required for the precision of remote place memory. Mol Brain, 5, 5. doi:10.1186/1756-6606-5-5 論文要旨(PubMedへリンク)

  1. 鈴木(大久保)玲子,井ノ口馨:恐怖記憶の形成・消去と海馬. 分子精神医学 12, 8(74)-16(82), (2012)

  1. 井ノ口馨:記憶形成のダイナミクス 脳を知る・創る・守る・育む 13 NPO法人 脳の世紀推進会議編, クバプロ, 59-88 (2012)

  1. 井ノ口馨:研究が芸術ならば、自分の研究はどんな芸術だろう?(せるてく・あらかると) 細胞工学 31, 692-693 (2012)


  1. Kataoka M., Yamamori S., Suzuki E., Watanabe S., Sato T., Miyaoka H., Azuma S., IkegamiS., Kuwahara R., Suzuki-Migishima R., Nakahara Y., Nihonmatsu I., Inokuchi K., Katoh-Fukui Y., Yokoyama M., and Takahashi M. (2011) A Single Amino Acid Mutation in SNAP-25 Induces Anxiety-Related Behavior in Mouse. PLoS One 6, e25158. doi: 10.1371/journal.pone.0025158 論文要旨(PubMedへリンク)
  2. Suzuki A., Stern S.A., Bozdagi O., Huntley G.W., Walker R.H., Magistretti P.J., and Alberini C.M. (2011) Astrocyte-neuron lactate transport is required for long-term memory formation. Cell 144, 810-823. doi:10.1016/j.cell.2011.02.018 論文要旨(PubMedへリンク)
  3. Suzuki A., Fukushima H., Mukawa T., Toyoda H., Wu L.J., Zhao M.G., Xu H., Shang Y., Endoh K., Iwamoto T., Mamiya N., Okano E., Hasegawa S., Mercaldo V., Zhang Y., Maeda R., Ohta M., Josselyn S.A., Zhuo M., and Kida S. (2011) Upregulation of CREB-Mediated Transcription Enhances Both Short- and Long-Term Memory. J Neurosci 31, 8786-8802. doi: 10.1523/JNEUROSCI.3257-10.2011 論文要旨(PubMedへリンク)
  4. Yamamoto K., Ueta Y., Wang L., Yamamoto R., Inoue N., Inokuchi K., Aiba A., Yonekura H., and Kato N. (2011) Suppression of a neocortical potassium channel activity by intracellular amyloid-β and its rescue with homerla. J Neurosci 31, 11100-11109. doi: 10.1523/?JNEUROSCI.6752-10.2011 論文要旨(PubMedへリンク)

  1. 鈴木章円,井ノ口馨:恐怖記憶の分子生物学. 最新医学 別冊 新しい診断と治療のABC 70 心的外傷後ストレス障害(PTSD), 精神 7, 80-90 (2011)
  2. 岡田大助,井ノ口馨:シナプスタグ仮説の実証. 生化学, 83, 395-399 (2011)
  3. 井ノ口馨:基礎の基礎. 細胞工学・特集:記憶を分子・細胞の言葉で理解する, 30, 466-469 (2011)
  4. 北村貴司,井ノ口馨:記憶の移行機構と生後の海馬神経新生. 細胞工学・特集:記憶を分子・細胞の言葉で理解する, 30, 493-499 (2011)
  5. 大川宜昭,井ノ口馨:新生ニューロンの経験依存的な海馬神経回路網への組み込み. 細胞工学・特集:記憶を分子・細胞の言葉で理解する, 30, 521-527 (2011)
  6. 井ノ口馨:記憶形成のメカニズム:分子・細胞認知学の展開. 生化学, 83, 93-104 (2011)
  7. Inokuchi K. (2011) Adult neurogenesis and modulation of neural circuit function. Curr Opin Neurobiol 21, 360-364. doi:10.1016/j.conb.2011.02.006 論文要旨(PubMedへリンク)

  1. 井ノ口馨:Eric R. Kandel.-記憶研究の開拓者(私のメンター ~受け継がれる研究の心~ 第7回) 実験医学 29, 3159-3163 (2011)
  2. 井ノ口馨:研究会 Reports 第11回八ヶ岳シンポジウム「Fear Circuit Disorder の基礎と臨床」. 分子精神医学, 11, 45 (2011)
  3. 井ノ口馨:研究会 Reports 第11回八ヶ岳シンポジウム「Fear Circuit Disorder の基礎と臨床」 神経新生による恐怖記憶の制御.. 分子精神医学, 11, 64-65 (2011)


  1. Umeda T., Takashima N., Nakagawa R., Maekawa M., Ikegami S., Yoshikawa T., Kobayashi K., Okanoya K., Inokuchi K., and Osumi N. (2010) Evaluation of Pax6 mutant rat as a model for autism. PloS One 5, e15500. 論文要旨(PubMedへリンク)
  2. Sagata N., Iwaki A., Aramaki T., Takao K., Kura S., Tsuzuki T., Kawakami R., Ito I., Kitamura T., Sugiyama H., Miyakawa T., and Fukumaki Y. (2010) Comprehensive behavioural study of GluR4 knockout mice: implication in cognitive functio. Genes, Brain and Behavior 9, 899-909. 論文要旨(PubMedへリンク)
  3. Kitanishi T., Sakai J., Kojima S., Saitoh Y., Inokuchi K., Fukaya M., Watanabe M., Matsuki N., and Yamada MK. (2010) Activity-dependent localization in spines of the F-actin capping protein CapZ screened in a rat model of dementia. Genes Cells. 15, 737-747. 論文要旨(PubMedへリンク)
  4. Kitamura T., Saitoh Y., Murayama A., Sugiyama H., and Inokuchi K. (2010) LTP induction within a narrow critical period of immature stages enhances the survival of newly generated neurons in the adult rat dentate gyrus. Mol. Brain 3, 13. 論文要旨(PubMedへリンク)
  5. Ageta H., IkegamiS., Miura M., Masuda M., Migishima R., Hino T., Takashima N., Murayama A., Sugino H., Setou M., Kida S., Yokoyama M., Hasegawa Y., Tsuchida K., Aosaki T., and Inokuchi K. (2010) Activin plays a key role in the maintenance of long-term memory and late-LTP. Learning and Memory 17, 176-185. 論文要旨(PubMedへリンク), 研究成果の内容(JSTへリンク)
  1. 北村貴司, 井ノ口馨:恐怖記憶を制御する生後の海馬神経細胞新生-ヒトPTSD治療に貢献できるか. 実験医学 増刊「脳神経系の情報伝達と疾患」伊佐正他編, 羊土社, 96-103 (2010)



  1. Kitamura T., Saitoh Y., Takashima N., Murayama A., Niibori Y., Ageta H., Sekiguchi M., Sugiyama H., and Inokuchi K. (2009) Adult neurogenesis modulates the hippocampus-dependent period of associative fear memory. Cell 139, 814-827. 論文要旨(PubMedへリンク) , 関連記事, 研究成果の内容
  2. Inoue, N., Nakao, H., Migishima, R., Hino, T., Matsui, M., Hayashi, F., Nakao, K. , Manabe, T., Aiba, A. & Inokuchi, K. Requirement of the immediate early gene vesl-1S/homer-1a for fear memory formation. Mol Brain 2, 7 (2009). 論文要旨(PubMedへリンク)
  3. Kawaguchi H., Okamoto S., Sikdar D., Kume A., Li F., Mohafez O.M., Shehata M.H., and Hiraga K. (2009) Genomic organization of regions that regulate chicken glycine decarboxylase gene transcription: physiological and pathological implications. Gene 432, 7-18. 論文要旨(PubMedへリンク)
  4. Maekawa, M., Takashima, N., Matsumata, M., Ikegami, S., Kontani, M., Hara, Y., Kawashima, H., Owada, Y., Kiso, Y., Yoshikawa, T., Inokuchi, K., & Osumi, N. Arachidonic acid drives postnatal neurogenesis and elicits a beneficial effect on prepulse inhibition, a biological trait of psychiatric illnesses. PLoS ONE 4(4): e5085 (2009). 論文要旨(PubMedへリンク)
  5. Okada, D., Ozawa, F. & Inokuchi, K. Input-specific spine entry of soma-derived Vesl-1S protein conforms to synaptic tagging. Science (Research Article) , 324, 904-909 (2009). 論文要旨(PubMedへリンク)
  6. Sekiguchi, M., Hayashi, F., Tsuchida, K. & Inokuchi, K. Neuron type-selective effects of activin on development of the hippocampus. Neurosci Lett , 452, 232-237 (2009) 論文要旨(PubMedへリンク)
  7. Suzuki H., Kato I., Usui I., Takasaki I., Tabuchi Y., Oya T., Tsuneyama K., Kawaguchi H., Hiraga K., Takasawa S., Okamoto H., Tobe K., and Sasahara M. (2009) Characterization of diabetic nephropathy in CaM kinase IIalpha (Thr286Asp) transgenic mice. Biochem. Biophys. Res. Comm. 379, 38-42 論文要旨(PubMedへリンク)
  8. Takahashi I., Noguchi N., Nata K., Yamada S., Kaneiwa T., Mizumoto S., Ikeda T., Sugihara K., Asano M., Yoshikawa T., Yamauchi A., Shervani NJ., Uruno A., Kato I., Unno M., Sugahara K., Takasawa S., Okamoto H., and Sugawara A. (2009) Important role of heparan sulfate in postnatal islet growth and insulin secretion. Biochem. Biophys. Res. Comm. 383, 113-118. 論文要旨(PubMedへリンク)
  1. Tsuchida, K., Nakatani, M., Hitachi, K., Uezumi, A., Sunada, Y., Ageta, H. & Inokuchi, K. Activin signaling as an emerging target for therapeutic interventions. Cell Commun Signal 7: 15 (2009)
  1. 井ノ口馨:脳と記憶.現代生物科学入門(浅島誠 他編)第4巻 脳神経生物学,岩波書店, 69-108 (2009)


  1. Abdel-Aziz H. O., Murai Y., Takasaki I., Tabuchi Y., Zheng H-C., Nomoto K., Takahashi H., Tsuneyama K., Kato I., Hsu D. K., Liu F-T., Hiraga K., and Takano Y. (2008) Targeted disruption of the galectin-3 gene results in decreased susceptibility to NNK-induced lung tumorigenesis: an oligonucleotide microarray study. J. Cancer Res. Clin. Oncol. 134, 777-788. 論文要旨(PubMedへリンク)
  2. Ageta, H., Murayama, A., Migishima, R., Kida, S., Tsuchida, K., Yokoyama, M. & Inokuchi, K. Activin in the brain modulates anxiety-related behavior and adult neurogenesis. PLoS ONE 3, e1869 (2008). 論文要旨(PubMedへリンク)
  3. Hayashi, F., Takashima, N., Murayama, A. & Inokuchi, K. Decreased postnatal neurogenesis in the hippocampus combined with stress experience during adolescence is accompanied by an enhanced incidence of behavioral pathologies in adult mice. Mol Brain 1, 22 (2008). 論文要旨(PubMedへリンク)
  4. Kato I., Oya T., Suzuki H., Takasawa K., Ichsan A.M., Nakada S., Ishii Y., Shimada Y., Sasahara M., Tobe K., Takasawa S., Okamoto H., and Hiraga K. (2008) A novel model of insulin-dependent diabetes with renal and retinal lesions by transgenic expression of CaMKIIα (Thr286Asp) in pancreatic β-cells. Diabetes Metab. Res. Rev. 24, 486-497. 論文要旨(PubMedへリンク)
  5. Liu H-X., Lopatina O., Higashida C., Tsuji T., Kato I., Takasawa S., Okamoto H., Yokoyama S., and Higashida H. (2008) Locomotor activity, ultrasonic vocalization and oxytocin levels in infant CD38 knockout mice. Neurosci. Lett. 448, 67-70. 論文要旨(PubMedへリンク)
  6. Nakanishi Y., Tsuneyama K., Nomoto K., Fujimoto M., Salunga T. L., Nakajima T., Miwa S., Murai Y., Hayashi S., Kato I., Hiraga K., Hsu DK., Liu FT., and Takano Y. (2008) Nonalcoholic steatohepatitis and hepatocellular carcinoma in galectin-3 knockout mice. Hepatol Res. 38, 1241-1521. 論文要旨(PubMedへリンク)
  7. Ohkawa, N., Sugisaki, S., Tokunaga, E., Fujitani, K., Hayasaka, T., Setou, M. & Inokuchi, K. N-acetyltransferase ARD1-NAT1 regulates neuronal dendritic development. Genes Cells 13, 1171-1183 (2008). 論文要旨(PubMedへリンク)
  8. Okubo-Suzuki, R., Okada, D., Sekiguchi, M. & Inokuchi, K. Synaptopodin maintains the neural activity-dependent enlargement of dendritic spines in hippocampal neurons. Mol Cell Neurosci 38, 266-276 (2008). 論文要旨(PubMedへリンク)
  9. Shimada I., Matsui K., Brinkmann B., Hohoff C., Hiraga K., Tabuchi Y., Takasaki I., Kato I., Kawaguchi H., Takasawa K., Iida R., Takizawa H., and Matsuki T. (2008) Novel transcript profiling of diffuse alveolar damage induced by hyperoxia exposure in mice: normalization by glyceraldehyde 3-phosphate dehydrogenase. Int. J. Legal Med. 122, 373-383. 論文要旨(PubMedへリンク)
  10. Takasawa A., Kato I., Takasawa K., Ishii Y., Yoshida T., Shehata M. H., Kawaguchi H., Mohafez O. M. M., Sasahara M., and Hiraga K. (2008) Mutation-, aging-, and gene dosage-dependent accumulation of neuroserpin (G392E) in endoplasmic reticula and lysosomes of neurons in transgenic mice. J. Biol. Chem. 283, 35606-35613.
  11. 論文要旨(PubMedへリンク)
  12. Ueta, Y., Yamamoto, R., Sugiura, S., Inokuchi, K. & Kato, N. Homer 1a suppresses neocortex long-term depression in a cortical layer-specific manner. J Neurophysiol 99, 950-7 (2008). 論文要旨(PubMedへリンク)
  13. Yang, H., Takagi, H., Konishi, Y., Ageta, H., Ikegami, K., Yao, I., Sato, S., Hatanaka, K., Inokuchi, K., Seog, D.H. & Setou, M. Transmembrane and ubiquitin-like domain-containing protein 1 (Tmub1/HOPS) facilitates surface expression of GluR2-containing AMPA receptors. PLoS ONE 3, e2809 (2008). 論文要旨(PubMedへリンク)
  1. 上田洋司,井ノ口 馨:マウスの記憶形成:再固定化のメカニズム.細胞工学,27, 1139-1145 (2008)


  1. Aiba, A., Inokuchi, K., Ishida, Y., Itohara, S., Kobayashi, K., Masu, M., Mishina, M., Miyakawa, T., Mori, H., Nakao, K., Obata, Y., Sakimura, K., Shiroishi, T., Wada, K., and Yagi, T.: Mouse liaison for integrative brain research. Neurosci Res. , 58: 103-104 (2007). 論文要旨(PubMedへリンク)
  2. Inoue, Y., Udo, H., Inokuchi, K. & Sugiyama, H. Homer1a regulates the activity-induced remodeling of synaptic structures in cultured hippocampal neurons. Neuroscience 150, 841-52 (2007). 論文要旨(PubMedへリンク)
  3. Jin D., Liu H-X., Hirai H., Torashima T., Nagai T., Lopatina O., Shnayder N. A., Yamada K., Noda M., Seike T., Fujita K., Takasawa S., Yokoyama S., Koizumi K., Shiraishi Y., Tanaka S., Hashii M., Yoshihara T., Higashida K., Islam M. S., Yamada N., Hayashi K., Noguchi N., Kato I., Okamoto H., Matsushima A., Salmina A., Munesue T., Shimizu N., Mochida S., Asano M. and Higashida H. (2007) CD38 is critical for social behaviour by regulating oxytocin secretion. Nature 446, 41-45. 論文要旨(PubMedへリンク)
  4. Kudo, T., Fujii, T., Ikegami, S., Inokuchi, K., Takayama, Y., Ikehara, Y., Nishihara, S., Togayachi, A., Takahashi, S., Tachibana, K., Yuasa, S. & Narimatsu, H. Mice lacking {alpha}1,3-fucosyltransferase IX demonstrate disappearance of Lewis x structure in brain and increased anxiety-like behaviors. Glycobiology 17, 1-9 (2007). 論文要旨(PubMedへリンク)
  5. Matsumoto, M., Setou, M. & Inokuchi, K. Transcriptome analysis reveals the population of dendritic RNAs and their redistribution by neural activity. Neurosci Res 57, 411-423 (2007). 論文要旨(PubMedへリンク)
  6. Niibori, Y., Hayashi, F., Hirai, K., Matsui, M. & Inokuchi, K. Alternative poly(A) site-selection regulates the production of alternatively spliced vesl-1/homer1 isoforms that encode postsynaptic scaffolding proteins. Neurosci Res 57, 399-410 (2007). 論文要旨(PubMedへリンク)
  7. Ohkawa, N., Fujitani, K., Tokunaga, E., Furuya, S. & Inokuchi, K. The microtubule destabilizer stathmin mediates the development of dendritic arbors in neuronal cells. J Cell Sci 120, 1447-56 (2007). 論文要旨(PubMedへリンク)
  8. Ohkawa, N., Hashimoto, K., Hino, T., Migishima, R., Yokoyama, M., Kano, M. & Inokuchi, K. Motor discoordination of transgenic mice overexpressing a microtubule destabilizer, stathmin, specifically in Purkinje cells. Neurosci Res 59, 93-100 (2007). 論文要旨(PubMedへリンク)
  9. Shoji-Kasai, Y., Ageta, H., Hasegawa, Y., Tsuchida, K., Sugino, H. & Inokuchi, K. Activin increases the number of synaptic contacts and the length of dendritic spine necks by modulating spinal actin dynamics. J Cell Sci 120, 3830-7 (2007). 論文要旨(PubMedへリンク)
  10. Umemura K., Kato I., Hirashima Y., Ishii Y., Inoue T., Aoki J., Kono N., Oya T., Hayashi N., Hamada H., Endo S., Oda M., Arai H., Kinouchi H., and Hiraga K. (2007) Neuroprotective role of transgenic PAF-acetylhydrolase II in mouse models of focal cerebral ischemia. Stroke 38, 1063-1068. 論文要旨(PubMedへリンク)
  11. Yao, I., Takagi, H., Ageta, H., Kahyo, T., Sato, S., Hatanaka, K., Fukuda, Y., Chiba, T., Morone, N., Yuasa, S., Inokuchi, K., Ohtsuka, T., Macgregor, G.R., Tanaka, K. & Setou, M. SCRAPPER-Dependent Ubiquitination of Active Zone Protein RIM1 Regulates Synaptic Vesicle Release. Cell 130, 943-57 (2007). 論文要旨(PubMedへリンク)


  1. Hibino Y., Usui T., Morita Y., Hirose N., Okazaki M., Sugano N., and Hiraga K. (2006) Molecular properties and intracellular localization of rat liver nuclear scaffold protein P130. Biochim. Biophys. Acta 1759, 195-207. 論文要旨(PubMedへリンク)
  2. Kataoka, M., Kuwahara, R., Matsuo, R., Sekiguchi, M., Inokuchi, K. & Takahashi, M. Development- and activity-dependent regulation of SNAP-25 phosphorylation in rat brain. Neurosci Lett 407, 258-62 (2006). 論文要旨(PubMedへリンク)
  3. Li F., Kato I., Kawaguchi H., Takasawa K., Hibino Y., and Hiraga K. (2006) The galectin-3 gene promoter binding proteins in the liver of rats 48-h post-treatment with CCl4. Gene 367, 46-55. 論文要旨(PubMedへリンク)
  4. Myint K.M., Yamamoto Y., Doi T., Kato I., Harashima A., Yonekura H., Watanabe T., Shinohara H., Takeuchi M., Tsuneyama K., Hashimoto N., Asano M., Takasawa S., Okamoto H., and Yamamoto H. (2006) RAGE control of diabetic nephropathy in a mouse model: effects of RAGE gene disruption and administration of low molecular weight heparin. Diabetes 55, 2510-2522. 論文要旨(PubMedへリンク)
  5. Nomoto K., Tsuneyama K., Aziz H.O.A., Takahashi H., Murai Y., Cui Z-G., Fujimoto M., Kato I., Hiraga K., Hsu D.K., Liu F-T., and Takano Y. (2006) Disrupted galectin-3 causes non-alcoholic fatty liver disease in male mice. J. Pathol. 210, 469-477. 論文要旨(PubMedへリンク)
  6. Stokely, M.E., Hwang, S.Y., Hwang, J.Y., Fan, B., King, M.A., Inokuchi, K. & Koulen, P. Polycystin-1 can interact with homer 1/Vesl-1 in postnatal hippocampal neurons. J Neurosci Res 84, 1727-37 (2006). 論文要旨(PubMedへリンク)
  7. Tada M., Shinohara Y., Kato I., Hiraga K., Aizawa T., Demura M., Mori Y., Shinoda H., Mizuguchi M., and Kawano K. (2006) Preparation and observation of fresh-frozen sections of the green fluorescent protein transgenic mouse head. Acta Histochem. Cytochem. 39, 31-34. 論文要旨(PubMedへリンク)
  8. Tanaka, M., Duncan, R.S., McClung, N., Yannazzo, J.A., Hwang, S.Y., Marunouchi, T., Inokuchi, K. & Koulen, P. Homer proteins control neuronal differentiation through IP(3) receptor signaling. FEBS Lett 580, 6145-50 (2006). 論文要旨(PubMedへリンク)
  1. 岡田大助, 井ノ口馨:後期長期増強の入力特異性に対するシナプスタグ仮説とHebb理論, 実験医学, 24, 2355-2361 (2006)
  2. 新堀洋介, 林文彦, 井ノ口馨:シナプス可塑性に伴う選択的ポリアデニル化による新規な遺伝子発現制御機構. 生化学, 78, 931-938 (2006)
  1. 井ノ口馨:スパインの動態と可塑性(森寿,真鍋俊也,渡辺雅彦,岡野栄之,宮川剛 編)  脳神経科学イラストレイテッド 改訂第2版,羊土社,61-66 (2006)


  1. Ichsan A.M., Kato I., Yoshida T., Takasawa K., Hayasaka S., and Hiraga K. (2005) Rhodoposin promoter-EGFP fusion transgene expression in photoreceptor neurons of retina and pineal complex in mice. Neurosci. Lett. 379, 138-143. 論文要旨(PubMedへリンク)
  2. Inoue, K., Fukazawa, Y., Ogura, A. & Inokuchi, K. Two-dimensional neural activity mapping of the entire population of hippocampal CA1 pyramidal cells responding to fear conditioning. Neurosci Res 51, 417-25 (2005). 論文要旨(PubMedへリンク)
  3. Maekawa, M., Takashima, N., Arai, Y., Nomura, T., Inokuchi, K., Yuasa, S. & Osumi, N. Pax6 is required for production and maintenance of progenitor cells in postnatal hippocampal neurogenesis. Genes Cells 10, 1001-14 (2005). 論文要旨(PubMedへリンク)
  4. Sakagami, Y., Yamamoto, K., Sugiura, S., Inokuchi, K., Hayashi, T. & Kato, N. Essential roles of Homer-1a in homeostatic regulation of pyramidal cell excitability: a possible link to clinical benefits of electroconvulsive shock. Eur J Neurosci 21, 3229-39 (2005). 論文要旨(PubMedへリンク)
  5. Yamamoto, K., Sakagami, Y., Sugiura, S., Inokuchi, K., Shimohama, S. & Kato, N. Homer 1a enhances spike-induced calcium influx via L-type calcium channels in neocortex pyramidal cells. Eur J Neurosci 22, 1338-48 (2005). 論文要旨(PubMedへリンク)
  6. Yamamoto Y., Doi T., Kato I., Shinohara H., Sakurai S., Yonekura H., Watanabe T., Myint K.M., Harashima A., Takeuchi M., Takasawa S., Okamoto H., Hashimoto N., Asano M., and Yamamoto H. (2005) RAGE is a promising target in diabetic nephropathy. Ann. NY Acad. Sci. 1043, 562-566. 論文要旨(PubMedへリンク)
  1. 井ノ口馨:シナプス可塑性におけるスパインアクチン動態の重要性(狩野方伸編) 遺伝子制御による選択的シナプス強化・除去機構の解明,クバプロ,13-22 (2005)
  2. 笠井陽子,井ノ口馨:アクチビンによるシナプス形態およびシナプス可塑性の制御(狩野方伸編) 遺伝子制御による選択的シナプス強化・除去機構の解明,クバプロ,23-38 (2005)


  1. Inaba, Y., Tian, Q.B., Okano, A., Zhang, J.P., Sakagami, H., Miyazawa, S., Li, W., Komiyama, A., Inokuchi, K., Kondo, H. & Suzuki, T. Brain-specific potential guanine nucleotide exchange factor for Arf, synArfGEF (Po), is localized to postsynaptic density. J Neurochem 89, 1347-57 (2004). 論文要旨(PubMedへリンク)
  2. Inoue, Y., Honkura, N., Kato, A., Ogawa, S., Udo, H., Inokuchi, K. & Sugiyama, H. Activity-inducible protein Homer1a/Vesl-1S promotes redistribution of postsynaptic protein Homer1c/Vesl-1L in cultured rat hippocampal neurons. Neurosci Lett 354, 143-147 (2004). 論文要旨(PubMedへリンク)
  3. Sugiyama, K., Niki, T.P., Inokuchi, K., Teranishi, Y., Ueda, M. & Tanaka, A. Heterologous expression of metabotropic glutamate receptor subtype 1 in Saccharomyces cerevisiae. Appl Microbiol Biotechnol 64, 531-536 (2004). 論文要旨(PubMedへリンク)
  4. Trivedi P., Takasawa K., Zompetta C., Cuomo L., Anastasiadou E., Carbone A., Uccini S., Belardelli F., Takada K., Frati L., and Faggioni A. (2004) Infection of HHV-8 positive primary effusionlymphoma cells with a recombinant Epstein-Barr virus lead to restricted EBV latency, altered phenotype, and increased tumorigenicity without affecting TCL1 expression. Blood 103, 313-316. 論文要旨(PubMedへリンク)
  1. Ehrengruber, M., Kato, A., Inokuchi, K., Hennou, S. Homer/Vesl proteins and their roles in CNS neurons. Mol. Neurobiol. , 29: 213-227 (2004). 論文要旨(PubMedへリンク)
  2. 井ノ口馨,斎藤喜人:スパインアクチンの動態とシナプス形態の可塑性,蛋白質 核酸 酵素,49,282-286 (2004)


  1. Fukazawa, Y., Saitoh, Y., Ozawa, F., Ohta, Y., Mizuno, K. & Inokuchi, K. Hippocampal LTP is accompanied by enhanced F-actin content within the dendritic spine that is essential for late LTP maintenance in vivo. Neuron 38, 447-460 (2003). 論文要旨(PubMedへリンク)
  2. Giustetto, M., Hegde, A.N., Si, K., Casadio, A., Inokuchi, K., Pei, W., Kandel, E.R. & Schwartz, J.H. Axonal transport of eukaryotic translation elongation factor 1{alpha} mRNA couples transcription in the nucleus to long-term facilitation at the synapse. Proc Natl Acad Sci U S A 100, 13680-13685 (2003). 論文要旨(PubMedへリンク)
  3. Hamada H., Zhang Y. L., Kawai A., Li F., Hibino Y., Hirashima Y., Kurimoto M., Hayashi N., Kato I., Endo S., and Hiraga K. (2003) Development-associated myristoylated alanine-rich C kinase substrate phosphorylation in rat brain. Childs. Nerv. Syst. 19, 152-158. 論文要旨(PubMedへリンク)
  4. Hennou, S., Kato, A., Schneider, E.M., Lundstrom, K., Gahwiler, B.H., Inokuchi, K., Gerber, U. & Ehrengruber, M.U. Homer-1a/Vesl-1S enhances hippocampal synaptic transmission. Eur J Neurosci 18, 811-819 (2003). 論文要旨(PubMedへリンク)
  5. Hwang, S.Y., Wei, J., Westhoff, J.H., Duncan, R.S., Ozawa, F., Volpe, P., Inokuchi, K. & Koulen, P. Differential functional interaction of two Vesl/Homer protein isoforms with ryanodine receptor type 1: a novel mechanism for control of intracellular calcium signaling. Cell Calcium 34, 177-184 (2003). 論文要旨(PubMedへリンク)
  6. Kaja, S., Yang, S.H., Wei, J., Fujitani, K., Liu, R., Brun-Zinkernagel, A.M., Simpkins, J.W., Inokuchi, K. & Koulen, P. Estrogen Protects the Inner Retina from Apoptosis and Ischemia-Induced Loss of Vesl-1L/Homer 1c Immunoreactive Synaptic Connections. Invest Ophthalmol Vis Sci 44, 3155-3162 (2003). 論文要旨(PubMedへリンク)
  7. Kato, A., Fukazawa, Y., Ozawa, F., Inokuchi, K. & Sugiyama, H. Activation of ERK cascade promotes accumulation of Vesl-1S/Homer-1a immunoreactivity at synapses. Brain Res Mol Brain Res 118, 33-44 (2003). 論文要旨(PubMedへリンク)
  8. Takahashi J., Kagaya Y., Kato I., Ohta J., Isoyama S., Miura M., Sugai Y., Hirose M., Wakayama Y., Ninomiya M., Watanabe J., Takasawa S., Okamoto H., and Shirato K. (2003) Deficit of CD38/cyclic ADP-ribose is differentially compensated in hearts by gender. Biochem. Biophys. Res. Commun. 312, 434-440. 論文要旨(PubMedへリンク)
  9. Mitsui-Saito M., Kato I., Takasawa S., Okamoto H., and Yanagisawa T. (2003) CD38 Gene Disruption Inhibits the Contraction Induced by alpha-Adrenoceptor Stimulation in Mouse Aorta. J. Vet. Med. Sci. 65, 1325-1330. 論文要旨(PubMedへリンク)
  10. Morita, M., Kobayashi, A., Yamashita, T., Shimanuki, T., Nakajima, O., Takahashi, S., Ikegami, S., Inokuchi, K., Yamashita, K., Yamamoto, M. & Fujii-Kuriyama, Y. Functional Analysis of Basic Transcription Element Binding Protein by Gene Targeting Technology. Mol Cell Biol 23, 2489-2500 (2003). 論文要旨(PubMedへリンク)
  11. Westhoff, J.H., Hwang, S.Y., Scott Duncan, R., Ozawa, F., Volpe, P., Inokuchi, K. & Koulen, P. Vesl/Homer proteins regulate ryanodine receptor type 2 function and intracellular calcium signaling. Cell Calcium 34, 261-269 (2003). 論文要旨(PubMedへリンク)


  1. Chini E.N., Chini C.C., Kato I., Takasawa S., and Okamoto H. (2002) CD38 is the major enzyme responsible for synthesis of nicotinic acid- adenine dinucleotide phosphate in mammalian tissues. Biochem. J. 15, 125-130. 論文要旨(PubMedへリンク)
  2. Kaku H., Horikawa K., Obata Y., Kato I., Okamoto H., Sakaguchi N., Gerondakis S., and Takatsu K. (2002) NF-kappaB is required for CD38-mediated induction of C(gamma)1 germline transcripts in murine B lymphocytes. Int. Immunol. 14, 1055-1064. 論文要旨(PubMedへリンク)
  3. Petrova R., Yamamoto Y., Muraki K., Yonekura H., Sakurai S., Watanabe T., Li H., Takeuchi M., Makita Z., Kato I., Takasawa S., Okamoto H., Imaizumi Y., and Yamamoto H. (2002) Advanced glycation endproduct-induced calcium handling impairment in mouse cardiac myocytes. J. Mol. Cell. Cardiol. 34, 1425-1431. 論文要旨(PubMedへリンク)
  4. Nanbo A., Inoue K., Adachi-Takasawa K., and Takeda K. (2002) Epstein-Barr virus RNA confers resistance to interferon-α-induced apoptosis in Burkitt's lymphoma. EMBO J. 21, 954-965. 論文要旨(PubMedへリンク)


  1. Ageta, H., Kato, A., Fukazawa, Y., Inokuchi, K. & Sugiyama, H. Effects of proteasome inhibitors on the synaptic localization of Vesl-1S/Homer-1a proteins. Brain Res Mol Brain Res 97, 186-9 (2001). 論文要旨(PubMedへリンク)
  2. Fukushi, Y., Kato, I., Takasawa, S., Sasaki, T., Ong, BH., Sato, M., Ohsaga, A., Sato, K., Shirato, K., Okamoto, H., and Maruyama, Y. (2001) Identification of cyclic ADP-ribose-dependent mechanisms in pancreatic muscarinic Ca2+ signaling using CD38 knockout mice. J Biol Chem. 276, 649-55. 論文要旨(PubMedへリンク)
  3. Kato, A., Fukuda, T., Fukazawa, Y., Isojima, Y., Fujitani, K., Inokuchi, K. & Sugiyama, H. Phorbol esters promote postsynaptic accumulation of Vesl-1S/Homer-1a protein. Eur J Neurosci 13, 1292-1302. (2001). 論文要旨(PubMedへリンク)
  4. Matsuo, R., Asada, A., Fujitani, K. & Inokuchi, K. LIRF, a gene induced during hippocampal long-term potentiation as an immediate-early gene, encodes a novel RING finger protein. Biochem Biophys Res Commun 289, 479-484 (2001). 論文要旨(PubMedへリンク)
  5. Nakazawa, T., Satoh, J., Takahashi, K., Sakata, Y., Ikehata, F., Takizawa, Y., Bando, SI., Housai, T., Li, Y., Chen, C., Masuda, T., Kure, S., Kato, I., Takasawa, S., Taniguchi, T., Okamoto, H., and Toyota, T. (2001) Complete suppression of insulitis and diabetes in NOD mice lacking interferon regulatory factor-1. J. Autoimmun. 17, 119-125. 論文要旨(PubMedへリンク)
  6. Saito, A., Kamii, H., Kato, I., Takasawa, S., Kondo, T., Chan, PH., Okamoto, H., and Yoshimoto, T. (2001) Transgenic CuZn-superoxide dismutase inhibits NO synthase induction in experimental subarachnoid hemorrhage. Stroke. 32, 1652-1657. 論文要旨(PubMedへリンク)
  7. Shinohara, T., Tomizuka, K., Miyabara, S., Takehara, S., Kazuki, Y., Inoue, J., Katoh, M., Nakane, H., Iino, A., Ohguma, A., Ikegami, S., Inokuchi, K., Ishida, I., Reeves, R.H. & Oshimura, M. Mice containing a human chromosome 21 model behavioral impairment and cardiac anomalies of Down's syndrome. Hum Mol Genet 10, 1163-1175 (2001). 論文要旨(PubMedへリンク)
  8. Yamamoto, Y., Kato, I., Doi, T., Yonekura, H., Ohashi, S., Takeuchi, M., Watanabe, T., Yamagishi, S., Sakurai, S., Takasawa, S., Okamoto, H. and Yamamoto, H. (2001) Development and prevention of advanced diabetic nephropathy in RAGE-overexpressing mice. J. Clin. Invest. 108, 261-268. 論文要旨(PubMedへリンク)
  9. Yamazaki, K., Kawai, A., Kawaguchi, M., Hibino, Y., Li, F., Sasahara, M., Tsukada, K., and Hiraga, K. (2001) Simultaneous induction of galectin-3 phosphorylated on tyrosine residue, p21WAF1/Cip1/Sdi1, and the proliferating cell nuclear antigen at a distinctive period of repair of hepatocytes injured by CCl4. Biochem. Biophys. Res. Commun. 280, 1077-1084. 論文要旨(PubMedへリンク)
  10. Yamazaki, M., Matsuo, R., Fukazawa, Y., Ozawa, F. & Inokuchi, K. Regulated expression of an actin-associated protein, synaptopodin, during long-term potentiation. J Neurochem 79, 192-199. (2001). 論文要旨(PubMedへリンク)
  1. 池上司郎,井ノ口馨:アンチセンスオリゴヌクレオチドを用いた神経機能の解析, CLINICAL NEUROSCIENCE,19,10-11 (2001)
  2. 加藤明彦,井ノ口馨:シナプス伝達の過疎的変化に伴い発現調節される遺伝子群: ポストシナプス部位で機能するVesl/Homerの解析を中心に,医学の歩み,199,527-530 (2001)