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Univ. of Toyama > Faculties & Graduate Schools > Graduate School of Medicine & Pharmaceutical Sciendes (Faculty of Medicine) > Biochemistry
Adult neurogenesis modulates the hippocampus-dependent period of associative fear memory
From Kitamura T., Saitoh Y., Takashima N., Murayama A., Niibori Y., Ageta H., Sekiguchi M., Sugiyama H., and Inokuchi K. (2009)
Mechanisms underlying the formation of long-term memory
Synaptic tag hypothesis
Okada, D., Ozawa, F. & Inokuchi, K. Input-specific spine entry of soma-derived Vesl-1S protein conforms to synaptic tagging. Science (Research Article) , 324, 904-909 (2009).
Long-term memory and morphological plasticity
Fukazawa, Y., Saitoh, Y., Ozawa, F., Ohta, Y., Mizuno, K. & Inokuchi, K. Hippocampal LTP is accompanied by enhanced F-actin content within the dendritic spine that is essential for late LTP maintenance in vivo. Neuron 38, 447-460 (2003).
Molecular mechanisms underlying long-term memory and long-lasting synaptic plasticity
Regulation by activin
Shoji-Kasai, Y., Ageta, H., Hasegawa, Y., Tsuchida, K., Sugino, H. & Inokuchi, K. Activin increases the number of synaptic contacts and the length of dendritic spine necks by modulating spinal actin dynamics. J Cell Sci 120, 3830-7 (2007).
Ageta, H., Murayama, A., Migishima, R., Kida, S., Tsuchida, K., Yokoyama, M. & Inokuchi, K. Activin in the brain modulates anxiety-related behavior and adult neurogenesis. PLoS ONE 3, e1869 (2008).