佐野　良威　(Yoshitake SANO)
特命助教

現在の研究テーマ（current research project）

記憶をつかさどる細胞集団の形成機構の解明

専門分野 （background scientific field）

神経科学

略 歴（personal history）

2000年3月　東邦大学　薬学部　卒業
2000年4月 - 2002年3月　東邦大学　薬学部薬学研究科（修士）
2002年4月 - 2005年3月　北海道大学　薬学部薬学研究科（鈴木利治　研究室）（博士）
2005年4月 - 2009年10月　理化学研究所　脳科学総合研究センター　研究員（糸原重美　研究室）
2009年11月 - 2014年3月
　University of California, Los Angeles, Research associate, （Alcino J. Silva's laboratory）
2014年4月 - 現職

業 績（publications）

• Yoshitake Sano, Justin L. Shobe, Miou Zhou, Shan Huang, Tristan Shuman, Denise J. Cai, Peyman Golshani, Masakazu Kamata and Alcino J. Silva.
  CREB Regulates Memory Allocation in the Insular Cortex.
  Curr Biol., online 11/13. 2014
• Yong-Seok Lee, Dan Ehninger, Miou Zhou, Jun-Young Oh, Minkyung Kang, Chuljung Kwak, Hyun-Hee Ryu, Delana Butz, Toshiyuki Araki, Ying Cai, J Balaji, Yoshitake Sano, Christine I Nam, Hyong Kyu Kim, Bong-Kiun Kaang, Corinna Burger, Benjamin G Neel and Alcino J Silva.
  Mechanism and treatment for learning and memory deficits in mouse models of Noonan syndrome.
  Nat Neurosci., online 11/10. 2014
• Thomas Rogerson, Denise J. Cai, Adam Frank, Yoshitake Sano, Justin Shobe, Manuel F. Lopez-Aranda and Alcino J. Silva.
  Synaptic tagging during memory allocation.
  Nat Rev Neurosci. 15(3):157-69. 2014
• Yuki Kobayashi, Yoshitake Sano, Elisabetta Vannoni, Hiromichi Goto, Hitomi Suzuki, Atsuko Oba, Hiroaki Kawasaki, Shigenobu Kanba, Hans-Peter Lipp, Niall P. Murphy, David P. Wolfer and Shigeyoshi Itohara.
  Genetic dissection of medial habenula-interpeduncular nucleus pathway function in mice.
  Front. Behav. Neurosci., volume 7, Article 17. 2013
• Miou Zhou, Weidong Li, Shan Huang, Juan Song, Ju Young Kim, Xiaoli Tian, Eunchai Kang, Yoshitake Sano, Cindy Liu, J. Balaji, Shumin Wu, Yu Zhou, Ying Zhou, Sherveen N. Parivash, Dan Ehninger, Lin He, Hongjun Song, Guo-li Ming and Alcino J Silva.
  mTOR Inhibition Ameliorates Cognitive and Affective Deficits Caused by Disc1 Knockdown in Adult-Born Dentate Granule Neurons.
  Neuron. 77(4):647-54. 2013
• Dan Ehninger, Yoshitake Sano, Petrus J. de Vries, Kira Dies, David Franz, Daniel H. Geschwind, Manpreet Kaur, Yong-Seok Lee, Weidong Li, Jennifer K. Lowe, Jo Anne Nakagawa, Mustafa Sahin, Katie Smith, Vicky Whittemore, Alcino J. Silva.
  Gestational immune activation and Tsc2 haploinsufficiency cooperate to disrupt fetal survival and may perturb social behavior in adult mice.
  Mol Psychiatry. 17(1):62-70. 2012
• Yoshitake Sano, Veravej G. Ornthanalai, Kazuyuki Yamada, Chihiro Homma, Hitomi Suzuki, Toshiharu Suzuki, Niall P. Murphy, and Shigeyoshi Itohara.
  X11-like protein deficiency is associated with impaired conflict resolution in mice.
  J Neurosci. 29(18): 5884-96. 2009
• Yuhki Saito, Yoshitake Sano, Robert Vassar, Sam Gandy, Tadashi Nakaya, Tohru Yamamoto, Toshiharu Suzuki.
  X11 proteins regulate the translocation of amyloid beta-protein precursor (APP) into detergent-resistant membrane and suppress the amyloidogenic cleavage of APP by beta-site-cleaving enzyme in brain.
  J Biol Chem. 283(51):35763-71. 2008
• Yoshitake Sano, Aiko Syuzo-Takabatake, Tadashi Nakaya, Yuhki Saito, Susumu Tomita, Shigeyoshi Itohara, Toshiharu Suzuki.
  Enhanced amyloidogenic metabolism of the amyloid beta-protein precursor in the X11L-deficient mouse brain.
  J Biol Chem. 2006 Dec 8;281(49):37853-60
• Yoshitake Sano, Tadashi Nakaya, Steve Pedrini, Shizu Takeda, Kanae Iijima-Ando, Koichi Iijima, Paul M. Mathews, Shigeyoshi Itohara, Sam Gandy, Toshiharu Suzuki.
  Physiological mouse brain Abeta levels are not related to the phosphorylation state of threonine-668 of Alzheimer's APP.
  PLoS ONE. 2006 Dec 20;1:e51.

趣味・特技（hobby, specialty）

気ままに散歩、美味しいものを食べる、酒を飲む、寝る。