野本 かおり
コーディネーター

抱負（ambitious future plan）

研究の推進・発展に貢献できるよう頑張ります！

専門分野 （background scientific field）

発生工学

略 歴（personal history）

2002-2006　　東京農業大学応用生物科学部バイオサイエンス学科
2006-2008　　東京農業大学大学院農学研究科バイオサイエンス専攻博士前期課程
2008-2009　　医療法人財団　荻窪病院　産婦人科
2009-2013　　東京大学医科学研究所　癌・細胞増殖部門癌細胞シグナル分野
2013-2017　　富山大学大学院医学薬学研究部(医学)　産科婦人科学講座
2017-2018　　富山大学大学院医学薬学研究部(医学)　臨床分子病態検査学講座
2018-2022　　富山大学和漢医薬学総合研究所　神経機能学領域
2022-現在　　富山大学大学院医学部医学　生化学講座

業 績（publications）

• High-frequency generation of viable mice from engineered bi-maternal embryos. Kawahara M, Wu Q, Takahashi N, Morita S, Yamada K, Ito M, Ferguson-Smith AC, Kono T. Nat Biotechnol. 2007 Sep;25(9):1045-50.
• Identification of the mouse paternally expressed imprinted gene Zdbf2 on chromosome 1 and its imprinted human homolog ZDBF2 on chromosome 2. Kobayashi H, Yamada K, Morita S, Hiura H, Fukuda A, Kagami M, Ogata T, Hata K, Sotomaru Y, Kono T. Genomics. 2009 May;93(5):461-72.
• Identification of inappropriately reprogrammed genes by large-scale transcriptome analysis of individual cloned mouse blastocysts. Fukuda A, Cao F, Morita S, Yamada K, Jincho Y, Tane S, Sotomaru Y, Kono T. PLoS One. 2010 Jun 30;5(6):e11274.
• Inactivation of mitogen-activated protein kinase is neither necessary nor sufficient for the onset of pronuclear formation in mouse oocytes. Soeda S, Yamada K, Ohsugi M. Genes Cells. 2013 Oct;18(10):850-8.
• Inferring the choreography of parental genomes during fertilization from ultralarge-scale whole-transcriptome analysis. Park SJ, Komata M, Inoue F, Yamada K, Nakai K, Ohsugi M, Shirahige K. Genes Dev. 2013 Dec 15;27(24):2736-48
• The microtubule-binding and coiled-coil domains of Kid are required to turn off the polar ejection force at anaphase. Soeda S, Yamada-Nomoto K, Ohsugi M. J Cell Sci. 2016 Oct 1;129(19):3609-3619
• Alpha-7 nicotinic acetyalcholine receptor (nAChR) agonist inhibits the development of endometriosis by regulating inflammation. Yamada-Nomoto K, Yoshino O, Akiyama I, Ushijima A, Ono Y, Shima T, Nakashima A, Hayashi S, Kadowaki M, Osuga Y, Saito S. Am J Reprod Immunol. 2016 Dec;76(6):491-498.
• Oral contraceptive therapy reduces serum relaxin-2 in elite female athletes. Nose-Ogura S, Yoshino O, Yamada-Nomoto K, Nakamura M, Harada M, Dohi M, Okuwaki T, Osuga Y, Kawahara T, Saito S. J Obstet Gynaecol Res. 2017 Mar;43(3):530-535.
• PAI-1 in granulosa cells is suppressed directly by statin and indirectly by suppressing TGF-? and TNF-? in mononuclear cells by insulin-sensitizing drugs. Yamada-Nomoto K, Yoshino O, Akiyama I, Iwase A, Ono Y, Nakamura T, Harada M, Nakashima A, Shima T, Ushijima A, Osuga Y, Chang RJ, Shimasaki S, Saito S. Am J Reprod Immunol. 2017 Jul;78(1).
• Bradykinin system is involved in endometriosis-related pain through endothelin-1 production. Yoshino O, Yamada-Nomoto K, Kobayashi M, Andoh T, Hongo M, Ono Y, Hasegawa-Idemitsu A, Sakai A, Osuga Y, Saito S. Eur J Pain. 2018 Mar;22(3):501-510.
• RSK-MASTL Pathway Delays Meiotic Exit in Mouse Zygotes to Ensure Paternal Chromosome Stability. Soeda S, Yamada-Nomoto K, Michiue T, Ohsugi M. Dev Cell. 2018 Nov;47(3):363-376.e5.
• Serum Brain-derived Neurotrophic Factor Levels Mirror Bone Mineral Density in Amenorrheic and Eumenorrheic Athletes. Nose S, Yoshino O, Nomoto K, Harada M, Dohi M, Kawahara T, Osuga Y, Fujii T, Saito S. Int J Sports Med. 2019 Apr;40(4):276-282.
• Sphingosine 1 Phosphate (S1P) Increased IL-6 Expression and Cell Growth in Endometriotic Cells. Yoshino O, Yamada-Nomoto K, Kano K, Ono Y, Kobayashi M, Ito M, Yoneda S, Nakashima A, Shima T, Onda T, Osuga Y, Aoki J, Saito S. Reprod Sci. 2019 Nov;26(11):1460-1467
• Relaxin-2 May Suppress Endometriosis by Reducing Fibrosis, Scar Formation, and Inflammation. Yoshino O, Ono Y, Honda M, Hattori K, Sato E, Hiraoka T, Ito M, Kobayashi M, Arai K, Katayama H, Tsuchida H, Yamada-Nomoto K, Iwahata S, Fukushi Y, Wada S, Iwase H, Koga K, Osuga Y, Iwaoka M, Unnno N. Biomedicines. 2020 Oct;8(11):467
• Diosgenin content is a novel criterion to assess memory enhancement effect of yam extracts. Yang X, Nomoto K, Tohda C. J Nat Med. 2021 Jan;75(1):207-216.
• Effects of Trigonella foenum-graecum seeds extract on Alzheimer’s disease transgenic model mouse and its potential active compound transferred to the brain. Farid MM, Nagase T, Yang X, Nomoto K, Kuboyama T, Inada Y, Tohda C. Jpn J Food Chem Safety. 2021 Mar;28(2)
• A Novel Heptapeptide, GPPGPAG Transfers to the Brain, and Ameliorates Memory Dysfunction and Dendritic Atrophy in Alzheimer’s Disease Model Mice. Tohda C, Kogure C, Nomoto K, de Toledo A, Yang X, Hirano E. Front Pharmacol. 2021 May;12:680652.
• Horse Placental Extract Enhances Neurogenesis in the Presence of Amyloid ?. de Toledo A, Nomoto K, Hirano E, Tohda C. Nutrients. 2021 May;13(5):1672.

趣味・特技（hobby, specialty）

スキー、山登り、手芸