2020.1.20
Pcdh beta deficiency affects hippocampal CA1 ensemble activity and contextual fear discrimination.

Asai H, Ohkawa N, Saitoh Y, Ghandour K, Murayama E, Nishizono H, Matsuo M, Hirayama T, Kaneko R, Muramatsu S, Yagi T and Inokuchi K.

Molecular Brain,13: 7, 2020.
doi:10.1186/s13041-020-0547-z

2019.9.9
The Japan Neuroscience Society open public lecture "The experts of neuroscience", which was held at the National Museum of Emerging Science and Innovation, was posted on Youtube.

Prof. Inokuchi's [Master of Brain Science x Parallel World Love Story] Kaoru Inokuchi "Reorganize Memory" has been released.

*Japanese Neuroscience Society Public Lecture "Brain Science Master" Channel
This archive video is NEURO2019 citizen open lecture "The brain science master x movie" Parallel World Love Story " "Memory, is it real?"


2019.6.14
Orchestrated ensemble activities constitute a hippocampal memory engram.

Ghandour K, Ohkawa N, Fung CCA, Asai H, Saitoh Y, Takekawa T, Okubo-Suzuki R, Soya S, Nishizono H, Matsuo M, Osanai M, Sato M, Ohkura M, Nakai J, Hayashi Y, Sakurai T, Kitamura T, Fukai T, and Inokuchi K.

Nature Communications,10: 2637, 2019.
doi:10.1038/s41467-019-10683-2

2019.5.30
Professor Kaoru Inokuchi was awarded a Medal of Honor with Purple Ribbon in the first year of Reiwa era.

The award ceremony was held at the Ministry of Education, Culture, Sports, Science and Technology on May 30th and he had an audience with the emperor at the Tokyo Imperial Palace.


-Enlarged version of certificate / medal photo-


2019.5.10
Professor Inokuchi received the title of emeritus professor from Xuzhou Medical University

The award ceremony was held at Xuzhou Medical University on May 10, 2019.


-Enlarged version of certificate / medal photo-


2019.3.19
Naito Memorial Science Promotion prize

Professor Inokuchi was awarded the 50th Naito Memorial prize (2018)
The ceremony was held at Keidanren Kaikeiren Hall on March 19, 2019


-Enlarged version of certificate / medal photo-

The award was given in recognition of the achievement of "Research on the biochemical mechanism of the storage and the association of the memories."

* Naito Memorial Foundation for Science Promotion Award 2018 winners
(Link to the website of the Naito Memorial Foundation for Science)


Takamine Conference Information

Takamine Conference will be held at Tokyo on March 1st, 2019 in commemoration of Professor Inokuchi receiving the Takamine memorial Daiichi Sankyo prize.

* Details


2019.2.10
Awarded Tamura Shiro Science Award.

Lecturer Noriaki Ohkawa received Tamura Shiro Science prize.
The award ceremony was held at the Nichiko auditorium on February 8, 2019 and a certificate and medal were awarded.

The award was given in recognition of the research achievement of "Elucidation of Rules for Neuronal Cell Acquisition of Memory".


-Enlarged version of certificate / medal photo-


2019.2.8
Received the Takamine Memorial Daiichi Sankyo Award.

Prof. Inokuchi won the 16th Takamine Memorial Daiichi Sankyo Award.
The award ceremony was held at the Tokyo Kaikan on February 8, 2019, and a certificate and medal were awarded.


-Enlarged version of certificate / medal photo-

* Awarded research
* Takamine Memorial Daiichi Sankyo Award
(Link to the website of Daiichi Sankyo Life Science Research Foundation)

* Toyama University Website Article


2019.1.8
Artificial association of memory events by optogenetic stimulation of hippocampal CA3 cell ensembles.

Naoya Oishi, Masanori Nomoto, Noriaki Ohkawa, Yoshito Saitoh, Yoshitake Sano, Shuhei Tsujimura, Hirofumi Nishizono, Mina Matsuo, Shin-ichi Muramatsu and Kaoru Inokuchi.

Molecular Brain,12: 2, 2019.
doi:https://doi.org/10.1186/s13041-018-0424-1 (2019)

2018.11.29
A specially appointed assistant professor Kareem Abdou received "The Young Scientist Award" from the director of Faculty of Medicine, University of Toyama.

Details: Announcement from Toyama University School of Medicine

[ Awarded papers ]
Abdou, K., Shehata, M., Choko, K., Nishizono, H., Matsuo, M., Muramatsu, S., and Inokuchi, K.
Synapse-specific representation of the identity of overlapping memory engrams.
Science, 360, Issue 6394, 1227-1231 (2018)
doi:10.1126/science.aat3810 treatise

-Enlarged version of certificate photo-


2018.7.20
A research fund proposal selected as a "New research project starting from 2018" under "Specially Promoted research"

The grant proposal represented by Professor Inokuchi was selected as the new research project starting from April 2018 to March 2023 under the "Specially Promoted Research"

Research Project Title:
Mechanisms underlying information processing in idling brain

Principal Investigator:
Kaoru Inokuchi, Professor, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama

Research Collaborators:
Tomoki Fukai, Team Leader, Neural Coding and Brain computing, RIKEN BSI
Keizo Takao, Professor, Behavioral Physiology, Research Promotion Organization, University of Toyama

FY2018 Grant-in-Aid for Scientific Research Newly selected projects for special promotion research
Research content (Japanese) / Research Project (English)
Findings of examination results


2018.7.9
Adult Neurogenesis Conserves Hippocampal Memory Capacity.

Alam J, Kitamura T, Saitoh Y , Ohkawa N , Kondo T, Inokuchi K.

J. Neurosci., 38: 6854-6863.
doi:https://doi.org/10.1523/JNEUROSCI.2976-17.2018

2018.6.15
Synapse-specific representation of the identity of overlapping memory engrams.

Abdou K, Shehata M, Choko K, Nishizono H, Matsuo M, Muramatsu S, and Inokuchi K.

Science, 360, Issue 6394, pp. 1227-1231.
doi:10.1126/science.aat3810 (2018)

JST Press Release


2018.4.17
The research achievements of the CREST funded projects in our lab are selected as the JST's "The Latest breakthrough of 2018".

Japan Science and Technology Agency (JST) business results


2018.4.11
Autophagy enhances memory erasure through synaptic destabilization.

Shehata M, Abdou K, Choko K, Matsuo M, Nishizono H, and Inokuchi K.

J. Neurosci., 38: 3809-3822.
doi:https://doi.org/10.1523/JNEUROSCI.3505-17.2018

2018.3.15
Awarded "Toray Science and Technology Prize"

Professor Inokuchi was awarded "2018 Toray Science and Technology Prize". The award ceremony was held at The Industry Club of Japan, Marunouchi, Tokyo on March 15th, 2018.
The prize was awarded in recognition of the achievement of "Research on the molecular mechanism and circuit formation of memory".

-Enlarged version of certificate / medal photo-

* The 58th Toray Science Society Presentation Ceremony
[Link to Toray Science Foundation]
*Toyama University Website Article


2017. 4. 8
Professor Inokuchi featured as a guest of the radio show "Tamagawa Misa Happily" to share about the research topics of memory covering such as Long-Term Memory, Reconsolidation, Neurogenesis and Replay.

The podcast link is provided below.
PODCAST QR "Misa Tamagawa happily-TamaColle"
You can listen to the 78th broadcast on April 8th.


2017. 3. 24
Assistant Prof. Masanori Nomoto and Specially Appointed Assistant Prof. Jun Yokose received the "Young Scientist Award".
Details: Announcement from Toyama University School of Medicine

[Awarded papers]

*Assistant Professor Masanori Nomoto (Right of photo)
Nomoto M, Ohkawa N, Nishizono H, Yokose J, Suzuki A, Matsuo M, Tsujimura S, Takahashi Y, Nagase M, Watabe A.M, Kato F, & Inokuchi K.
Cellular tagging as a neural network mechanism for behavioral tagging.   
Nature Communications, 7: 12319.
doi:10.1038/ncomms12319 (2016) Abstract

*Specially Appointed Assistant Prof. Jun Yokose (Left of photo)
Yokose J, Okubo-Suzuki R, Nomoto M, Ohkawa N, Nishizono H, Suzuki A, Matsuo M, Tsujimura S, Takahashi Y, Nagase M, Watabe A.M, Sasahara M, Kato F, & Inokuchi K.
Overlapping memory trace indispensable for linking, but not recalling, individual memories.   
Science, 355: 398-403.
doi:10.1126/science.aal2690 (2017) Abstract




2017.1.27
Overlapping memory trace indispensable for linking, but not recalling, individual memories.

Yokose J, Okubo-Suzuki R, Nomoto M, Ohkawa N, Nishizono H, Suzuki A, Matsuo M, Tsujimura S, Takahashi Y, Nagase M, Watabe AM, Sasahara M, Kato F, Inokuchi K.

Science, 355: 398-403.
doi:10.1126/science.aal2690 (2017)

JST Press Release


2016.9.16
Selected as new research project of 2016 "Sakigake JST Presto"

The research proposal of the lecturer Noriaki Ohkawa was selected as the new research project of "Sakigake" under JST Presto program which starts from October 2016 to March 2020.

Research area: Light manipulation technology for elucidating the mechanism of biological functions
Research Topic : Creation of new methods for manipulation of memory by extracting the pattern characteristics of the engrams.

Japan Science and Technology Agency
New research topics / Overview


2016.9.14
The episode of NHK TV show "Science Zero" which Professor Inokuchi featured as a guest was rebroadcasted due to the popularity and the positive views from the public.

NHK E Tele Science Education Program "Science ZERO"
The mystery of "Memory"
-The true nature of memory that latest neuroscience will unravel-


*Encore broadcast date
September 4 (Sun) 23:30-24:00 (NHK, E Tele)
September 10 (Sat) 12:30-13:00 (NHK, E Tele)
* NHK on demand
Special library (1 year)


2016.8.5
Cellular tagging as a neural network mechanism for behavioral tagging.

Nomoto M., Ohkawa N., Nishizono H., Yokose J., Suzuki A., Matsuo M., Tsujimura S., Takahashi Y., Nagase M., Watabe A.M., Kato F., and Inokuchi K.

Nature Communications, 7: 12319.
doi:10.1038/ncomms12319 (2016)

JST Press Release


2016.3.25
This university will begin a large-scale effort to build a world-class research center which specializes in the field of neuroscience.

*It was introduced on KNB TV.
You can see the aired video.
June 5, 2016 (Sunday) 11:45-12:00(KNB North Japan Broadcasting)

*An article was published in the Kita Nihon newspaper.


2016.2.28
Professor Inokuchi featured in NHK E Television program called "Science ZERO".
You can watch the show on "NHK On Demand" for one year after airing.

NHK E Tele Science Education Program "Science ZERO"
Mystery of "Memory"
-The true nature of memory revealed by the latest neuroscience-


* Broadcast date
February 28 (Sun) 23:30-24:00 (NHK, E Tele)
* Rebroadcast
March 5 (Sat) 12:30-13:00 (NHK, E Tele)
*NHK On Demand
Missed service + special library (1 year)
*Japanese international broadcasting
NHK World Premium (Thursday 00: 20 ~, Sunday 13: 05 ~)


2016.1.29
Professor Inokuchi featured in "Thinking about the wonder of life" with junior and senior high school students - Biological Science DOKIDOKI Laboratory
Life Science DOKIDOKI Laboratory
Dr. Owl's Forest Classroom "Let's think about the wonders of the brain"


2015.6.25
A book was published by Kadokawa Sensho
"Manipulating memory" by Kaoru Inokuchi

This book especially discusses the latest research of memory in an easy-to-understand manner for general public readers. He shared the updates at the forefront of research in memory and the potentials of the future.

Kadokawa Shoten website


2015.4.3
Artificial Association of Pre-stored Information to Generate a Qualitatively New Memory.

Ohkawa N., Saitoh Y., Suzuki A., Tsujimura S., Murayama E., Kosugi S., Nishizono H., Matsuo M., Takahashi Y., Nagase M., Sugimura Y.K., Watabe A.M., Kato F., and Inokuchi K.

Cell Reports, Volume 11, Issue 2, p261-269, 14 April 2015.
DOI: http://dx.doi.org/10.1016/j.celrep.2015.03.017

1. JST
2. PRESS
   Nature
   EurekAlert
   SciGuru Science News


2014.12.1
Department of Biochemistry has moved to the 3rd floor of the Center for Innovation in Medical and Pharmaceutical Sciences

If you are a visitor, Please come to the building of Center for Innovation in Medical and Pharmaceutical Sciences.
Phone numbers are the same as before.


2014.11.18
Synaptic Tagging and Capture was published by Springer (New York).

Lecturer Daisuke Okada (Kitasato University) and Prof. Inokuchi wrote a Chapter 6 "Activity-Dependent Protein Transport as a Synaptic Tag".
-- Please see the [Publications] page for details.--


2014.4.24
" Experience and the Refinement of Synaptic Connections "
translated by Prof. Inokuchi and Assistant prof. Nomoto, and "Neural Network" translated by Prof. Inokuchi and Assistant prof. Yokose were published in the 5th edition of Kandel Neuroscience.
-- Please see the [Publications] page for details.--


2014.4.18
Dr. Suzuki, Dr. Ohkawa, Dr. Nomoto, and Dr. Inokuchi's "Memory Traces" has been published in the Brain Science Dictionary (online dictionary).
-- Please see the [Publications] page for details.--


2014.2.17
"Does autophagy work in synaptic plasticity and memory?", authored by Dr. Shehata and Prof. Inokuchi, was published in Reviews in the Neurosciences.
-- Please see the [Publications] page for details.--


2014.2.16
"Role of the Adult Neurogenesis in Hippocampal-Cortical Memory Consolidation" by Dr.Takashi Kitamura and Professor Inokuchi was published in Molecular Brain.
-- Please see the [Publications] page for details.--


2013.10.1
Research proposal is selected as the new project starting from 2013 for JST CREST.

The research plan, represented by Prof. Inokuchi, was selected as a new CREST research project from October 2013 to March 2019 (5 and a half years).

Research area:
Creation of Fundamental Technologies for Understanding and Control of Biosystem Dynamics

Research subject:
Memory integration process based on cell assembly and neural circuit model

Principal Investigator:
University of Toyama, Graduate School of Medicine and Pharmaceutical Sciences Professor Kaoru Inokuchi

Collaborator:
RIKEN Brain Science Institute Brain Circuit Functional Theory Research Team, Team Leader Tomoki Fukai
The University of Tokyo, Graduate School of Frontier Sciences Associate, Professor Tatsuhiro Hisatsune


FY2013 New applicant information (JST)

2013.5.7
Book is published from Iwanami Science Library.

I published a book that explains the "frontier research of memory" in an easy-to-understand manner for the general public. Due to a remarkable progress in the memory research in recent years, I think it will soon be possible to understand the true nature of memory. The motivation was to share these newest findings and I hope that there will be more various people in general start taking an interest in the field of neuroscience.

I included my research philosophy and a message for young people.

Iwanami Shoten website


2013.4.16
Awarded the Ministry of Education, Culture, Sports, Science and Technology (MEXT) Prize.

Professor Inokuchi was awarded the prize of Ministry of Education, Culture, Sports, Science and Technology (MEXT). The award ceremony was held at the auditorium of MEXT on April 16,2013.

The award was given in recognition of the achievement of "Research on the molecular mechanisms of long-term memory storage"

For details, see the MEXT website:
About the decision of the 2013 Minister of Education, Culture, Sports, Science and Technology Award winners
-Enlarged version of articles and photos-

Medical School Website Article

2012.6.28
Won AND Investigator Award

At the 7th International Conference of Neurons and Brain Diseases (ICNBD) held in Montreal, Canada, Prof. Inokuchi received the AND Investigator Award (June 28, 2012).

The award was given in recognition of its contribution to "Development of the International Society for AND (Association for the Study of Neurons and Diseases)" and "Research on Memory Mechanism".

-Enlarged version of articles and photos-

2011.8.3-5
The 6th ICNBD International Conference, an annual meeting of the Association for the Study of Neurons and Diseases (AND), was held in Toyama City on August 3-5.

This ICNBD international conference presents the latest research with many top researchers from overseas, focusing on basic medical research on neuroplasticity, synaptic function, learning and memory, pain, neurodegenerative diseases, mental disorders, etc.
2011 International Summer Conference of Neurons and Brain Diseases website

Poster (A4 / pdf file)
Access to Toyama: pdf file (116 KB)
Restaurants_and_sightseeing in Toyama: pdf file (85 KB)

2011.5.1
Review articles written by Dr. Ohkawa and Dr. Kitamura were published in the special issue "Understanding memory in terms of molecules and cells" of Cell Engineering supervised by Prof. Inokuchi.

Kaoru Inokuchi: Basics of Fundamentals. Cell Engineering, 30, 466-469 (2011)

Takashi Kitamura and Kaoru Inokuchi: Memory transition mechanism and postnatal hippocampal neurogenesis. Cell engineering, 30, 493-499 (2011)

Noriaki Ohkawa, Kaoru Inokuchi: Embedding new neurons into experience-dependent hippocampal neural networks. Cell engineering, 30, 521-527 (2011)

2010.3.23
Activin plays a key role in the maintenance of long-term memory and late-LTP

Ageta H., IkegamiS., Miura M., Masuda M., Migishima R., Hino T., Takashima N., Murayama A., Sugino H., Setou M., Kida S., Yokoyama M., Hasegawa Y., Tsuchida K., Aosaki T., and Inokuchi K. (2010) Activin plays a key role in the maintenance of long-term memory and late-LTP.

2009.11.13
Adult neurogenesis modulates the hippocampus-dependent period of associative fear memory

Kitamura T., Saitoh Y., Takashima N., Murayama A., Niibori Y., Ageta H., Sekiguchi M., Sugiyama H., & Inokuchi K. Adult neurogenesis modulates the hippocampus-dependent period of associative fear memory.

2009.5.15
Mechanisms underlying the formation of long-term memory
Synaptic tag hypothesis

Okada, D., Ozawa, F. & Inokuchi, K. Input-specific spine entry of soma-derived Vesl-1S protein conforms to synaptic tagging.

2003.5.23
Long-term memory and morphological plasticity

Fukazawa, Y., Saitoh, Y., Ozawa, F., Ohta, Y., Mizuno, K. & Inokuchi, K. Hippocampal LTP is accompanied by enhanced F-actin content within the dendritic spine that is essential for late LTP maintenance in vivo.