1. Kareem Abdou, Masanori Nomoto, Mohamed H. Aly, Ahmed Z. Ibrahim, Kiriko Choko, Reiko Okubo-Suzuki, Shin-ichi Muramatsu, and Kaoru Inokuchi.(2024)
    Prefrontal coding of learned and inferred knowledge during REM and NREM sleep.
    Nature Communications, 15: 4566, 2024. doi:10.1038/s41467-024-48816-x
    (Nature Communications)
  2. Ali Choucry, Masanori Nomoto and Kaoru Inokuchi. (2024)
    Engram mechanisms of memory linking and identity.
    nature reviews neuroscience, 25 April 2024. doi: 10.1038/s41583-024-00814-0
    (nature reviews neuroscience)
    Article PDF


  1. Ohno S, Nomoto M, Inokuchi K.(2023)
    Sleep state-specific neuronal activity dynamics in the prefrontal cortex. Toyama Medical Journal ,33:1
  2. Masanori Nomoto, Noriaki Ohkawa, Kaoru Inokuchi and Naoya Oishi.(2023)
    Requirement for hippocampal CA3 NMDA receptors in artificial association of memory events stored in CA3 cell ensembles.
    Molecular Brain,(2023) 16:12. doi:10.1186/s13041-023-01004-2
    (Molecular Brain)
  3. Ghandour K., and Inokuchi K. (2023)
    Memory reactivations during sleep.
    Neuroscience Research,Available online 26 December 2022. doi:10.1016/j.neures.2022.12.018
    (Neuroscience Research)


  1. Akiyo Kameyama, Hirotaka Asai, Masanori Nomoto, Shuntaro Ohno, Khaled Ghandour, Noriaki Ohkawa, Yoshito Saitoh, Mitsuaki Yamazak, and Kaoru Inokuchi.(2022)
    Sevoflurane-induced amnesia is associated with inhibition of hippocampal cell ensemble activity after learning.
    Biology Open (2022) 11, bio059666. doi:10.1242/bio.059666
    (Biology Open)
  2. Nomoto Masanori, Murayama Emi, Ohno Shuntaro, Okubo-Suzuki Reiko, Muramatsu Shin-ichi and Inokuchi Kaoru.(2022)
    Hippocampus as a sorter and reverberatory integrator of sensory inputs.
    Nature Communications, 13: 7413, 2022. doi:10.1038/s41467-022-35119-2
    (Nature Communications)
  3. Wally, Maha E., Nomoto, Masanori, Abdou, Kareem, Murayama, Emi, and Kaoru Inokuchi. (2022)
    A short-term memory trace persists for days in the mouse hippocampus.
    Communications Biology, 5 (1) doi: 10.1038/s42003-022-04167-1
    (Communications Biology)
  4. Ali Choucry, Khaled Ghandour and Kaoru Inokuchi. (2022)
    The locus coeruleus as a regulator of memory linking.
    Neuron, 110 (20), 3227-3229. doi: 10.1016/j.neuron.2022.09.014
  5. Mohamed H. Aly, Kareem Abdou, Reiko Okubo-Suzuki, Masanori Nomoto, and Kaoru Inokuchi. (2022)
    Selective engram coreactivation in idling brain inspires implicit learning.
    Proc Natl Acad Sci USA,119 (32) e2201578119. doi:10.1073/pnas.2201578119
    ( PNAS )
  6. Suzuki A, Kosugi S, Murayama E, Sasakawa E, Ohkawa N, Konno A, Hirai H and Inokuchi K. (2022)
    A cortical cell ensemble in the posterior parietal cortex controls past experience-dependent memory updating.
    Nature Communications,13:41, 2022. doi:10.1038/s41467-021-27763-x
    ( Nature Communications )


  1. Asai H, Ohkawa N, Saitoh Y, Ghandour K, Murayama E, Nishizono H, Matsuo M, Hirayama T, Kaneko R, Muramatsu S, Yagi T and Inokuchi K. (2020)
    Pcdhß deficiency affects hippocampal CA1 ensemble activity and contextual fear discrimination.
    Molecular Brain,13: 7, 2020. doi:10.1186/s13041-020-0547-z
    ( Molecular Brain )


  1. Ghandour K, Ohkawa N, Fung CCA, Asai H, Saitoh Y, Takekawa T, Okubo-Suzuki R, Soya S, Nishizono H, Matsuo M, Osanai M, Sato M, Ohkura M, Nakai J, Hayashi Y, Sakurai T, Kitamura T, Fukai T, and Inokuchi K. (2019)
    Orchestrated ensemble activities constitute a hippocampal memory engram.
    Nature Communications,14: 10, 2019. doi:10.1038/s41467-019-10683-2
    ( Nature Communications )
  2. Naoya Oishi, Masanori Nomoto, Noriaki Ohkawa, Yoshito Saitoh, Yoshitake Sano, Shuhei Tsujimura, Hirofumi Nishizono, Mina Matsuo, Shin-ichi Muramatsu and Kaoru Inokuchi (2019)
    Artificial association of memory events by optogenetic stimulation of hippocampal CA3 cell ensembles.
    Molecular Brain,12: 2, 2019. doi:
    ( Molecular Brain )


  1. Jing-Shan Lu, Qi-Yu Chen, Sibo Zhou, Kaoru Inokuchi and Min Zhuo (2018)
    Dual roles of anterior cingulate cortex neurons in pain and pleasure in adult mice.
    Molecular Brain,11: 72, 2018. doi:10.1186/s13041-018-0416-1
    ( Molecular Brain )
  2. Alam J, Kitamura T, Saitoh Y , Ohkawa N , Kondo T, and Inokuchi K. (2018)
    Adult Neurogenesis Conserves Hippocampal Memory Capacity.
    J. Neurosci.,38: 6854-6863, 2018. doi:
    ( J. Neurosci.)
  3. Abdou K, Shehata M, Choko K, Nishizono H, Matsuo M, Muramatsu S, Inokuchi K. (2018)
    Synapse-specific representation of the identity of overlapping memory engrams.
    Science, 360, Issue 6394, pp. 1227-1231. doi:10.1126/science.aat3810
    ( Science )
  4. Shehata M, Abdou K, Choko K, Matsuo M, Nishizono H, Inokuchi K. (2018)
    Autophagy enhances memory erasure through synaptic destabilization.
    J. Neurosci., 38: 3809-3822. doi:
    ( J. Neuroscic.)


  1. Nomoto M, Inokuchi K. (2018)
    Behavioral, cellular, and synaptic tagging frameworks.
    Neurobiology of Learning and Memory, in press. doi:
    ( Neurobiology of Learning and Memory )
  2. Yokose J, Okubo-Suzuki R, Nomoto M, Ohkawa N, Nishizono H, Suzuki A, Matsuo M, Tsujimura S, Takahashi Y, Nagase M, Watabe AM, Sasahara M, Kato F, Inokuchi K. (2017)
    Overlapping memory trace indispensable for linking, but not recalling, individual memories. Science, 355: 398-403. doi:10.1126/science.aal2690
    ( Science )


  1. Nomoto M., Ohkawa N., Nishizono H., Yokose J., Suzuki A., Matsuo M., Tsujimura S., Takahashi Y., Nagase M., Watabe A.M., Kato F., and Inokuchi K. (2016)
    Cellular tagging as a neural network mechanism for behavioral tagging.
    Nature Communications, 7: 12319. doi:10.1038/ncomms12319
    ( Nature Communications )

  2. Okubo-Suzuki R., Saitoh Y., Shehata M., Zhao Q., Enomoto H., and Inokuchi K. (2016)
    Frequency-specific stimulations induce reconsolidation of long-term potentiation in freely moving rats.
    Molecular Brain, 9:36. doi:10.1186/s13041-016-0216-4
    ( Molecular Brain )


  1. Omura Y., Carvalho M., Inokuchi K. and Fukai T. (2015)
    A lognormal recurrent network model for burst generation during hippocampal sharp waves.
    J. Neurosci., 35(43), 14585-14601. doi:10.1523/JNEUROSCI.4944-14.2015
    (J. Neurosci.)

  2. Nihonmatsu I., Ohkawa N., Saitoh Y. and Inokuchi K. (2015)
    Targeting of ribosomal protein S6 to dendritic spines by in vivo high frequency stimulation to induce long-term potentiation in the dentate gyrus.
    Biology Open, 4, 1387-1394. doi: 10.1242/bio.013243 (Biology Open)

  3. Ohkawa N., Saitoh Y., Suzuki A., Tsujimura S., Murayama E., Kosugi S., Nishizono H., Matsuo M., Takahashi Y., Nagase M., Sugimura Y.K., Watabe A.M., Kato F., and Inokuchi K. (2015)
    Artificial Association of Pre-stored Information to Generate a Qualitatively New Memory.
    Cell Reports, Volume 11, Issue 2, p261-269, 14 April 2015. DOI: 10.1371/journal.pbio.1002070
    (Cell Reports)
  4. Tsubota T., Okubo-Suzuki R., Ohashi Y., Tamura K., Ogata K., Yaguchi M., Matsuyama M., Inokuchi K., and Miyashita Y. (2015)
    Cofilin1 Controls Transcolumnar Plasticity in Dendritic Spines in Adult Barrel Cortex.
    PLoS. Biol., online 2/27. DOI: 10.1371/journal.pbio.1002070
    (PLoS. Biol.)


  1. Sano Y., Shobe J.L., Zhou M., Huang S., Shuman T., Cai D.J., Golshani P., Kamata M. and Silva A.J. (2014) CREB Regulates Memory Allocation in the Insular Cortex. Curr. Biol., online 11/13. DOI: (Curr. Biol.)
  2. Lee Y.S., Ehninger D., Zhou M., Oh J.Y., Kang M., Kwak C., Ryu H.H., Butz D., Araki T., Cai Y., Balaji J., Sano Y., Nam C.I., Kim H.K., Kaang B.K., Burger C., Neel B.G. and Silva A.J. (2014) Mechanism and treatment for learning and memory deficits in mouse models of Noonan syndrome. Nat. Neurosci., online 11/10. doi:10.1038/nn.3863 (Nat. Neurosci.)
  3. Shehata M. and Inokuchi K. (2014) Does autophagy work in synaptic plasticity and memory? Reviews in the Neurosciences, 25, 543-557. doi:10.1515/revneuro-2014-0002 (Reviews in the Neurosciences)
  4. Kitamura T. and Inokuchi K. (2014) Role of the Adult Neurogenesis in Hippocampal-Cortical Memory Consolidation. Molecular Brain, 7, 13. doi:10.1186/1756-6606-7-13 (Molecular Brain)


  1. Ohkawa N., Saitoh Y., Tokunaga E., Nihonmatsu I., Ozawa F., Murayama A., Shibata F., Kitamura T. and Inokuchi K. (2012) Spine formation pattern of adult-born neurons is differentially modulated by the induction timing and location of hippocampal plasticity. PLoS ONE, 7, e45270. doi:10.1371/journal.pone.0045270 Article (PLoS ONE)
  2. Shehata, M., Matsumura, H., Okubo-Suzuki, R., Ohkawa, N. and Inokuchi, K. (2012) Neuronal-stimulation induces autophagy in hippocampal neurons that is involved in AMPA receptor degradation after chemical LTD. Journal of Neuroscience, 32, 10413-10422. doi:10.1523/JNEUROSCI.4533-11.2012 Abstract (The Journal of Neuroscience)
  3. Kitamura T., Okubo-Suzuki R., Takashima N., Murayama A., Hino T., Nishizono H., Kida S., and Inokuchi K. (2012) Hippocampal function is not required for the precision of remote place memory. Mol Brain, 5, 5. doi:10.1186/1756-6606-5-5 Abstract(PubMed)


  1. Kataoka M., Yamamori S., Suzuki E., Watanabe S., Sato T., Miyaoka H., Azuma S., IkegamiS., Kuwahara R., Suzuki-Migishima R., Nakahara Y., Nihonmatsu I., Inokuchi K., Katoh-Fukui Y., Yokoyama M., and Takahashi M. (2011) A Single Amino Acid Mutation in SNAP-25 Induces Anxiety-Related Behavior in Mouse. PLoS One 6, e25158. doi: 10.1371/journal.pone.0025158 Abstract(PubMed)
  2. Suzuki A., Stern S.A., Bozdagi O., Huntley G.W., Walker R.H., Magistretti P.J., and Alberini C.M. (2011) Astrocyte-neuron lactate transport is required for long-term memory formation. Cell 144, 810-823. doi:10.1016/j.cell.2011.02.018 Abstract(PubMed)
  3. Suzuki A., Fukushima H., Mukawa T., Toyoda H., Wu L.J., Zhao M.G., Xu H., Shang Y., Endoh K., Iwamoto T., Mamiya N., Okano E., Hasegawa S., Mercaldo V., Zhang Y., Maeda R., Ohta M., Josselyn S.A., Zhuo M., and Kida S. (2011) Upregulation of CREB-Mediated Transcription Enhances Both Short- and Long-Term Memory. J Neurosci 31, 8786-8802. doi: 10.1523/JNEUROSCI.3257-10.2011 Abstract(PubMed)
  4. Yamamoto K., Ueta Y., Wang L., Yamamoto R., Inoue N., Inokuchi K., Aiba A., Yonekura H., and Kato N. (2011) Suppression of a neocortical potassium channel activity by intracellular amyloid-ƒÀ and its rescue with homerla. J Neurosci 31, 11100-11109. doi: 10.1523/?JNEUROSCI.6752-10.2011 Abstract(PubMed)
  5. Inokuchi K. (2011) Adult neurogenesis and modulation of neural circuit function, Curr Opin Neurobiol 21, 360-364. doi:10.1016/j.conb.2011.02.006 Abstract(PubMed)


  1. Umeda T., Takashima N., Nakagawa R., Maekawa M., Ikegami S., Yoshikawa T., Kobayashi K., Okanoya K., Inokuchi K., and Osumi N. (2010) Evaluation of Pax6 mutant rat as a model for autism. PloS One 5, e15500. Abstract(PubMed)
  2. Sagata N., Iwaki A., Aramaki T., Takao K., Kura S., Tsuzuki T., Kawakami R., Ito I., Kitamura T., Sugiyama H., Miyakawa T., and Fukumaki Y. (2010) Comprehensive behavioural study of GluR4 knockout mice: implication in cognitive functio. Genes, Brain and Behavior 9, 899-909. Abstract(PubMed)
  3. Kitanishi T., Sakai J., Kojima S., Saitoh Y., Inokuchi K., Fukaya M., Watanabe M., Matsuki N., and Yamada MK. (2010) Activity-dependent localization in spines of the F-actin capping protein CapZ screened in a rat model of dementia. Genes Cells. 15, 737-747. Abstract(PubMed)
  4. Kitamura T., Saitoh Y., Murayama A., Sugiyama H., and Inokuchi K. (2010) LTP induction within a narrow critical period of immature stages enhances the survival of newly generated neurons in the adult rat dentate gyrus. Mol. Brain, 3, 13. Abstract(PubMed)
  5. Ageta H., IkegamiS., Miura M., Masuda M., Migishima R., Hino T., Takashima N., Murayama A., Sugino H., Setou M., Kida S., Yokoyama M., Hasegawa Y., Tsuchida K., Aosaki T., and Inokuchi K. (2010) Activin plays a key role in the maintenance of long-term memory and late-LTP. Learning and Memory, 17, 176-185. Abstract(PubMed)


  1. Kitamura T., Saitoh Y., Takashima N., Murayama A., Niibori Y., Ageta H., Sekiguchi M., Sugiyama H., and Inokuchi K. (2009) Adult neurogenesis modulates the hippocampus-dependent period of associative fear memory. Cell 139, 814-827. Abstract(PubMed)
  2. Inoue, N., Nakao, H., Migishima, R., Hino, T., Matsui, M., Hayashi, F., Nakao, K. , Manabe, T., Aiba, A. & Inokuchi, K. Requirement of the immediate early gene vesl-1S/homer-1a for fear memory formation. Mol Brain , 2, 7 (2009). Abstract(PubMed)
  3. Kawaguchi H., Okamoto S., Sikdar D., Kume A., Li F., Mohafez O.M., Shehata M.H., and Hiraga K. (2009) Genomic organization of regions that regulate chicken glycine decarboxylase gene transcription: physiological and pathological implications. Gene 432, 7-18. Abstract(PubMed)
  4. Maekawa, M., Takashima, N., Matsumata, M., Ikegami, S., Kontani, M., Hara, Y., Kawashima, H., Owada, Y., Kiso, Y., Yoshikawa, T., Inokuchi, K., & Osumi, N. Arachidonic acid drives postnatal neurogenesis and elicits a beneficial effect on prepulse inhibition, a biological trait of psychiatric illnesses. PLoS ONE 4(4): e5085 (2009). Abstract(PubMed)
  5. Okada, D., Ozawa, F. & Inokuchi, K. Input-specific spine entry of soma-derived Vesl-1S protein conforms to synaptic tagging. Science (Research Article) , 324, 904-909 (2009). Abstract(PubMed)
  6. Sekiguchi, M., Hayashi, F., Tsuchida, K. & Inokuchi, K. Neuron type-selective effects of activin on development of the hippocampus. Neurosci Lett , 452, 232-237 (2009) Abstract(PubMed)
  7. Suzuki H., Kato I., Usui I., Takasaki I., Tabuchi Y., Oya T., Tsuneyama K., Kawaguchi H., Hiraga K., Takasawa S., Okamoto H., Tobe K., and Sasahara M. (2009) Characterization of diabetic nephropathy in CaM kinase IIalpha (Thr286Asp) transgenic mice. Biochem. Biophys. Res. Comm. 379, 38-42 Abstract(PubMed)
  8. Takahashi I., Noguchi N., Nata K., Yamada S., Kaneiwa T., Mizumoto S., Ikeda T., Sugihara K., Asano M., Yoshikawa T., Yamauchi A., Shervani NJ., Uruno A., Kato I., Unno M., Sugahara K., Takasawa S., Okamoto H., and Sugawara A. (2009) Important role of heparan sulfate in postnatal islet growth and insulin secretion. Biochem. Biophys. Res. Comm. 383, 113-118. Abstract(PubMed)


  1. Abdel-Aziz H. O., Murai Y., Takasaki I., Tabuchi Y., Zheng H-C., Nomoto K., Takahashi H., Tsuneyama K., Kato I., Hsu D. K., Liu F-T., Hiraga K., and Takano Y. (2008) Targeted disruption of the galectin-3 gene results in decreased susceptibility to NNK-induced lung tumorigenesis: an oligonucleotide microarray study. J. Cancer Res. Clin. Oncol. 134, 777-788. Abstract(PubMed)
  2. Ageta, H., Murayama, A., Migishima, R., Kida, S., Tsuchida, K., Yokoyama, M. & Inokuchi, K. Activin in the brain modulates anxiety-related behavior and adult neurogenesis. PLoS ONE 3, e1869 (2008). Abstract(PubMed)
  3. Hayashi, F., Takashima, N., Murayama, A. & Inokuchi, K. Decreased postnatal neurogenesis in the hippocampus combined with stress experience during adolescence is accompanied by an enhanced incidence of behavioral pathologies in adult mice. Mol Brain 1, 22 (2008). Abstract(PubMed)
  4. Kato I., Oya T., Suzuki H., Takasawa K., Ichsan A.M., Nakada S., Ishii Y., Shimada Y., Sasahara M., Tobe K., Takasawa S., Okamoto H., and Hiraga K. (2008) A novel model of insulin-dependent diabetes with renal and retinal lesions by transgenic expression of CaMKII?? (Thr286Asp) in pancreatic ?A-cells. Diabetes Metab. Res. Rev. 24, 486-497. Abstract(PubMed)
  5. Liu H-X., Lopatina O., Higashida C., Tsuji T., Kato I., Takasawa S., Okamoto H., Yokoyama S., and Higashida H. (2008) Locomotor activity, ultrasonic vocalization and oxytocin levels in infant CD38 knockout mice. Neurosci. Lett. 448, 67-70. Abstract(PubMed)
  6. Nakanishi Y., Tsuneyama K., Nomoto K., Fujimoto M., Salunga T. L., Nakajima T., Miwa S., Murai Y., Hayashi S., Kato I., Hiraga K., Hsu DK., Liu FT., and Takano Y. (2008) Nonalcoholic steatohepatitis and hepatocellular carcinoma in galectin-3 knockout mice. Hepatol Res. 38, 1241-1521. Abstract(PubMed)
  7. Ohkawa, N., Sugisaki, S., Tokunaga, E., Fujitani, K., Hayasaka, T., Setou, M. & Inokuchi, K. N-acetyltransferase ARD1-NAT1 regulates neuronal dendritic development. Genes Cells 13, 1171-1183 (2008). Abstract(PubMed)
  8. Okubo-Suzuki, R., Okada, D., Sekiguchi, M. & Inokuchi, K. Synaptopodin maintains the neural activity-dependent enlargement of dendritic spines in hippocampal neurons. Mol Cell Neurosci 38, 266-276 (2008). Abstract(PubMed)
  9. Shimada I., Matsui K., Brinkmann B., Hohoff C., Hiraga K., Tabuchi Y., Takasaki I., Kato I., Kawaguchi H., Takasawa K., Iida R., Takizawa H., and Matsuki T. (2008) Novel transcript profiling of diffuse alveolar damage induced by hyperoxia exposure in mice: normalization by glyceraldehyde 3-phosphate dehydrogenase. Int. J. Legal Med. 122, 373-383. Abstract(PubMed)
  10. Takasawa A., Kato I., Takasawa K., Ishii Y., Yoshida T., Shehata M. H., Kawaguchi H., Mohafez O. M. M., Sasahara M., and Hiraga K. (2008) Mutation-, aging-, and gene dosage-dependent accumulation of neuroserpin (G392E) in endoplasmic reticula and lysosomes of neurons in transgenic mice. J. Biol. Chem. 283, 35606-35613.
  11. Abstract(PubMed)
  12. Ueta, Y., Yamamoto, R., Sugiura, S., Inokuchi, K. & Kato, N. Homer 1a suppresses neocortex long-term depression in a cortical layer-specific manner. J Neurophysiol 99, 950-7 (2008). Abstract(PubMed)
  13. Yang, H., Takagi, H., Konishi, Y., Ageta, H., Ikegami, K., Yao, I., Sato, S., Hatanaka, K., Inokuchi, K., Seog, D.H. & Setou, M. Transmembrane and ubiquitin-like domain-containing protein 1 (Tmub1/HOPS) facilitates surface expression of GluR2-containing AMPA receptors. PLoS ONE 3, e2809 (2008). Abstract(PubMed)


  1. Aiba, A., Inokuchi, K., Ishida, Y., Itohara, S., Kobayashi, K., Masu, M., Mishina, M., Miyakawa, T., Mori, H., Nakao, K., Obata, Y., Sakimura, K., Shiroishi, T., Wada, K., and Yagi, T.: Mouse liaison for integrative brain research. Neurosci Res. , 58: 103-104 (2007). Abstract(PubMed)
  2. Inoue, Y., Udo, H., Inokuchi, K. & Sugiyama, H. Homer1a regulates the activity-induced remodeling of synaptic structures in cultured hippocampal neurons. Neuroscience 150, 841-52 (2007). Abstract(PubMed)
  3. Jin D., Liu H-X., Hirai H., Torashima T., Nagai T., Lopatina O., Shnayder N. A., Yamada K., Noda M., Seike T., Fujita K., Takasawa S., Yokoyama S., Koizumi K., Shiraishi Y., Tanaka S., Hashii M., Yoshihara T., Higashida K., Islam M. S., Yamada N., Hayashi K., Noguchi N., Kato I., Okamoto H., Matsushima A., Salmina A., Munesue T., Shimizu N., Mochida S., Asano M. and Higashida H. (2007) CD38 is critical for social behaviour by regulating oxytocin secretion. Nature 446, 41-45. Abstract(PubMed)
  4. Kudo, T., Fujii, T., Ikegami, S., Inokuchi, K., Takayama, Y., Ikehara, Y., Nishihara, S., Togayachi, A., Takahashi, S., Tachibana, K., Yuasa, S. & Narimatsu, H. Mice lacking {alpha}1,3-fucosyltransferase IX demonstrate disappearance of Lewis x structure in brain and increased anxiety-like behaviors. Glycobiology 17, 1-9 (2007). Abstract(PubMed)
  5. Matsumoto, M., Setou, M. & Inokuchi, K. Transcriptome analysis reveals the population of dendritic RNAs and their redistribution by neural activity. Neurosci Res 57, 411-423 (2007). Abstract(PubMed)
  6. Niibori, Y., Hayashi, F., Hirai, K., Matsui, M. & Inokuchi, K. Alternative poly(A) site-selection regulates the production of alternatively spliced vesl-1/homer1 isoforms that encode postsynaptic scaffolding proteins. Neurosci Res 57, 399-410 (2007). Abstract(PubMed)
  7. Ohkawa, N., Fujitani, K., Tokunaga, E., Furuya, S. & Inokuchi, K. The microtubule destabilizer stathmin mediates the development of dendritic arbors in neuronal cells. J Cell Sci 120, 1447-56 (2007). Abstract(PubMed)
  8. Ohkawa, N., Hashimoto, K., Hino, T., Migishima, R., Yokoyama, M., Kano, M. & Inokuchi, K. Motor discoordination of transgenic mice overexpressing a microtubule destabilizer, stathmin, specifically in Purkinje cells. Neurosci Res 59, 93-100 (2007). Abstract(PubMed)
  9. Shoji-Kasai, Y., Ageta, H., Hasegawa, Y., Tsuchida, K., Sugino, H. & Inokuchi, K. Activin increases the number of synaptic contacts and the length of dendritic spine necks by modulating spinal actin dynamics. J Cell Sci 120, 3830-7 (2007). Abstract(PubMed)
  10. Umemura K., Kato I., Hirashima Y., Ishii Y., Inoue T., Aoki J., Kono N., Oya T., Hayashi N., Hamada H., Endo S., Oda M., Arai H., Kinouchi H., and Hiraga K. (2007) Neuroprotective role of transgenic PAF-acetylhydrolase II in mouse models of focal cerebral ischemia. Stroke 38, 1063-1068. Abstract(PubMed)
  11. Yao, I., Takagi, H., Ageta, H., Kahyo, T., Sato, S., Hatanaka, K., Fukuda, Y., Chiba, T., Morone, N., Yuasa, S., Inokuchi, K., Ohtsuka, T., Macgregor, G.R., Tanaka, K. & Setou, M. SCRAPPER-Dependent Ubiquitination of Active Zone Protein RIM1 Regulates Synaptic Vesicle Release. Cell 130, 943-57 (2007). Abstract(PubMed)


  1. Hibino Y., Usui T., Morita Y., Hirose N., Okazaki M., Sugano N., and Hiraga K. (2006) Molecular properties and intracellular localization of rat liver nuclear scaffold protein P130. Biochim. Biophys. Acta 1759, 195-207. Abstract(PubMed)
  2. Kataoka, M., Kuwahara, R., Matsuo, R., Sekiguchi, M., Inokuchi, K. & Takahashi, M. Development- and activity-dependent regulation of SNAP-25 phosphorylation in rat brain. Neurosci Lett 407, 258-62 (2006). Abstract(PubMed)
  3. Li F., Kato I., Kawaguchi H., Takasawa K., Hibino Y., and Hiraga K. (2006) The galectin-3 gene promoter binding proteins in the liver of rats 48-h post-treatment with CCl4. Gene 367, 46-55. Abstract(PubMed)
  4. Myint K.M., Yamamoto Y., Doi T., Kato I., Harashima A., Yonekura H., Watanabe T., Shinohara H., Takeuchi M., Tsuneyama K., Hashimoto N., Asano M., Takasawa S., Okamoto H., and Yamamoto H. (2006) RAGE control of diabetic nephropathy in a mouse model: effects of RAGE gene disruption and administration of low molecular weight heparin. Diabetes 55, 2510-2522. Abstract(PubMed)
  5. Nomoto K., Tsuneyama K., Aziz H.O.A., Takahashi H., Murai Y., Cui Z-G., Fujimoto M., Kato I., Hiraga K., Hsu D.K., Liu F-T., and Takano Y. (2006) Disrupted galectin-3 causes non-alcoholic fatty liver disease in male mice. J. Pathol. 210, 469-477. Abstract(PubMed)
  6. Stokely, M.E., Hwang, S.Y., Hwang, J.Y., Fan, B., King, M.A., Inokuchi, K. & Koulen, P. Polycystin-1 can interact with homer 1/Vesl-1 in postnatal hippocampal neurons. J Neurosci Res 84, 1727-37 (2006). Abstract(PubMed)
  7. Tada M., Shinohara Y., Kato I., Hiraga K., Aizawa T., Demura M., Mori Y., Shinoda H., Mizuguchi M., and Kawano K. (2006) Preparation and observation of fresh-frozen sections of the green fluorescent protein transgenic mouse head. Acta Histochem. Cytochem. 39, 31-34. Abstract(PubMed)
  8. Tanaka, M., Duncan, R.S., McClung, N., Yannazzo, J.A., Hwang, S.Y., Marunouchi, T., Inokuchi, K. & Koulen, P. Homer proteins control neuronal differentiation through IP(3) receptor signaling. FEBS Lett 580, 6145-50 (2006). Abstract(PubMed)


  1. Ichsan A.M., Kato I., Yoshida T., Takasawa K., Hayasaka S., and Hiraga K. (2005) Rhodoposin promoter-EGFP fusion transgene expression in photoreceptor neurons of retina and pineal complex in mice. Neurosci. Lett. 379, 138-143. Abstract(PubMed)
  2. Inoue, K., Fukazawa, Y., Ogura, A. & Inokuchi, K. Two-dimensional neural activity mapping of the entire population of hippocampal CA1 pyramidal cells responding to fear conditioning. Neurosci Res 51, 417-25 (2005). Abstract(PubMed)
  3. Maekawa, M., Takashima, N., Arai, Y., Nomura, T., Inokuchi, K., Yuasa, S. & Osumi, N. Pax6 is required for production and maintenance of progenitor cells in postnatal hippocampal neurogenesis. Genes Cells 10, 1001-14 (2005). Abstract(PubMed)
  4. Sakagami, Y., Yamamoto, K., Sugiura, S., Inokuchi, K., Hayashi, T. & Kato, N. Essential roles of Homer-1a in homeostatic regulation of pyramidal cell excitability: a possible link to clinical benefits of electroconvulsive shock. Eur J Neurosci 21, 3229-39 (2005). Abstract(PubMed)
  5. Yamamoto, K., Sakagami, Y., Sugiura, S., Inokuchi, K., Shimohama, S. & Kato, N. Homer 1a enhances spike-induced calcium influx via L-type calcium channels in neocortex pyramidal cells. Eur J Neurosci 22, 1338-48 (2005). Abstract(PubMed)
  6. Yamamoto Y., Doi T., Kato I., Shinohara H., Sakurai S., Yonekura H., Watanabe T., Myint K.M., Harashima A., Takeuchi M., Takasawa S., Okamoto H., Hashimoto N., Asano M., and Yamamoto H. (2005) RAGE is a promising target in diabetic nephropathy. Ann. NY Acad. Sci. 1043, 562-566. Abstract(PubMed)


  1. Ehrengruber, M., Kato, A., Inokuchi, K., Hennou, S. Homer/Vesl proteins and their roles in CNS neurons. Mol. Neurobiol. , 29: 213-227 (2004). Abstract(PubMed)
  2. Inaba, Y., Tian, Q.B., Okano, A., Zhang, J.P., Sakagami, H., Miyazawa, S., Li, W., Komiyama, A., Inokuchi, K., Kondo, H. & Suzuki, T. Brain-specific potential guanine nucleotide exchange factor for Arf, synArfGEF (Po), is localized to postsynaptic density. J Neurochem 89, 1347-57 (2004). Abstract(PubMed)
  3. Inoue, Y., Honkura, N., Kato, A., Ogawa, S., Udo, H., Inokuchi, K. & Sugiyama, H. Activity-inducible protein Homer1a/Vesl-1S promotes redistribution of postsynaptic protein Homer1c/Vesl-1L in cultured rat hippocampal neurons. Neurosci Lett 354, 143-147 (2004). Abstract(PubMed)
  4. Sugiyama, K., Niki, T.P., Inokuchi, K., Teranishi, Y., Ueda, M. & Tanaka, A. Heterologous expression of metabotropic glutamate receptor subtype 1 in Saccharomyces cerevisiae. Appl Microbiol Biotechnol 64, 531-536 (2004). Abstract(PubMed)
  5. Trivedi P., Takasawa K., Zompetta C., Cuomo L., Anastasiadou E., Carbone A., Uccini S., Belardelli F., Takada K., Frati L., and Faggioni A. (2004) Infection of HHV-8 positive primary effusionlymphoma cells with a recombinant Epstein-Barr virus lead to restricted EBV latency, altered phenotype, and increased tumorigenicity without affecting TCL1 expression. Blood 103, 313-316. Abstract(PubMed)


  1. Fukazawa, Y., Saitoh, Y., Ozawa, F., Ohta, Y., Mizuno, K. & Inokuchi, K. Hippocampal LTP is accompanied by enhanced F-actin content within the dendritic spine that is essential for late LTP maintenance in vivo. Neuron 38, 447-460 (2003). Abstract(PubMed)
  2. Giustetto, M., Hegde, A.N., Si, K., Casadio, A., Inokuchi, K., Pei, W., Kandel, E.R. & Schwartz, J.H. Axonal transport of eukaryotic translation elongation factor 1{alpha} mRNA couples transcription in the nucleus to long-term facilitation at the synapse. Proc Natl Acad Sci U S A 100, 13680-13685 (2003). Abstract(PubMed)
  3. Hamada H., Zhang Y. L., Kawai A., Li F., Hibino Y., Hirashima Y., Kurimoto M., Hayashi N., Kato I., Endo S., and Hiraga K. (2003) Development-associated myristoylated alanine-rich C kinase substrate phosphorylation in rat brain. Childs. Nerv. Syst. 19, 152-158. Abstract(PubMed)
  4. Hennou, S., Kato, A., Schneider, E.M., Lundstrom, K., Gahwiler, B.H., Inokuchi, K., Gerber, U. & Ehrengruber, M.U. Homer-1a/Vesl-1S enhances hippocampal synaptic transmission. Eur J Neurosci 18, 811-819 (2003). Abstract(PubMed)
  5. Hwang, S.Y., Wei, J., Westhoff, J.H., Duncan, R.S., Ozawa, F., Volpe, P., Inokuchi, K. & Koulen, P. Differential functional interaction of two Vesl/Homer protein isoforms with ryanodine receptor type 1: a novel mechanism for control of intracellular calcium signaling. Cell Calcium 34, 177-184 (2003). Abstract(PubMed)
  6. Kaja, S., Yang, S.H., Wei, J., Fujitani, K., Liu, R., Brun-Zinkernagel, A.M., Simpkins, J.W., Inokuchi, K. & Koulen, P. Estrogen Protects the Inner Retina from Apoptosis and Ischemia-Induced Loss of Vesl-1L/Homer 1c Immunoreactive Synaptic Connections. Invest Ophthalmol Vis Sci 44, 3155-3162 (2003). Abstract(PubMed)
  7. Kato, A., Fukazawa, Y., Ozawa, F., Inokuchi, K. & Sugiyama, H. Activation of ERK cascade promotes accumulation of Vesl-1S/Homer-1a immunoreactivity at synapses. Brain Res Mol Brain Res 118, 33-44 (2003). Abstract(PubMed)
  8. Takahashi J., Kagaya Y., Kato I., Ohta J., Isoyama S., Miura M., Sugai Y., Hirose M., Wakayama Y., Ninomiya M., Watanabe J., Takasawa S., Okamoto H., and Shirato K. (2003) Deficit of CD38/cyclic ADP-ribose is differentially compensated in hearts by gender. Biochem. Biophys. Res. Commun. 312, 434-440. Abstract(PubMed)
  9. Mitsui-Saito M., Kato I., Takasawa S., Okamoto H., and Yanagisawa T. (2003) CD38 Gene Disruption Inhibits the Contraction Induced by alpha-Adrenoceptor Stimulation in Mouse Aorta. J. Vet. Med. Sci. 65, 1325-1330. Abstract(PubMed)
  10. Morita, M., Kobayashi, A., Yamashita, T., Shimanuki, T., Nakajima, O., Takahashi, S., Ikegami, S., Inokuchi, K., Yamashita, K., Yamamoto, M. & Fujii-Kuriyama, Y. Functional Analysis of Basic Transcription Element Binding Protein by Gene Targeting Technology. Mol Cell Biol 23, 2489-2500 (2003). Abstract(PubMed)
  11. Westhoff, J.H., Hwang, S.Y., Scott Duncan, R., Ozawa, F., Volpe, P., Inokuchi, K. & Koulen, P. Vesl/Homer proteins regulate ryanodine receptor type 2 function and intracellular calcium signaling. Cell Calcium 34, 261-269 (2003). Abstract(PubMed)


  1. Chini E.N., Chini C.C., Kato I., Takasawa S., and Okamoto H. (2002) CD38 is the major enzyme responsible for synthesis of nicotinic acid- adenine dinucleotide phosphate in mammalian tissues. Biochem. J. 15, 125-130. Abstract(PubMed)
  2. Kaku H., Horikawa K., Obata Y., Kato I., Okamoto H., Sakaguchi N., Gerondakis S., and Takatsu K. (2002) NF-kappaB is required for CD38-mediated induction of C(gamma)1 germline transcripts in murine B lymphocytes. Int. Immunol. 14, 1055-1064. Abstract(PubMed)
  3. Petrova R., Yamamoto Y., Muraki K., Yonekura H., Sakurai S., Watanabe T., Li H., Takeuchi M., Makita Z., Kato I., Takasawa S., Okamoto H., Imaizumi Y., and Yamamoto H. (2002) Advanced glycation endproduct-induced calcium handling impairment in mouse cardiac myocytes. J. Mol. Cell. Cardiol. 34, 1425-1431. Abstract(PubMed)
  4. Nanbo A., Inoue K., Adachi-Takasawa K., and Takeda K. (2002) Epstein-Barr virus RNA confers resistance to interferon-??-induced apoptosis in Burkitt's lymphoma. EMBO J. 21, 954-965. Abstract(PubMed)


  1. Ageta, H., Kato, A., Fukazawa, Y., Inokuchi, K. & Sugiyama, H. Effects of proteasome inhibitors on the synaptic localization of Vesl-1S/Homer-1a proteins. Brain Res Mol Brain Res 97, 186-9 (2001). Abstract(PubMed)
  2. Fukushi, Y., Kato, I., Takasawa, S., Sasaki, T., Ong, BH., Sato, M., Ohsaga, A., Sato, K., Shirato, K., Okamoto, H., and Maruyama, Y. (2001) Identification of cyclic ADP-ribose-dependent mechanisms in pancreatic muscarinic Ca2+ signaling using CD38 knockout mice. J Biol Chem. 276, 649-55. Abstract(PubMed)
  3. Kato, A., Fukuda, T., Fukazawa, Y., Isojima, Y., Fujitani, K., Inokuchi, K. & Sugiyama, H. Phorbol esters promote postsynaptic accumulation of Vesl-1S/Homer-1a protein. Eur J Neurosci 13, 1292-1302. (2001). Abstract(PubMed)
  4. Matsuo, R., Asada, A., Fujitani, K. & Inokuchi, K. LIRF, a gene induced during hippocampal long-term potentiation as an immediate-early gene, encodes a novel RING finger protein. Biochem Biophys Res Commun 289, 479-484 (2001). Abstract(PubMed)
  5. Nakazawa, T., Satoh, J., Takahashi, K., Sakata, Y., Ikehata, F., Takizawa, Y., Bando, SI., Housai, T., Li, Y., Chen, C., Masuda, T., Kure, S., Kato, I., Takasawa, S., Taniguchi, T., Okamoto, H., and Toyota, T. (2001) Complete suppression of insulitis and diabetes in NOD mice lacking interferon regulatory factor-1. J. Autoimmun. 17, 119-125. Abstract(PubMed)?j
  6. Saito, A., Kamii, H., Kato, I., Takasawa, S., Kondo, T., Chan, PH., Okamoto, H., and Yoshimoto, T. (2001) Transgenic CuZn-superoxide dismutase inhibits NO synthase induction in experimental subarachnoid hemorrhage. Stroke. 32, 1652-1657. Abstract(PubMed)
  7. Shinohara, T., Tomizuka, K., Miyabara, S., Takehara, S., Kazuki, Y., Inoue, J., Katoh, M., Nakane, H., Iino, A., Ohguma, A., Ikegami, S., Inokuchi, K., Ishida, I., Reeves, R.H. & Oshimura, M. Mice containing a human chromosome 21 model behavioral impairment and cardiac anomalies of Down's syndrome. Hum Mol Genet 10, 1163-1175 (2001). Abstract(PubMed)
  8. Yamamoto, Y., Kato, I., Doi, T., Yonekura, H., Ohashi, S., Takeuchi, M., Watanabe, T., Yamagishi, S., Sakurai, S., Takasawa, S., Okamoto, H. and Yamamoto, H. (2001) Development and prevention of advanced diabetic nephropathy in RAGE-overexpressing mice. J. Clin. Invest. 108, 261-268. Abstract(PubMed)
  9. Yamazaki, K., Kawai, A., Kawaguchi, M., Hibino, Y., Li, F., Sasahara, M., Tsukada, K., and Hiraga, K. (2001) Simultaneous induction of galectin-3 phosphorylated on tyrosine residue, p21WAF1/Cip1/Sdi1, and the proliferating cell nuclear antigen at a distinctive period of repair of hepatocytes injured by CCl4. Biochem. Biophys. Res. Commun. 280, 1077-1084. Abstract(PubMed)
  10. Yamazaki, M., Matsuo, R., Fukazawa, Y., Ozawa, F. & Inokuchi, K. Regulated expression of an actin-associated protein, synaptopodin, during long-term potentiation. J Neurochem 79, 192-199. (2001). Abstract(PubMed)