研究業績
2025年
64. Yaku K, Palikhe S, Iqbal T, Hayat F, Watanabe Y, Fujisaka S, Izumi
H, Yoshida T, Karim M, Uchida H, Nawaz A, Tobe K, Mori H, Migaud ME, Nakagawa T*. Nicotinamide riboside and nicotinamide mononucleotide facilitate NAD+ synthesis via enterohepatic circulation. Sci Adv. 11(12): eadr1538. (2025)
63. Phuong NQ, Bilal M, Nawaz A, Anh LD, Memoona, Aslam M, Khalid S, Kado
T, Watanabe Y, Nishimura A, Igarashi Y, Okabe K, Hirabayashi K, Yamamoto
S, Nakagawa T, Mori H, Usui I, Fujisaka S, Hayashi R, Tobe K. Role of transforming growth
factor-β1 in regulating adipocyte progenitors.Sci Rep. 15(1): 941. (2025)
2024年
62. Sakamoto I, Shibuya S, Nojiri H, Takeno K, Nishimune H, Yaku K, Nakagawa T, Ishijima M, Shimizu T. Mitochondrial redox status regulates glycogen
metabolism via glycogen phosphorylase activity. Antioxidants.13(11): 1421. (2024)
61. Kamei K, Yahara Y, Kim JD, Tsuji M, Mami Iwasaki D, Takemori H, Seki
S, Makino H, Futakawa H, Hirokawa T, Nguyen TCT, Nakagawa T, Kawaguchi Y. Impact of the SIK3 Pathway Inhibition on Osteoclast Differentiation
via Oxidative Phosphorylation. J Bone Miner Res. 39(9):1340-1355. (2024)
60. Iqbal T, Nakagawa T*. The therapeutic perspective of NAD+ precursors in age-related diseases.
Biochem Biophys Res Commun. 702: 149590. (2024)
59. Membrez M, Migliavacca E, Christen S, Yaku K, Trieu J, Lee AK, Morandini
F, Giner MP, Stiner J, Makarov MV, Garratt ES, Vasiloglou MF, Chanvillard
L, Dalbram E, Ehrlich AM, Sanchez-Garcia JL, Canto C, Karagounis LG, Treebak
JT, Migaud ME, Heshmat R, Razi F, Karnani N, Ostovar A, Farzadfar F, Tay
SKH, Sanders MJ, Lillycrop KA, Godfrey KM, Nakagawa T, Moco S, Koopman R, Lynch GS, Sorrentino V, Feige JN. Trigonelline is
a Novel NAD+ Precursor that Improves Muscle Function during Ageing and
is Reduced in Human Sarcopenia. Nat Metab.6: 433–447. (2024)
58. Nawaz A, Manzoor A, Ahmed S, Ahmed N, Abbas W, Ahmad M, Bilal M, Sheikh
A, Ahmad S, Jeelani I, Nakagawa T. Therapeutic approaches for chronic hepatitis C: a concise review. Front. Pharmacol.14:1334160. (2024)
2023年
57. Nomura M, Ohuchi M, Sakamoto Y, Kudo K, Yaku K, Soga T, Sugiura Y,
Morita M, Hayashi K, Miyahara S, Sato T, Yamashita Y, Ito S, Kikuchi N,
Sato I, Saito R, Yaegashi N, Fukuhara T, Yamada H, Shima H, Nakayama KI,
Hirao A, Kawasaki K, Arai Y, Akamatsu S, Tanuma SI, Sato T, Nakagawa T, Tanuma N. Niacin restriction with NAMPT-inhibition is synthetic lethal
to neuroendocrine carcinoma. Nat Commun. 14(1):8095. (2023)
56. Watanabe Y, Fujisaka S, Morinaga Y, watababe S, Nawaz A, Hatta H, Kado
T, Nishimura A, Bilal M, Aslam MR, Yagi K, Honda K, Nakagawa Y, Sofic S,
Hirabayashi K, Nakagawa T, Nagai Y, Tobe K. Isoxanthohumol improves obesity and glucose metabolism
via inhibiting intestinal lipidabsorption with a bloom of Akkermansia muciniphila
in mice. Mol Metab. 77:101797. (2023)
55. Yamaguchi S, Kojima D, Iqbal T, Kosugi S, Franczyk MP, Qi N, Sasaki
Y, Yaku K, Kaneko K, Kinouchi K, Itoh H, Hayashi K, Nakagawa T, Yoshino J. Adipocyte NMNAT1 expression is essential for nuclear NAD+
biosynthesis but dispensable for regulating thermogenesis and whole-body
energy metabolism. Biochem Biophys Res Commun. 674(1): 162-159. (2023)
54. Funaro A, Nakagawa T, Ishihara K. Editorial: Revisiting Immunological Roles for Bone Marrow
Stromal Cell Antigen-1, an Entero-Neuro-Immune Regulator. Front Immunol. 14:1239546. (2023)
53. Yaku K, Nakagawa T*. NAD+ Precursors in Human Health and Disease: Current Status and Future
Prospects. Antioxid Redox Signal. 39(16-18):1133-1149. (2023)
52. Ni X, Inoue R, Wu Y, Yoshida T, Yaku K, Nakagawa T, Saito T, Saido T, Takao K, Mori H. Contributions of D-serine to Alzheimer's
disease pathology in male App NL-G-F/NL-G-F mice. Front Aging Neurosci.15:1211067. (2023)
51. Karim M, Iqbal T, Nawaz A, Yaku K, Nakagawa T*. Deletion of Nmnat1 in skeletal muscle leads to the reduction of NAD+
levels but has no impact on skeletal muscle morphology and fiber types.
J Nutr Sci Vitaminol. 69(3): 184-189. (2023)
50. Nakagawa-Nagahama Y, Igarashi M, Miura M, Kashiwabara K, Yaku K, Fukamizu
Y, Sato T, Sakurai T, Nakagawa T, Kadowaki T, Yamauchi T. Blood levels of nicotinic acid negatively correlate
with hearing ability in healthy older men. BMC Geriatr. 23(1):97. (2023)
2022年
49. Mahmood A, Yaku K*, Hikosaka K, Gulshan M, Inoue SI, Kobayashi F, Nakagawa T*. Nmnat3 deficiency in hemolytic anemia exacerbates malaria infection.
Biochem Biophys Res Commun. 637(1): 58-65. (2022)(*Corresponding author)
48. Iqbal T, Nawaz A, Karim M, Yaku K, Hikosaka K, Matsumoto M, Nakagawa T*. Loss of hepatic Nmnat1 has no impact on diet-induced fatty liver disease.
Biochem Biophys Res Commun. 636(1): 89-95. (2022)(*Corresponding author)
47. Nawaz A, Bilal M, Fujisaka S, Kado T, Aslam MR, Ahmed S, Okabe K, Igarashi
Y, Watanabe Y, Kuwano T, Tsuneyama K, Nishimura A, Nishida Y, Yamamoto
S, Sasahara M, Imura J, Mori H, Matzuk MM, Kudo F, Manabe I, Uezumi A,
Nakagawa T, Oishi Y, Tobe K. Depletion of CD206+ M2-like macrophages induces fibro-adipogenic
progenitors activation and muscle regeneration. Nat Commun. 13(1):7058. (2022)
46. Tsuneki H, Sugiyama M, Ito T, Sato K, Matsuda H, Onishi K, Yubune K,
Matsuoka Y, Nagai S, Yamagishi T, Maeda T, Honda K, Okekawa A, Watanabe
S, Yaku K, Okuzaki D, Otsubo R, Nomoto M, Inokuchi K, Nakagawa T, Wada T, Yasui T, Sasaoka T. Food odor perception promotes systemic lipid
utilization. Nat Metab. 4(11):1514-1531. (2022)
45. Palikhe S,Nakagawa T*: NAD+ metabolism in Aging. "Aging Mechanisms II: Longevity, Metabolism, and Brain Aging" Edited by Niozomu Mori.
Springer. Chapter 8. 141-156. (2022) (*Corresponding author)
44. Igarashi M, Nakagawa-Nagahama Y, Miura M, Kashiwabara K, Yaku K, Sawada
M, Sekine R, Fukamizu Y, Sato T, Sakurai T, Sato J, Ino K, Kubota N, Nakagawa T, Kadowaki T, Yamauchi T. Chronic nicotinamide mononucleotide supplementation
elevates blood nicotinamide adenine dinucleotide levels and alters muscle
function in healthy older men. npj Aging. 8:3 (2022)
43. Okabe K, Yaku K, Uchida Y, Fukamizu Y, Sato T, Sakurai T, Tobe T, Nakagawa T*. Oral administration of nicotinamide mononucleotide is safe and efficiently
increases blood NAD+ levels in healthy subjects. Front Nutr.9(1):868640. (2022) (*Corresponding author)
2021年
42. Nawaz A, Nishida Y, Takikawa A, Fujisaka S, Kado T, Aminuddin A, Bilal M, Jeelani I, Aslam MR, Nishimura A, Kuwano T, Watanabe Y, Igarashi Y, Okabe K, Ahmed S, Manzoor A, Usui I, Yagi K, Nakagawa T, Tobe T. Astaxanthin, a Marine Carotenoid Maintains the Tolerance and Integrity of Adipose Tissue and Contributes to its Healthy Functions.Nutrients.13(12): 4374. (2021)
41. Yaku K, Palikhe S, Izumi H, Yoshida T, Hikosaka H, Hayat F, Karim M,
Iqbal T, Nitta Y, Sato A, Migaud ME, Ishihara K, Mori H, Nakagawa T*. BST1 regulates nicotinamide riboside metabolism via its glycohydrolase
and base-exchange activities. Nat Commun. 12(1): 6767. (2021) (*Corresponding author)
40. Fushimura Y, Hoshino A, Furukawa S, Nakagawa T, Hino T, Taminishi S, Minami Y, Urata R, Iwai-Kanai E, Matoba S. Orotic acid protects pancreatic β cell by p53 inactivation in diabetic mouse model. Biochem Biophys Res Commun. 585(1):191-195. (2021)
39. Bilal M, Nawaz A, Kado T, Aslam MR, Igarashi Y, Nishimura Y, Watanabe
Y, Kuwano T, Liu J, Miwa H, Era T, Ikuta J, Imura J, Yagi K, Nakagawa T, Fujisaka S, Tobe K. Fate of adipocyte progenitors during adipogenesis
in mice fed a high-fat diet. Mol Metab. 54: 101328. (2021)
38. Hikosaka K, Yaku K, Okabe K, Nakagawa T*. Implications of NAD Metabolism in Pathophysiology and Therapeutics for Neurodegenerative Diseases. Nutr Neurosci.24(5):371-383. (2021) (*Corresponding author)
37. Yamamoto T, Yaku K, Nakagawa T*. Simultaneous Measurement of Amino Acid Enantiomers in Aged Mouse Brain
Samples by LC/MS/MS Combined with Derivatization Using Nα-(5-Fluoro-2,4-dinitrophenyl)-L-leucinamide
(L-FDLA). Metabolites. 11(1): 57. (2021)(*Corresponding author)
2020年
36. Hanasaki M, Yaku K , Yamauchi M, Nakagawa T, Masumoto H. Deletion of the GAPDH gene contributes to genome stability in Saccharomyces cerevisiae. Sci Rep. 10(1): 21146. (2020)
35. Okabe K, Nawaz A, Nishida Y, Yaku K, Usui I, Tobe K, Nakagawa T*. NAD+ metabolism regulates preadipocyte differentiation by enhancing α-ketoglutarate-mediated histone H3K9 demethylation at the PPARγ promoter. Front Cell Dev Biol. 8(1): 586179. (2020)(*Corresponding author)
34. Fujisaka S, Usui I, Nawaz A, Igarashi Y, Okabe K, Furusawa Y, Watanabe S, Yamamoto S, Sasahara M, Watanabe Y, Nagai Y, Yagi K, Nakagawa T, Tobe K. Bofutsushosan improves gut barrier function with a bloom of Akkermansia muciniphila and improves glucose metabolism in mice with diet-induced obesity. Sci Rep. 10(1): 5544. (2020)
33. Nishida Y, Nawaz A, Kado T, Takikawa A, Igarashi Y, Yamamoto S, Sasahara
M, Imura J, Tokuyama K, Usui I, Nakagawa T, Fujisaka S, Yagi K, Tobe K. Astaxanthin stimulates mitochondrial biogenesis
in insulin resistant muscle via activation of AMPK pathway. J Cachexia Sarcopenia Muscle.11(1):241-258. (2020)
32. Yasukawa K, Kinoshita D, Yaku K, Nakagawa T, Koshiba T. The microRNAs miR-302b and miR-372 regulate mitochondrial
metabolism via the SLC25A12 transporter, which controls MAVS-mediated antiviral
innate immunity. J Biol Chem.295(2):444-457. (2020)
2019年
31.Yaku K, Okabe K, Gulshan M, Takatsu K, Okamoto H, Nakagawa T*. Metabolism and biochemical properties of nicotinamide adenine dinucleotide (NAD) analogs, nicotinamide guanine dinucleotide (NGD) and nicotinamide hypoxanthine dinucleotide (NHD). Sci Rep. 9(1): 13102. (2019) (*Corresponding author)
30. Okabe K, Yaku K, Tobe K, Nakagawa T*. Implications of altered NAD metabolism in metabolic disorders. J Biomed Sci. 26: 34. (2019) (*Corresponding author).
29. Takikawa A, Usui I, Fujisaka S, Tsuneyama T, Okabe K, Nakagawa T, Nawaz A, Kado T, Jojima T, Aso Y, Hayakawa Y, Yagi K, Tobe T.Macrophage-specific HIF-1α deletion suppresses the development of liver tumors in high fat diet-fed obese and diabetic mice. J Diabetes Investig.10(6):1411-1418.(2019)
2018年
28. Yaku K, Okabe K, Hikosaka K, Nakagawa T*. NAD metabolism in cancer therapeutics. Front Oncol. 8: 622. (2018) (*Corresponding author)
27. Matsui S, Sasaki T, Kohno D, Yaku K, Inutsuka A, Yokota-Hashimoto H, Kikuchi O, Suga T, Kobayashi M, Yamanaka A, Harada A, Nakagawa T, Onaka T, Kitamura T. Neuronal SIRT1 regulates macronutrient-based diet selection through FGF21 and oxytocin signaling in mice. Nat Commun. 9(1): 4640. (2018)
26. Okabe K, Usui I, Yaku K, Hirabayashi Y, Tobe K, Nakagawa T*. Deletion of PHGDH in adipocytes improves glucose intolerance in diet-induced
obese mice. Biochem Biophys Res Commun. 504(1): 309-314. (2018) (*Corresponding author)
25. Nawaz A, Mehmood A, Kanatani Y, Kado T, Igarashi Y, Takikawa A, Yamamoto S, Okabe K, Nakagawa T, Yagi K, Fujisaka S, Tobe K. Sirt1 activator induces proangiogenic genes in preadipocytes to rescue insulin resistance in diet-induced obese mice. Sci Rep. 8(1):11370. (2018)
24. Gulshan M, Yaku K, Okabe K, Mahmood A, Sasaki T, Yamamoto M, Hikosaka K, Usui I, Kitamura T, Tobe K, Nakagawa T*. Overexpression of Nmnat3 efficiently increases NAD and NGD levels and ameliorates age-associated insulin resistance. Aging Cell.17(4): e12798. (2018) (in press) (*Corresponding author)
23. Yaku K, Okabe K, Nakagawa T*. NAD metabolism: Implications in aging and longevity. Ageing Res Rev. 47: 1-17. (2018) (*Corresponding author)
22. Yaku K, Okabe K, Nakagawa T*. Simultaneous Measurement of NAD Metabolome in Aged Mice Tissue Using Liquid Chromatography Tandem-Mass Spectrometry (LC/MS/MS). Biomed Chromatogr. 32(6):e4205. (*Corresponding author)
2017年
21. Yamamoto M, Inohara H, Nakagawa T*. Targeting Metabolic Pathways for Head and Neck Cancers Therapeutics.
Cancer Metastasis Rev. 36(3): 503-514. (2017) (*Corresponding author)
20. Nawaz A, Aminuddin A, Kado T, Takikawa A, Yamamoto S, Tsuneyama K,
Igarashi Y, Ikutani M, Nishida Y, Nagai Y, Takatsu K, Imura J, Sasahara
M, Okazaki Y, Ueki K, Okamura T, Tokuyama K, Ando A, Matsumoto M, Mori
H, Nakagawa T, Kobayashi N, Saeki K, Usui I, Fujisaka S, Tobe T. CD206+ M2-like macrophages
regulate systemic glucose metabolism by inhibiting proliferation of adipocyte
progenitors. Nat Commun. 8(1): 286. (2017)
19. Talukdar G, Inoue R, Yoshida T, Ishimoto T, Yaku K, Nakagawa T, Mori H. Novel role of serine racemase in anti-apoptosis and metabolism.
Biochim Biophys Acta. 1861(1): 3378–3387. (2017)
2016年
18. Takikawa A, Mahmood A, Nawaz A, Kado T, Okabe K, Yamamoto S, Arif A,
Senda S, Tsuneyama K, Igarashi Y, Ikutani M, Nagai Y, Takatsu K, Fukuhara
A, Koizumi K, Imura J, Goda N, Sasahara S, Shimomura I, Matsumoto M, Saeki
K, Nakagawa T, Fujisaka S, Usui I, Tobe T. HIF-1α in myeloid cells promotes adipose
tissue remodeling toward insulin resistance. Diabetes. 65(12): 3649-3659. (2016)
17. Sasaki Y, Nakagawa T, Mao X, DiAntonio A, Milbrandt J. NMNAT1 inhibits axon degeneration via
blockade of SARM1-mediated NAD+ depletion. eLife. 5:e19749 (2016)
16. Takikawa A, Usui I, Fujisaka S, Ikutani M, Senda S, Hattori S, Tsuneyama
K, Koshimizu Y, Inoue R, Tanaka-Hayashi A, Nakagawa T, Nagai Y, Takatsu K, Sasaoka T, Mori H, Tobe K. Deletion of SIRT1 in myeloid
cells impairs glucose metabolism with enhancing inflammatory response to
adipose tissue hypoxia. Diabetology Int. 7(1): 59-68. (2016)
15. Yamamoto M, Hikosaka K, Mahmood A, Tobe K, Shojaku H, Nakagawa T*. Nmnat3 is dispensable in mitochondrial NAD level maintenance in vivo.
PLOS ONE 11(1): e0147037. (2016) (*Corresponding author)
2015年
14. Yoon MJ, Yoshida M, Johnson S, Takikawa A, Usui I, Tobe K, Nakagawa T, Yoshino J, Imai SI. SIRT1-Mediated eNAMPT Secretion from Adipose Tissue Regulates Hypothalamic NAD+ and Function in Mice. Cell Metab. 21(1): 1-12. (2015)
2014年
13. Hikosaka K, Ikutani M, Shito M, Kazuma K, Gulshan M, Nagai Y, Takatsu
K, Konno H, Tobe K, Kanno H, Nakagawa T*. Deficiency of Nicotinamide Mononucleotide Adenylyltransferase 3 (Nmnat3)
Causes Hemolytic Anemia by Altering the Glycolytic Flow in Mature Erythrocytes.
J Biol Chem. 289(21): 14796-14811. (2014) (*Corresponding author)
12. Nakagawa T*, Guarente L, SnapShot: Sirtuins, NAD and Aging. Cell Metab. 20(1): 192. (2014) (*Co-Corresponding author)
11. Sasaki T, Kikuchi O, Shimpuku M, Susanti VY, Yokota-Hashimoto H, Taguchi
R, Shibusawa N, Sato T, Tang L, Amano K, Kitazumi T, Kuroko M, Fujita Y,
Maruyama J, Lee YS, Kobayashi M, Nakagawa T, Minokoshi Y, Harada A, Yamada M, Kitamura T. Hypothalamic SIRT1 prevents
age-associated weight gain by improving leptin sensitivity in mice. Diabetologia. 57(4): 819-831. (2014)
2013年以前
10. Nakagawa T, Guarente L, Sirtuins at a glance. J Cell Sci. 124(6): 833-838. (2011)
9. Nakagawa T, Guarente L. Urea Cycle Regulation by Mitochondrial Sirtuin, SIRT5. Aging. 1(6): 578-581. (2009)
8. Nakagawa T, Lomb D, Haigis MC, Guarente L. SIRT5 Deacetylates Carbamoyl Phosphate
Synthetase 1 and Regulates the Urea Cycle. Cell. 137(3): 560–570. (2009)
7. Mizuta T, Shimizu S, Matsuoka Y, Nakagawa T, Tsujimoto Y. A BAX/BAK- independent mechanism of cytochrome c release.
J Biol Chem. 282(22): 16623-16630. (2007)
6. Tsujimoto Y, Nakagawa T, Shimizu S. Mitochondrial membrane permeability transition and cell death.
Biochim Biophys Acta. 1757(9-10): 1297-1300. (2006)
5. Nakagawa T, Shimizu S, Watanabe T, Yamaguchi O, Otsu K, Hirotaka Y, Inohara H, Kubo
T, Tsujimoto Y. Cyclophilin D-dependent mitochondrial permeability transition
regulates some necrotic, but not apoptotic cell death. Nature. 434(7033): 652-658. (2005)
4. Inohara H, Inoue T, Akahani S, Yamamoto Y, Takenaka Y, Nakagawa T, Isohashi F, Kubo T. Concurrent Chemoradiotherapy with Cisplatin and Docetaxel
for Advanced Head and Neck Cancer. A Phase I Study. Anticancer Research. 24(6): 4135-4140. (2004)
3. Nakagawa T, Hattori K, Iwata N, Tsujimura T. Papillary cystadenocarcinoma arising
from minor salivary glands in the anterior portion of the tongue. Auris Nasus Larynx. 29(1): 87-90. (2002)
2. Iwata N, Hattori K, Nakagawa T, Tsujimura T. Hemangioma of the nasal cavity: a clinicopathologic study.
Auris Nasus Larynx. 29(4): 335-339. (2002)
1. Kawai Y, Morimoto S, Sakaguchi K, Yoshino H, Yotsui T, Hirota S, Inohara
H, Nakagawa T, Hattori K, Kubo T, Yang J, Fujiwara N, Ogihara T. Oncogenic osteomalacia
secondary to nasal tumor with decreased urinary excretion of cAMP. J Bone Miner Metab. 19(1): 61-64. (2001)