Research and Development of
Hyper Dry human amniotic membrane
(HD-AM)

Achievements

2020

Original work

  1. Fathy M, Okabe M, Saad Eldien HM, Yoshida T. AT-MSCs Antifibrotic Activity is Improved by Eugenol through Modulation of TGF- β /Smad Signaling Pathway in Rats. Molecules. 2020 Jan 15; 25(2): 348. doi: 10.3390/molecules25020348.
  2. Fathy M, Okabe M, M Othman E, Saad Eldien HM, Yoshida T. Preconditioning of Adipose-Derived Mesenchymal Stem-Like Cells with Eugenol Potentiates Their Migration and Proliferation In Vitro and Therapeutic Abilities in Rat Hepatic Fibrosis. Molecules. 2020 Apr 26; 25(9): 2020. doi: 10.3390/molecules25092020.
  3. Oba J, Okabe M, Yoshida T, Soko C, Fathy M, Amano K, Kobashi D, Wakasugi M, Okudera H. Hyperdry human amniotic membrane application as a wound dressing for a full-thickness skin excision after a third-degree burn injury. Burns Trauma. 2020 Jul 27; 8: tkaa014. doi: 10.1093/burnst/tkaa014. eCollection 2020.

Patent application

  1. inventors:Motonori OKABE, Toyama, Toshiko YOSHIDA, Kyouko HAYASHI, Masahiko ARAKAWA，assignee：Motonori OKABE, Toyama, Toshiko YOSHIDA, Kyouko HAYASHI，SAKURA SEIKI CO., LTD.，VIRAL INACTIVATION METHOD, METHOD FOR PRODUCING DRIED AMNION, AND DRIED AMNION．JP.P. 2021 / 527055

2021

book

  1. Toshiko YOSHIDA,Motonori OKABE, ．Placenta and regenerative medicine (including fetal membrane)；p. 43-50.,HORMONE FRONTER IN GYNECOLOGY. Japan：Medical Review Co., Ltd.,2021

Original work

  1. Zukawa M, Okabe M, Osada R, Makino H, Nogami M, Seki S, Yoshida T, Kimura T, Kawaguchi Y. Effect of hyperdry amniotic membrane in preventing tendon adhesion in a rabbit model. J Orthop Sci. 2021 Apr 28; S0949-2658(21): 122-126., doi: 10.1016/j.jos.2021.03.005.
  2. Abdel-Hamid NM, Fathy M, Koike C, Yoshida T, Okabe M, Zho K, Abouzied M, Nikaido T. Identification of Chemo and Radio-Resistant Sub-Population of Stem Cells in Human Cervical Cancer HeLa Cells. Cancer Invest. 2021 Sep; 39(8): 661-674., doi:10.1080/07357907.2021.1931875. Epub 2021 Jul 8.
  3. Koike N, Sugimoto J, Okabe M, Arai K, Nogami M, Okudera H, Yoshida T. Distribution of Amniotic Stem Cells in Human Term Amnion Membrane. Microscopy (Oxf). 2021 Sep 18; edfab035. doi: 10.1093/jmicro/dfab035.

2022

Original work

  1. Kumiko Fujiwara , Hiroaki Tsuno , Motonori Okabe , Toshiko Yoshida , Shuichi Imaue , Kei Tomihara, Naoya Arai , Makoto Noguchi, Clinical Application of Hyperdry Amniotic Membrane in Cleft Palate Repair., The Cleft Palate Craniofacial Journal, 2022, doi: 10.1177/10556656221075937
  2. Arai Kenichi, Okabe Motonori, Kobashi Daisuke, Ichimura Kenji, Fathy Moustafa, Oba Jiro, Furuichi Etsuko, Yoshida Satoshi, Yoshida Toshiko, Importance of Housekeeping Gene Optimization for the Analysis of mRNA Expression During Wound Healing in a Third-Degree Burn Injury Model, Journal of burn care & research : official publication of the American Burn Association, 2023, 44, 146 – 157
  3. Amano Koji, Okabe Motonori, Yoshida Toshiko, Oba Jiro, Yoshid Satoshi, Wakasugi Masahiroe, Usui Akihiro, Nakata Yasuki, Okudera Hiroshi, Hyperdry Human Amniotic Membrane as a Protective Dressing for Open Wounds With Exposed Bowel in Mice, Journal of Surgical Research, 2023, 283, 898 - 913

Patent acquisition

  1. inventors:Motonori OKABE, Toyama, Toshiko YOSHIDA, Kyouko HAYASHI, Masahiko ARAKAWA，assignee：Motonori OKABE, Toyama, Toshiko YOSHIDA, Kyouko HAYASHI，SAKURA SEIKI CO., LTD.，VIRAL INACTIVATION METHOD, METHOD FOR PRODUCING DRIED AMNION, AND DRIED AMNION．JP,7202582,B. Application Date：2021.1.26(R03.1.26)

2023

Original work

  1. Kenichi Arai, Motonori Okabe, Daisuke Kobashi, Kenji Ichimura, Moustafa Fathy, Jiro Oba, Etsuko Furuichi, Satoshi Yoshida, Toshiko Yoshida. Importance of Housekeeping Gene Optimization for the Analysis of mRNA Expression During Wound Healing in a Third-Degree Burn Injury Model. Journal of burn care & research : official publication of the American Burn Association. 2023 Jan 5; 44(1): 146-157. doi: 10.1093/jbcr/irac161.
  2. Koji Amano, Motonori Okabe, Toshiko Yoshida, Jiro Oba, Satoshi Yoshida, Masahiro Wakasugi, Akihiro Usui, Yasuki Nakata, Hiroshi Okudera. Hyperdry Human Amniotic Membrane as a Protective Dressing for Open Wounds With Exposed Bowel in Mice. Journal of Surgical Research. 2023 Mar; 283: 898-913. doi: 10.1016/j.jss.2022.09.028.

Patent acquisition

  1. Inventors;ToshikoYoshida,Motonori Okabe,RyusukeOsada,Mineyuki Zukawa,Masahiko Arakawa, Assignee;ToshikoYoshida,Motonori Okabe,RyusukeOsada,Mineyuki Zukawa,SAKURA SEIKI CO., LTD.. 「REGENERATIONOFTENDONAND TENDON SHEATH,RESTORATIO MATERIAL,ANDUSEOFRESTORATION MATERIAL」. JAPAN:P7219903. 2023.2.1(R5.02.01)
  2. Inventors;Kouji Amano,ToshikoYoshida,Motonori Okabe,Chika Souko,Masahiko Arakawa, Assignee;Univ. TOYAMA,SAKURA SEIKI CO., LTD..WOUND CONTACT MEMBER. JAPAN, P7336784. Registration:2023.08.24(R5.08.24)

2024

Original work

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Patent acquisition

  1. Inventors;ToshikoYoshida,Motonori Okabe,RyusukeOsada,Mineyuki Zukawa,Masahiko Arakawa,Assignees:ToshikoYoshida,Motonori Okabe, RyusukeOsada, Mineyuki Zukawa, SAKURA SEIKICO.,LTD.,「REGENERATIONOFTENDONAND TENDON SHEATH,RESTORATION MATERIAL,ANDUSEOFRESTORATION MATERIAL」US 12,246,109B2, 20250311

2025

Original work

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Patent acquisition

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2026

Original work

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Patent acquisition

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