遺伝子解析
当教室では2000年頃より遺伝子研究用の血液検体収集を行っており、特に研究用の頭部MRI撮像を行う際に同意が得られれば遺伝子採血も併せて行ってきました。2014年頃までは富山大で収集したデータを用いたImaging geneticsの論文が公表できていましたが（論文1-5, 7）、精神科領域の遺伝子研究で求められる症例数はここ最近では膨大となっており、単一施設のみで収集した検体を用いて遺伝子研究を行っていくのは困難な状況です。このため、現在は主に「認知ゲノム共同研究機構 (Cognitive collaborative research organization, COCORO)」などの多施設共同研究の枠組みのなかで遺伝子解析のための血液検体収集を継続しています（論文6）。最近では、Broad Instituteと本邦多施設の共同研究である「多施設共同研究による精神疾患関連遺伝子の探索」に検体を提供しました。また名古屋大学を中心とした共同研究により、富山のDNAサンプルも加えた遺伝子研究を質の高い雑誌に公表しています（論文8-10）。
当グループの論文業績
1) Takahashi T, Suzuki M, Tsunoda M, Kawamura Y, Takahashi N, Tsuneki H, Kawasaki Y, Zhou S-Y, Kobayashi S, Sasaoka T, Seto H, Kurachi M, Ozaki N. Association between the brain-derived neurotrophic factor Val66Met polymorphism and brain morphology in a Japanese sample of schizophrenia and healthy comparisons. Neurosci Lett 435 (1): 34-39, 2008.
2) Takahashi T, Suzuki M, Tsunoda M, Kawamura Y, Takahashi N, Maeno N, Kawasaki Y, Zhou S-Y, Hagino H, Niu L, Tsuneki H, Kobayashi S, Sasaoka T, Seto H, Kurachi M, Ozaki N. The association of genotypic combination of the DRD3 and BDNF polymorphisms on the adhesio interthalamica and medial temporal lobe structures. Prog Neuropsychopharmacol Biol Psychiatry 32 (5): 1236-1242, 2008.
3) Takahashi T, Suzuki M, Tsunoda M, Maeno N, Kawasaki Y, Zhou S-Y, Hagino H, Niu L, Tsuneki H, Kobayashi S, Sasaoka T, Seto H, Kurachi M, Ozaki N: The Disrupted-in-Schizophrenia-1 Ser704Cys polymorphism and brain morphology in schizophrenia. Psychiatry Res Neuroimaging 172 (2): 128-135, 2009.
4) Takahashi T, Nakamura Y, Nakamura Y, Aleksic B, Takayanagi Y, Furuichi A, Kido M, Nakamura M, Sasabayashi D, Ikeda M, Noguchi K, Kaibuchi K, Iwata N, Ozaki N, Suzuki M. The polymorphism of YWHAE, a gene encoding 14-3-3epsilon, and orbitofrontal sulcogyral pattern in schizophrenia and healthy subjects. Prog Neuropsychopharmacol Biol Psychiatry 51: 166-171, 2014.
5) Kido M, Nakamura Y, Nemoto K, Takahashi T, Aleksic B, Furuichi A, Nakamura Y, Ikeda M, Noguchi K, Kaibuchi K, Iwata N, Ozaki N, Suzuki M. The polymorphism of YWHAE, a gene encoding 14-3-3epsilon, and brain morphology in schizophrenia: a voxel-based morphometric study. PLoS ONE 9(8): e103571, 2014. DOI: 10.1371/journal.pone.0103571
6) Hashimoto R, Ikeda M, Yamashita F, Ohi K, Yamamori H, Yasuda Y, Fujimoto M, Fukunaga M, Nemoto K, Takahashi T, Tochigi M, Onitsuka T, Yamasue H, Matsuo K, Iidaka T, Iwata N, Suzuki M, Takeda M, Kasai K, Ozaki N. Common variants at 1q36 are associated with superior frontal gyrus volume. Transl Psychiatry 4: e472, 2014.
7) Takahashi T, Nakamura M, Nakamura Y, Aleksic B, Kido M, Sasabayashi D, Takayanagi Y, Furuichi A, Nishikawa Y, Noguchi K, Ozaki N, Suzuki M. The Disrupted-in-Schizophrenia-1 Ser704Cys polymorphism and brain neurodevelopmental markers in schizophrenia and healthy subjects. Prog Neuropsychopharmacol Biol Psychiatry 56: 11-17, 2015.
8) Kushima I, Aleksic B, Nakatochi M, Shimamura T, Shiino T, Yoshimi A, Kimura H, Takasaki Y, Wang C, Xing J, Ishizuka K, Oya-Ito T, Nakamura Y, Arioka Y, Maeda T, Yamamoto M, Yoshida M, Noma H, Hamada S, Morikawa M, Uno Y, Okada T, Iidaka T, Iritani S, Yamamoto T, Miyashita M, Kobori A, Arai M, Itokawa M, Cheng MC, Chuang YA, Chen CH, Suzuki M, Takahashi T, Hashimoto R, Yamamori H, Yasuda Y, Watanabe Y, Nunokawa A, Someya T, Ikeda M, Toyota T, Yoshikawa T, Numata S, Ohmori T, Kunimoto S, Mori D, Iwata N, Ozaki N. High-resolution copy number variation analysis of schizophrenia in Japan. Mol Psychiatry 22(3):430-440, 2017.
9) Kushima I, Aleksic B, Nakatochi M, Shimamura T, Okada T, Uno Y, Morikawa M, Ishizuka K, Shiino T, Kimura H, Arioka Y, Yoshimi A, Takasaki Y, Yu Y, Nakamura Y, Yamamoto M, Iidaka T, Iritani S, Inada T, Ogawa N, Shishido E, Torii Y, Kawano N, Omura Y, Yoshikawa T, Uchiyama T, Yamamoto T, Ikeda M, Hashimoto R, Yamamori H, Yasuda Y, Someya T, Watanabe Y, Egawa J, Nunokawa A, Itokawa M, Arai M, Miyashita M, Kobori A, Suzuki M, Takahashi T, Usami M, Kodaira M, Watanabe K, Sasaki T, Kuwabara H, Tochigi M, Nishimura F, Yamasue H, Eriguchi Y, Benner S, Kojima M, Yassin W, Munesue T, Yokoyama S, Kimura R, Funabiki Y, Kosaka H, Ishitobi M, Ohmori T, Numata S, Yoshikawa T, Toyota T, Yamakawa K, Suzuki T, Inoue Y, Nakaoka K, Goto YI, Inagaki M, Hashimoto N, Kusumi I, Son S, Murai T, Ikegame T, Okada N, Kasai K, Kunimoto S, Mori D, Iwata N, Ozaki N. Comparative Analyses of Copy number variation in autism spectrum disorder and schizophrenia reveal etiological overlap and biological insights. Cell Rep 24(11): 2838-2856, 2018.
10) Kato H, Kushima I, Mori D, Yoshimi A, Aleksic B, Nawa Y, Toyama M, Furuta S, Yu Y, Ishizuka K, Kimura H, Arioka Y, Tsujimura K, Morikawa M, Okada T, Inada T, Shinjo K, Kondo Y, Kaibuchi K, Funabiki Y, Kimura R, Suzuki T, Yamakawa K, Ikeda M, Iwata N, Takahashi T, Suzuki M, Okahisa Y, Takaki M, Egawa J, Someya T, Ozaki N. Rare genetic variants in the gene encoding histone lysine demethylase 4C (KDM4C) and their contributions to susceptibility to schizophrenia and autism spectrum disorder. Transl Psychiatry, 10(1): 421, 2020.